Abstract:
OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism, seven patients with subclinical hypothyroidism and 16 healthy controls. MEASUREMENTS:Computer-assisted analysis by the Desade and Cluster programs. RESULTS:Both computer-assisted programs revealed an increased TSH pulse amplitude in both overt and subclinical hypothyroidism versus controls (Desade: 36.9 +/- 31.4 (mean +/- SD) (P < 0.001) and 2.8 +/- 1.9 (P < 0.001) vs 0.4 +/- 0.2 mU/l; Cluster: 25.6 +/- 25.1 (P < 0.001) and 2.4 +/- 1.4 (P < 0.001) vs 0.4 +/- 0.2 mU/l). TSH pulse frequency remained unchanged with approximately 10 pulses/24 hours. A highly significant correlation was found between the mean 24-hour TSH concentration and the TSH pulse amplitude in all controls and patients but not to TSH pulse frequency. The nocturnal TSH surge was absent in six out of nine patients with overt primary hypothyroidism. The deficient nocturnal rise of TSH in primary hypothyroidism vs controls (22 +/- 51 vs 82 +/- 41%, P < 0.001), was associated with a loss of the usual nocturnal increase in TSH pulse amplitude and frequency. CONCLUSIONS:Mean 24-hour TSH pulse amplitude is increased in primary hypothyroidism, but TSH pulse frequency remains unchanged. The decrease of the nocturnal TSH increase in primary hypothyroidism is associated with a loss of the usual nocturnal increase in TSH pulse amplitude and frequency.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WMdoi
10.1111/j.1365-2265.1992.tb01481.xkeywords:
subject
Has Abstractpub_date
1992-12-01 00:00:00pages
504-10issue
6eissn
0300-0664issn
1365-2265journal_volume
37pub_type
杂志文章abstract:OBJECTIVE:A recent report showing disappointingly low sensitivity and specificity for the oral high dose dexamethasone test in the differential diagnosis of Cushing's syndrome prompted us to re-evaluate the results obtained in our centre using the continuous 7-hour intravenous dexamethasone suppression test for this pu...
journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1992.tb00955.x
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doi:10.1046/j.1365-2265.2002.01618.x
更新日期:2002-10-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.1984.tb00070.x
更新日期:1984-02-01 00:00:00
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doi:10.1111/j.1365-2265.1983.tb02881.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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更新日期:1981-10-01 00:00:00
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doi:10.1111/j.1365-2265.1979.tb02090.x
更新日期:1979-04-01 00:00:00
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doi:10.1111/j.1365-2265.2005.02246.x
更新日期:2005-04-01 00:00:00
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journal_title:Clinical endocrinology
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更新日期:1985-05-01 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2015-10-01 00:00:00
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更新日期:2002-03-01 00:00:00
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更新日期:1983-04-01 00:00:00
abstract::A modified short ACTH test for the detection of heterozygote carriers of 21-hydroxylase deficiency (21-OHD) was applied to twenty-one controls and fourteen parents of children with 21-OHD. The following modifications were introduced: (1) Endogenous ACTH was suppressed by dexamethasone administration prior to the test,...
journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1980.tb01372.x
更新日期:1980-06-01 00:00:00