Abstract：
OBJECTIVE:The frequency and the degree of recovery of anterior pituitary hormone deficits in patients with macroprolactinoma responsive to cabergoline are not clear. Our aim was to evaluate pituitary function in these patients with particular reference to an assessment of the possible restoration of pituitary deficits. SUBJECTS AND METHODS:The records of all subjects prospectively presenting to our Department with macroprolactinomas treated with cabergoline over a 2-year period were reviewed. Pituitary function was assessed at diagnosis and, if abnormal, for three consecutive years for the GH, FSH/LH and ACTH axes, and at 3 years for the TSH axis. RESULTS:Twelve patients were included. Severe GH deficiency was found in 83% at diagnosis and did not resolve in any patient at last assessment. Gonadotrophin deficiency was found in 90% at diagnosis and in 50% at last evaluation (showing reversal in 44% of deficient patients, all achieved within 1 year). ACTH deficiency was found in 17% at diagnosis and it did not reverse in any patient at last assessment. TSH deficiency was found in 36% at diagnosis and in 27% at last assessment (reversal in 25% of deficient patients). CONCLUSIONS:In our study, in a group of patients with macroprolactinoma systematically assessed at intervals, pituitary dysfunction in response to cabergoline was found to be mostly irreversible, except for the gonadotroph axis which showed restoration in a subset of subjects following achievement of normoprolactinaemia. It would appear that the reversibility of pituitary axes may be less common than previously thought.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Karavitaki N,Dobrescu R,Byrne JV,Grossman AB,Wass JAdoi
10.1111/cen.12124subject
Has Abstractpub_date
2013-08-01 00:00:00pages
217-23issue
2eissn
0300-0664issn
1365-2265journal_volume
79pub_type
临床试验,杂志文章abstract：:Seven synthetic analogues of somatostatin helped clarify structural requirements for suppression of growth hormone secretion in rats. Size of the ring is not critical; deletions of serine-13, lysine-4 or asparagine-5 result in peptides which retain an appreciable fraction of the activity. The analogue des-Ala1, Gly2, ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1976.tb03835.x
更新日期：1976-01-01 00:00:00
abstract：:Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1978.tb03581.x
更新日期：1978-11-01 00:00:00
abstract：OBJECTIVE:The prevalence of autoimmune polyendocrine syndrome type 1 (APS1) among isolated hypoparathyroidism (HP) or primary adrenal insufficiency (PAI) is not well established. We studied the frequency of APS1 in patients with HP or PAI by measuring interferon-α (IFN-α) antibody levels, a highly sensitive and specifi...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.13111
更新日期：2016-10-01 00:00:00
abstract：BACKGROUND:Between 10 and 30% of the fine needle aspiration biopsies (FNABs) of thyroid nodules are diagnosed as 'indeterminate'. A molecular diagnostic method is needed to reduce unnecessary surgery in this group. In Korea, most thyroid cancer is the classic papillary type and the BRAF(V600E) mutation is highly preval...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2006.02646.x
更新日期：2006-11-01 00:00:00
abstract：:The results obtained with a new test of prolactin (PRL) release in six panhypopituitary patients as compared to fourteen normal subjects (eight females and six males) are presented. The test consists of the i.m. administration of 100 mg of sulpiride and the measurement of plasma PRL by a double antibody radioimmunoass...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1978.tb01494.x
更新日期：1978-03-01 00:00:00
abstract：:A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...
journal_title：Clinical endocrinology
pub_type： 杂志文章,评审
doi：10.1111/j.1365-2265.1987.tb00805.x
更新日期：1987-04-01 00:00:00
abstract：:The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1982.tb01616.x
更新日期：1982-11-01 00:00:00
abstract：:Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1977.tb02005.x
更新日期：1977-02-01 00:00:00
abstract：:Prospective observational studies uniformly link vitamin D deficiency with the incidence of type 2 diabetes mellitus (T2DM), yet trials supplementing participants at risk of T2DM with vitamin D to reduce progression to T2DM have yielded inconsistent results. Inconsistencies between supplementation trials may be due to...
journal_title：Clinical endocrinology
pub_type： 杂志文章,评审
doi：10.1111/cen.12567
更新日期：2014-12-01 00:00:00
abstract：OBJECTIVE:The disruption between the brain and the spinal cord leads to a decentralized sympathetic nervous system in people with chronic, cervical spinal cord lesions. These tetraplegic subjects are prone to disorders of energy metabolism and osteoporosis, and they experience alterations in their body composition with...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2005.02204.x
更新日期：2005-02-01 00:00:00
abstract：OBJECTIVE:There is increasing evidence for the role of cytokines in pituitary differentiated function and tumorigenesis, but the spectrum of cytokines found in the pituitary is unknown. Therefore profiles of cytokine expression were determined in different human anterior pituitary adenoma sub-types. DESIGN:The reverse...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.1996.d01-1554.x
更新日期：1996-08-01 00:00:00
abstract：:A major physiological role of calcitonin in humans appears to be regulation of skeletal turnover. It has been suggested that another function of calcitonin is to prevent post-prandial rises in calcium, particularly in animals, but the importance of such a function in man remains to be determined. Although it is known ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1985.tb03002.x
更新日期：1985-05-01 00:00:00
abstract：OBJECTIVE:Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore, we investigated the adi...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12639
更新日期：2015-02-01 00:00:00
abstract：OBJECTIVE:The success of a low-iodine diet (LID) is best determined by measurement of 24-h urine iodine (U-I) excretion. The aim of this study was to determine reliable estimates for 24-h U-I based on spot-urine samples and to provide cut-offs to determine the effectiveness of LID preparation. DESIGN:We prospectively ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2009.03774.x
更新日期：2010-07-01 00:00:00
abstract：OBJECTIVE:Oestradiol sensitizes the pituitary to GnRH, while gonadotrophin surge attenuating factor (GnSAF) may oppose this action. Using the LH response to GnRH during treatment with FSH as an in vivo bioassay for GnSAF, we tested the hypothesis that the augmented LH response to GnRH in the late follicular phase is re...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12306
更新日期：2014-03-01 00:00:00
abstract：:An ornithine infusion test was performed in fifty-four children with constitutional short stature. The ornithine infusion induced an elevated level of GH at 45 min (mean value = 873 pmol/l) and a similar rise of cortisol levels (mean value = 544 nmol/l). An important peak of ACTH appeared 15 min before the increase of...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1982.tb01571.x
更新日期：1982-08-01 00:00:00
abstract：:It has been reported that administration of nomifensine (Nom) or of L-dopa + carbidopa (L-dopa + Carb) potentiates central dopaminergic tonus, resulting in decreased prolactin (PRL) secretion. It has been proposed that these drugs would help to discriminate patients with PRL-secreting pituitary tumours from those with...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1980.tb03420.x
更新日期：1980-12-01 00:00:00
abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.1997.1841000.x
更新日期：1997-06-01 00:00:00
abstract：:Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multifactorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances and, in some patients, supraphysiologic glucocorticoid replacement...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12730
更新日期：2015-08-01 00:00:00
abstract：:Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1984.tb00089.x
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2007.03145.x
更新日期：2008-07-01 00:00:00
abstract：OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2008.03456.x
更新日期：2009-07-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to group patients with MODY (maturity-onset diabetes of the young) according to the genetic alterations underlying the disease and to investigate their clinical characteristics. PATIENTS AND METHODS:Molecular analysis of GCK (MODY2), HNF-1alpha (MODY3), HNF-4alpha (MODY1) and HNF-1b...
journal_title：Clinical endocrinology
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1365-2265.2007.02921.x
更新日期：2007-10-01 00:00:00
abstract：OBJECTIVE:We assessed body composition, bone mineral density (BMD), glucose and lipids in Williams syndrome (WS), a rare microdeletion disorder. DESIGN:Individuals with WS had outpatient assessment at Massachusetts General Hospital. Controls were selected from the National Health and Nutrition Examination Survey (NHAN...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.13829
更新日期：2018-11-01 00:00:00
abstract：OBJECTIVE:In the present study we have performed a grey-scale quantitative analysis of thyroid echogenicity in the patients affected by Hashimoto's thyroiditis (HT), obtaining a numerical estimate of the degree of hypoechogenicity associated with the appearance of thyroid dysfunction. MATERIALS AND METHODS:The study g...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.2003.01829.x
更新日期：2003-08-01 00:00:00
abstract：OBJECTIVE:Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in lack of cortisol and often aldosterone and overproduction of androgens. Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice. D...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2008.03347.x
更新日期：2009-01-01 00:00:00
abstract：OBJECTIVE:Reduction of plasma free fatty acids leads to enhanced GH response after stimulation by GH-releasing hormone (GHRH). We studied the clinical usefulness of combined administration of acipimox and GHRH for the diagnosis of GH deficiency. DESIGN:We evaluated 35 patients [mean age 53.0 years; mean body mass inde...
journal_title：Clinical endocrinology
pub_type： 临床试验,杂志文章
doi：10.1046/j.1365-2265.2003.01684.x
更新日期：2003-02-01 00:00:00
abstract：OBJECTIVE:Microprolactinomas have been reported to resolve spontaneously after pregnancy and there have been suggestions that oestrogen therapy increases the size of microprolactinomas. Little is known, however, about the effect of the menopause in patients previously known to be hyperprolactinaemic. The aim of this st...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.2001.01190.x
更新日期：2001-03-01 00:00:00
abstract：:In order to investigate the endocrine requirements for induction of follicle maturation, ovulation and luteal function we have measured plasma LH and FSH concentrations in 109 cycles induced by treatment with LHRH in 25 women with amenorrhoea of diverse aetiology. The major clinical and endocrine subgroupings were pol...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1985.tb01122.x
更新日期：1985-12-01 00:00:00
abstract：BACKGROUND:Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume. OBJECTIVE:To evaluate the potential usefulness of MR methodology, to estimate adrenal size ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12414
更新日期：2014-08-01 00:00:00
