Voice characteristics in women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

Abstract:

OBJECTIVE:Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in lack of cortisol and often aldosterone and overproduction of androgens. Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice. DESIGN/PATIENTS:A follow-up study of voice characteristics in 38 women with CAH and 24 age-matched controls between 18 and 63 years of age using subjective self-ratings of voice symptoms and acoustic and perceptual analyses. The results were correlated to mutation and treatment. MEASUREMENTS:The subjects rated degree of hoarseness, dark voice, voice problems and vocal fatigue on visual analogue scales. Audio recordings were made of a standard reading passage in a sound treated booth. Acoustic analyses were made of the subjects' mean, minimum and maximum F0 in the habitual speech range. Three voice clinicians made perceptual evaluations of dark voice in terms of timbre. RESULTS:Women with CAH rated higher values than controls with regard to the statement 'my voice is a problem in my daily life'. They spoke with significantly lower mean, lower minimum and lower maximum F0, as well as darker voice quality as compared with the controls. Affected voice symptoms were associated with a late diagnosis or problems with medication. CONCLUSION:The voices in women with CAH can be virilized because of late diagnosis or suboptimal treatment with glucocorticoids. These voice problems may need referral for voice assessment and should be considered when treating CAH.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Nygren U,Södersten M,Falhammar H,Thorén M,Hagenfeldt K,Nordenskjöld A

doi

10.1111/j.1365-2265.2008.03347.x

subject

Has Abstract

pub_date

2009-01-01 00:00:00

pages

18-25

issue

1

eissn

0300-0664

issn

1365-2265

pii

CEN3347

journal_volume

70

pub_type

杂志文章
  • Percutaneous coronary intervention increases leptin and decreases adiponectin levels.

    abstract:OBJECTIVE:The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabol...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02654.x

    authors: Azar RR,Sarkis A,Salameh E,Gannagé-Yared MH,Amm-Azar M,Badaoui G,Germanos M,Kassab R

    更新日期:2006-12-01 00:00:00

  • Distinct clonal composition of primary and metastatic adrencorticotrophic hormone-producing pituitary carcinoma.

    abstract::The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.2001.01322.x

    authors: Zahedi A,Booth GL,Smyth HS,Farrell WE,Clayton RN,Asa SL,Ezzat S

    更新日期:2001-10-01 00:00:00

  • Subclinical hypercortisolism: correlation between biochemical diagnostic criteria and clinical aspects.

    abstract:OBJECTIVE:Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the presence of complications....

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2265.2010.03794.x

    authors: Morelli V,Masserini B,Salcuni AS,Eller-Vainicher C,Savoca C,Viti R,Coletti F,Guglielmi G,Battista C,Iorio L,Beck-Peccoz P,Ambrosi B,Arosio M,Scillitani A,Chiodini I

    更新日期:2010-08-01 00:00:00

  • Insulin-like growth factor-II: its role in metabolic and endocrine disease.

    abstract::Insulin-like growth factor-II (IGF-II) is a widely expressed 7·5 kDa mitogenic peptide hormone. Although it is abundant in serum, understanding of its physiological role is limited compared with that of IGF-I. IGF-II regulates foetal development and differentiation, but its role in adults is less well understood. Evid...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1111/cen.12446

    authors: Livingstone C,Borai A

    更新日期:2014-06-01 00:00:00

  • Osmoregulation of thirst and vasopressin secretion in Kallmann's syndrome.

    abstract::It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1989.tb01426.x

    authors: Thompson CJ,White MC,Baylis PH

    更新日期:1989-05-01 00:00:00

  • Failure of positive feedback of oestradiol during chronic intranasal luteinizing hormone-releasing hormone agonist treatment.

    abstract::An oestrogen provocation test was performed in five healthy women during chronic intranasal treatment with 400 or 600 micrograms of the superactive LHRH agonist D-Ser(TBU)6-EA10-LHRH daily. Oestradiol benzoate 2.5 mg was administered intramuscularly after at least 3 months of LHRH agonist treatment. The serum levels o...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1982.tb03158.x

    authors: Bergquist C,Nillius SJ,Wide L

    更新日期:1982-02-01 00:00:00

  • A comparison of the overnight and the standard metyrapone test for the differential diagnosis of adrenocorticotrophin-dependent Cushing's syndrome.

    abstract:OBJECTIVE:We wished to develop optimal criteria for interpreting the single-dose overnight metyrapone test and to compare the diagnostic efficiency of the overnight and the standard 6-dose metyrapone tests for the differential diagnosis of ACTH-dependent Cushing's syndrome. DESIGN:Retrospective pilot study based on al...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1996.8170827.x

    authors: Avgerinos PC,Nieman LK,Oldfield EH,Cutler GB Jr

    更新日期:1996-10-01 00:00:00

  • A new germline VHL gene mutation in three patients with apparently sporadic pheochromocytoma.

    abstract:CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12032

    authors: D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

    更新日期:2013-03-01 00:00:00

  • Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF-I and endogenous IGFBP-3.

    abstract::Seckel syndrome is an autosomal-recessive disorder with a frequency of less than 1/10 000 births in which there are multiple malformations including severe short stature. We report on a patient with Seckel syndrome with a current body height of -7.5 SDS. Laboratory investigations at the age of 19 months revealed high ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.2002.01590.x

    authors: Schmidt A,Chakravarty A,Brommer E,Fenne BD,Siebler T,De Meyts P,Kiess W

    更新日期:2002-08-01 00:00:00

  • Gonadal-pituitary hormone levels in gynaecomastia.

    abstract::Plasma levels of LH, FSH, oestradiol 17 beta and testosterone were measured in twenty-two men with gynaecomastia. The group was divided by age into those under and those over 50-years-old and the mean hormone levels of the two groups were compared with two groups of age-matched normal men. In the young men with gynaec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1980.tb01025.x

    authors: McFadyen IJ,Bolton AE,Cameron EH,Hunter WM,Raab G,Forrest AP

    更新日期:1980-07-01 00:00:00

  • Association of LMNA 1908C/T polymorphism with cerebral vascular disease and diabetic nephropathy in Japanese men with type 2 diabetes.

    abstract:OBJECTIVE:The LMNA 1908C/T polymorphism has been reported to be associated with dyslipidaemia, metabolic syndrome, adipose tissue metabolism and obesity phenotypes, suggesting that this polymorphism presents an increased risk of atherosclerosis and vascular diseases. However, there have been no previous reports on the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02344.x

    authors: Liang H,Murase Y,Katuta Y,Asano A,Kobayashi J,Mabuchi H

    更新日期:2005-09-01 00:00:00

  • Effect of thyroxine on the inactivation of thyrotrophin-releasing hormone by rat and human plasma.

    abstract::The inactivation of synthetic [3H]thyrotrophin-releasing hormone (TRH) by plasma was studied in rats treated with propylthiouracil (PTU) alone or with PTU and thyroxine. 48 h after the onset of treatment with thyroxine, the capacity of rat plasma to inactivate [3H]TRH was significantly increased. The percentage of dea...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1976.tb01961.x

    authors: Dupont A,Labrie F,Levasseur L,Dussault JH,Schally AV

    更新日期:1976-07-01 00:00:00

  • Growth hormone (GH) responses to arginine and L-dopa alone and after GHRH pretreatment.

    abstract::In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.), arginine (30 g i.v. over 30 min) and L-dopa (500 mg orally) administered alone and 120 minutes following pretreatment with GHRH 1-44 (200 micrograms i.v.) in no...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1988.tb03690.x

    authors: Page MD,Dieguez C,Valcavi R,Edwards C,Hall R,Scanlon MF

    更新日期:1988-05-01 00:00:00

  • Recent concerns surrounding HRT.

    abstract::Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1046/j.1365-2265.2003.01815.x

    authors: Armitage M,Nooney J,Evans S

    更新日期:2003-08-01 00:00:00

  • Acute pancreatitis and parotitis induced by methimazole in a patient with Graves' disease.

    abstract::A wide variety of adverse effects of methimazole (MMI) have been reported. Here we report a new MMI-induced disorder, acute pancreatitis and parotitis. Three weeks after a woman started MMI treatment for Graves' disease, she developed a high fever, painful parotid swelling and dull pain in the upper abdomen with eleva...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1999.00888.x

    authors: Taguchi M,Yokota M,Koyano H,Endo Y,Ozawa Y

    更新日期:1999-11-01 00:00:00

  • Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum.

    abstract:BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13150

    authors: Rogers SL,Hughes BA,Tomlinson JW,Blissett J

    更新日期:2016-12-01 00:00:00

  • Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self-reporting very good health: the healthy man study.

    abstract:OBJECTIVE:To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men. DESIGN:Observational, repeated measures study. PARTICIPANTS:Men (n = 325) with 40 years and older s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2012.04432.x

    authors: Sartorius G,Spasevska S,Idan A,Turner L,Forbes E,Zamojska A,Allan CA,Ly LP,Conway AJ,McLachlan RI,Handelsman DJ

    更新日期:2012-11-01 00:00:00

  • Plasma androgenic activity in women with acne vulgaris and in healthy girls before, during and after puberty.

    abstract::The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increase during p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1982.tb00713.x

    authors: Odlind V,Carlström K,Michaëlsson G,Vahlqvist A,Victor A,Mellbin T

    更新日期:1982-03-01 00:00:00

  • A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients.

    abstract::The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1987.tb00834.x

    authors: Lamberts SW,Verleun T,Hofland L,Del Pozo E

    更新日期:1987-07-01 00:00:00

  • The basal plasma glucose: a simple relevant index of maturity-onset diabetes.

    abstract::The 'basal' plasma glucose, defined as the stable overnight concentration, has been assessed as an index of diabetes control by comparison with plasma glucose measurements during 24-h profiles in diet-treated maturity-onset diabetic patients and normal subjects. The basal plasma glucose correlated with the total (r=0....

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1981.tb00196.x

    authors: Holman RR,Turner RC

    更新日期:1981-03-01 00:00:00

  • A new and distinctive albumin variant with increased affinities for both triiodothyronines and causing hyperthyroxinaemia.

    abstract::A new variant albumin with increased affinities for iodothyronines has been identified. A euthyroid woman had raised total serum concentrations of T4 (155 nmol/l), T3 (3.0 nmol/l) and rT3 (700 pmol/l) but normal levels of all three iodothyronine-binding proteins. The affinity constant for T3 binding to the albumin was...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb00152.x

    authors: Lalloz MR,Byfield PG,Himsworth RL

    更新日期:1985-04-01 00:00:00

  • What is the best approach to the teenage patient presenting with nonclassical congenital adrenal hyperplasia: should we always treat with glucocorticoids?

    abstract::Patients with Congenital adrenal hyperplasia due to partial deficiency in the enzyme 21-hydroxylase can present in childhood or adolescence with signs of adrenal androgen excess. Strategies to reduce the impact of androgen excess in females include cosmetic measures as well as antiandrogens and agents such as the comb...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12065

    authors: Matthews D,Cheetham T

    更新日期:2013-03-01 00:00:00

  • Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area.

    abstract::Subjects living in iodine deficient areas were reported to have elevated serum thyroglobulin (Tg) concentrations. This finding was interpreted as related to thyroid stimulation. Discrepant results, however, were found when serum Tg concentrations were correlated either with serum TSH or with goitre size. In this study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1985.tb00205.x

    authors: Fenzi GF,Ceccarelli C,Macchia E,Monzani F,Bartalena L,Giani C,Ceccarelli P,Lippi F,Baschieri L,Pinchera A

    更新日期:1985-08-01 00:00:00

  • Bone mineral density and bone turnover in relation to serum leptin, alpha-ketoglutarate and sex steroids in overweight and obese postmenopausal women.

    abstract:OBJECTIVE:Recent studies have shown that parallel changes in body weight and bone mass can be partially mediated via circulating leptin. Therefore, among the hormones involved in bone and mineral metabolism, such as oestrogens, testosterone and parathormone, leptin has recently become a subject of considerable interest...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2008.03313.x

    authors: Filip R,Raszewski G

    更新日期:2009-02-01 00:00:00

  • Evidence for a hypothalamic alteration of catecholamine metabolism in polycystic ovary syndrome.

    abstract::The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1988.tb01230.x

    authors: Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

    更新日期:1988-09-01 00:00:00

  • Impaired body balance, fine motor function and hearing in women with Turner syndrome.

    abstract:OBJECTIVE:Fractures are related to falling. Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures and has been considered as a syndrome of early ageing. The aim was to study whether fine motor function (FM) and body balance (BB) were impaired and related to genotype, fractures, metabolic vari...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2008.03473.x

    authors: El-Mansoury M,Barrenäs ML,Bryman I,Hanson C,Landin-Wilhelmsen K

    更新日期:2009-08-01 00:00:00

  • Problems in diagnosing atypical Gitelman's syndrome presenting with normomagnesaemia.

    abstract:OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2009.03649.x

    authors: Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

    更新日期:2010-02-01 00:00:00

  • Growth hormone receptor isoforms and fracture risk in adult-onset growth hormone-deficient patients.

    abstract:INTRODUCTION:Growth hormone deficiency is considered the most important factor determining skeletal fragility in hypopituitary patients. Osteoblasts and chondrocytes express growth hormone (GH) receptor. Two GH receptor isoforms (GHRi) have been identified: they differ for the presence/absence of a protein fragment enc...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13161

    authors: Mormando M,Chiloiro S,Bianchi A,Giampietro A,Angelini F,Tartaglione L,Nasto L,Milardi D,Formenti AM,Giustina A,De Marinis L

    更新日期:2016-11-01 00:00:00

  • Effects of alpha-1 adrenergic blockade on the hormonal response to hypoglycaemic stress in normal man.

    abstract::In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1987.tb03632.x

    authors: Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

    更新日期:1987-01-01 00:00:00

  • Vitamin A and iron supplementation is as efficient as hormonal therapy in constitutionally delayed children.

    abstract:OBJECTIVE:To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. PATIENTS:One hundred and two boys, 13.6-15.5 years of age, who were referred because of short stature and delayed puberty. METHODS:The boys were randomly allocated to one of the following treatmen...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.2004.02034.x

    authors: Zadik Z,Sinai T,Zung A,Reifen R

    更新日期:2004-06-01 00:00:00