A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients.

abstract：:Prospective observational studies uniformly link vitamin D deficiency with the incidence of type 2 diabetes mellitus (T2DM), yet trials supplementing participants at risk of T2DM with vitamin D to reduce progression to T2DM have yielded inconsistent results. Inconsistencies between supplementation trials may be due to...

journal_title：Clinical endocrinology

authors： Shore-Lorenti C,Brennan SL,Sanders KM,Neale RE,Lucas RM,Ebeling PR

更新日期：2014-12-01 00:00:00

abstract：BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In ...

journal_title：Clinical endocrinology

authors： de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr T

更新日期：2010-06-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

journal_title：Clinical endocrinology

authors： Rogol AD,Blethen SL,Sy JP,Veldhuis JD

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined. OBJECTIVE:To investigate its clinical significance in humans, we have established a new specific enzyme-linked i...

journal_title：Clinical endocrinology

authors： Tsuchiya T,Shimizu H,Yamada M,Osaki A,Oh-I S,Ariyama Y,Takahashi H,Okada S,Hashimoto K,Satoh T,Kojima M,Mori M

更新日期：2010-10-01 00:00:00

abstract：:Pituitary-dependent Cushing's syndrome is rare in childhood. Two patients are reported who had unsuccessful transsphenoidal microadenomectomy and therefore underwent pituitary radiotherapy. In both patients there was progressive normalization of hypothalamo-pituitary-adrenal function and at 8 and 10 years after radiot...

journal_title：Clinical endocrinology

authors： Johnston LB,Grossmann AB,Plowman PN,Besser GM,Savage MO

更新日期：1998-05-01 00:00:00

abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...

journal_title：Clinical endocrinology

authors： Dahlberg PA,Karlsson FA,Lundqvist G

更新日期：1981-02-01 00:00:00

abstract：:In order to investigate the endocrine requirements for induction of follicle maturation, ovulation and luteal function we have measured plasma LH and FSH concentrations in 109 cycles induced by treatment with LHRH in 25 women with amenorrhoea of diverse aetiology. The major clinical and endocrine subgroupings were pol...

journal_title：Clinical endocrinology

authors： Abdulwahid NA,Adams J,van der Spuy ZM,Jacobs HS

更新日期：1985-12-01 00:00:00

abstract：OBJECTIVE:Subclinical hypercortisolism (SH) has been associated with increased prevalence of hypertension, type 2 diabetes mellitus, dyslipidaemia, central obesity, osteoporosis and vertebral fractures. We aimed to investigate the accuracy of different SH diagnostic criteria in predicting the presence of complications....

journal_title：Clinical endocrinology

authors： Morelli V,Masserini B,Salcuni AS,Eller-Vainicher C,Savoca C,Viti R,Coletti F,Guglielmi G,Battista C,Iorio L,Beck-Peccoz P,Ambrosi B,Arosio M,Scillitani A,Chiodini I

更新日期：2010-08-01 00:00:00

abstract：:In order to evaluate the possible influence of GABAergic neurotransmission on the arginine vasopressin (AVP) response to osmotic and pressure volumetric stimuli, the GABAergic drug sodium valproate was administered by mouth (200 or 400 mg 16 h, 8 h and just before tests) to eight normal men before osmotic (i.v. infusi...

journal_title：Clinical endocrinology

authors： Chiodera P,Gnudi A,Volpi R,Marchesi C,Marchesi M,Davoli D,Capretti L,Coiro V

更新日期：1989-04-01 00:00:00

abstract：BACKGROUND:Between 10 and 30% of the fine needle aspiration biopsies (FNABs) of thyroid nodules are diagnosed as 'indeterminate'. A molecular diagnostic method is needed to reduce unnecessary surgery in this group. In Korea, most thyroid cancer is the classic papillary type and the BRAF(V600E) mutation is highly preval...

journal_title：Clinical endocrinology

authors： Chung KW,Yang SK,Lee GK,Kim EY,Kwon S,Lee SH,Park DJ,Lee HS,Cho BY,Lee ES,Kim SW

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:Constitutional delay in growth and adolescence (CDGA) is common in boys, some of whom request treatment to accelerate growth and attainment of secondary sexual characteristics. The aims of this study were to confirm that a 3-month course of intramuscular testosterone oenanthate does not impair final height i...

journal_title：Clinical endocrinology

authors： Kelly BP,Paterson WF,Donaldson MD

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVES:Hyponatraemia is strongly associated with increased inpatient mortality, but it is unknown whether hyponatraemia per se contributes to excess mortality. Our hypothesis was that if hyponatraemic patients had significantly greater mortality compared with controls despite no difference with regard to gender, ag...

journal_title：Clinical endocrinology

authors： Tzoulis P,Bagkeris E,Bouloux PM

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

journal_title：Clinical endocrinology

authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:A recent report showing disappointingly low sensitivity and specificity for the oral high dose dexamethasone test in the differential diagnosis of Cushing's syndrome prompted us to re-evaluate the results obtained in our centre using the continuous 7-hour intravenous dexamethasone suppression test for this pu...

journal_title：Clinical endocrinology

authors： van den Bogaert DP,de Herder WW,de Jong FH,Biemond P,van der Lely AJ,Lamberts SW

更新日期：1999-08-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：:Computed tomography of the pituitary fossa was performed in 12 patients with primary hypothyroidism before and after thyroxine treatment. In three, herniation of the diaphragma sellae precluded accurate measurement of the density of the hypophysis. Eight of the remaining patients showed abnormally increased density of...

journal_title：Clinical endocrinology

authors： Katevuo K,Välimäki M,Ketonen L,Lamberg BA,Pelkonen R

更新日期：1985-05-01 00:00:00

abstract：:We designed a systematic study of patients with Cushing's disease to compare the results of acute experiments with cyproheptadine, sodium valproate and bromocriptine with the results of chronic treatment with sodium valproate. In 13 patients the plasma cortisol response to single doses of 2.5 mg bromocriptine, 6 mg cy...

journal_title：Clinical endocrinology

authors： Koppeschaar HP,Croughs RJ,Thijssen JH,Schwarz F

更新日期：1986-12-01 00:00:00

abstract：:The uterine cross-sectional area (UXA) of women with polycystic (PCO) or multifollicular ovaries (MFO) is significantly larger and smaller, respectively, than those of normal women during the early-mid-follicular phase of the menstrual cycle. In the present study the distribution of oestradiol in plasma from normal wo...

journal_title：Clinical endocrinology

authors： Polson DW,Franks S,Reed MJ,Cheng RW,Adams J,James VH

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...

journal_title：Clinical endocrinology

authors： Wide L,Naessén T

更新日期：1994-06-01 00:00:00

abstract：:Growth hormone and prolactin are secreted episodically in man and experimental animals. To investigate physiologic mechanisms of GH and PRL secretion, a series of experiments were performed in individual, unanaesthetized male and female rats. GH secretion in the male rat is characterized by intermittent surges that oc...

journal_title：Clinical endocrinology

authors： Terry LC,Saunders A,Audet J,Willoughby JO,Brazeau P,Martin JB

更新日期：1977-01-01 00:00:00

abstract：OBJECTIVE:Expression of ghrelin has been reported in pancreatic endocrine tumours, but data on ghrelin receptor protein expression are lacking. The aim of this study was to examine the ghrelin receptor, as well as ghrelin, in a selected series of these tumours, including multiple endocrine neoplasia 1 (MEN1) associated...

journal_title：Clinical endocrinology

authors： Ekeblad S,Lejonklou MH,Grimfjärd P,Johansson T,Eriksson B,Grimelius L,Stridsberg M,Stålberg P,Skogseid B

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Durham JA,Kljakovic M,Cooke RR

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine serum adiponectin concentrations in adolescent girls with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin levels with insulin and androgen levels. DESIGN:Prospective case-control study. SETTING:Endocrine clinics in the community. PATIENTS:Forty-f...

journal_title：Clinical endocrinology

authors： Pinhas-Hamiel O,Singer S,Pilpel N,Koren I,Boyko V,Hemi R,Pariente C,Kanety H

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

journal_title：Clinical endocrinology

authors： Laursen T,Jørgensen JO,Christiansen JS

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). DESIGN:Prospective, intervention with both ...

journal_title：Clinical endocrinology

authors： Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

更新日期：2006-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The differentiation of benign from malignant phaeochromocytoma is difficult. We have examined whether the use of flow cytometric determination of nuclear DNA content would be useful as a predictor of malignant behaviour in patients with phaeochromocytoma as some previous studies had suggested t...

journal_title：Clinical endocrinology

authors： Heaney AP,O'Rourke D,Arthur K,Beatty OL,Russell CF,Sloan JM,Hamilton P,Atkinson AB

更新日期：1996-02-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

journal_title：Clinical endocrinology

authors： Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

更新日期：2003-07-01 00:00:00

abstract：:Objective African-Americans have been shown to have low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. Design A survey, representative of the population of Rio de Janeiro, a large metropolitan city in ...

journal_title：Clinical endocrinology

authors： Sichieri R,Baima J,Marante T,de Vasconcellos MT,Moura AS,Vaisman M

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:In January 1997 we introduced a protocol for the treatment with GH of children with impaired growth after unfractionated total body irradiation (TBI). This study is an evaluation of that protocol. PATIENTS AND METHODS:Between January 1997 and July 2005, 66 patients (48 male) treated for haematological malign...

journal_title：Clinical endocrinology

authors： Bakker B,Oostdijk W,Geskus RB,Stokvis-Brantsma WH,Vossen JM,Wit JM

更新日期：2007-10-01 00:00:00

abstract：:Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...

journal_title：Clinical endocrinology

authors： McCormick KL

更新日期：1986-03-01 00:00:00