Abstract:
BACKGROUND:While an association between androgens and the metabolic syndrome (MS) is well established in obese women, studies concerning this relationship are scarce in obese adolescent girls. Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group. METHODS:In 160 obese girls (aged 12-18 years, mean BMI: 32.6 +/- 5.0 kg/m((2))), androgens [testosterone, dehydroepiandrosterone sulphate (DHEA-S), androstenedione], SHBG and the components of MS (waist circumference, blood pressure (BP), lipids, uric acid, insulin, glucose, 2 h glucose in oral glucose tolerance test (oGTT)) were studied. Furthermore, IMT was determined in a subgroup of 71 randomly chosen girls. RESULTS:Testosterone correlated significantly to systolic BP (r = 0.20), diastolic BP (r = 0.24), 2 h glucose in oGTT (r = 0.30), triglycerides (r = 0.19), uric acid (r = 0.17), waist circumference (r = 0.25) and IMT (r = 0.54). These relationships (except for waist circumference and uric acid) were independent of BMI and insulin resistance index homeostasis model assessment. In contrast to testosterone, DHEA-S, androstenedione and SHBG showed no or weaker correlations to any parameter of MS. The 48 girls with MS demonstrated significantly higher testosterone (1.8 +/- 0.7 nmol/l; P = 0.025) and DHEA-S (4.7 +/- 2.3 micromol/l; P = 0.008) concentrations as compared with the 112 girls without MS (mean testosterone 1.5 +/- 0.7 nmol/l, mean DHEA-S 3.6 +/- 2.3 micromol/l). CONCLUSIONS:Testosterone was significantly related to MS and its components in obese adolescent girls independently of BMI and insulin resistance. As IMT was significantly associated with testosterone, this supports the clinical relevance of this finding.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
de Sousa G,Brodoswki C,Kleber M,Wunsch R,Reinehr Tdoi
10.1111/j.1365-2265.2009.03710.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
770-4issue
6eissn
0300-0664issn
1365-2265pii
CEN3710journal_volume
72pub_type
杂志文章abstract::The concentration of immunoreactive inhibin in serum was measured in three pregnant women with premature ovarian failure involved in a donor oocyte in-vitro fertilization programme. Inhibin was not detectable in peripheral serum prior to conception but rose within 2-4 weeks of embryo transfer, whereafter levels rose g...
journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1987.tb02949.x
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doi:10.1046/j.1365-2265.2003.01633.x
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doi:10.1111/j.1365-2265.2008.03177.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1979.tb01359.x
更新日期:1979-02-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1365-2265.1982.tb00729.x
更新日期:1982-04-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章,评审
doi:10.1111/j.1365-2265.2008.03396.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1994.tb02525.x
更新日期:1994-08-01 00:00:00
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1978.tb02222.x
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journal_title:Clinical endocrinology
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pub_type: 杂志文章,评审
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更新日期:2018-09-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1987.tb01183.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1979.tb01360.x
更新日期:1979-02-01 00:00:00
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更新日期:2011-09-01 00:00:00
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更新日期:1996-11-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1985.tb01077.x
更新日期:1985-02-01 00:00:00
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更新日期:2004-12-01 00:00:00
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doi:10.1111/j.1365-2265.1984.tb01405.x
更新日期:1984-12-01 00:00:00