Transient thyrotoxicosis in endemic goitre patients following exposure to a normal iodine intake.

abstract：OBJECTIVE:Since panhypopituitarism in patients with Sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum TSH levels would be low but its circadian rhythm preserved in these patients. DESIGN AND PATIENTS:Basal and TRH-stimulated mean afternoon (150...

journal_title：Clinical endocrinology

authors： Abucham J,Castro V,Maccagnan P,Vieira JG

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

journal_title：Clinical endocrinology

authors： Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

更新日期：2012-01-01 00:00:00

abstract：OBJECTIVE:We have evaluated parameters of growth, the pubertal process and attained adult height in patients with congenital hypothyroidism (CH) of various aetiologies, diagnosed by the neonatal screening programme, and followed up longitudinally. To the best of our knowledge, no such data are available in the publishe...

journal_title：Clinical endocrinology

authors： Dickerman Z,De Vries L

更新日期：1997-12-01 00:00:00

abstract：:In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH respons...

journal_title：Clinical endocrinology

authors： Brown GM,Verhaegan H,Van Wimersma Greidanus TB,Brugmans J

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (PHPT) is an uncommonly diagnosed condition among adolescents and young adults. We review the clinical characteristics of these patients based on our institutional experience. SUBJECTS:Patients aged 12-28 years treated for PHPT at our institution from 1990 to 1996 were evaluated b...

journal_title：Clinical endocrinology

authors： Loh KC,Duh QY,Shoback D,Gee L,Siperstein A,Clark OH

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:Parathyroid carcinoma remains difficult to diagnose. Recently, it has been shown that mutations in the HRPT2 gene (encoding parafibromin) are associated with the development of parathyroid carcinoma. Although MEN1 is not typically thought to be involved in carcinoma formation, parathyroid carcinoma may be an ...

journal_title：Clinical endocrinology

authors： Haven CJ,van Puijenbroek M,Tan MH,Teh BT,Fleuren GJ,van Wezel T,Morreau H

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether, in the absence of gonads, GH could bring forward the age of neuroendocrine activation resulting in onset of puberty. DESIGN:In girls with Turner's syndrome, we evaluated the effects of GH therapy on developmental changes in FSH serum concentrations used as an indicator of ...

journal_title：Clinical endocrinology

authors： Bourguignon JP,Gérard A,Deby-Dupont G,Franchimont P

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and auto...

journal_title：Clinical endocrinology

authors： Jennings CE,Owen CJ,Wilson V,Pearce SH

更新日期：2005-03-01 00:00:00

abstract：OBJECTIVE:Surgery of bone metastases from differentiated thyroid carcinoma seems indicated in individual patients. This study was performed (1) to analyse retrospectively patients with bone metastases from differentiated thyroid carcinoma and (2) to evaluate the impact of surgery of bone metastases on survival. PATIEN...

journal_title：Clinical endocrinology

authors： Zettinig G,Fueger BJ,Passler C,Kaserer K,Pirich C,Dudczak R,Niederle B

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:Polymorphisms in the thyroid transcription factor forkhead factor E1 (FOXE1) gene have been implicated in the genetic susceptibility to differentiated thyroid cancer, but little is known about their effect on tumour characteristics. The objective of this study was to determine the contribution of the FOXE1 po...

journal_title：Clinical endocrinology

authors： Raimundo J,Alvelos MI,Azevedo T,Martins T,Rodrigues FJ,Lemos MC

更新日期：2017-02-01 00:00:00

abstract：PURPOSE:To evaluate whether thyroid scintigraphy would alter the clinical management of patients referred for fine-needle aspiration cytology (FNA). METHODS:We reviewed the medical and imaging records of patients referred to our Department between 2016 and 2019. All the patients had to take a serum thyrotropin test ad...

journal_title：Clinical endocrinology

authors： Pirola I,Di Lodovico E,Casella C,Pezzaioli L,Facondo P,Ferlin A,Lombardi D,Cappelli C

更新日期：2020-12-17 00:00:00

abstract：OBJECTIVE:Thyrotoxic hypokalaemic periodic paralysis (THPP) is an uncommon condition with intermittent episodes of muscle weakness and occasionally severe paralysis. THPP is a common complication of hyperthyroidism in Asian populations, and has also been reported in other ethnic groups including Caucasians. This study ...

journal_title：Clinical endocrinology

authors： Cesur M,Bayram F,Temel MA,Ozkaya M,Kocer A,Ertorer ME,Koc F,Kaya A,Gullu S

更新日期：2008-01-01 00:00:00

abstract：:Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

journal_title：Clinical endocrinology

authors： Napier C,Pearce SH

更新日期：2015-04-01 00:00:00

abstract：:In 44 patients with acromegaly treated by transsphenoidal pituitary microsurgery, the relationship between changes in pre- and post-operative GH dynamics and postoperative fasting plasma GH levels was examined to clarify which is the optimal approach for evaluating postoperative removal of the tumour. TRH, LHRH and br...

journal_title：Clinical endocrinology

authors： Karashima T,Kato K,Nawata H,Ikuyama S,Ibayashi H,Nakagaki H,Kitamura K

更新日期：1986-08-01 00:00:00

abstract：OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

journal_title：Clinical endocrinology

authors： Hammami MM,Haq A,AlSedairy S

更新日期：1994-03-01 00:00:00

abstract：:Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...

journal_title：Clinical endocrinology

authors： Krassas G,McHardy-Young S,Ramsay I,Florin-Christensen A

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that a relatively high number of diabetic patients may have unsuspected Cushing's syndrome (CS). The aim of the present study was to screen for CS in adult patients with newly diagnosed diabetes mellitus who were not selected for clinical characteristics, such as poor control and obe...

journal_title：Clinical endocrinology

authors： Reimondo G,Pia A,Allasino B,Tassone F,Bovio S,Borretta G,Angeli A,Terzolo M

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To examine quality of life (QoL) measured by a utility-weighted index in GH-deficient adults on GH replacement and analyse the impact of demographic and clinical characteristics on changes in utilities during treatment. DESIGN:Utilities for items in the QoL-Assessment of Growth Hormone Deficiency in Adults ...

journal_title：Clinical endocrinology

authors： Kołtowska-Häggström M,Kind P,Monson JP,Jonsson B

更新日期：2008-01-01 00:00:00

abstract：:Transdermal oestradiol, 100 micrograms/d, was used to treat 11 women suffering from postmenopausal symptoms. After 3 weeks therapy there was a significant rise in the plasma oestradiol into the premenopausal range and a significant fall in plasma FSH level and symptom score. Bone resorption, assessed by urinary excret...

journal_title：Clinical endocrinology

authors： Selby PL,Peacock M

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVES:There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well-being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of...

journal_title：Clinical endocrinology

authors： Siegmund W,Spieker K,Weike AI,Giessmann T,Modess C,Dabers T,Kirsch G,Sänger E,Engel G,Hamm AO,Nauck M,Meng W

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEA...

journal_title：Clinical endocrinology

authors： Mäntyselkä A,Jääskeläinen J,Eloranta AM,Väistö J,Voutilainen R,Ong K,Brage S,Lakka TA,Lindi V

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

journal_title：Clinical endocrinology

authors： Vilar L,Burke CW

更新日期：1994-12-01 00:00:00

abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...

journal_title：Clinical endocrinology

authors： Li WF,Wang G,Zhao ZB,Liu CA

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:There is evidence showing that GH and IGF-I have specific receptors in the heart and that these hormones are able to promote cardiac remodelling and inotropism. It has been reported that patients with dilated cardiomyopathy (DCM) benefit from treatment with rhGH showing a striking increase in cardiac contract...

journal_title：Clinical endocrinology

authors： Broglio F,Fubini A,Morello M,Arvat E,Aimaretti G,Gianotti L,Boghen MF,Deghenghi R,Mangiardi L,Ghigo E

更新日期：1999-04-01 00:00:00

abstract：OBJECTIVE:We describe four patients with ovarian hyperthecosis and the effects of gonadotrophin releasing hormone on clinical and metabolic variables. DESIGN:Open out-patient study. PATIENTS:Four women presented with post-menopausal hirsuties. They had significant hair growth across the chest, upper back and shoulder...

journal_title：Clinical endocrinology

authors： Barth JH,Jenkins M,Belchetz PE

更新日期：1997-02-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：:Several weeks after thyroidectomy (T), female rats stopped growing, and their pituitary GH content had decreased to less than 2--3% of the values found for age-matched controls (C). The liver membranes of such animals were explored with human GH (hGH). It was found that in the severely hypothyroid T rat, the number, b...

journal_title：Clinical endocrinology

authors： Duran-Garcia S,Gomez-Nieto J,Fouchereau-Peron M,Padron VF,Obregon MJ,Morreale de Escobar G,Escobar del Rey F

更新日期：1979-09-01 00:00:00

abstract：OBJECTIVE:Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with ...

journal_title：Clinical endocrinology

authors： Otsuka F,Noh JY,Chino T,Shimizu T,Mukasa K,Ito K,Ito K,Taniyama M

更新日期：2012-08-01 00:00:00

abstract：:We studied day/night (D:N) patterns of urinary sodium excretion and the 24 hour ambulatory electrocardiogram in seven normal subjects before and during the administration of T4. Thyroxine increased thyroid hormone levels within the normal range and inhibited the plasma TSH response to TRH. This was associated with a s...

journal_title：Clinical endocrinology

authors： Bell GM,Sawers JS,Forfar JC,Doig A,Toft AD

更新日期：1983-05-01 00:00:00