High expression of metadherin correlates with malignant pathological features and poor prognostic significance in papillary thyroid carcinoma.

abstract：OBJECTIVE:Sex steroid hormones influence bone mineral density (BMD) in women, but are less well-studied in men. We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years. DESIGN:BMD and sex steroid hormones were mea...

journal_title：Clinical endocrinology

authors： Paller CJ,Shiels MS,Rohrmann S,Basaria S,Rifai N,Nelson W,Platz EA,Dobs A

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:There has been much debate concerning the relative contribution of insulin resistance to the development of polycystic ovaries (PCO). We therefore aimed to assess ovarian morphology and insulin/androgen status in females with the hepatic glycogen storage diseases types Ia (GSD-Ia) and III (GSD-III), disorders...

journal_title：Clinical endocrinology

authors： Lee PJ,Patel A,Hindmarsh PC,Mowat AP,Leonard JV

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

journal_title：Clinical endocrinology

authors： Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

更新日期：2011-02-01 00:00:00

abstract：OBJECTIVE:Poorly differentiated thyroid cancer (PDTC) is a rare, but aggressive thyroid cancer (TC) and a main cause of death from non-anaplastic follicular cell-derived TC. Assessing the risk of PDTC-related death and the risk of recurrence is important for clinicians. The recent American Thyroid Association (ATA) 201...

journal_title：Clinical endocrinology

authors： Walczyk A,Kopczyński J,Gąsior-Perczak D,Pałyga I,Kowalik A,Chrapek M,Hejnold M,Góźdź S,Kowalska A

更新日期：2019-08-01 00:00:00

abstract：CONTEXT:The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts. OBJECTIVE:To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel. DESIGN:A population-based coh...

journal_title：Clinical endocrinology

authors： Libruder C,Blumenfeld O,Dichtiar R,Laron Z,Zadik Z,Shohat T,Afek A

更新日期：2016-11-01 00:00:00

abstract：:The effect of pretreatment with biosynthetic methionyl human GH (hGH) on the GH response to GHRH has been studied in normal subjects. Eight volunteers were given either 4 IU hGH or placebo s.c. 12-hourly for 72 h before a GHRH test, or a single s.c. dose of 4 IU hGH 12 h before a GHRH test. Somatomedin-C (Sm-C) levels...

journal_title：Clinical endocrinology

authors： Ross RJ,Borges F,Grossman A,Smith R,Ngahfoong L,Rees LH,Savage MO,Besser GM

更新日期：1987-01-01 00:00:00

abstract：:We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH...

journal_title：Clinical endocrinology

authors： Pringle PJ,Stanhope R,Hindmarsh P,Brook CG

更新日期：1988-05-01 00:00:00

abstract：OBJECTIVE:To elucidate the interaction between insulin and dehydroepi-androsterone (DHEA) concentrations, we evaluated serum DHEA and DHEA-sulphate (DHEA-S) levels in diabetic patients with hyperinsulinaemia. PATIENTS AND DESIGN:Twenty-four subjects with non-insulin dependent diabetes mellitus, 12 hyperinsulinaemic su...

journal_title：Clinical endocrinology

authors： Yamaguchi Y,Tanaka S,Yamakawa T,Kimura M,Ukawa K,Yamada Y,Ishihara M,Sekihara H

更新日期：1998-09-01 00:00:00

abstract：:The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We su...

journal_title：Clinical endocrinology

authors： Geurts J,Demeester-Mirkine N,Glinoer D,Prigogine T,Fernandez-Deville M,Corvilain J

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Quality of life is impaired in polycystic ovary syndrome (PCOS). In this study, we compared the time to first prescription of antidepressants (ADM) in PCOS vs two control groups. DESIGN:Register-based cohort study. PATIENTS:One thousand and one hundred and twenty-four premenopausal women with hirsutism and/...

journal_title：Clinical endocrinology

authors： Altinok ML,Glintborg D,Depont Christensen R,Hallas J,Andersen M

更新日期：2014-06-01 00:00:00

abstract：:Two patients with profound hypocalcaemia due to uraemia and hypoparathyroidism respectively presented with alterations of mental state as their dominant symptom. 1-Alpha-hydroxycholecalciferol (1-alpha-OHD3) was chosen as the principal therapy because of its potency and rapid action. In both patients the plasma calciu...

journal_title：Clinical endocrinology

authors： Gertner JM,Hodsman AB,Neuberger JN

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND:A number of surgical series have been reported on the treatment of acromegaly and their results vary widely. The acceptable definition of remission has changed in recent years and it is known, though in a small series, that growth hormone levels of > 5 mU/l are still associated with an increased mortality fr...

journal_title：Clinical endocrinology

authors： Ahmed S,Elsheikh M,Stratton IM,Page RC,Adams CB,Wass JA

更新日期：1999-05-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

journal_title：Clinical endocrinology

authors： Chubb SA,Davis WA,Inman Z,Davis TM

更新日期：2005-04-01 00:00:00

abstract：:Obesity may be characterized by abnormal sex steroid secretion and reduced sex hormone binding globulin (SHBG) which in turn is related to fat distribution and insulin secretion. Recent in-vitro and in-vivo evidence suggests that insulin is the common mechanism regulating the secretion of SHBG and insulin-like growth ...

journal_title：Clinical endocrinology

authors： Weaver JU,Holly JM,Kopelman PG,Noonan K,Giadom CG,White N,Virdee S,Wass JA

更新日期：1990-09-01 00:00:00

abstract：:Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) prese...

journal_title：Clinical endocrinology

authors： Bannister P,Sheridan P,Losowsky MS

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Hyperandrogenism is one of the characteristic features of the polycystic ovary syndrome (PCOS). Androgens are important for bone mass. Studies on bone mineral density (BMD) and fractures in postmenopausal women with PCOS are lacking. The aim of this study was to investigate whether postmenopausal women with P...

journal_title：Clinical endocrinology

authors： Schmidt J,Dahlgren E,Brännström M,Landin-Wilhelmsen K

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

journal_title：Clinical endocrinology

authors： Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

更新日期：2015-01-01 00:00:00

abstract：UNLABELLED:Objective To evaluate the effect of strontium ranelate (SR) on bone turnover markers in women with established osteoporosis previously treated with teriparatide (TPTD--recombinant human PTH 1-34). DESIGN PATIENTS: Twenty-two postmenopausal Caucasian women (aged 65.7 +/- 1.7 years) with established osteoporos...

journal_title：Clinical endocrinology

authors： Anastasilakis AD,Goulis DG,Polyzos SA,Gerou S,Ballaouri I,Efstathiadou Z,Kita M,Avramidis A

更新日期：2009-04-01 00:00:00

abstract：:As long ago as 1970, it was proposed that Ca2+ can act as a 'second messenger' like cAMP (Rasmussen & Nagata, 1979). The recognition that calmodulin is a major Ca2+ binding protein in non-muscle cells has prompted the suggestion that calmodulin may serve an analogous role for Ca2+ to that served by protein kinase for ...

journal_title：Clinical endocrinology

authors： Brown BL,Walker SW,Tomlinson S

更新日期：1985-08-01 00:00:00

abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

journal_title：Clinical endocrinology

authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:We examined the individual pharmacological effects of the addition of rosiglitazone and metformin to glimepiride on inflammatory markers and adipokines in patients with type 2 diabetes mellitus. We analysed the relationships between these variables, the measurements of insulin sensitivity and beta-cell functi...

journal_title：Clinical endocrinology

authors： Kim HJ,Kang ES,Kim DJ,Kim SH,Ahn CW,Cha BS,Nam M,Chung CH,Lee KW,Nam CM,Lee HC

更新日期：2007-02-01 00:00:00

abstract：CONTEXT:Hypoparathyroidism is characterized by hypocalcaemia, hyperphosphataemia, and low or inappropriately normal parathyroid hormone (PTH) levels. Idiopathic or genetic drivers are the predominant causes of hypoparathyroidism in paediatric-age patients. OBJECTIVE:This study investigated the aetiology and clinical c...

journal_title：Clinical endocrinology

authors： Kim JH,Shin YL,Yang S,Cheon CK,Cho JH,Lee BH,Kim GH,Lee JO,Seo EJ,Choi JH,Yoo HW

更新日期：2015-12-01 00:00:00

abstract：DESIGN:Prevalence of type 2 diabetes and glucose intolerance increase with age. It has been demonstrated that beta cell function declines at about 1% per year in glucose tolerant Caucasians. However, this relationship is not known to exist in other ethnic groups. SUBJECTS AND MEASUREMENTS:We investigated the relations...

journal_title：Clinical endocrinology

authors： Chiu KC,Martinez DS,Chu A

更新日期：2005-03-01 00:00:00

abstract：:The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increase during p...

journal_title：Clinical endocrinology

authors： Odlind V,Carlström K,Michaëlsson G,Vahlqvist A,Victor A,Mellbin T

更新日期：1982-03-01 00:00:00

abstract：CONTEXT:Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE:To investigate the changes in bone mineral densi...

journal_title：Clinical endocrinology

authors： Hong N,Kim JE,Lee SJ,Kim SH,Rhee Y

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVE:This study explored leptin concentrations in Prader-Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied. STUDY DESIGN:Plasma leptin concentrations...

journal_title：Clinical endocrinology

authors： Myers SE,Davis A,Whitman BY,Santiago JV,Landt M

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Appropriate replacement doses of glucocorticoid are important to determine in primary and secondary adrenal deficiency in children, both to avoid the risks of hypoglycaemia and adrenal crisis associated with undertreatment, and to avoid growth suppression and reduced final height potential associated with ste...

journal_title：Clinical endocrinology

authors： DeVile CJ,Stanhope R

更新日期：1997-07-01 00:00:00

abstract：:Patients with thyrotoxic Graves' disease were treated daily for 10 d with 1 g sodium ipodate, an iodine rich X-ray contrast agent which impairs outer ring (5'-) deiodination of T4 to T3, or with 12 drops of a saturated solution of potassium iodide (SSKI). T4, T3 and reverse T3 (rT3) concentrations were measured before...

journal_title：Clinical endocrinology

authors： Roti E,Robuschi G,Manfredi A,D'Amato L,Gardini E,Salvi M,Montermini M,Barlli AL,Gnudi A,Braverman LE

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:To document current practices in the approach to low testosterone in older men. Given that recommendations are based on low-level evidence, we hypothesized that there would be a wide variability in clinical practice patterns. DESIGN:Members of all major endocrine and andrological societies were invited to pa...

journal_title：Clinical endocrinology

authors： Grossmann M,Anawalt BD,Wu FC

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune thyroiditis is one of the most common autoimmune disorders. Autoantibodies against the thyroid gland, with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common autoantibodies, can often be demonstrated in serum in population surveys. In the present st...

journal_title：Clinical endocrinology

authors： Pedersen IB,Knudsen N,Jørgensen T,Perrild H,Ovesen L,Laurberg P

更新日期：2003-01-01 00:00:00