Effects of rosiglitazone and metformin on inflammatory markers and adipokines: decrease in interleukin-18 is an independent factor for the improvement of homeostasis model assessment-beta in type 2 diabetes mellitus.

abstract：OBJECTIVE:We describe four patients with ovarian hyperthecosis and the effects of gonadotrophin releasing hormone on clinical and metabolic variables. DESIGN:Open out-patient study. PATIENTS:Four women presented with post-menopausal hirsuties. They had significant hair growth across the chest, upper back and shoulder...

journal_title：Clinical endocrinology

authors： Barth JH,Jenkins M,Belchetz PE

更新日期：1997-02-01 00:00:00

abstract：:Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The ...

journal_title：Clinical endocrinology

authors： Fraioli F,Cappa M,Fabbri A,Gnessi L,Moretti C,Borrelli P,Isidori A

更新日期：1984-03-01 00:00:00

abstract：:We have investigated the role of endogenous opioid peptides in the release of oxytocin (OT) in response to breast feeding and breast stimulation in humans. Five breast feeding women were studied on two separate occasions within 4 weeks of delivery. Saline or naloxone, 4 mg bolus and 6 mg/h, was administered intravenou...

journal_title：Clinical endocrinology

authors： Johnson MR,Andrews MA,Seckl JR,Lightman SL

更新日期：1990-07-01 00:00:00

abstract：CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

journal_title：Clinical endocrinology

authors： D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). ...

journal_title：Clinical endocrinology

authors： Cahoon EK,Rozhko A,Hatch M,Polyanskaya O,Ostroumova E,Tang M,Nadirov E,Yauseyenka V,Savasteeva I,McConnell RJ,Pfeiffer RM,Brenner AV

更新日期：2013-07-01 00:00:00

abstract：:In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid-luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterecto...

journal_title：Clinical endocrinology

authors： Bäckström T,Smith S,Lothian H,Baird DT

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:The recent American Thyroid Association management guidelines suggest cervical ultrasonography (US) surveillance in patients with differentiated thyroid cancer (DTC). This study was conducted to identify predictive factors that can determine whether subsequent fine needle aspiration guided by ultrasound (US-...

journal_title：Clinical endocrinology

authors： Hahn SY,Shin JH,Han BK,Ko EY,Kang SS,Chung JH,Kim JH,Oh YL,Son YI

更新日期：2011-02-01 00:00:00

abstract：:We report the case of a male infant who at 10 days of life presented with salt-wasting. Congenital adrenal hyperplasia was excluded on the basis of normal 17 alpha-hydroxy-progesterone plasma levels evaluated before the onset of steroid replacement therapy. The incidental finding of hypertriglyceridaemia led us to sus...

journal_title：Clinical endocrinology

authors： Balducci R,Municchi G,Toscano V,Mangiantini A,Sabatini R,Caiola S,Tedeschi B,Orlandi L,Boscherini B

更新日期：1995-04-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Fracture risk in type 2 diabetes mellitus with insulin resistance is increased, despite relatively preserved bone mineral density (BMD). In this study, we investigated the relationship between insulin resistance and composite indices of femoral neck strength in Koreans. DESIGN:A population-based, cross-secti...

journal_title：Clinical endocrinology

authors： Ahn SH,Kim H,Kim BJ,Lee SH,Koh JM

更新日期：2016-02-01 00:00:00

abstract：BACKGROUND:Iodide (I(-)) is crucial for foetal thyroid function. Foetal iodide results from maternal circulating iodide and from deiodination of iodothyronines within the placenta. The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Low NIS expression has been reported...

journal_title：Clinical endocrinology

authors： Di Cosmo C,Fanelli G,Tonacchera M,Ferrarini E,Dimida A,Agretti P,De Marco G,Vitti P,Pinchera A,Bevilacqua G,Naccarato AG,Viacava P

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:This study was designed in order to evaluate bone turnover with bone formation and resorption markers in hyperthyroidism and its possible relationship with serum cytokines interleukin 6 (IL-6) and tumour necrosis-alpha (TNF-alpha), levels of thyroid hormones and thyroid autoantibodies. DESIGN AND PATIENTS:Tw...

journal_title：Clinical endocrinology

authors： Akalin A,Colak O,Alatas O,Efe B

更新日期：2002-07-01 00:00:00

abstract：:The possibility that oleic acid is the thyroxine binding inhibitor in the serum of seriously ill patients was investigated. 3H-Oleic acid was shown to bind directly to human thyroxine-binding globulin (TBG) by the techniques of one and two-dimensional immunoelectrophoresis in combination with autoradiography. However,...

journal_title：Clinical endocrinology

authors： Haynes IG,Lockett SJ,Farmer MJ,Fitch NJ,Bradwell AR,Sheppard MC,Ramsden DB

更新日期：1989-07-01 00:00:00

abstract：PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

journal_title：Clinical endocrinology

authors： Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:Transient thelarche (TT), that is, the appearance, regression and subsequent reappearance of breast buds, is a frequent phenomenon, but little is known about pubertal transition in these girls. OBJECTIVE:To describe pubertal progression, growth, genotypes, reproductive hormones and growth factors in girls with...

journal_title：Clinical endocrinology

authors： Soto J,Pereira A,Busch AS,Almstrup K,Corvalan C,Iñiguez G,Juul A,Mericq V

更新日期：2020-09-01 00:00:00

abstract：OBJECTIVE:Mutations in SLC16A2, the gene encoding the thyroid hormone (TH)-specific transporter monocarboxylate transporter 8 (MCT8), result in a thyroid phenotype and severe mental retardation caused by neuronal TH deficiency. These mutational effects raise the question of whether polymorphic variation in SLC16A2 may ...

journal_title：Clinical endocrinology

authors： Lago-Lestón R,Iglesias MJ,San-José E,Areal C,Eiras A,Araújo-Vilar D,Lado-Abeal J,Domínguez-Gerpe L

更新日期：2009-04-01 00:00:00

abstract：:We have examined the characteristics of circulating immunoreactive human calcitonin (IR-hCT) by studying its different molecular weight (MW) forms under various secretory conditions in a patient with medullary carcinoma of the thyroid. Plasma IR-hCT (318 mg/l basal) increased 9 and 12 times, respectively, after calciu...

journal_title：Clinical endocrinology

authors： Bertagna XY,Bloomgarden ZT,Rabin D,Roberts LJ,Orth DN

更新日期：1980-08-01 00:00:00

abstract：CONTEXT:In contrast to the cardiac hormones, atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP), variations in plasma concentrations of C-type natriuretic peptide (CNP) in healthy adults are ill-defined, limiting their clinical application. OBJECTIVE:Our objective was to define the effect of age, ph...

journal_title：Clinical endocrinology

authors： Prickett TC,Olney RC,Cameron VA,Ellis MJ,Richards AM,Espiner EA

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:This case series documents the response of nine individuals with glucocorticoid-refractory Graves' orbitopathy (GO) to B cell depletion therapy with rituximab (RTX). CONTEXT:Graves' disease (GD) is one of the commonest autoimmune conditions and is frequently associated with inflammatory changes around the ey...

journal_title：Clinical endocrinology

authors： Mitchell AL,Gan EH,Morris M,Johnson K,Neoh C,Dickinson AJ,Perros P,Pearce SH

更新日期：2013-09-01 00:00:00

abstract：:Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

journal_title：Clinical endocrinology

authors： Nowak R,McMillen IC,Redman J,Short RV

更新日期：1987-10-01 00:00:00

abstract：OBJECTIVE:Recent increases in the sensitivity of methods used to measure TSH, especially third generation assays, have enabled separation of partial from complete pituitary suppression in patients with thyrotoxicosis. We have investigated the use of a sensitive chemiluminescent enzymeimmunoassay in the differential dia...

journal_title：Clinical endocrinology

authors： Kasagi K,Kousaka T,Misaki T,Iwata M,Alam MS,Konishi J

更新日期：1999-02-01 00:00:00

abstract：:Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. It is produced exclusively in the gonads and is involved in the regulation of follicular growth and development. In the ovary AMH is produced by the granulosa cells of early developing follicles and se...

journal_title：Clinical endocrinology

authors： La Marca A,Volpe A

更新日期：2006-06-01 00:00:00

abstract：OBJECTIVES:The differentiation of constitutional delayed puberty (CDP) from gonadotrophin deficiency (GD) in boys at referral poses a difficult challenge. The effectiveness of the GnRH agonist (GnRH-a) test in distinguishing between the two conditions was evaluated and compared with findings of the GnRH and hCG stimula...

journal_title：Clinical endocrinology

authors： Kauschansky A,Dickerman Z,Phillip M,Weintrob N,Strich D

更新日期：2002-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

journal_title：Clinical endocrinology

authors： Laursen T,Jørgensen JO,Christiansen JS

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as t...

journal_title：Clinical endocrinology

authors： Grimnes G,Emaus N,Cashman KD,Jorde R

更新日期：2017-07-01 00:00:00

abstract：:A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/l, physiological concentrations of insulin (50 mu/l) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung respond...

journal_title：Clinical endocrinology

authors： Stubbs WA,Morgan I,Lloyd B,Alberti KG

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) is a marker of residual differentiated thyroid cancer (DTC) after total thyroidectomy; however, circulating antithyroglobulin antibodies (TgAb) may interfere with the immunoassay for Tg. Ultrasensitive assays may have a more significant role in detecting circulating Tg in the context ...

journal_title：Clinical endocrinology

authors： McGrath RT,Preda VA,Clifton-Bligh P,Robinson B,Sywak M,Delbridge L,Ward P,Clifton-Bligh RJ,Learoyd DL

更新日期：2016-02-01 00:00:00

abstract：CONTEXT:It has been suggested that patients with papillary thyroid cancer (PTC) harbouring the BRAF(V600E) mutation have a worse prognosis. We showed in PTC that high levels of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) inversely correlate with disease-free interval (DFI). OBJECTIVES:To inv...

journal_title：Clinical endocrinology

authors： Ulisse S,Baldini E,Sorrenti S,Barollo S,Prinzi N,Catania A,Nesca A,Gnessi L,Pelizzo MR,Mian C,De Vito C,Calvanese A,Palermo S,Persechino S,De Antoni E,D'Armiento M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:Hyponatraemia is strongly associated with increased inpatient mortality, but it is unknown whether hyponatraemia per se contributes to excess mortality. Our hypothesis was that if hyponatraemic patients had significantly greater mortality compared with controls despite no difference with regard to gender, ag...

journal_title：Clinical endocrinology

authors： Tzoulis P,Bagkeris E,Bouloux PM

更新日期：2014-09-01 00:00:00