Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.

Abstract:

OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficient patients. An improved growth response is obtained in GH deficient children when a fixed weekly GH dose is administered by daily subcutaneous injections instead of twice or thrice-weekly intramuscular injections. A more pulsatile pattern and serum GH levels above zero might be achieved by further increasing the injection frequency. Increased daytime GH levels might, however, adversely affect the circadian patterns of metabolic indices, which have been demonstrated to be more successfully reproduced by evening compared with morning GH administration. DESIGN AND MEASUREMENTS:In a cross-over study, 8 GH deficient patients (age 16-43 years) were treated with 3 IU/m2/24 h of human GH. The dose was injected in the evening for 4 weeks and for another 4 weeks two-thirds was injected in the evening and one-third in the morning. At the end of each period the patients were admitted to the hospital for 37 hours. Steady-state profiles of GH, IGF-I, IGF binding proteins 1 and 3, insulin, glucose, lipid intermediates and metabolites were obtained following administration of 3 IU/m2 of GH (at 1900 h (one injection) and at 1900 and 0800 h (two injections)). RESULTS:Similar mean integrated levels of serum GH (mU/l) were obtained (7.46 +/- 0.84 (one injection) vs 6.46 +/- 0.62 (two injections) (P = 0.15)). Mean levels +/- SEM of serum IGF-I (micrograms/l) were significantly increased (P < 0.01) following two daily GH injections (330.3 +/- 48.1 (one injection) vs 399.1 +/- 53.0 (two injections)). Serum IGFBP-3 levels were not significantly different on the two occasions, while levels of the GH independent IGFBP-1 (micrograms/l) were slightly but significantly lower following twice-daily GH injections (1.61 +/- 0.42 vs 1.13 +/- 0.56, respectively (P < 0.04)). The pattern of IGFBP-1 was opposite to that of insulin. Similar levels of insulin and glucose were obtained with both GH regimens, while levels of non-esterified fatty acids were significantly higher following once-daily GH injection (P < 0.001). CONCLUSIONS:Twice-daily GH injections, apart from producing a more physiological serum GH profile, were superior to one injection in increasing serum IGF-I and decreasing IGFBP-1 levels. Both of these changes tend to amplify the effects of the administered GH. Twice-daily injections, however, resulted in lower night-time levels of lipid intermediates.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Laursen T,Jørgensen JO,Christiansen JS

doi

10.1111/j.1365-2265.1994.tb02554.x

subject

Has Abstract

pub_date

1994-09-01 00:00:00

pages

337-43

issue

3

eissn

0300-0664

issn

1365-2265

journal_volume

41

pub_type

临床试验,杂志文章,随机对照试验
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    abstract::We report an 11-year-old boy with undermasculinized genitalia and an abnormally expanded CAG repeat length at exon 1 of the androgen receptor (AR) gene. He had microphallus and scrotal hypospadias with chordee, and underwent urethroplasty at 4 years of age. At 11 years of age, a gonadotropin releasing hormone (GnRH) t...

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    doi:10.1046/j.1365-2265.2001.01205.x

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    更新日期:2001-06-01 00:00:00

  • In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval.

    abstract:CONTEXT:It has been suggested that patients with papillary thyroid cancer (PTC) harbouring the BRAF(V600E) mutation have a worse prognosis. We showed in PTC that high levels of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) inversely correlate with disease-free interval (DFI). OBJECTIVES:To inv...

    journal_title:Clinical endocrinology

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    更新日期:2012-11-01 00:00:00

  • Incidence of abnormal liver biochemical tests in hyperthyroidism.

    abstract:OBJECTIVE:Abnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen the severity of the abnormal serum liver biochemistries. There is a wide range of the incidence of these abnormalities in the published literature...

    journal_title:Clinical endocrinology

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    doi:10.1111/cen.13312

    authors: Lin TY,Shekar AO,Li N,Yeh MW,Saab S,Wilson M,Leung AM

    更新日期:2017-05-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1976.tb01983.x

    authors: Gertner JM,Hodsman AB,Neuberger JN

    更新日期:1976-09-01 00:00:00

  • PROP1 gene analysis in Portuguese patients with combined pituitary hormone deficiency.

    abstract:OBJECTIVE:Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS:A mul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1365-2265.2006.02617.x

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  • The maternal ovary is not the source of circulating inhibin levels during human pregnancy.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1987.tb02949.x

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    更新日期:1987-12-01 00:00:00

  • Pituitary-ovarian function before, during and after the menopause: a longitudinal study.

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    doi:10.1111/j.1365-2265.1982.tb01616.x

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    更新日期:1982-11-01 00:00:00

  • Incidentally discovered pituitary lesions: high frequency of macroadenomas and hormone-secreting adenomas - results of a prospective study.

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    更新日期:1999-07-01 00:00:00

  • Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2007.02830.x

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    更新日期:2007-07-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.2001.01397.x

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    pub_type: 杂志文章

    doi:

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    更新日期:1990-10-01 00:00:00

  • Prophylactic 1alpha-hydroxyvitamin D3 therapy in haemodialysis patients.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1977.tb03372.x

    authors: Walker GS,Peacock M,Aaron J,Robinson PJ,Davison AM

    更新日期:1977-12-01 00:00:00

  • The role of opiate peptides in the control of prolactin in the puerperium, and TSH in primary hypothyroidism.

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    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1982.tb00722.x

    authors: Grossman A,West S,Williams J,Evans J,Rees LH,Besser GM

    更新日期:1982-03-01 00:00:00

  • Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotrophin and its free beta-subunit.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1994.tb02524.x

    authors: Badonnel Y,Barbé F,Legagneur H,Poncelet E,Schweitzer M

    更新日期:1994-08-01 00:00:00

  • Diagnosis and complications of Cushing's disease: gender-related differences.

    abstract:OBJECTIVE:Cushing's disease (CD) presents a remarkable preponderance in female gender, with a female-to-male ratio of 3-8:1. The aim of this study was to evaluate gender-related differences in the presentation of CD, as regards: biochemical indices of hypercortisolism; sensitivity of diagnostic tests; clinical features...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12299

    authors: Zilio M,Barbot M,Ceccato F,Camozzi V,Bilora F,Casonato A,Frigo AC,Albiger N,Daidone V,Mazzai L,Mantero F,Scaroni C

    更新日期:2014-03-01 00:00:00

  • No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02367.x

    authors: Liu RT,Chen YJ,Chou FF,Li CL,Wu WL,Tsai PC,Huang CC,Cheng JT

    更新日期:2005-10-01 00:00:00

  • Prevalence of thyroid dysfunction in a Large Southern European Population. Analysis of modulatory factors. The APNA study.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13764

    authors: Santos Palacios S,Llavero Valero M,Brugos-Larumbe A,Díez JJ,Guillén-Grima F,Galofré JC

    更新日期:2018-09-01 00:00:00

  • Discrepancy between ACTH and cortisol responses to insulin induced hypoglycaemia.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1978.tb02222.x

    authors: Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

    更新日期:1978-10-01 00:00:00

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    pub_type: 杂志文章

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    更新日期:2000-07-01 00:00:00

  • A case of multiple endocrine adenomatosis (Type 1) with nesidioblastosis, terminating with an exocrine pancreatic carcinoma.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1983.tb02879.x

    authors: Oliver MH,Drury PL,Van't Hoff W

    更新日期:1983-05-01 00:00:00

  • Altered pulsatile secretion of luteinizing hormone in hypogonadal men with hyperprolactinaemia.

    abstract::To explore the mechanism for the hypogonadism associated with prolactin hypersecretion in men we examined luteinizing hormone (LH) secretory profiles in four hyperprolactinaemic men before and during treatment with bromocriptine. Pretreatment serum prolactin levels were increased 4-100 fold and serum testosterone leve...

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    doi:10.1111/j.1365-2265.1984.tb03467.x

    authors: Winters SJ,Troen P

    更新日期:1984-09-01 00:00:00

  • Acute management of pituitary apoplexy--surgery or conservative management?

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  • Circulating thyroid cancer biomarkers: Current limitations and future prospects.

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    doi:10.1111/j.1365-2265.1986.tb03605.x

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    更新日期:1986-11-01 00:00:00

  • Effect of surgical stress on pituitary-testicular function.

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    doi:10.1111/j.1365-2265.1978.tb02208.x

    authors: Wang C,Chan V,Yeung RT

    更新日期:1978-09-01 00:00:00

  • Adrenal vein sampling: External validation of multinomial regression modelling and left adrenal vein-to-peripheral vein ratio to predict lateralization index without right adrenal vein sampling.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.14295

    authors: Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

    更新日期:2020-12-01 00:00:00

  • Nephrogenous cyclic AMP in primary hepatocellular carcinoma patients with or without hypercalcaemia.

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    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1991.tb00939.x

    authors: Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

    更新日期:1991-12-01 00:00:00

  • Percutaneous ethanol injection treatment of autonomous thyroid adenoma: hormonal and clinical evaluation.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1992.tb02251.x

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