当前位置： SCI文献检索 > CLINICAL ENDOCRINOLOGY期刊下所有文献 > Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic-hyperinsulinemic clamps.

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic-hyperinsulinemic clamps.

Abstract：

OBJECTIVE:The euglycemic-hyperinsulinemic clamp is the gold standard to evaluate insulin resistance (IR), but there are only a few studies on the prevalence of IR in Chinese Han women with polycystic ovary syndrome (PCOS). This study investigated: (a) the prevalence of IR in Chinese Han women with PCOS by clamp, (b) the degree of reduction in insulin sensitivity (IS) and the contribution of body mass index (BMI). DESIGN:Retrospective cross-sectional analysis. PATIENTS:Chinese Han women with PCOS (n = 448) visiting the Department of Endocrinology or the Department of Obstetrics and Gynaecology of the First Affiliated Hospital of Chongqing Medical University. Chinese Han women without PCOS (controls) from the same area (n = 40). MEASUREMENTS:Clamp-measured IS, age, BMI, and total testosterone. RESULTS:The prevalence of IR and reduction in IS were 56.3% and 30.3%, respectively, in Chinese Han women with PCOS (both P < 0.001). The inherent reduction in IS was 18.8% in lean women with PCOS and BMI independently reduced IS by 37.9% in obese women with PCOS. The prevalence of IR estimated by homeostatic model assessment (HOMA) was lower than that determined by clamp. The multivariable analysis showed that IR by clamp (R2 = 0.48, P < 0.001) was independently associated with BMI (β = -0.52, P < 0.001), waist-hip ratio (β = -0.23, P < 0.001), total testosterone (β = -0.07, P = 0.045) and age (β = 0.17, P < 0.001), while IR by HOMA was only associated with BMI (R2 = 0.25, β = 0.50, P < 0.001). There were no differences in BMI groups distribution, HOMA-IR and M values among the four PCOS subtypes (all P > 0.05). CONCLUSIONS:56.3% of Chinese Han women with PCOS had IR and their reduction in IS was 30.3%. Obesity exacerbated the reduction in IS. When being evaluated by HOMA, the prevalence and the risk factors of IR in Chinese women with PCOS were underestimated.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Li W,Chen Q,Xie Y,Hu J,Yang S,Lin M

doi

10.1111/cen.13860

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

138-144

issue

eissn

0300-0664

issn

1365-2265

journal_volume

pub_type

杂志文章

在线工具

Prevalence and degree of insulin resistance in Chinese Han women with PCOS: Results from euglycemic-hyperinsulinemic clamps.