Correlation of circulating full-length visfatin (PBEF/NAMPT) with metabolic parameters in subjects with and without diabetes: a cross-sectional study.

abstract：OBJECTIVE:The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin re...

journal_title：Clinical endocrinology

authors： Cuatrecasas G,Granada ML,Formiguera X,Rull M,Alastrué A,Remesar X,Alemany M,Foz M

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:To elucidate the interaction between insulin and dehydroepi-androsterone (DHEA) concentrations, we evaluated serum DHEA and DHEA-sulphate (DHEA-S) levels in diabetic patients with hyperinsulinaemia. PATIENTS AND DESIGN:Twenty-four subjects with non-insulin dependent diabetes mellitus, 12 hyperinsulinaemic su...

journal_title：Clinical endocrinology

authors： Yamaguchi Y,Tanaka S,Yamakawa T,Kimura M,Ukawa K,Yamada Y,Ishihara M,Sekihara H

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:Growth hormone release in response to all known stimuli of GH secretion is blunted in obese subjects. Several studies, using d,l-fenfluramine (d,l-FF) as a serotoninergic tool, suggest that brain serotonin plays a role in the pathogenesis of this phenomenon. However, the effect of d,l-FF appears to be depende...

journal_title：Clinical endocrinology

authors： Kars ME,Pijl H,Cohen AF,Frölich M,Schoemaker HC,Brandenburg HC,Meinders AE

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

journal_title：Clinical endocrinology

authors： Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

journal_title：Clinical endocrinology

authors： Hopkins KD,Holdaway IM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), ther...

journal_title：Clinical endocrinology

authors： Churchill SJ,Wang ET,Bhasin G,Alexander C,Bresee C,Pall M,Azziz R,Mathur R,Pisarska MD

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

journal_title：Clinical endocrinology

authors： Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

更新日期：1992-12-01 00:00:00

abstract：OBJECTIVE:It has been postulated that a decrease in thyroid size can be achieved by thyroxine treatment in patients with goitrous Hashimoto's thyroiditis but no objective data are available. We have therefore investigated the influence of thyroxine treatment on ultrasonically determined thyroid size. We also measured s...

journal_title：Clinical endocrinology

authors： Hegedüs L,Hansen JM,Feldt-Rasmussen U,Hansen BM,Høier-Madsen M

更新日期：1991-09-01 00:00:00

abstract：:Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order. The peak serum GH concentrations elicited by clonidine or GHRH were variable but one factor influencing the GH response to GHRH was the GH secretory status in the hour prior to the administration of the GHRH. Pe...

journal_title：Clinical endocrinology

authors： Suri D,Hindmarsh PC,Brain CE,Pringle PJ,Brook CG

更新日期：1990-09-01 00:00:00

abstract：:The human population which lives and works in polar environments has been increasing steadily over the last 15 years. Very little is known about how these residents adjust to their environment. Cold adaptation in man is a poorly understood phenomenon. Euthermic mammals maintain body temperature during cold exposure vi...

journal_title：Clinical endocrinology

authors： Reed HL,Burman KD,Shakir KM,O'Brian JT

更新日期：1986-07-01 00:00:00

abstract：:Familial neurohypophysial diabetes insipidus (FNDI) is a rare autosomal dominant syndrome stemming from the absence of arginine vasopressin (AVP). More than thirty-five different germline mutations in the arginine vasopressin-neurophysin II gene have been reported. These mutations are either in the signal peptide or s...

journal_title：Clinical endocrinology

authors： Boson WL,Sarubi JC,d'Alva CB,Friedman E,Faria D,De Marco L,Wajchenberg B

更新日期：2003-01-01 00:00:00

abstract：:delta 5 and delta 4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean +/- SEM) of DHA (11.2 +/- 2.4 ng/ml), DHAS (1.45 +/- 0.6 micrograms/ml) and cortisol 277 +/- 15.7 ng/ml) was found; in follicular ...

journal_title：Clinical endocrinology

authors： Inaudi P,Bernabei A,Gioffré W,Franchi F,Mazzullo G,De Leo V,D'Antona N

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVE:We investigated correlations between age-related changes in circulating metabolites and arterial stiffness in impaired fasting glucose (IFG). DESIGN, SUBJECTS, MEASUREMENT:This prospective cohort study included 602 healthy, normal fasting glucose (NFG) subjects (30-65 years old) who underwent triennial medic...

journal_title：Clinical endocrinology

authors： Jung S,Kim M,Lee YJ,Lee SH,Lee JH

更新日期：2015-08-01 00:00:00

abstract：:Exposure to maternal hypothyroxinemia during pregnancy, which is characterized by low free T4 but normal thyroid-stimulating hormone (TSH) levels, can negatively affect the foetus. This review provides an overview of present findings concerning the association between maternal hypothyroxinemia during pregnancy and chi...

journal_title：Clinical endocrinology

authors： Henrichs J,Ghassabian A,Peeters RP,Tiemeier H

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：:Polyglandular syndromes have been described for many years but only one case of panhypopituitarism with adrenal and thyroid insufficiencies has been documented. We present a 69-year-old woman with the initial diagnosis of idiopathic primary hypopituitarism. An associated primary adrenal disease was suspected on low pl...

journal_title：Clinical endocrinology

authors： Pholsena M,Young J,Couzinet B,Schaison G

更新日期：1994-05-01 00:00:00

abstract：:The uterine cross-sectional area (UXA) of women with polycystic (PCO) or multifollicular ovaries (MFO) is significantly larger and smaller, respectively, than those of normal women during the early-mid-follicular phase of the menstrual cycle. In the present study the distribution of oestradiol in plasma from normal wo...

journal_title：Clinical endocrinology

authors： Polson DW,Franks S,Reed MJ,Cheng RW,Adams J,James VH

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...

journal_title：Clinical endocrinology

authors： Wide L,Naessén T

更新日期：1994-06-01 00:00:00

abstract：BACKGROUND:Postsurgical regrowth or recurrence of nonfunctioning pituitary adenomas (NFAs) is not uncommon and often requires further surgery or radiotherapy (DXT). Routine postoperative DXT increases the incidence of hypopituitarism, which is associated with increased morbidity and mortality. Identification of genetic...

journal_title：Clinical endocrinology

authors： Buch HN,Raskauskiene D,Bahar A,Bicknell EJ,Farrell WE,Clayton RN

更新日期：2004-07-01 00:00:00

abstract：:Thyroid status was estimated serially by measuring triiodothyronine (T3), thyroxine (T4) and thyrotrophin (hTSH) in 20 patients suffering from meningococcal meningitis, typhoid fever and other acute febrile illnesses. Significantly low T3 and only slightly increased T4 were observed in all the patients. hTSH was norma...

journal_title：Clinical endocrinology

authors： Maharajan G,Etta KM,Singh A,Ahuja IS,Ahuja GK

更新日期：1978-11-01 00:00:00

abstract：OBJECTIVE:Observational studies have suggested positive associations between serum 25-hydroxyvitamin D (25(OH)D) levels and muscular strength, balance and quality of life. Our aim was to examine whether high-dose vitamin D supplementation would improve these measures as compared to standard-dose vitamin D, as well as t...

journal_title：Clinical endocrinology

authors： Grimnes G,Emaus N,Cashman KD,Jorde R

更新日期：2017-07-01 00:00:00

abstract：OBJECTIVE:Androgens have paradoxically different effects on hair follicles depending on body site, stimulating beard growth while inducing regression in some areas of the scalp. The mesenchyme derived dermal papilla at the base of the hair follicle regulates many aspects of the growth of follicular epithelium, and is p...

journal_title：Clinical endocrinology

authors： Thornton MJ,Laing I,Hamada K,Messenger AG,Randall VA

更新日期：1993-12-01 00:00:00

abstract：:In a series of hyperthyroid subjects treated with a high dose 'block-replace' regime, mean thyroidal technetium uptake was shown to fall progressively over an 18 month period. Furthermore, sub-total inhibition of hormone biosynthesis could be demonstrated, without evidence of proportionate inhibition of organification...

journal_title：Clinical endocrinology

authors： Wise PH,Marion M,Pain R

更新日期：1979-06-01 00:00:00

abstract：:We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH...

journal_title：Clinical endocrinology

authors： Pringle PJ,Stanhope R,Hindmarsh P,Brook CG

更新日期：1988-05-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

journal_title：Clinical endocrinology

authors： Polderman KH,Gooren LJ,van der Veen EA

更新日期：1994-05-01 00:00:00

abstract：:Raised activity of the LH axis caused by activating mutations of LH receptor gene presents with precocious puberty in boys, analogous to the presentation of LH secreting pituitary adenomas (Faggiano et al., 1983; Ambrosi et al., 1990). LH "hyperactivity' in females appears to have no effect. Hyperactivity of the FSH a...

journal_title：Clinical endocrinology

authors： Conway GS

更新日期：1996-12-01 00:00:00

abstract：:Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold diffe...

journal_title：Clinical endocrinology

authors： Andersen AN,Hertz J,Kjer JJ,Eskildsen PC,Larsen PS,Svenstrup B,Nielsen J,Arends J

更新日期：1980-08-01 00:00:00

abstract：INTRODUCTION:Prader-Willi syndrome (PWS) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. The clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. Even though central hypothyroidism has been...

journal_title：Clinical endocrinology

authors： Vaiani E,Herzovich V,Chaler E,Chertkoff L,Rivarola MA,Torrado M,Belgorosky A

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

journal_title：Clinical endocrinology

authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

更新日期：1997-06-01 00:00:00