Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why?

abstract：BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

journal_title：Clinical endocrinology

authors： Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to address the effect of endurance training on monocyte glucocorticoid sensitivity in vitro. METHODS:For this purpose, in vitro dexamethasone inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in cultures of peripheral monocytes was compared in 6 untrained...

journal_title：Clinical endocrinology

authors： Duclos M,Minkhar M,Sarrieau A,Bonnemaison D,Manier G,Mormede P

更新日期：1999-12-01 00:00:00

abstract：:The possibility that oleic acid is the thyroxine binding inhibitor in the serum of seriously ill patients was investigated. 3H-Oleic acid was shown to bind directly to human thyroxine-binding globulin (TBG) by the techniques of one and two-dimensional immunoelectrophoresis in combination with autoradiography. However,...

journal_title：Clinical endocrinology

authors： Haynes IG,Lockett SJ,Farmer MJ,Fitch NJ,Bradwell AR,Sheppard MC,Ramsden DB

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Milk-alkali syndrome, once a common cause of hypercalcaemia, is now considered rare. Our aim was to estimate the prevalence of milk-alkali syndrome among hypercalcaemic, non-end-stage renal disease (non-ESRD) inpatients of a University Hospital and identify patients' and syndrome characteristics. DESIGN AND ...

journal_title：Clinical endocrinology

authors： Picolos MK,Lavis VR,Orlander PR

更新日期：2005-11-01 00:00:00

abstract：:We have examined the characteristics of circulating immunoreactive human calcitonin (IR-hCT) by studying its different molecular weight (MW) forms under various secretory conditions in a patient with medullary carcinoma of the thyroid. Plasma IR-hCT (318 mg/l basal) increased 9 and 12 times, respectively, after calciu...

journal_title：Clinical endocrinology

authors： Bertagna XY,Bloomgarden ZT,Rabin D,Roberts LJ,Orth DN

更新日期：1980-08-01 00:00:00

abstract：:Acid glycosaminoglycans were measured in the tissues of a virtually untreated 83-year-old woman with myxoedema. Intercellular oedema was demonstrated histologically in the tongue, myocardium, striated muscles, and in the skin. Tissue oedema was absent in two female control patients. All tissues from the patient with m...

journal_title：Clinical endocrinology

authors： Parving HH,Helin G,Garbarsch C,Johansen AA,Jensen BA,Helin P,Lund P,Lyngsøe J

更新日期：1982-02-01 00:00:00

abstract：UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

journal_title：Clinical endocrinology

authors： Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

更新日期：2007-07-01 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00

abstract：BACKGROUND:Previous studies report impaired health-related quality of life (HRQoL) in patients with functional pituitary adenomas (FPA). We assessed HRQoL in FPA patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal ...

journal_title：Clinical endocrinology

authors： Ritvonen E,Karppinen A,Sintonen H,Vehkavaara S,Kivipelto L,Roine RP,Niemelä M,Schalin-Jäntti C

更新日期：2015-03-01 00:00:00

abstract：:In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid-luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterecto...

journal_title：Clinical endocrinology

authors： Bäckström T,Smith S,Lothian H,Baird DT

更新日期：1985-06-01 00:00:00

abstract：:Using a sensitive enzyme amplified immunoassay for TSH, the evening rise and pulsatile release of TSH were studied in 10 men with chronic renal failure treated by haemodialysis. Compared to euthyroid male controls the evening rise of TSH was attenuated (median 0.066 vs 0.195 mU/l/h, P less than 0.01) and the rate of r...

journal_title：Clinical endocrinology

authors： Wheatley T,Clark PM,Clark JD,Holder R,Raggatt PR,Evans DB

更新日期：1989-07-01 00:00:00

abstract：:The catechol oestrogen 2-hydroxyoestrone has been reported to lower serum prolactin concentrations acutely in normal women and it has been proposed that it may be effective in suppressing prolactin secretion in hyperprolactinaemic patients. Five women with hyperprolactinaemia and anovulation were studied. Following a ...

journal_title：Clinical endocrinology

authors： Franks S,Lightman SL,MaClusky NJ,Naftolin F,Lynch SS,Butt WR,Jacobs HS

更新日期：1981-10-01 00:00:00

abstract：OBJECTIVE:To compare the value of the thyroid imaging reporting and data system proposed by Kwak (KWAK TI-RADS) and the 2015 American Thyroid Association (ATA) guidelines for diagnosis of medullary thyroid carcinoma (MTC) and papillary thyroid carcinoma (PTC). To confirm the role of cell block (CB)-assisted fine-needle...

journal_title：Clinical endocrinology

authors： Li J,Li H,Yang Y,Zhang X,Qian L

更新日期：2020-05-01 00:00:00

abstract：BACKGROUND:Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and ...

journal_title：Clinical endocrinology

authors： Mitchell AL,Hickey J,Vaidya B,Mason R,Ajjan R,Zammitt N,Perros P,Dayan C,TEAMeD.

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:Alterations in protein expression of histone deacetylase 2 (HDAC2) have been demonstrated in various neoplasms, and lack of nuclear expression of HDAC2 has previously been shown in some human and canine corticotroph adenomas. This study aimed to examine HDAC2 expression in a Norwegian cohort of corticotroph ...

journal_title：Clinical endocrinology

authors： Evang JA,Borota OC,Melum E,Holm R,Ramm-Pettersen J,Bollerslev J,Berg JP

更新日期：2010-08-01 00:00:00

abstract：:A 32-year-old Caucasian male, clinically euthyroid, with paranoid schizophrenia and granulocytopenia, had elevated total and free serum T4 and T3; serum TSH was normal (2.7 +/- 0.7 micronU/ml). There was no goitre present, no evidence of Graves' disease, and no evidence of pituitary tumour. He had a normal response to...

journal_title：Clinical endocrinology

authors： Tamagna EI,Carlson HE,Hershman JM,Reed AW

更新日期：1979-05-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Growth hormone treatment in children with idiopathic short stature (ISS) leads to growth acceleration in the first years, but the effect on final height is still poorly documented. We therefore studied the long-term effect of GH therapy in children with idiopathic short stature. DESIGN:We have...

journal_title：Clinical endocrinology

authors： Wit JM,Boersma B,de Muinck Keizer-Schrama SM,Nienhuis HE,Oostdijk W,Otten BJ,Delemarre-Van de Waal HA,Reeser M,Waelkens JJ,Rikken B

更新日期：1995-04-01 00:00:00

abstract：:There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

journal_title：Clinical endocrinology

authors： Ginsberg J,Rafter DJ,von Westarp C,Murray PG

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:The goal of our study was to determine the rate of neoplasms in patients with other pituitary adenomas (non-functioning and prolactinomas) in comparison with acromegaly which is known to favour the development of neoplasia. DESIGN AND PATIENTS:We reviewed clinical records for 220 patients with acromegaly, 15...

journal_title：Clinical endocrinology

authors： Popovic V,Damjanovic S,Micic D,Nesovic M,Djurovic M,Petakov M,Obradovic S,Zoric S,Simic M,Penezic Z,Marinkovic J

更新日期：1998-10-01 00:00:00

abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...

journal_title：Clinical endocrinology

authors： Dahlberg PA,Karlsson FA,Lundqvist G

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

journal_title：Clinical endocrinology

authors： Polderman KH,Gooren LJ,van der Veen EA

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：:Radioiodine has been in use for over 60 years as a treatment for hyperthyroidism. Major changes in clinical practice have occurred with the realization that accurate dosimetry is incapable of avoiding the risks of hypothyroidism, while more accurate assessment of the risks of other adverse effects of radioiodine such ...

journal_title：Clinical endocrinology

authors： Weetman AP

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Androgen insensitivity syndromes (AIS) in subjects with 46, XY karyotype and normal or even elevated androgen blood levels are characterized by various aberrations in male differentiation and virilization. AIS is often accompanied by a broad spectrum of abnormal binding characteristics of the androgen recepto...

journal_title：Clinical endocrinology

authors： Weidemann W,Linck B,Haupt H,Mentrup B,Romalo G,Stockklauser K,Brinkmann AO,Schweikert HU,Spindler KD

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:To systematically evaluate low serum adiponectin level as a risk factor for cardiovascular disease (CVD). A meta-analysis was performed to quantitatively analyse the association of serum total adiponectin level with CVD using previous case-control studies in Han Chinese populations. METHODS:Several electroni...

journal_title：Clinical endocrinology

authors： Zhang BC,Liu WJ,Che WL,Xu YW

更新日期：2012-09-01 00:00:00

abstract：:In the present study, effects of domperidone, a peripheral dopamine blocking agent, on prolactin and growth hormone were examined to determine whether dopamine regulation of these hormones involved structures external to the blood-brain barrier. A clearcut elevation in prolactin was produced by domperidone. GH respons...

journal_title：Clinical endocrinology

authors： Brown GM,Verhaegan H,Van Wimersma Greidanus TB,Brugmans J

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to review our long-term use of subcutaneous oestradiol (E2) implant therapy for the treatment of climacteric symptoms in post-menopausal women. On the grounds that the aim is to restore premenopausal serum E2 levels, our declared clinical policy is not to repeat implants even in the ...

journal_title：Clinical endocrinology

authors： Buckler HM,Kalsi PK,Cantrill JA,Anderson DC

更新日期：1995-05-01 00:00:00

abstract：CONTEXT:Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover, children with ISS appear to need higher GH doses than children with GH deficiency (GHD) to achieve the same amount of growth and may therefore be at increased risk of adverse events du...

journal_title：Clinical endocrinology

authors： Decker R,Albertsson-Wikland K,Kriström B,Nierop AF,Gustafsson J,Bosaeus I,Fors H,Hochberg Z,Dahlgren J

更新日期：2010-09-01 00:00:00

abstract：:The paradoxical GH response to TRH observed in certain adolescents with constitutional tall stature is associated with a 60% fall in plasma levels of somatostatin. Conversely, those tall subjects who do not show a GH increase after TRH, or during a saline control infusion maintain steady levels of somatostatin in plas...

journal_title：Clinical endocrinology

authors： Garcia Blanco M,Evain Brion D

更新日期：1984-10-01 00:00:00

abstract：OBJECTIVE:The optimal treatment regimen with thionamide drugs remains a matter for debate. We have investigated whether high doses of carbimazole, when compared with low doses, reduce relapse rates of Graves' disease. DESIGN:In an open label, randomized, prospective trial of treatment of Graves' disease we compared hi...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Ford HC,Fagerström JN,Cordwell DP,Delahunt JW,Toomath RJ

更新日期：1998-05-01 00:00:00