Abnormalities of thyrotrophin (TSH) evening rise and pulsatile release in haemodialysis patients: evidence for hypothalamic-pituitary changes in chronic renal failure.

abstract：BACKGROUND:Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and ...

journal_title：Clinical endocrinology

authors： Mitchell AL,Hickey J,Vaidya B,Mason R,Ajjan R,Zammitt N,Perros P,Dayan C,TEAMeD.

更新日期：2017-12-01 00:00:00

abstract：:Bone biopsies were performed and serum concentrations of vitamin D metabolites were measured in twenty-four patients with chronic renal failure. The concentrations of three metabolites--25-dihydroxyvitamin D (25-OHD), 24,25-dihydroxyvitamin D (24,25-OH2D) and 1,25-dihydroxyvitamin D (1,25-OH2D)--were significantly low...

journal_title：Clinical endocrinology

authors： Mason RS,Lissner D,Wilkinson M,Posen S

更新日期：1980-10-01 00:00:00

abstract：OBJECTIVES:There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this a...

journal_title：Clinical endocrinology

authors： Choi SH,An JH,Lim S,Koo BK,Park SE,Chang HJ,Choi SI,Park YJ,Park KS,Jang HC,Shin CS

更新日期：2009-11-01 00:00:00

abstract：:The improvement in iodine status among the UK population from the 1930s onwards has been described as an 'accidental public health triumph' despite the lack of any iodine fortification program. However, iodine deficiency in the UK has re-emerged in vulnerable groups and is likely due to a combination of changing farmi...

journal_title：Clinical endocrinology

authors： Woodside JV,Mullan KR

更新日期：2020-11-29 00:00:00

abstract：:We describe here two patients with hypothyroidism due to pituitary-hypothalamic disease in whom basal thyrotrophin (TSH) levels measured by radioimmunoassay (RIA) were elevated yet when measured by a cytochemical bioassay (CBA) were found to be normal. This finding and the absence of the normal rise of thyroid hormone...

journal_title：Clinical endocrinology

authors： Petersen VB,McGregor AM,Belchetz PE,Elkeles RS,Hall R

更新日期：1978-05-01 00:00:00

abstract：BACKGROUND:The intensive physical activity is often associated with cardiac changes. OBJECTIVES:(i) To evaluate the IGF-I system and myocardial structure and function by standard Doppler echocardiography and Tissue Doppler in athletes and sedentary controls; and (ii) to determine any relationship between IGF-I system ...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Colao A,Innelli P,Guerra G,Guerra E,Dini FL,Orio F Jr,Soscia A,De Divitiis O,Lombardi G

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:We wished to develop optimal criteria for interpreting the single-dose overnight metyrapone test and to compare the diagnostic efficiency of the overnight and the standard 6-dose metyrapone tests for the differential diagnosis of ACTH-dependent Cushing's syndrome. DESIGN:Retrospective pilot study based on al...

journal_title：Clinical endocrinology

authors： Avgerinos PC,Nieman LK,Oldfield EH,Cutler GB Jr

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

journal_title：Clinical endocrinology

authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

更新日期：2004-02-01 00:00:00

abstract：:We have examined the characteristics of circulating immunoreactive human calcitonin (IR-hCT) by studying its different molecular weight (MW) forms under various secretory conditions in a patient with medullary carcinoma of the thyroid. Plasma IR-hCT (318 mg/l basal) increased 9 and 12 times, respectively, after calciu...

journal_title：Clinical endocrinology

authors： Bertagna XY,Bloomgarden ZT,Rabin D,Roberts LJ,Orth DN

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:It is generally accepted that there is no clinically significant circadian variation in total insulin-like growth factor (IGF)-I or total IGF-II in healthy subjects. In contrast there is a significant nocturnal decrease in free IGF-I in healthy subjects, corresponding to the nocturnal increase in IGF binding ...

journal_title：Clinical endocrinology

authors： Skjaerbaek C,Frystyk J,Kaal A,Laursen T,Møller J,Weeke J,Jørgensen JO,Sandahl Christiansen J,Orskov H

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

journal_title：Clinical endocrinology

authors： Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:Hypothalamic-pituitary-adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid ...

journal_title：Clinical endocrinology

authors： Stirrat LI,Walker JJ,Stryjakowska K,Jones N,Homer NZM,Andrew R,Norman JE,Lightman SL,Reynolds RM

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Type 1 diabetes mellitus (T1DM) is associated with skeletal fragility. While previous meta-analyses have demonstrated an increased risk of fracture in individuals with T1DM, little is known about fracture risk in T1DM, in the absence of age-related confounders. AIMS:To determine the risk of fracture in youn...

journal_title：Clinical endocrinology

authors： Thong EP,Herath M,Weber DR,Ranasinha S,Ebeling PR,Milat F,Teede H

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Women with polycystic ovary syndrome (PCOS) have an increased risk of cardiovascular disease. The contribution of lipid abnormalities to this higher risk, in particular atherogenic modifications of low density lipoprotein (LDL) such as a shift towards smaller LDL, has not been properly explored. We aimed to e...

journal_title：Clinical endocrinology

authors： Dejager S,Pichard C,Giral P,Bruckert E,Federspield MC,Beucler I,Turpin G

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:We assessed the relationship between serum IGFBP-3 levels with IGF-I and quantitative GH secretory status in poorly growing children. DESIGN:We studied the relationship between 24-hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF-I and the IGFBP-3 serum levels. PATIENT...

journal_title：Clinical endocrinology

authors： Phillip M,Chalew SA,Kowarski AA,Stene MA

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients. PATIENTS:Patients were grouped as follows: nine patients with APA at high titre (> 1 : 8) affected by apparent...

journal_title：Clinical endocrinology

authors： De Bellis A,Bizzarro A,Perrino S,Coronella C,Conte M,Pasquali D,Sinisi AA,Betterle C,Bellastella A

更新日期：2005-07-01 00:00:00

abstract：CONTEXT:Disturbances in thyroid function have been described in small-for-gestational age (SGA) children but the influence of prematurity is unclear. In addition, the effect of GH treatment on thyroid function has not been studied in short SGA children. OBJECTIVES:To determine whether short SGA children have higher TS...

journal_title：Clinical endocrinology

authors： de Kort SW,Willemsen RH,van der Kaay DC,van Dijk M,Visser TJ,Hokken-Koelega AC

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:Postablation whole-body scintigraphy, which is performed 5-7 days after administration of ablation activity of radioactive iodine-131 (131 I) in patients with thyroid cancer, is considered a routine procedure for remnant ablation and a useful tool for disease staging. However, the relationship of pre-ablation...

journal_title：Clinical endocrinology

authors： Liu B,Chen Y,Jiang L,He Y,Huang R,Kuang A

更新日期：2017-01-01 00:00:00

abstract：:To test whether the administration of sodium fluoride in vivo results in an increase in osteocalcin concentration, we administered sodium fluoride to seven healthy male subjects for a period of 3 weeks. Fasting calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone and osteocalcin were meas...

journal_title：Clinical endocrinology

authors： Dandona P,Coumar A,Gill DS,Bell J,Thomas M

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVE:A relationship between the serotoninergic and the opiatergic system in the pathogenesis of head pain is supported by several data. This study was carried out to investigate the neuroendocrine effects of sumatriptan, a specific serotonin agonist used in the treatment of migraine, on hypothalamic-pituitary-adre...

journal_title：Clinical endocrinology

authors： Facchinetti F,Nappi RE,Sances G,Fioroni L,Nappi G,Genazzani AR

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:We examined the effect of GH substitution on adipose tissue-derived hormones and cytokines and sought to identify predictors for changes in body composition during therapy. Long-standing adult-onset GH deficiency (AO-GHD) is associated with increased body fat mass (FM) which, through production of hormones an...

journal_title：Clinical endocrinology

authors： Ueland T,Jørgensen AP,Godang K,Fougner KJ,Aukrust P,Burman P,Bollerslev J

更新日期：2011-01-01 00:00:00

abstract：:The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second...

journal_title：Clinical endocrinology

authors： Wang C,Chan V,Yeung RT

更新日期：1978-09-01 00:00:00

abstract：:A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

journal_title：Clinical endocrinology

authors： Nabarro JD

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVE:A recent report showing disappointingly low sensitivity and specificity for the oral high dose dexamethasone test in the differential diagnosis of Cushing's syndrome prompted us to re-evaluate the results obtained in our centre using the continuous 7-hour intravenous dexamethasone suppression test for this pu...

journal_title：Clinical endocrinology

authors： van den Bogaert DP,de Herder WW,de Jong FH,Biemond P,van der Lely AJ,Lamberts SW

更新日期：1999-08-01 00:00:00

abstract：:The purpose of this study was to assess the normal relationship between plasma ACTH and cortisol during insulin induced hypoglycaemia. Twenty-six healthy persons were studied. Peak plasma concentration and the amounts of ACTH and cortisol secreted during hypoglycaemia were compared. There was no significant correlatio...

journal_title：Clinical endocrinology

authors： Lindholm J,Kehlet H,Blichert-Toft M,Riishede J,Hummer L,Dinesen B

更新日期：1978-10-01 00:00:00

abstract：CONTEXT:To study the prevalence of thyroid dysfunction in a very large unselected population. OBJECTIVE:To determine the prevalence of abnormal thyroid function and evaluate potential modulatory factors. DESIGN AND SETTING:The Estudio de Atención Primaria de Navarra, The APNA Study, is a cross-sectional study conduct...

journal_title：Clinical endocrinology

authors： Santos Palacios S,Llavero Valero M,Brugos-Larumbe A,Díez JJ,Guillén-Grima F,Galofré JC

更新日期：2018-09-01 00:00:00

abstract：:Biochemical markers of bone turnover are widely used in clinical practice. These indices have been shown to be associated with the occurrence, prognosis and therapeutic response of malignant bone lesions. For example, markers of bone resorption are often elevated in patients with established bone metastases and while ...

journal_title：Clinical endocrinology

authors： Seibel MJ

更新日期：2008-06-01 00:00:00

abstract：:We report an 11-year-old boy with undermasculinized genitalia and an abnormally expanded CAG repeat length at exon 1 of the androgen receptor (AR) gene. He had microphallus and scrotal hypospadias with chordee, and underwent urethroplasty at 4 years of age. At 11 years of age, a gonadotropin releasing hormone (GnRH) t...

journal_title：Clinical endocrinology

authors： Ogata T,Muroya K,Ishii T,Suzuki Y,Nakada T,Sasagawa I

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:The use of thyrotropin (TSH) in the initial assessment of thyroid nodules is inefficient and leads to unnecessary assessment costs. We compared the total costs of thyroid nodule assessment with or without the use of TSH in the initial assessment. METHODS:A total of 1808 patients with thyroid nodules received...

journal_title：Clinical endocrinology

authors： Cai H,Qiao Y,Xi H,Luo Q,Yuan X,Yang Y,Lv Z

更新日期：2017-02-01 00:00:00

abstract：:A 30 year old woman presenting with infertility was found to have elevated serum immunoreactive prolactin, TSH and total T3. These findings were eventually attributed to assay artifact when she was shown to have anti-rabbit antibodies in her serum. The possibility of laboratory artifact should be considered in clinica...

journal_title：Clinical endocrinology

authors： Jeffcoate WJ,Selby C,Powell RJ

更新日期：1988-01-01 00:00:00