Vitamin D metabolites and their relationship to azotaemic osteodystrophy.

abstract：BACKGROUND:Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE:To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian). DESIGN AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Madeira JL,Nishi MY,Nakaguma M,Benedetti AF,Biscotto IP,Fernandes T,Pequeno T,Figueiredo T,Franca MM,Correa FA,Otto AP,Abrão M,Miras MB,Santos S,Jorge AA,Costalonga EF,Mendonca BB,Arnhold IJ,Carvalho LR

更新日期：2017-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (PCOM) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, r...

journal_title：Clinical endocrinology

authors： Hong SH,Sung YA,Hong YS,Jeong K,Chung H,Lee H

更新日期：2017-10-01 00:00:00

abstract：BACKGROUND:It has previously been shown that higher serum TSH is associated with increased thyroid cancer incidence and advanced-stage disease. In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for thyroid cancer, it is important to know whether higher TS...

journal_title：Clinical endocrinology

authors： Haymart MR,Glinberg SL,Liu J,Sippel RS,Jaume JC,Chen H

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients. PATIENTS:Patients were grouped as follows: nine patients with APA at high titre (> 1 : 8) affected by apparent...

journal_title：Clinical endocrinology

authors： De Bellis A,Bizzarro A,Perrino S,Coronella C,Conte M,Pasquali D,Sinisi AA,Betterle C,Bellastella A

更新日期：2005-07-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to examine (1) the diurnal variation in SHBG and (2) the inter-relationships of insulin, IGF-I, SHBG and IGFBP-1 over 24 hours in 10 women with anovulatory PCOS and compare them with weight-matched ovulatory controls. PATIENTS AND METHODS:The two groups comprised 10 anovulatory wom...

journal_title：Clinical endocrinology

authors： Hamilton-Fairley D,White D,Griffiths M,Anyaoku V,Koistinen R,Seppälä M,Franks S

更新日期：1995-08-01 00:00:00

abstract：OBJECTIVE:To study circulating adiponectin concentrations in relation to diabetes duration and endogenous insulin secretion in patients with type 1 diabetes. PATIENTS:Patients with haemoglobin A1c (HbA1c) < 6% (reference range 3.6-5.4%) were selected for the study. Twenty-two men and 24 women [age 41.3 +/- 13.8 years ...

journal_title：Clinical endocrinology

authors： Lindström T,Frystyk J,Hedman CA,Flyvbjerg A,Arnqvist HJ

更新日期：2006-12-01 00:00:00

abstract：:Immunoreactive calcitonin was found in extracts of seven out of eight consecutive breast carcinomas and four selected lung carcinomas, but not in extracts of benign breast lesions or normal tissues. This suggests that the high plasma calcitonin levels observed in patients with a wide variety of cancers reflect ectopic...

journal_title：Clinical endocrinology

authors： Hillyard CJ,Coombes RC,Greenberg PB,Galante LS,MacIntyre I

更新日期：1976-01-01 00:00:00

abstract：:Post-prandial plasma gastrointestinal hormone profiles were measured in nine chronic alcoholics, one and fourteen days after complete alcohol withdrawal. Basal plasma pancreatic polypeptide concentration (PP--mean +/- SE mean) was significantly greater in alcoholics (control, 28 +/- 5 pmol/l; alcoholics, post-withdraw...

journal_title：Clinical endocrinology

authors： Fink RS,Adrian TE,Margot DH,Bloom SR

更新日期：1983-04-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：:A 30-year-old presented in 1984 with a clinically nonfunctional tumour which subsequently developed into a metastatic corticotrophinoma from which he died despite surgery in 1984, 1986 and 1991 and external radiotherapy in 1986. Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity...

journal_title：Clinical endocrinology

authors： Bates AS,Buckley N,Boggild MD,Bicknell EJ,Perrett CW,Broome JC,Clayton RN

更新日期：1995-06-01 00:00:00

abstract：:Recent evidence suggests that oxytocin (OXT) and arginine vasopressin (AVP) are involved in the response to stress. We have examined the changes in peripheral plasma OXT during abdominal surgery in eight patients (six males, two female; ages 60-82 years) undergoing hemicolectomy and compared the results with those for...

journal_title：Clinical endocrinology

authors： Nussey SS,Page SR,Ang VT,Jenkins JS

更新日期：1988-03-01 00:00:00

abstract：:Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) prese...

journal_title：Clinical endocrinology

authors： Bannister P,Sheridan P,Losowsky MS

更新日期：1985-11-01 00:00:00

abstract：:Transsphenoidal surgery is the treatment of choice for nonfunctioning pituitary macroadenomas but is seldom curative. Tumour progression rates are high in patients with postoperative remnants. Therefore, long-term monitoring is necessary to detect tumour growth, which may be asymptomatic or manifest with visual field ...

journal_title：Clinical endocrinology

authors： Greenman Y,Stern N

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although the latter has not been firmly demonstrated in humans. So far, little data have been reported in relation to its potential association with metabolic syndrome (MS). The objective was to study obestatin concentrations in...

journal_title：Clinical endocrinology

authors： Mora M,Granada ML,Roca M,Palomera E,Puig R,Serra-Prat M,Puig-Domingo M

更新日期：2013-06-01 00:00:00

abstract：:Biochemical markers of bone turnover are widely used in clinical practice. These indices have been shown to be associated with the occurrence, prognosis and therapeutic response of malignant bone lesions. For example, markers of bone resorption are often elevated in patients with established bone metastases and while ...

journal_title：Clinical endocrinology

authors： Seibel MJ

更新日期：2008-06-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. DESIGN:Blood samples of 440 participants of the Metabol...

journal_title：Clinical endocrinology

authors： Bobbert T,Schwarz F,Fischer-Rosinsky A,Maurer L,Möhlig M,Pfeiffer AF,Mai K,Spranger J

更新日期：2015-06-01 00:00:00

abstract：OBJECTIVE:The molecular events leading to the development of GH-secreting pituitary tumours remain largely unknown. Gsalpha (GNAS1) mutations are found in 27-43% of sporadic GH-secreting adenomas in the Caucasian population, but the frequency of GNAS1 mutations in Japanese and Korean acromegalic patients was reported t...

journal_title：Clinical endocrinology

authors： Yamasaki H,Mizusawa N,Nagahiro S,Yamada S,Sano T,Itakura M,Yoshimoto K

更新日期：2003-04-01 00:00:00

abstract：:An LHRH test was performed on twenty-eight regularly menstruating females during follicular phase of their cycles. Twenty-four were then given an intramuscular injection of progesterone in oil and retested with LHRH 20 or 44 h later, the remaining four received no pretreatment and acted as controls. The twelve subject...

journal_title：Clinical endocrinology

authors： Shaw RW,Butt WR,London DR

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to address the effect of endurance training on monocyte glucocorticoid sensitivity in vitro. METHODS:For this purpose, in vitro dexamethasone inhibition of lipopolysaccharide (LPS)-induced interleukin-6 (IL-6) secretion in cultures of peripheral monocytes was compared in 6 untrained...

journal_title：Clinical endocrinology

authors： Duclos M,Minkhar M,Sarrieau A,Bonnemaison D,Manier G,Mormede P

更新日期：1999-12-01 00:00:00

abstract：:A wide variety of adverse effects of methimazole (MMI) have been reported. Here we report a new MMI-induced disorder, acute pancreatitis and parotitis. Three weeks after a woman started MMI treatment for Graves' disease, she developed a high fever, painful parotid swelling and dull pain in the upper abdomen with eleva...

journal_title：Clinical endocrinology

authors： Taguchi M,Yokota M,Koyano H,Endo Y,Ozawa Y

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

journal_title：Clinical endocrinology

authors： Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

journal_title：Clinical endocrinology

authors： Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

更新日期：1991-07-01 00:00:00

abstract：BACKGROUND:The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors. AIM:The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellula...

journal_title：Clinical endocrinology

authors： Mattera D,Capuano G,Colao A,Pivonello R,Manguso F,Puzziello A,D'Agostino L

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:A relationship between the serotoninergic and the opiatergic system in the pathogenesis of head pain is supported by several data. This study was carried out to investigate the neuroendocrine effects of sumatriptan, a specific serotonin agonist used in the treatment of migraine, on hypothalamic-pituitary-adre...

journal_title：Clinical endocrinology

authors： Facchinetti F,Nappi RE,Sances G,Fioroni L,Nappi G,Genazzani AR

更新日期：1994-02-01 00:00:00

abstract：OBJECTIVE:In the 8th edition American Joint Committee on Cancer (AJCC) tumour-node-metastasis (TNM) staging system (TNM-8), changes have been made regarding anaplastic thyroid carcinoma (ATC) compared with the 7th edition (TNM-7). The major changes are that anaplastic ATC now has the same T stage definitions as differe...

journal_title：Clinical endocrinology

authors： Xiang J,Wang Z,Sun W,Zhang H

更新日期：2020-12-26 00:00:00

abstract：OBJECTIVE:The relationship of quantitative GH secretion to height, growth velocity and puberty is complex and has been the subject of extensive study in children. This study was designed to relate quantitative GH secretion to final height. SUBJECTS:Twenty tall (> 183 cm, 90th centile for adult height) and 20 short (< ...

journal_title：Clinical endocrinology

authors： Trainer PJ,Palermo M,Kirk JM,Fanciulli G,Perry LH,Delitala G,Besser GM

更新日期：1999-11-01 00:00:00

abstract：CONTEXT:In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE:To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) ...

journal_title：Clinical endocrinology

authors： Gautier A,Bonnet F,Dubois S,Massart C,Grosheny C,Bachelot A,Aubé C,Balkau B,Ducluzeau PH

更新日期：2013-03-01 00:00:00

abstract：:Severe pituitary Cushing's disease of sudden onset after 18 years of unsuccessful treatment for a previously non-functioning chromophobe adenoma is described in a middle-aged woman. Initial presentation with symptoms of optic nerve compression had been preceded by two years of amenorrhoea. Transfrontal resection of a ...

journal_title：Clinical endocrinology

authors： Vaughan NJ,Laroche CM,Goodman I,Davies MJ,Jenkins JS

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that Graves' disease (GD) is linked to and associated with alleles of the cytotoxic T lymphocyte antigen-4 (CTLA4) locus. However, the true pathogenic polymorphism(s) at this locus remains uncertain. Moreover, the association studies of the promoter CTLA4(-318)C/T polymorphism in whi...

journal_title：Clinical endocrinology

authors： Vaidya B,Oakes EJ,Imrie H,Dickinson AJ,Perros P,Kendall-Taylor P,Pearce SH

更新日期：2003-06-01 00:00:00