Vitamin D metabolites and their relationship to azotaemic osteodystrophy.


:Bone biopsies were performed and serum concentrations of vitamin D metabolites were measured in twenty-four patients with chronic renal failure. The concentrations of three metabolites--25-dihydroxyvitamin D (25-OHD), 24,25-dihydroxyvitamin D (24,25-OH2D) and 1,25-dihydroxyvitamin D (1,25-OH2D)--were significantly lower in uraemic than in normal sera. There was a positive correlation between serum 24,25-OH2D and serum 25-OHD, whereas serum 1,25-OH2D values, which were independent of those of the other vitamin D metabolites, were negatively correlated with serum creatinine and serum inorganic phosphate. The two major skeletal lesions, osteomalacia and parathyroid osteopathy, while coexisting in many patients, varied independently in relation to their severity and were correlated with different vitamin D metabolites. The severity of osteomalacia was negatively correlated with the serum concentrations of 25-OHD and 24,25-OH2D while th severity of parathyroid osteopathy was negatively correlated with serum 1,25-OH2D values. To our knowledge these are the first systematic studies correlating skeletal histology with dihydroxylated vitamin D metabolites in renal failure in man.


Clin Endocrinol (Oxf)


Clinical endocrinology


Mason RS,Lissner D,Wilkinson M,Posen S




Has Abstract


1980-10-01 00:00:00












  • Acanthosis nigricans, hirsutism, insulin resistance and insulin receptor defect.

    abstract::A 24-year-old negress with the triad of acanthosis nigricans, hirsutism associated with polycystic ovaries and insulin resistance is reported. Metabolic studies were done 3 years after a bilateral ovarian wedge resection. Partial remission of the hirsutism and return of menstrual cycles occurred after surgery. Extreme...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Leme CE,Wajchenberg BL,Lerário AC,Goldman J,Borges JL

    更新日期:1982-07-01 00:00:00

  • The use of molecular markers of bone turnover in the management of patients with metastatic bone disease.

    abstract::Biochemical markers of bone turnover are widely used in clinical practice. These indices have been shown to be associated with the occurrence, prognosis and therapeutic response of malignant bone lesions. For example, markers of bone resorption are often elevated in patients with established bone metastases and while ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Seibel MJ

    更新日期:2008-06-01 00:00:00

  • Calcium and parathyroid hormone behaviour after exogenous secretin infusion in man.

    abstract::The response of serum calcium, PTH, CT and gastrin to an infusion of secretin (3 CU/kg/h) over a period of 90 min was studied in ten healthy males and two female patients with hypoparathyroidism. In the healthy males serum calcium, after a transient fall, significantly increased at 45 min after the onset of the infusi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lo Cascio V,Piubello W,Cominacini L,Vantini I,Galvanini G,Ederle A,Cavallini G,Scuro LA

    更新日期:1982-04-01 00:00:00

  • Thyroid axis dysfunction in patients with Prader-Willi syndrome during the first 2 years of life.

    abstract:INTRODUCTION:Prader-Willi syndrome (PWS) is a genetic disorder caused by the loss of expression of paternally transcribed genes in a highly imprinted region of chromosome 15q11-13. The clinical phenotype has been well characterized, mostly related to hypothalamic dysfunction. Even though central hypothyroidism has been...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vaiani E,Herzovich V,Chaler E,Chertkoff L,Rivarola MA,Torrado M,Belgorosky A

    更新日期:2010-10-01 00:00:00

  • Acute management of pituitary apoplexy--surgery or conservative management?

    abstract:BACKGROUND AND OBJECTIVE:The rarity of pituitary apoplexy renders it a difficult subject for audit; hence there are no evidence-based standards of optimum care for such patients. The key controversy in management relates to the role of acute neurosurgical intervention. In recent years we have adopted a relatively conse...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ayuk J,McGregor EJ,Mitchell RD,Gittoes NJ

    更新日期:2004-12-01 00:00:00

  • Changes in the expression of suppressor of cytokine signalling (SOCS) 2 in the colonic mucosa of acromegalic patients are associated with hyperplastic polyps.

    abstract:BACKGROUND:Acromegalic patients have increased prevalence of colonic polyps. Development of hyperplastic polyps was related to suppressor of cytokine signalling (SOCS) 2 haploinsufficiency in animal models of acromegaly. OBJECTIVE AND PATIENTS:To evaluate whether variations in SOCS2 expression in the colonic mucosa of...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bogazzi F,Ultimieri F,Raggi F,Russo D,Costa A,Marciano E,Bartalena L,Martino E

    更新日期:2009-06-01 00:00:00

  • Final height outcome and value of height prediction in boys with constitutional delay in growth and adolescence treated with intramuscular testosterone 125 mg per month for 3 months.

    abstract:OBJECTIVES:Constitutional delay in growth and adolescence (CDGA) is common in boys, some of whom request treatment to accelerate growth and attainment of secondary sexual characteristics. The aims of this study were to confirm that a 3-month course of intramuscular testosterone oenanthate does not impair final height i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kelly BP,Paterson WF,Donaldson MD

    更新日期:2003-03-01 00:00:00

  • Correction by bromocriptine of hypothalamic dysfunction and post-prandial hypoglycaemic symptoms in a 31-year-old woman.

    abstract::A 31-year old female presented with recurrent episodes of post-prandial hypoglycaemic symptoms. Basal serum levels of ACTH, cortisol, GH, insulin and glucagon were normal. An adrenaline test demonstrated a normal peripheral response. An exercise test failed to produce ACTH, cortisol or FFA responses. Insulin (0.1 u/kg...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Corcos AP,Weidenfeld J,Levy J,Barash V,Siegel RA,Gutman A,Chowers I

    更新日期:1983-10-01 00:00:00

  • Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism.

    abstract:OBJECTIVE:A high prevalence of diabetes mellitus has been shown in patients with primary hyperparathyroidism (PHPT). However, it is unclear whether this is related to the metabolic abnormalities in PHPT or to the presence of other risk factors for glucose intolerance in these patients. The aim of our study was to deter...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kumar S,Olukoga AO,Gordon C,Mawer EB,France M,Hosker JP,Davies M,Boulton AJ

    更新日期:1994-01-01 00:00:00

  • Clinical utility of telomerase for the diagnosis of malignant well-differentiated endocrine tumours.

    abstract:OBJECTIVE:The distinction between benign and malignant well-differentiated endocrine tumours is hard to achieve. The aim of the present study was to determine whether detection of telomerase or quantification of human telomerase reverse transcriptase protein subunit (hTERT) differ between benign and malignant endocrine...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vezzosi D,Bouisson M,Escourrou G,Laurell H,Selves J,Seguin P,Pradayrol L,Caron P,Buscail L

    更新日期:2006-01-01 00:00:00

  • Prediction of recurrence of nonfunctioning pituitary tumours by loss of heterozygosity analysis.

    abstract:BACKGROUND:Postsurgical regrowth or recurrence of nonfunctioning pituitary adenomas (NFAs) is not uncommon and often requires further surgery or radiotherapy (DXT). Routine postoperative DXT increases the incidence of hypopituitarism, which is associated with increased morbidity and mortality. Identification of genetic...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Buch HN,Raskauskiene D,Bahar A,Bicknell EJ,Farrell WE,Clayton RN

    更新日期:2004-07-01 00:00:00

  • Aromatase deficiency: A case series of 46, XX Chinese children and a systematic review of the literature.

    abstract:BACKGROUND:Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion. OBJECTIVE:To investigate the clinical characteristics and accurate management of aromatase-deficient children. PATIENTS AND METHOD...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fan L,Zhang B,Li L,Gong C

    更新日期:2020-12-01 00:00:00

  • Very low or undetectable intact parathyroid hormone levels in patients with surgically verified parathyroid adenomas.

    abstract:OBJECTIVES:To report and explore potential reasons for undetectable or low-normal serum intact PTH levels in patients with surgically verified primary hyperparathyroidism with parathyroid adenomas, review the relevant literature, and offer suggestions for management of such patients occasionally encountered in clinical...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bhadada SK,Cardenas M,Bhansali A,Mittal BR,Behera A,Chanukya GV,Nahar U,Rao DS

    更新日期:2008-09-01 00:00:00

  • Effect of oral glucose on the late growth hormone rise and growth hormone responses to GHRH in normal subjects.

    abstract::A late rise in serum GH occurs 3-5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Valcavi R,Zini M,Dieguez C,Portioli I,Scanlon MF

    更新日期:1990-05-01 00:00:00

  • Prevalence of coeliac disease in idiopathic hypoparathyroidism and effect of gluten-free diet on calcaemic control.

    abstract:BACKGROUND:Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1-α-(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium/vitamin D malabsorption. OBJECTIVE:We assessed t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Saha S,Saini S,Makharia GK,Datta Gupta S,Goswami R

    更新日期:2016-04-01 00:00:00

  • Growth hormone response to low dose intravenous injections of growth hormone releasing factor in obese and normal weight women.

    abstract::We have recently reported an impaired growth hormone (GH) response to a single i.v. bolus dose of growth hormone releasing factor (1 microgram/kg body weight) in obese women. We have now investigated whether the i.v. administration of low dose GHRF(1-29)NH2 (0.33 microgram/kg/h) by 15 min pulsed injections for 3 h fol...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kopelman PG,Noonan K

    更新日期:1986-02-01 00:00:00

  • Screening of Cushing's syndrome in adult patients with newly diagnosed diabetes mellitus.

    abstract:OBJECTIVE:Recent studies have shown that a relatively high number of diabetic patients may have unsuspected Cushing's syndrome (CS). The aim of the present study was to screen for CS in adult patients with newly diagnosed diabetes mellitus who were not selected for clinical characteristics, such as poor control and obe...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reimondo G,Pia A,Allasino B,Tassone F,Bovio S,Borretta G,Angeli A,Terzolo M

    更新日期:2007-08-01 00:00:00

  • Prolactinomas in adolescents: persistent bone loss after 2 years of prolactin normalization.

    abstract:OBJECTIVE:To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults. PATIENTS:Forty patients with hyperprolactinaemia (20 with disease onset during adolescence and 20 during adulthood) and 40 healthy control subjects. DES...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Colao A,Di Somma C,Loche S,Di Sarno A,Klain M,Pivonello R,Pietrosante M,Salvatore M,Lombardi G

    更新日期:2000-03-01 00:00:00

  • An improved method for the detection of heterozygosity of congenital virilizing adrenal hyperplasia.

    abstract::A modified short ACTH test for the detection of heterozygote carriers of 21-hydroxylase deficiency (21-OHD) was applied to twenty-one controls and fourteen parents of children with 21-OHD. The following modifications were introduced: (1) Endogenous ACTH was suppressed by dexamethasone administration prior to the test,...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lejeune-Lenain C,Cantraine F,Dufrasnes M,Prevot F,Wolter R,Franckson JR

    更新日期:1980-06-01 00:00:00

  • Prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes: the Fremantle Diabetes Study.

    abstract:OBJECTIVE:To assess the prevalence and progression of subclinical hypothyroidism in women with type 2 diabetes. DESIGN AND PATIENTS:Cross-sectional and longitudinal observational assessment of thyroid function in 420 adult females with type 2 diabetes randomly selected from participants in the community-based Fremantl...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chubb SA,Davis WA,Inman Z,Davis TM

    更新日期:2005-04-01 00:00:00

  • Phospholipase C activity in human endometrium: its significance in endometrial pathology.

    abstract::Phospholipase C activity was measured in human endometrium using an assay based on the release of total labelled water soluble products (inositol, inositol phosphates) from L-3-phosphatidyl-[2-3H] inositol. The enzyme was shown to be calcium dependent and to have an optimum pH of 5.5. There was no difference between p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bonney RC,Franks S

    更新日期:1987-09-01 00:00:00

  • Growth in children with craniopharyngioma following surgery.

    abstract:OBJECTIVE:Hypopituitarism, including severe GH deficiency, is an almost inevitable outcome of craniopharyngioma. However, some GH deficient children with this tumour may grow normally or even have accelerated growth postoperatively. To study this phenomenon we have investigated the endocrine status, including IGF-1 and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tiulpakov AN,Mazerkina NA,Brook CG,Hindmarsh PC,Peterkova VA,Gorelyshev SK

    更新日期:1998-12-01 00:00:00

  • Parathyroid hormone and parathyroid hormone-related protein in the investigation of hypercalcaemia in two hospital populations.

    abstract:BACKGROUND AND OBJECTIVE:Parathyroid hormone-related protein (PTHrP) produced by cancers has a central role as a humoral mediator of hypercalcaemia in patients with malignancy. Since the prevalences of hypercalcaemia of malignancy and parathyroid disease reflect the population studied, hypercalcaemic patients from a di...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Walls J,Ratcliffe WA,Howell A,Bundred NJ

    更新日期:1994-10-01 00:00:00

  • High precursor level in maternal blood results from the alternate mode of proopiomelanocortin processing in human placenta.

    abstract:OBJECTIVE:ACTH-producing non-pituitary tumours are often associated with altered precursor processing, particularly in the most aggressive ones. Since placental tissue is characterized by its ability to express the proopiomelanocortin (POMC) gene and rapid cellular proliferation, we examined whether intact POMC could b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Raffin-Sanson ML,Massias JF,Ankotche A,Coste J,de Keyzer Y,Oliver C,Dumont C,Cabrol D,Ferré F,Bertagna X

    更新日期:1999-01-01 00:00:00

  • Autonomous cortisol secretion in adrenal incidentalomas and increased visceral fat accumulation during follow-up.

    abstract:OBJECTIVE:Autonomous cortisol secretion of adrenal incidentalomas (AIs) is associated with poor cardiovascular outcome. Because centripetal obesity is a cardiovascular risk factor, we aimed to investigate whether autonomous cortisol secretion is associated with increased visceral fat accumulation. DESIGN:Retrospective...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yener S,Baris M,Peker A,Demir O,Ozgen B,Secil M

    更新日期:2017-11-01 00:00:00

  • Asymptomatic bilateral adrenal pheochromocytoma in a patient with a germline V804M mutation in the RET proto-oncogene.

    abstract:UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

    更新日期:2007-07-01 00:00:00

  • Impact of menopause on outcomes in prolactinomas after dopamine agonist treatment withdrawal.

    abstract:OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

    更新日期:2018-09-01 00:00:00

  • Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women.

    abstract:CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

    更新日期:2009-11-01 00:00:00

  • Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.

    abstract:OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

    更新日期:1996-09-01 00:00:00

  • The association between vitamin D status and type 2 diabetes in a Thai population, a cross-sectional study.

    abstract:OBJECTIVE:To explore vitamin D status in relation to diabetes, based on data from a national health examination survey in Thailand. DESIGN AND METHODS:A total of 2641 adults, aged 15-98 years, were randomly selected according to geographical region from the Thai 4th National Health Examination Survey sample. Logistic ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Chailurkit LO,Aekplakorn W,Ongphiphadhanakul B

    更新日期:2012-11-01 00:00:00