Comparison of high intensity focused ultrasound and radioiodine for treating toxic thyroid nodules.


PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were also evaluated as secondary end-points. MATERIALS AND METHODS:Among patients ≥18 years old with TTN observed at our centre between January 1st, 2016 and December 31th, 2016 we prospectively enrolled 17 and 15 age and sex-matched patients treated with RAI and HIFU, respectively. Biochemical thyroid tests and nodules' volume were assessed before and 3, 6 and 12 months after treatments. A thyroid scintigraphy was performed before and 1 year after treatment, respectively. RESULTS:The final series included 17 patients treated with RAI and 15 patients treated with HIFU, respectively. Neither demographic nor clinical differences were found at baseline. One year after treatment 14 of 17 RAI-treated and 4 of 15 HIFU-treated patients fulfilled criteria for response to treatment (P = .0008). Indeed, the median TSH value was 1.5 IU/mL and 0.2 IU/mL in HIFU and RAI groups, respectively (P < .0001). Finally, despite a similar decrease in nodules' volume in both groups, a scintigraphic response was achieved in 16 of 17 (94%) RAI-treated compared to 8 of 15 (53%) HIFU-treated patients (P = .024), respectively. CONCLUSIONS:In our series, RAI clearly outperforms HIFU in treating patients carrying TTN and remains the first-line noninvasive treatment in such cases.


Clin Endocrinol (Oxf)


Clinical endocrinology


Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P




Has Abstract


2018-08-01 00:00:00












  • Plasma IGFBP-3 and its relationship with quantitative growth hormone secretion in short children.

    abstract:OBJECTIVE:We assessed the relationship between serum IGFBP-3 levels with IGF-I and quantitative GH secretory status in poorly growing children. DESIGN:We studied the relationship between 24-hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF-I and the IGFBP-3 serum levels. PATIENT...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Phillip M,Chalew SA,Kowarski AA,Stene MA

    更新日期:1993-10-01 00:00:00

  • Hexokinase III, cyclin A and galectin-3 are overexpressed in malignant follicular thyroid nodules.

    abstract:BACKGROUND:Distinguishing malignant thyroid nodules in patients with follicular cytology by fine-needle aspiration (FNA) remains problematic. The large majority of thyroid nodules (> 85%) are overtreated. Therefore, a clear need exists to develop more accurate initial diagnostic tests for follicular thyroid nodules. Ga...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hooft L,van der Veldt AA,Hoekstra OS,Boers M,Molthoff CF,van Diest PJ

    更新日期:2008-02-01 00:00:00

  • The effect of oxytocin infusion on adenohypophysial and adrenal cortical responses to insulin-induced hypoglycaemia.

    abstract::The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion. Blood sugar nadir occurred at the onset of symptoms (t...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Nussey SS,Page SR,Ang VT,Jenkins JS,White A

    更新日期:1988-09-01 00:00:00

  • Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency.

    abstract:OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

    更新日期:2018-01-01 00:00:00

  • Response to neurotransmitter modulating drugs in patients with Cushing's disease.

    abstract::We designed a systematic study of patients with Cushing's disease to compare the results of acute experiments with cyproheptadine, sodium valproate and bromocriptine with the results of chronic treatment with sodium valproate. In 13 patients the plasma cortisol response to single doses of 2.5 mg bromocriptine, 6 mg cy...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Koppeschaar HP,Croughs RJ,Thijssen JH,Schwarz F

    更新日期:1986-12-01 00:00:00

  • Isolated growth hormone (GH) deficiency due to compound heterozygosity for two new mutations in the GH-releasing hormone receptor gene.

    abstract:OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

    更新日期:2001-05-01 00:00:00

  • A new and distinctive albumin variant with increased affinities for both triiodothyronines and causing hyperthyroxinaemia.

    abstract::A new variant albumin with increased affinities for iodothyronines has been identified. A euthyroid woman had raised total serum concentrations of T4 (155 nmol/l), T3 (3.0 nmol/l) and rT3 (700 pmol/l) but normal levels of all three iodothyronine-binding proteins. The affinity constant for T3 binding to the albumin was...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lalloz MR,Byfield PG,Himsworth RL

    更新日期:1985-04-01 00:00:00

  • Fasting concentrations of nesfatin-1 are negatively correlated with body mass index in non-obese males.

    abstract:BACKGROUND:We recently identified a novel anorexigenic protein, nesfatin-1, which is processed from nesfatin/nucleobindin-2 (NUCB2). However, the clinical importance of this protein has not been determined. OBJECTIVE:To investigate its clinical significance in humans, we have established a new specific enzyme-linked i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Tsuchiya T,Shimizu H,Yamada M,Osaki A,Oh-I S,Ariyama Y,Takahashi H,Okada S,Hashimoto K,Satoh T,Kojima M,Mori M

    更新日期:2010-10-01 00:00:00

  • The hypothalamic-pituitary-adrenal axis in infantile malnutrition.

    abstract::We studied the circadian rhythm and the response of the hypothalamic-pituitary-adrenal (HPA) axis to ovine corticotrophin releasing hormone (oCRH) stimulation and dexamethasone suppression in 32 children with grade II-III marasmus. Children were studied prior to and after nutritional rehabilitation. Mean baseline plas...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Malozowski S,Muzzo S,Burrows R,Leiva L,Loriaux L,Chrousos G,Winterer J,Cassorla F

    更新日期:1990-04-01 00:00:00

  • Factors affecting inadequate sampling of ultrasound-guided fine-needle aspiration biopsy of thyroid nodules.

    abstract:PURPOSE:The aim of this study was to evaluate the overall ultrasonographic features and clinical factors that contribute to inadequate sampling in ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules. MATERIALS AND METHODS:From April 2008 to December 2008, 4077 US-FNABs in 3767 consecutive pati...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Choi SH,Han KH,Yoon JH,Moon HJ,Son EJ,Youk JH,Kim EK,Kwak JY

    更新日期:2011-06-01 00:00:00

  • The impact of gender, puberty and body mass on reference values for urinary growth hormone (GH) excretion in normally growing non-obese and obese children.

    abstract:OBJECTIVE:There is a lack of normal reference data on urinary GH (u-GH) excretion in children. We have investigated the impact of age, gender, pubertal development and body mass on reference values for u-GH excretion in normally growing non-obese and obese children. STUDY DESIGN:u-GH levels were evaluated in 1153 heal...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bona G,Petri A,Rapa A,Conti A,Sartorio A

    更新日期:1999-06-01 00:00:00

  • Impaired quality of life in patients with treated acromegaly despite long-term biochemically stable disease: Results from a 5-years prospective study.

    abstract:OBJECTIVE:Patients with acromegaly demonstrate impaired quality of life (QoL), but data on long-term QoL changes in treated acromegaly are limited. This study evaluates and identifies factors that influence QoL in patients with long-term biochemical remission. DESIGN:The study consists of a cross-sectional arm compari...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kyriakakis N,Lynch J,Gilbey SG,Webb SM,Murray RD

    更新日期:2017-06-01 00:00:00

  • Gonadal-pituitary hormone levels in gynaecomastia.

    abstract::Plasma levels of LH, FSH, oestradiol 17 beta and testosterone were measured in twenty-two men with gynaecomastia. The group was divided by age into those under and those over 50-years-old and the mean hormone levels of the two groups were compared with two groups of age-matched normal men. In the young men with gynaec...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McFadyen IJ,Bolton AE,Cameron EH,Hunter WM,Raab G,Forrest AP

    更新日期:1980-07-01 00:00:00

  • Effect of oral glucose on the late growth hormone rise and growth hormone responses to GHRH in normal subjects.

    abstract::A late rise in serum GH occurs 3-5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Valcavi R,Zini M,Dieguez C,Portioli I,Scanlon MF

    更新日期:1990-05-01 00:00:00

  • In-vivo and in-vitro endocrine investigation of pure gonadal dysgenesis.

    abstract::Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wilson SC,Oakey RE,Scott JS

    更新日期:1988-11-01 00:00:00

  • Effects of peroral and transdermal oestrogen replacement therapy on glucose and insulin metabolism.

    abstract:OBJECTIVE:Conflicting data have been reported previously on the effects of oestrogen replacement therapy on glucose tolerance, and the effects on glycosylated haemoglobin GHbA(1c) have been studied only among diabetics. The objective of this study was to evaluate the effects on glucose and insulin metabolism among nond...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Karjalainen A,Paassilta M,Heikkinen J,Bäckström AC,Savolainen M,Kesäniemi YA

    更新日期:2001-02-01 00:00:00

  • Hepatotoxicity and cutaneous reactions after antithyroid drug administration.

    abstract:OBJECTIVE:Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Otsuka F,Noh JY,Chino T,Shimizu T,Mukasa K,Ito K,Ito K,Taniyama M

    更新日期:2012-08-01 00:00:00

  • BRAF mutations in an Italian cohort of thyroid cancers.

    abstract:OBJECTIVE:Recently, a somatic point mutation of the BRAF gene (V599E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (about 25-70%) in different series from USA, Japan, Portugal and Ukraine. DESIGN:In the present study, the genetic analysis of BRAF i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fugazzola L,Mannavola D,Cirello V,Vannucchi G,Muzza M,Vicentini L,Beck-Peccoz P

    更新日期:2004-08-01 00:00:00

  • Application of a disease-specific, quality-of-life measure (QoL-AGHDA) in growth hormone-deficient adults and a random population sample in Sweden: validation of the measure by rasch analysis.

    abstract:OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

    journal_title:Clinical endocrinology

    pub_type: 评论,杂志文章


    authors: Wirén L,Whalley D,McKenna S,Wilhelmsen L

    更新日期:2000-02-01 00:00:00

  • Prevalence of hypocalcaemia and its associated features in 22q11·2 deletion syndrome.

    abstract:BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

    更新日期:2014-08-01 00:00:00

  • What is the optimal bone-preserving strategy for patients with Addison's disease?

    abstract::Addison's disease is associated with low bone mineral density and increased risk of hip fractures. Causes are multifactorial, contributed by underlying adrenocortical hormonal deficiency, associated autoimmune endocrinopathies, electrolyte disturbances and, in some patients, supraphysiologic glucocorticoid replacement...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lee P,Greenfield JR

    更新日期:2015-08-01 00:00:00

  • Usefulness of iodine/creatinine ratio from spot-urine samples to evaluate the effectiveness of low-iodine diet preparation for radioiodine therapy.

    abstract:OBJECTIVE:The success of a low-iodine diet (LID) is best determined by measurement of 24-h urine iodine (U-I) excretion. The aim of this study was to determine reliable estimates for 24-h U-I based on spot-urine samples and to provide cut-offs to determine the effectiveness of LID preparation. DESIGN:We prospectively ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Kim HK,Lee SY,Lee JI,Jang HW,Kim SK,Chung HS,Tan AH,Hur KY,Kim JH,Chung JH,Kim SW

    更新日期:2010-07-01 00:00:00

  • Characterization of antipituitary antibodies targeting pituitary hormone-secreting cells in idiopathic growth hormone deficiency and autoimmune endocrine diseases.

    abstract:OBJECTIVE:In order to investigate whether somatotrophs are the target of antipituitary antibodies (APA) in adult patients with growth hormone deficiency (GHD), we studied the sera of 37 APA positive patients. PATIENTS:Patients were grouped as follows: nine patients with APA at high titre (> 1 : 8) affected by apparent...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: De Bellis A,Bizzarro A,Perrino S,Coronella C,Conte M,Pasquali D,Sinisi AA,Betterle C,Bellastella A

    更新日期:2005-07-01 00:00:00

  • Transient thyrotoxicosis in endemic goitre patients following exposure to a normal iodine intake.

    abstract::Twenty-three endemic goitrous subjects (goitre grade: III and IV) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms I/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of São Paulo, where daily iodine intake is estimat...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lima N,Medeiros-Neto G

    更新日期:1984-12-01 00:00:00

  • Cross-sectional association of coffee and caffeine consumption with sex hormone-binding globulin in healthy nondiabetic women.

    abstract:OBJECTIVE:Low sex hormone-binding globulin (SHBG) is a consistent risk factor for type 2 diabetes, particularly in women. Coffee consumption has been associated with a lower risk of type 2 diabetes, but its effects on SHBG are less known. DESIGN AND METHODS:This was a cross-sectional study of 2377 nondiabetic pre- and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pihan-Le Bars F,Gusto G,Boutron-Ruault MC,Fagherazzi G,Bonnet F

    更新日期:2017-11-01 00:00:00

  • Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women.

    abstract::Objective African-Americans have been shown to have low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. Design A survey, representative of the population of Rio de Janeiro, a large metropolitan city in ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Sichieri R,Baima J,Marante T,de Vasconcellos MT,Moura AS,Vaisman M

    更新日期:2007-06-01 00:00:00

  • Reduced uterine volume after induction of puberty in women with hypogonadism.

    abstract:OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

    更新日期:2019-12-01 00:00:00

  • Impaired circulating glucagon-like peptide-1 response to oral glucose in women with previous gestational diabetes.

    abstract:BACKGROUND AND OBJECTIVE:Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon-like peptide-1 (GLP-1) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP-1 secretion might be ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Forbes S,Moonan M,Robinson S,Anyaoku V,Patterson M,Murphy KG,Ghatei MA,Bloom SR,Johnston DG

    更新日期:2005-01-01 00:00:00

  • Lymphocytic traffic and homing into target tissue and the generation of endocrine autoimmunity.

    abstract::Endocrine autoimmunity is known to be characterized by the presence of specific autoantibodies and from the histopathological point of view by lymphocytic infiltration in the target tissue. The presence of mononuclear cell infiltrates is the pathological hallmark of most endocrine diseases characterized by an autoimmu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Pozzilli P,Carotenuto P,Delitala G

    更新日期:1994-11-01 00:00:00

  • Gender and age influence the relationship between serum GH and IGF-I in patients with acromegaly.

    abstract:BACKGROUND:In patients with acromegaly serum IGF-I is increasingly used as a marker of disease activity. As a result, the relationship between serum GH and IGF-I is of profound interest. Healthy females secrete three times more GH than males but have broadly similar serum IGF-I levels, and women with GH deficiency requ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Parkinson C,Renehan AG,Ryder WD,O'Dwyer ST,Shalet SM,Trainer PJ

    更新日期:2002-07-01 00:00:00