Changes in pituitary gonadotropins during the amenorrhoea-galactorrhoea syndrome due to sulpiride.

abstract：:Differentiated thyroid cancer (DTC) is the most common malignancy of the endocrine system. There has been a significant increase in its incidence over the past two decades attributable mainly to the use of more sensitive diagnostic modalities. Ultrasound-guided fine needle aspiration cytology is the mainstay of diagno...

journal_title：Clinical endocrinology

authors： Nixon AM,Provatopoulou X,Kalogera E,Zografos GN,Gounaris A

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVE:To determine serum concentrations, intra-individual variability and impact of age-related co-morbidities on serum testosterone (T), dihydrotestosterone (DHT), estradiol (E(2)) and estrone (E(1)) in older men. DESIGN:Observational, repeated measures study. PARTICIPANTS:Men (n = 325) with 40 years and older s...

journal_title：Clinical endocrinology

authors： Sartorius G,Spasevska S,Idan A,Turner L,Forbes E,Zamojska A,Allan CA,Ly LP,Conway AJ,McLachlan RI,Handelsman DJ

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteoca...

journal_title：Clinical endocrinology

authors： Rochefort GY,Rocher E,Aveline PC,Garnero P,Bab I,Chappard C,Jaffré C,Benhamou CL

更新日期：2011-08-01 00:00:00

abstract：:Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

journal_title：Clinical endocrinology

authors： Napier C,Pearce SH

更新日期：2015-04-01 00:00:00

abstract：:A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/l, physiological concentrations of insulin (50 mu/l) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung respond...

journal_title：Clinical endocrinology

authors： Stubbs WA,Morgan I,Lloyd B,Alberti KG

更新日期：1977-09-01 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

journal_title：Clinical endocrinology

authors： Holmer H,Link K,Erfurth EM

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

journal_title：Clinical endocrinology

authors： Ogilvy-Stuart AL,Wallace WH,Shalet SM

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:The prevalence of cardiovascular risk factors in congenital adrenal hyperplasia (CAH) varies widely. In the light of recent changes in treatment regimens, we have reassessed the prevalence of these risk factors in our current cohort of patients with CAH due to P450c21 deficiency. METHODS:A retrospective cros...

journal_title：Clinical endocrinology

authors： Subbarayan A,Dattani MT,Peters CJ,Hindmarsh PC

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:With increasing use of computed tomography and magnetic resonance imaging, pituitary adenomas are being discovered incidentally with increasing frequency. However, limited data are available concerning the clinical importance and natural history of such 'incicentalomas'. We have undertaken a prospective study...

journal_title：Clinical endocrinology

authors： Feldkamp J,Santen R,Harms E,Aulich A,Mödder U,Scherbaum WA

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in different forms of AI. DESIGN/PATIENTS:The Statutory Health Insurance (SHI) database of the Techniker Krankenkasse - covering more tha...

journal_title：Clinical endocrinology

authors： Meyer G,Badenhoop K,Linder R

更新日期：2016-09-01 00:00:00

abstract：:The HLA-A and -B antigen distribution in 132 Hong Kong Chinese patients with Graves' disease, including 24 with thyrotoxic periodic paralysis, was compared with that in 110 controls. The HLA-DR antigen distribution in 68 patients was compared with that in 47 controls. The prevalence of Bw46 was significantly increased...

journal_title：Clinical endocrinology

authors： Hawkins BR,Ma JT,Lam KS,Wang CC,Yeung RT

更新日期：1985-09-01 00:00:00

abstract：CONTEXT:Patients with primary adrenal insufficiency (PAI) and patients with congenital adrenal hyperplasia (CAH) receive weight-adapted standard glucocorticoid replacement therapy. Clinically, some patients appear more sensitive to therapeutic administration of glucocorticoids than others. Glucocorticoid sensitivity is...

journal_title：Clinical endocrinology

authors： Koetz KR,van Rossum EF,Ventz M,Diederich S,Quinkler M

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVES:Cytokines have an important role in orchestrating the pathophysiology in autoimmune thyroid disease. The aim of the current study was to analyse the expression of interleukin (IL)-14 and IL-16 in the thyroid tissue of patients with Graves' disease (GD), Hashimoto's thyroiditis (HT) or multinodular goitre (MN...

journal_title：Clinical endocrinology

authors： Kemp EH,Ajjan RA,Metcalfe RA,Watson PF,Weetman AP

更新日期：2015-11-01 00:00:00

abstract：PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

journal_title：Clinical endocrinology

authors： Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

更新日期：2018-08-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：:Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

journal_title：Clinical endocrinology

authors： Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

journal_title：Clinical endocrinology

authors： Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

journal_title：Clinical endocrinology

authors： Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:This study explored leptin concentrations in Prader-Willi syndrome (PWS), a genetic disorder characterized by significant obesity and presumed hypothalamic dysfunction. The potential interaction of leptin metabolism with the growth hormone (GH) axis was also studied. STUDY DESIGN:Plasma leptin concentrations...

journal_title：Clinical endocrinology

authors： Myers SE,Davis A,Whitman BY,Santiago JV,Landt M

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:Phaeochromocytomas (PHEO) and functional paragangliomas (PGLs) are catecholamine-secreting neuroendocrine tumours. Although most PHEO/PGLs are benign, 10-35% present as (or develop into) malignant tumours with a poor prognosis. Overexpression of ERBB2 (v-erb-b2 erythroblastic leukaemia viral oncogene homologu...

journal_title：Clinical endocrinology

authors： Qi Y,Su T,Zhang X,Jiang Y,Yuan W,Wang W,Cui B,Ning G

更新日期：2012-09-01 00:00:00

abstract：OBJECTIVE:IGF-1 stimulates growth, development and function of lymphocytes. The aim of this study was to examine whether functional variants of the IGF-1 gene are associated with absolute lymphocyte subset counts in neonates. STUDY DESIGN AND MEASUREMENTS:This study was embedded in the Generation R Study, a prospectiv...

journal_title：Clinical endocrinology

authors： Duijts L,Bakker-Jonges LE,Mook-Kanamori DO,Labout JA,Hofman A,van Duijn CM,van Dongen JJ,Hooijkaas H,Moll HA,Jaddoe VW

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVE:Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late-maturing adolescents grow slower than postulated by age-related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity refe...

journal_title：Clinical endocrinology

authors： Binder G,Lehrian TJ,Hoffmann E,Blumenstock G,Rahmaoui A,Trzaskoma B,Reinehr T

更新日期：2021-02-01 00:00:00

abstract：:Current guidelines do not recommend the routine use of somatostatin analogue pretreatment prior to surgery in patients with growth hormone-secreting pituitary tumours. In theory, presurgical use of somatostatin analogues should improve metabolic control and reduce soft tissue swelling, leading to improved anaesthetic ...

journal_title：Clinical endocrinology

authors： Jacob JJ,Bevan JS

更新日期：2014-12-01 00:00:00

abstract：OBJECTIVE:Recently, a somatic point mutation of the BRAF gene (V599E) has been identified as the most common genetic event in papillary thyroid carcinoma (PTC) with a variable frequency (about 25-70%) in different series from USA, Japan, Portugal and Ukraine. DESIGN:In the present study, the genetic analysis of BRAF i...

journal_title：Clinical endocrinology

authors： Fugazzola L,Mannavola D,Cirello V,Vannucchi G,Muzza M,Vicentini L,Beck-Peccoz P

更新日期：2004-08-01 00:00:00

abstract：UNLABELLED:A diagnosis of bilateral pheochromocytoma warrants exclusion of hereditary pheochromocytoma. OBJECTIVE:To describe the first case of a bilateral pheochromocytoma associated with V804M mutation in the RET proto-oncogene. PATIENTS:The index case was a 54-year-old man with bilateral adrenal masses discovered ...

journal_title：Clinical endocrinology

authors： Recasens M,Oriola J,Fernández-Real JM,Roig J,Rodríguez-Hermosa JI,Font JA,Galofre P,López-Bermejo A,Ricart W

更新日期：2007-07-01 00:00:00

abstract：OBJECTIVE:Serum IGF-I levels are monitored during GH replacement treatment in adults with GH deficiency (GHD) to guide GH dose adjustment and to minimize occurrence of GH-related side-effects. This is not routine practice in children treated with GH. The aim of this study was to evaluate changes in (1) serum IGF-I, IGF...

journal_title：Clinical endocrinology

authors： Tillmann V,Patel L,Gill MS,Whatmore AJ,Price DA,Kibirige MS,Wales JK,Clayton PE

更新日期：2000-09-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin re...

journal_title：Clinical endocrinology

authors： Cuatrecasas G,Granada ML,Formiguera X,Rull M,Alastrué A,Remesar X,Alemany M,Foz M

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. DESIGN:Blood samples of 440 participants of the Metabol...

journal_title：Clinical endocrinology

authors： Bobbert T,Schwarz F,Fischer-Rosinsky A,Maurer L,Möhlig M,Pfeiffer AF,Mai K,Spranger J

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma gene has been associated in some, but not all, studies with lower body mass index (BMI) and improved insulin sensitivity; how an altered transcriptional activity of PPARgamma2 could influence insulin sensitivity is curre...

journal_title：Clinical endocrinology

authors： Vaccaro O,Mancini FP,Ruffa G,Sabatino L,Iovine C,Masulli M,Colantuoni V,Riccardi G

更新日期：2002-10-01 00:00:00