Osteocalcin-insulin relationship in obese children: a role for the skeleton in energy metabolism.


OBJECTIVE:Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteocalcin fulfils the same function in humans. METHODS:We investigated the relationship between serum osteocalcin and insulin concentrations in 27 prepubertal obese children (9-12 years old) randomly divided into two groups, one of which entered a physical training programme, and 16 nonobese control children. Whole body bone mineral density (WB-BMD), serum osteocalcin, circulating insulin and adiponectin were measured at baseline and after 6 months. RESULTS:Trained and untrained obese children had higher WB-BMD than controls at baseline. Trained children also displayed a significant insulin increase and a significant adiponectin decrease while osteocalcin was increased compared to untrained obese children. Significant linear correlations between WB-BMD and adiponectin, delta BMD (variation between baseline and after-training values) and delta adiponectin, insulin and osteocalcin, delta insulin and delta osteocalcin, delta insulin and delta under-carboxylated osteocalcin were found only in trained obese children with no significant relationship in control and untrained obese children. CONCLUSIONS:In trained obese children, correlations indicate that when BMD is increased, osteocalcin is increased and insulin lowered. This suggests that increased BMD is associated with increased energy metabolism and a decreased level of insulin. We thus report statistically significant relationships between the skeleton (osteocalcin) and energy metabolism (insulin), suggesting a regulatory hormonal loop including osteocalcin and insulin.


Clin Endocrinol (Oxf)


Clinical endocrinology


Rochefort GY,Rocher E,Aveline PC,Garnero P,Bab I,Chappard C,Jaffré C,Benhamou CL




Has Abstract


2011-08-01 00:00:00












  • Extra-adrenal effects of metyrapone include inhibition of the 11-oxoreductase activity of 11 beta-hydroxysteroid dehydrogenase: a model for 11-HSD I deficiency.

    abstract:BACKGROUND AND OBJECTIVE:Previous studies suggesting effects of metyrapone on extra-adrenal corticosteroid metabolism have involved significant alterations in plasma cortisol. We have therefore studied effects of metyrapone on urinary excretion of steroids in a group of patients treated concurrently with hydrocortisone...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Raven PW,Checkley SA,Taylor NF

    更新日期:1995-11-01 00:00:00

  • Oncoprotein immunoreactivity in human pituitary tumours.

    abstract:OBJECTIVE AND DESIGN:The immediate early gene locus AP-1, incorporating the cellular oncogenes c-fos and c-jun (and their oncoprotein products Fos and Jun respectively) play a key role in regulating cell growth and differentiation. The myc-gene is also known to promote cell growth. In order to investigate the possible ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Raghavan R,Harrison D,Ince PG,James RA,Daniels M,Birch P,Caldwell GI,Kendall-Taylor P

    更新日期:1994-01-01 00:00:00

  • Effects of testosterone on sexual function in men: results of a meta-analysis.

    abstract:OBJECTIVES:The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta-analysis of placebo-controlled studies publ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析,评审


    authors: Isidori AM,Giannetta E,Gianfrilli D,Greco EA,Bonifacio V,Aversa A,Isidori A,Fabbri A,Lenzi A

    更新日期:2005-10-01 00:00:00

  • Reduced levels of E-cadherin correlate with progression of corticotroph pituitary tumours.

    abstract:OBJECTIVES:Loss of E-cadherin is an important marker of epithelial tumour progression. The aims of this study were to explore whether E-cadherin expression and localization correlate to corticotroph tumour progression, relate the expression of the E-cadherin gene (CDH1) to immunohistochemical E-cadherin staining patter...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Evang JA,Berg JP,Casar-Borota O,Lekva T,Kringen MK,Ramm-Pettersen J,Bollerslev J

    更新日期:2011-12-01 00:00:00

  • Alterations in circulating thyroid hormones and thyroxine binding globulin in chronic alcoholism.

    abstract::The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We su...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Geurts J,Demeester-Mirkine N,Glinoer D,Prigogine T,Fernandez-Deville M,Corvilain J

    更新日期:1981-02-01 00:00:00

  • Calcitonin in breast and lung cancer.

    abstract::Immunoreactive calcitonin was found in extracts of seven out of eight consecutive breast carcinomas and four selected lung carcinomas, but not in extracts of benign breast lesions or normal tissues. This suggests that the high plasma calcitonin levels observed in patients with a wide variety of cancers reflect ectopic...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hillyard CJ,Coombes RC,Greenberg PB,Galante LS,MacIntyre I

    更新日期:1976-01-01 00:00:00

  • Effects of alpha-1 adrenergic blockade on the hormonal response to hypoglycaemic stress in normal man.

    abstract::In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

    更新日期:1987-01-01 00:00:00

  • Ovarian morphology and insulin sensitivity in women with bulimia nervosa.

    abstract:OBJECTIVE:Hyperinsulinaemia has a role in the development of hyperandrogenism and polycystic ovary syndrome in women of normal weight. Polycystic ovaries are common in women with bulimia nervosa and this study aimed to determine whether women with bulimia nervosa are insulin resistant and to examine the relation betwee...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Raphael FJ,Rodin DA,Peattie A,Bano G,Kent A,Nussey SS,Lacey JH

    更新日期:1995-10-01 00:00:00

  • In-vivo and in-vitro endocrine investigation of pure gonadal dysgenesis.

    abstract::Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wilson SC,Oakey RE,Scott JS

    更新日期:1988-11-01 00:00:00

  • Does hypopituitarism recover when macroprolactinomas are treated with cabergoline?

    abstract:OBJECTIVE:The frequency and the degree of recovery of anterior pituitary hormone deficits in patients with macroprolactinoma responsive to cabergoline are not clear. Our aim was to evaluate pituitary function in these patients with particular reference to an assessment of the possible restoration of pituitary deficits....

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Karavitaki N,Dobrescu R,Byrne JV,Grossman AB,Wass JA

    更新日期:2013-08-01 00:00:00

  • Normal prolactin response following thyrotrophin releasing hormone in patients with autonomously functioning euthyroid multinodular goitre.

    abstract::Twelve female patients (mean age 60 years, range 41--74) with euthyroid multinodular goitre and a flat TRH test (median delta TSH 0.9 muIU/ml, range 0--3.5) had normal prolactin responses to TRH (median data prolactin 48 ng/ml, range 6--115). The results are comparable with those in euthyroid patients receiving full s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Elte JW,Wiarda KS,Frölich M,Haak A

    更新日期:1978-11-01 00:00:00

  • Pituitary-ovarian function before, during and after the menopause: a longitudinal study.

    abstract::The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Metcalf MG,Donald RA,Livesey JH

    更新日期:1982-11-01 00:00:00

  • The sodium-iodide symporter expression in placental tissue at different gestational age: an immunohistochemical study.

    abstract:BACKGROUND:Iodide (I(-)) is crucial for foetal thyroid function. Foetal iodide results from maternal circulating iodide and from deiodination of iodothyronines within the placenta. The Na(+)/I(-) symporter (NIS) localized in placental cells appears to be involved in iodide exchange. Low NIS expression has been reported...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Di Cosmo C,Fanelli G,Tonacchera M,Ferrarini E,Dimida A,Agretti P,De Marco G,Vitti P,Pinchera A,Bevilacqua G,Naccarato AG,Viacava P

    更新日期:2006-10-01 00:00:00

  • Hormone replacement therapy may improve hepatic function in women with Turner's syndrome.

    abstract:OBJECTIVE:Women with Turner's syndrome (TS) have recently been shown to be at an increased risk of developing chronic liver disease. There has been some concern that oestrogen replacement therapy may exacerbate hepatic dysfunction. The aim of this study was to assess hepatic function in women with TS and to determine t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Elsheikh M,Hodgson HJ,Wass JA,Conway GS

    更新日期:2001-08-01 00:00:00

  • Pyridostigmine fails to increase either spontaneous or GHRH-stimulated GH secretion during day or night in growth hormone-insufficient children.

    abstract::OBJECTIVE The aim of the study was to investigate whether pyridostigmine, a cholinesterase inhibitor which is thought to act at the hypothalamus to inhibit somatostatin secretion, would augment spontaneous or GHRH-stimulated serum GH levels in patients with GH-insufficiency. DESIGN Oral pyridostigmine 60 mg or placebo...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Kirk JM,Ross RJ,Trainer PJ,Froud AL,Davies SC,Savage MO,Besser GM

    更新日期:1991-05-01 00:00:00

  • No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease.

    abstract:OBJECTIVE:A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and auto...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Jennings CE,Owen CJ,Wilson V,Pearce SH

    更新日期:2005-03-01 00:00:00

  • Suppressed TSH levels secondary to thyroxine replacement therapy are not associated with osteoporosis.

    abstract:OBJECTIVE:Recent studies have suggested that patients receiving thyroxine are at increased risk of osteoporosis. We set out to measure bone mineral densities in two groups of post-menopausal women receiving thyroxine replacement therapy (those with serum TSH levels persistently suppressed or non-suppressed) and to comp...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Grant DJ,McMurdo ME,Mole PA,Paterson CR,Davies RR

    更新日期:1993-11-01 00:00:00

  • Suppression of plasma ACTH concentration by angiotensin II infusion in normal humans and in a subject with a steroid 17 alpha-hydroxylase defect.

    abstract::Six healthy subjects were infused with angiotensin II and plasma concentrations of angiotensin, ACTH and cortisol were measured before, during and after the infusion. In all cases the plasma ACTH concentration fell as plasma angiotensin increased and rose again, sometimes to higher than basal levels, when the angioten...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Semple PF,Buckingham JC,Mason PA,Fraser R

    更新日期:1979-02-01 00:00:00

  • Determinants of sex hormone-binding globulin in normal postmenopausal women.

    abstract:OBJECTIVE:To examine the factors influencing the levels of sex hormone-binding globulin (SHBG) in normal postmenopausal women by assessing the relationship between SHBG and measured anthropometric, metabolic and hormonal variables. DESIGN:Cross-sectional, observational study. SUBJECTS AND METHODS:Seventy normal postm...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wu F,Ames R,Evans MC,France JT,Reid IR

    更新日期:2001-01-01 00:00:00

  • The effect of transdermal oestrogen on bone, calcium-regulating hormones and liver in postmenopausal women.

    abstract::Transdermal oestradiol, 100 micrograms/d, was used to treat 11 women suffering from postmenopausal symptoms. After 3 weeks therapy there was a significant rise in the plasma oestradiol into the premenopausal range and a significant fall in plasma FSH level and symptom score. Bone resorption, assessed by urinary excret...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Selby PL,Peacock M

    更新日期:1986-11-01 00:00:00

  • Diagnostic accuracy of [¹⁸F]-fluoro-L-dihydroxyphenylalanine positron emission tomography scan for persistent congenital hyperinsulinism in Japan.

    abstract:OBJECTIVE:We aimed to elucidate the accuracy and limitations of [(18)F]-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism. Although [(18)F]DOPA PET is reported to be useful for precisely localizing the focal form of congenital hyperin...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Masue M,Nishibori H,Fukuyama S,Yoshizawa A,Okamoto S,Doi R,Uemoto S,Tokumi T,Kasai T,Yorifuji T

    更新日期:2011-09-01 00:00:00

  • Influence of different genotypes on 17-hydroxyprogesterone levels in patients with nonclassical congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:The diagnosis of the nonclassical form of 21-hydroxylase (NC-21OH) deficiency, established before molecular studies, is based on basal 17OH-progesterone (17OH-P) values > 15 nmol/l or ACTH-stimulated 17OH-P values > 30 nmol/l. This disease is caused by mutations in the structural gene that can be grouped into...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bachega TA,Billerbeck AE,Marcondes JA,Madureira G,Arnhold IJ,Mendonca BB

    更新日期:2000-05-01 00:00:00

  • Which parameters predict the beneficial effect of GnRHa treatment on height in girls with central precocious puberty?

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vuralli D,Gonc EN,Ozon ZA,Kandemir N,Alikasifoglu A

    更新日期:2021-01-18 00:00:00

  • Symptoms of thyrotoxicosis, bone metabolism and occult atrial fibrillation in older women with mild endogenous subclinical hyperthyroidism.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Rosario PW,Carvalho M,Calsolari MR

    更新日期:2016-07-01 00:00:00

  • Association between polycystic ovary syndrome and the vaginal microbiome: A case-control study.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hong X,Qin P,Huang K,Ding X,Ma J,Xuan Y,Zhu X,Peng D,Wang B

    更新日期:2020-07-01 00:00:00

  • Recent concerns surrounding HRT.

    abstract::Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Armitage M,Nooney J,Evans S

    更新日期:2003-08-01 00:00:00

  • Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF-I and endogenous IGFBP-3.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schmidt A,Chakravarty A,Brommer E,Fenne BD,Siebler T,De Meyts P,Kiess W

    更新日期:2002-08-01 00:00:00

  • The effect of quinagolide and cabergoline, two selective dopamine receptor type 2 agonists, in the treatment of prolactinomas.

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    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Di Sarno A,Landi ML,Marzullo P,Di Somma C,Pivonello R,Cerbone G,Lombardi G,Colao A

    更新日期:2000-07-01 00:00:00

  • Changes in treatment needs of hypoparathyroidism during pregnancy and lactation: A case series.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hartogsohn EAR,Khan AA,Kjaersulf LU,Sikjaer T,Hussain S,Rejnmark L

    更新日期:2020-09-01 00:00:00

  • Radiation and neuroregulatory control of growth hormone secretion.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ogilvy-Stuart AL,Wallace WH,Shalet SM

    更新日期:1994-08-01 00:00:00