Inhibin as a marker for hydatidiform mole: a comparative study with the determinations of intact human chorionic gonadotrophin and its free beta-subunit.

abstract：AIM:A high level of matrix metalloproteinase 9 (MMP-9) is a predictor of poor wound healing in diabetic foot ulcers. In skin keratinocytes, site-specific DNA demethylation plays an important role in MMP-9 expression. Ten-eleven translocation enzyme 2 (TET2) protein, one member of TET family, could rely on α-ketoglutara...

journal_title：Clinical endocrinology

authors： Tan Q,Wang W,Yang C,Zhang J,Sun K,Luo HC,Mai LF,Lao Y,Yan L,Ren M

更新日期：2016-07-01 00:00:00

abstract：:Men with hypogonadotropic hypogonadism (HH) are typically azoospermic, and yet HH is one of the few treatable forms of male infertility. Sperm induction protocols using gonadotrophins aim to replicate the natural endocrine control of spermatogenesis. Previously virilised men with adult-onset HH and normal testicular v...

journal_title：Clinical endocrinology

authors： Prior M,Stewart J,McEleny K,Dwyer AA,Quinton R

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Antithyroidal drugs (ATD) are used in the management of Graves' disease either as primary therapy for several months while awaiting remission of the disease or as pretreatment for several weeks prior to definitive radioactive iodine therapy (RAI). We have reported previously that pretreatment with propylthiou...

journal_title：Clinical endocrinology

authors： Hancock LD,Tuttle RM,LeMar H,Bauman J,Patience T

更新日期：1997-10-01 00:00:00

abstract：RATIONALE:Low serum testosterone is commonly observed in men with type 2 diabetes (T2DM), but the neuroendocrine pathophysiology remains to be elucidated. OBJECTIVES:The hypothalamic neuropeptide kisspeptin integrates metabolic signals with the reproductive axis in animal models. We hypothesized that administration of...

journal_title：Clinical endocrinology

authors： George JT,Veldhuis JD,Tena-Sempere M,Millar RP,Anderson RA

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

journal_title：Clinical endocrinology

authors： Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

更新日期：2007-03-01 00:00:00

abstract：:Nutrition and growth during infancy are an emerging issue because of their potential link to metabolic health disorders in later life. Moreover, prolonged breast-feeding appears to be associated with a lower risk of obesity than formula feeding. Human milk is a source of various hormones and growth factors, namely adi...

journal_title：Clinical endocrinology

authors： Savino F,Fissore MF,Liguori SA,Oggero R

更新日期：2009-12-01 00:00:00

abstract：OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

journal_title：Clinical endocrinology

authors： McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

更新日期：2000-06-01 00:00:00

abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...

journal_title：Clinical endocrinology

authors： Li WF,Wang G,Zhao ZB,Liu CA

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:We investigated the content and compared the molecular forms of parathyroid hormone-related protein in tumour tissue, plasma and pleural fluid. DESIGN:Measurement of parathyroid hormone-related protein in tumour extracts and biological fluids and comparison of the elution profiles of parathyroid hormone-rela...

journal_title：Clinical endocrinology

authors： Bowden SJ,Hughes SV,Ratcliffe WA

更新日期：1993-03-01 00:00:00

abstract：:Twenty-four hyperprolactinaemic women were treated for 6 months with the new, non-ergot, long-acting dopamine agonist, CV 205-502. The treatment resulted in normalization of PRL secretion in 17 of the 24 women at once-daily doses of 0.05 to 0.15 mg of the drug. Sixteen of these women as well as 4 of those who remained...

journal_title：Clinical endocrinology

authors： Rasmussen C,Bergh T,Wide L,Brownell J

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

journal_title：Clinical endocrinology

authors： Rogol AD,Blethen SL,Sy JP,Veldhuis JD

更新日期：2003-02-01 00:00:00

abstract：:Alopecia is a frequent feature in hereditary resistance to (1,25(OH)2D). We sought insight into this feature by analysing data from affected members of 30 kindreds. We assessed indices of mineral metabolism in one group with normal hair compared with a group with alopecia. Hereditary resistance to 1,25(OH)2D was diagn...

journal_title：Clinical endocrinology

authors： Marx SJ,Bliziotes MM,Nanes M

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

journal_title：Clinical endocrinology

authors： Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

更新日期：2018-01-01 00:00:00

abstract：OBJECTIVE:The protein polymorphism of the GH receptor caused by genomic deletion of exon 3 (d3) has been linked to the magnitude of the first-year-growth response to GH in girls with Turner syndrome. Here, we studied the long-term effect of GH therapy in Turner syndrome in correlation to this polymorphism. DESIGN:The ...

journal_title：Clinical endocrinology

authors： Binder G,Trebar B,Baur F,Schweizer R,Ranke MB

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:A high prevalence of diabetes mellitus has been shown in patients with primary hyperparathyroidism (PHPT). However, it is unclear whether this is related to the metabolic abnormalities in PHPT or to the presence of other risk factors for glucose intolerance in these patients. The aim of our study was to deter...

journal_title：Clinical endocrinology

authors： Kumar S,Olukoga AO,Gordon C,Mawer EB,France M,Hosker JP,Davies M,Boulton AJ

更新日期：1994-01-01 00:00:00

abstract：:The biological response, as measured in the cytochemical bioassay, to the high circulating levels of immunoreactive parathyroid hormone (iPTH) in patients with pseudohypoparathyroidism type I (PSPI) is affected by the presence of an endogenous inhibitor. This is evidenced by the reduced recovery of the biological acti...

journal_title：Clinical endocrinology

authors： Loveridge N,Fischer JA,Devogelaer JP,Nagant de Deuxchaisnes C

更新日期：1986-05-01 00:00:00

abstract：CONTEXT:Previous studies suggested that plasma aldosterone (PAC) response to ACTH stimulation could predict the subtypes of primary aldosteronism (PA) and avoid adrenal venous sampling (AVS). OBJECTIVE:Assess the usefulness of peripheral (P) PAC response to ACTH stimulation during AVS to identify the source of aldoste...

journal_title：Clinical endocrinology

authors： St-Jean M,Bourdeau I,Therasse É,Lacroix A

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND:Macroadenomas represent 50% of pituitary tumours and are often (30%) nonfunctioning. Their immunophenotype suggests differentiation toward a specific pituitary cell line. A substantial proportion of tumours with particularly aggressive behaviour are so called 'silent subtype 3 adenoma'. Its diagnosis require...

journal_title：Clinical endocrinology

authors： Erickson D,Scheithauer B,Atkinson J,Horvath E,Kovacs K,Lloyd RV,Young WF Jr

更新日期：2009-07-01 00:00:00

abstract：BACKGROUND:Papillary thyroid cancer (PTC) is a common endocrine cancer and commonly presents with lymph node (LN) metastases. The role of surgical removal of the central cervical LN compartment is poorly defined. There are no prospective randomized controlled trials addressing the relevance to the extent of the initial...

journal_title：Clinical endocrinology

authors： Mulla M,Schulte KM

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:GH replacement improves numerous metabolic abnormalities in GH-deficient patients; increased lipid peroxidation (LPO) has been observed in GH-deficient patients; however, it is unknown if LPO is influenced by GH replacement. AIM AND METHODS:To evaluate the extent to which GH replacement might reverse the in...

journal_title：Clinical endocrinology

authors： Karbownik-Lewinska M,Kokoszko A,Lewandowski KC,Shalet SM,Lewinski A

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:The Dlk1 gene encodes for dlk1, a transmembrane protein belonging to the EGF-like repeat-containing family. Dlk1 has been shown to act as a regulator of adipogenesis. Fc-dlk1 transgenic mice show a decrease in adipose tissue and glucose tolerance, hypertriglyceridaemia and lower insulin sensitivity. Dlk1-def...

journal_title：Clinical endocrinology

authors： Hermida C,Garcés C,de Oya M,Cano B,Martínez-Costa OH,Rivero S,García-Ramírez JJ,Laborda J,Aragón JJ

更新日期：2008-08-01 00:00:00

abstract：:A single-dose study was performed to examine the pharmacokinetics of subcutaneous octreotide in acromegalic patients and to investigate the relationship between growth hormone and the elimination half-life of the drug. Fourteen acromegalic patients (six men and eight women; age range 35-59 years) who had previously re...

journal_title：Clinical endocrinology

authors： Nicholls J,Wynick D,Domin J,Sandler LM,Bloom SR

更新日期：1990-05-01 00:00:00

abstract：:Plasma glucagon response to an arginine infusion was studied in children and adolescents belonging to the following groups: (I) twenty-two controls; (II) six subjects with delayed insulin peak during oral GTT; (III) ten diabetics on diet and/or oral therapy; (IV) six newly diagnosed uncompensated diabetics; and (V) ei...

journal_title：Clinical endocrinology

authors： Josefsberg Z,Laron Z,Doron M,Keret R,Belinski Y,Weismann I

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:To study the relationship between the excretion of nephrogenous cyclic AMP (NcAMP) and other blood and urine parameters as an index of PTH-like activity in patients with primary hepatocellular carcinoma. DESIGN:After overnight fast, a double voided urine and a blood sample were collected from each subject fo...

journal_title：Clinical endocrinology

authors： Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

更新日期：1991-12-01 00:00:00

abstract：:Thyroid antibodies were demonstrated in 57% of thirty pernicious anaemia patients without overt thyroid disease. Elevated basal thyroid stimulating hormone (TSH) levels and an enhaced TSH response to thyrotrophin releasing hormone (TRH) only occurred in thyroid antibody positive subjects; by contrast the thyroid antib...

journal_title：Clinical endocrinology

authors： Krassas G,McHardy-Young S,Ramsay I,Florin-Christensen A

更新日期：1977-02-01 00:00:00

abstract：BACKGROUND:Peroxisomal proliferator-activated receptors (PPAR)- gamma are expressed abundantly in ACTH-secreting pituitary tumours. The PPAR-gamma activator rosiglitazone has been shown to suppress ACTH secretion in human adrenocorticotroph tumour cells in vitro, and prevent and reduce adrenocorticotroph tumour develop...

journal_title：Clinical endocrinology

authors： Mullan KR,Leslie H,McCance DR,Sheridan B,Atkinson AB

更新日期：2006-05-01 00:00:00

abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...

journal_title：Clinical endocrinology

authors： Dahlberg PA,Karlsson FA,Lundqvist G

更新日期：1981-02-01 00:00:00

abstract：:Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

journal_title：Clinical endocrinology

authors： Armitage M,Nooney J,Evans S

更新日期：2003-08-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00