Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?


OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal children (n = 825) with idiopathic growth failure who were subsequently treated with GH were divided into two groups, based on their maximum GH response to pharmacological stimulation testing: (1) idiopathic GH deficiency (IGHD), defined by a maximum GH response < 10 microg/l (n = 300); and (2) idiopathic short stature (ISS), with a maximum GH response > or = 10 microg/l (n = 525) (GH conversion factor: 3 IU = 1 mg). MEASUREMENTS:Overnight spontaneous GH secretion was measured in all patients. The following characteristics of spontaneous GH secretion were studied: maximum or peak GH, mean peak GH, number of GH peaks, pooled GH, mean GH, and approximate entropy of GH secretion. RESULTS:Although children with IGHD had lower indices of spontaneous GH secretion, there were no differences between IGHD and ISS groups in baseline Ht SDS, growth rate or IGF-I level. The dose and duration of GH therapy were similar. There was no statistically significant difference in the mean (+/- SD) change in Ht SDS (deltaHt SDS) in the two groups (IGHD 1.3 +/- 0.9 and ISS 1.2 +/- 0.8). Measures of spontaneous secretion, such as peak GH, mean of GH peaks, mean area under GH peaks, and mean GH, as well as IGF-I concentrations, were all statistically significantly correlated with deltaHt SDS in IGHD children (P < 0.0001). A significant correlation was also observed for pooled GH (P = 0.002) and approximate entropy (P = 0.01). Children with the most severe ISS (Ht SDS < -3.33) demonstrated a more disorganized pattern of GH secretion compared to children who were not as short (Ht SDS -2.33 to -1.64), as indicated by a higher approximate entropy (0.673 +/- 0.193 vs. 0.607 +/- 0.161, P < 0.004). This increased disorder in GH secretion was accompanied by lower IGF-I levels (104 +/- 99 microg/l vs. 137 +/- 74 microg/l, P < 0.001), even though pooled GH concentrations were indistinguishable between the two groups (2.2 +/- 1.3 microg/l vs. 2.0 +/- 1.0 microg/l). Children with IGHD demonstrated lower approximate entropy than did those with ISS (0.551 +/- 0.235 vs. 0.631 +/- 0.182, P < 0.0001). Duration of GH treatment, height deficit and genetic potential (midparental Ht SDS) were the most important variables influencing deltaHt SDS in children receiving GH therapy. Maximum stimulated GH, IGF-I and indices of spontaneous GH secretion also correlated with deltaHt SDS, but their relative importance varied among diagnostic groups. CONCLUSIONS:Patients with GH deficiency demonstrate a reduced capacity for GH secretion, while those with idiopathic short stature exhibit a more disorderly and less functional secretory pattern. Although effective in predicting a response to GH treatment in patients with severe GH deficiency, overnight serial sampling is less practical than other methods currently available. In addition, serial sampling was less useful as a predictor of growth response to exogenous GH in patients with idiopathic short stature.


Clin Endocrinol (Oxf)


Clinical endocrinology


Rogol AD,Blethen SL,Sy JP,Veldhuis JD





Has Abstract


2003-02-01 00:00:00














  • Prescription of antidepressants is increased in Danish patients with polycystic ovary syndrome and is associated with hyperandrogenism. A population-based cohort study.

    abstract:OBJECTIVE:Quality of life is impaired in polycystic ovary syndrome (PCOS). In this study, we compared the time to first prescription of antidepressants (ADM) in PCOS vs two control groups. DESIGN:Register-based cohort study. PATIENTS:One thousand and one hundred and twenty-four premenopausal women with hirsutism and/...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Altinok ML,Glintborg D,Depont Christensen R,Hallas J,Andersen M

    更新日期:2014-06-01 00:00:00

  • Postoperative plasma GH levels and restoration of GH dynamics in acromegalic patients surgically treated by the transsphenoidal approach.

    abstract::In 44 patients with acromegaly treated by transsphenoidal pituitary microsurgery, the relationship between changes in pre- and post-operative GH dynamics and postoperative fasting plasma GH levels was examined to clarify which is the optimal approach for evaluating postoperative removal of the tumour. TRH, LHRH and br...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Karashima T,Kato K,Nawata H,Ikuyama S,Ibayashi H,Nakagaki H,Kitamura K

    更新日期:1986-08-01 00:00:00

  • Evaluation of an inexpensive calcium absorption index in healthy older men and women.

    abstract:OBJECTIVE:Calcium absorption is an important determinant of calcium retention and bone metabolism. However, most methods of measuring calcium absorption, including the well-established dual stable isotope method, are costly and cumbersome to implement. We evaluated whether an oral calcium tolerance test (OCTT), which i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Ceglia L,Abrams SA,Harris SS,Rasmussen HM,Dallal GE,Dawson-Hughes B

    更新日期:2010-01-01 00:00:00

  • The effect of thyroxine on small intestinal motility in the elderly.

    abstract:OBJECTIVE:To study the effects of thyroxine on orocaecal transit time in a group of elderly hypothyroid patients on long-term thyroxine replacement therapy. DESIGN:Measurement of the effect of withdrawal and subsequent replacement of thyroxine replacement therapy on orocaecal transit time. PATIENTS:Fifteen elderly, p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Rahman Q,Haboubi NY,Hudson PR,Lee GS,Shah IU

    更新日期:1991-11-01 00:00:00

  • The distribution of oestradiol in plasma in relation to uterine cross-sectional area in women with polycystic or multifollicular ovaries.

    abstract::The uterine cross-sectional area (UXA) of women with polycystic (PCO) or multifollicular ovaries (MFO) is significantly larger and smaller, respectively, than those of normal women during the early-mid-follicular phase of the menstrual cycle. In the present study the distribution of oestradiol in plasma from normal wo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Polson DW,Franks S,Reed MJ,Cheng RW,Adams J,James VH

    更新日期:1987-05-01 00:00:00

  • Addison's disease with polyglandular autoimmunity carries a more than 2·5-fold risk for adrenal crises: German Health insurance data 2010-2013.

    abstract:OBJECTIVE:Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in different forms of AI. DESIGN/PATIENTS:The Statutory Health Insurance (SHI) database of the Techniker Krankenkasse - covering more tha...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Meyer G,Badenhoop K,Linder R

    更新日期:2016-09-01 00:00:00

  • Serum iodothyronine concentrations during introduction of thyroxine replacement therapy in hypothyroidism.

    abstract::Serum concentrations of total and free T4 (TT4 and FT4), total and free T3 (TT3 and FT3), rT3, T4 binding globulin (TBG), T3 uptake (T3U) and TSH were measured in 12 patients with severe hypothyroidism before and during the introduction of replacement therapy with oral T4. The dose of T4 was increased by increments of...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pearce CJ,Himsworth RL

    更新日期:1986-09-01 00:00:00

  • A randomized trial of short-term treatment of Graves' disease with high-dose carbimazole plus thyroxine versus low-dose carbimazole.

    abstract:OBJECTIVE:The optimal treatment regimen with thionamide drugs remains a matter for debate. We have investigated whether high doses of carbimazole, when compared with low doses, reduce relapse rates of Graves' disease. DESIGN:In an open label, randomized, prospective trial of treatment of Graves' disease we compared hi...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Grebe SK,Feek CM,Ford HC,Fagerström JN,Cordwell DP,Delahunt JW,Toomath RJ

    更新日期:1998-05-01 00:00:00

  • Follicular and endocrine dose responses according to anti-Müllerian hormone levels in IVF patients treated with a novel human recombinant FSH (FE 999049).

    abstract:OBJECTIVE:To study the association between serum anti-Müllerian hormone (AMH) levels and follicular development and endocrine responses induced by increasing doses (5·2-12·1 μg/day) of a novel recombinant human FSH (rhFSH, FE 999049) in patients undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Bosch E,Nyboe Andersen A,Barri P,García-Velasco JA,de Sutter P,Fernández-Sánchez M,Visnova H,Klein BM,Mannaerts B,Arce JC

    更新日期:2015-12-01 00:00:00

  • The effect of B cell depletion therapy on anti-TSH receptor antibodies and clinical outcome in glucocorticoid-refractory Graves' orbitopathy.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mitchell AL,Gan EH,Morris M,Johnson K,Neoh C,Dickinson AJ,Perros P,Pearce SH

    更新日期:2013-09-01 00:00:00

  • Replacement therapy with levothyroxine plus triiodothyronine (bioavailable molar ratio 14 : 1) is not superior to thyroxine alone to improve well-being and cognitive performance in hypothyroidism.

    abstract:OBJECTIVES:There is evidence from recent controlled clinical studies that replacement therapy of hypothyroidism with T4 in combination with a small amount of T3 may improve the well-being of the patients. As the issue is still the subject of controversial discussion, our study was assigned to confirm the superiority of...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Siegmund W,Spieker K,Weike AI,Giessmann T,Modess C,Dabers T,Kirsch G,Sänger E,Engel G,Hamm AO,Nauck M,Meng W

    更新日期:2004-06-01 00:00:00

  • Anti-Müllerian hormone (AMH) in female reproduction: is measurement of circulating AMH a useful tool?

    abstract::Anti-Müllerian hormone (AMH) is a dimeric glycoprotein, a member of the transforming growth factor (TGF) superfamily. It is produced exclusively in the gonads and is involved in the regulation of follicular growth and development. In the ovary AMH is produced by the granulosa cells of early developing follicles and se...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: La Marca A,Volpe A

    更新日期:2006-06-01 00:00:00

  • Adiponectin levels in adolescent girls with polycystic ovary syndrome (PCOS).

    abstract:OBJECTIVE:To determine serum adiponectin concentrations in adolescent girls with and without polycystic ovary syndrome (PCOS) and to assess possible correlations of adiponectin levels with insulin and androgen levels. DESIGN:Prospective case-control study. SETTING:Endocrine clinics in the community. PATIENTS:Forty-f...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pinhas-Hamiel O,Singer S,Pilpel N,Koren I,Boyko V,Hemi R,Pariente C,Kanety H

    更新日期:2009-12-01 00:00:00

  • Factors affecting the secretion of 18-hydroxycortisol, a novel steroid of relevance to Conn's syndrome.

    abstract::A recently developed radioimmunoassay for direct measurement of 18-hydroxycortisol (18-OH-F) in plasma and urine has been used to study the physiology of this newly described steroid in normal subjects. Plasma levels of 18-OH-F show a circadian variation similar to that of cortisol and are increased and suppressed by ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Corrie JE,Edwards CR,Jones DB,Padfield PL,Budd PS

    更新日期:1985-11-01 00:00:00

  • Circulating obestatin levels in normal subjects and in patients with impaired glucose regulation and type 2 diabetes mellitus.

    abstract:BACKGROUND:Obestatin is a novel hormone that is encoded by the Ghrelin gene and produced in the gut. Ghrelin is profoundly orexogenic and adipogenic, increasing food intake and body weight. This new ghrelin-associated peptide behaves as a physiological opponent of ghrelin in rodent animals, but its pathophysiological r...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Qi X,Li L,Yang G,Liu J,Li K,Tang Y,Liou H,Boden G

    更新日期:2007-04-01 00:00:00

  • Adipose tissue IL-8 is increased in normal weight women after menopause and reduced after gastric bypass surgery in obese women.

    abstract:OBJECTIVE:The menopausal transition is characterized by increased body fat accumulation, including redistribution from peripheral to central fat depots. This distribution is associated with an increased risk of type 2 diabetes and cardiovascular disease that are linked to low-grade inflammation. We determined whether p...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Alvehus M,Simonyte K,Andersson T,Söderström I,Burén J,Rask E,Mattsson C,Olsson T

    更新日期:2012-11-01 00:00:00

  • A comparison between the effects of SMS 201-995, bromocriptine and a combination of both drugs on hormone release by the cultured pituitary tumour cells of acromegalic patients.

    abstract::The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Lamberts SW,Verleun T,Hofland L,Del Pozo E

    更新日期:1987-07-01 00:00:00

  • GH-secreting pituitary adenomas infrequently contain inactivating mutations of PRKAR1A and LOH of 17q23-24.

    abstract:OBJECTIVE:The molecular events leading to the development of GH-secreting pituitary tumours remain largely unknown. Gsalpha (GNAS1) mutations are found in 27-43% of sporadic GH-secreting adenomas in the Caucasian population, but the frequency of GNAS1 mutations in Japanese and Korean acromegalic patients was reported t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yamasaki H,Mizusawa N,Nagahiro S,Yamada S,Sano T,Itakura M,Yoshimoto K

    更新日期:2003-04-01 00:00:00

  • Does hypopituitarism recover when macroprolactinomas are treated with cabergoline?

    abstract:OBJECTIVE:The frequency and the degree of recovery of anterior pituitary hormone deficits in patients with macroprolactinoma responsive to cabergoline are not clear. Our aim was to evaluate pituitary function in these patients with particular reference to an assessment of the possible restoration of pituitary deficits....

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Karavitaki N,Dobrescu R,Byrne JV,Grossman AB,Wass JA

    更新日期:2013-08-01 00:00:00

  • Concepts in ectopic hormone production.

    abstract::Non-endocrine tumours are capable of production of ectopic hormones, precursor molecules subunits and hormone-related fragments. The measurement of these may provide biochemical markers of malignancy, allowing presymptomatic diagnosis which may lead ultimately to an improved prognosis for the patient. The study of ect...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Rees LH

    更新日期:1976-01-01 00:00:00

  • Changes in gonadotrophin response to gonadotrophin releasing hormone in normal women following bilateral ovariectomy.

    abstract:OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

    更新日期:1997-12-01 00:00:00

  • Effect of corticotrophin-releasing hormone on arginine vasopressin and atrial natriuretic factor in patients with Cushing's disease.

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    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Colao A,Pivonello R,Ferone D,Faggiano A,Facciolli G,Di Somma C,Boudouresque F,Oliver C,Lombardi G

    更新日期:1998-07-01 00:00:00

  • Clinical indicators of biochemical remission in acromegaly: does incomplete disease control always mean therapeutic failure?

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Damjanovic SS,Neskovic AN,Petakov MS,Popovic V,Macut D,Vukojevic P,Joksimovic MM

    更新日期:2005-04-01 00:00:00

  • Cushing's disease due to female gonadotroph adenoma of the pituitary.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ikeda H,Yoshimoto T,Kovacs K,Horvath E

    更新日期:1995-09-01 00:00:00

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Roti E,Robuschi G,Manfredi A,D'Amato L,Gardini E,Salvi M,Montermini M,Barlli AL,Gnudi A,Braverman LE

    更新日期:1985-04-01 00:00:00

  • Skewed X chromosome inactivation in girls and female adolescents with autoimmune thyroid disease.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Santiwatana S,Mahachoklertwattana P,Limwongse C,Khlairit P,Pongratanakul S,Roothumnong E,Prangphan K,Choubtum L,Songdej D,Poomthavorn P

    更新日期:2018-12-01 00:00:00

  • Cystic fibrosis and normal fibroblasts have identical glucocorticoid receptor profiles and induced protein responses.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Khalid BA,Gyorki S,Warne GL,Funder JW

    更新日期:1983-04-01 00:00:00

  • Ultrastructural and steroidogenic characteristics of an androgen-producing adrenocortical tumour.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

    更新日期:1978-04-01 00:00:00

  • Interleukin 1 receptor antagonist is associated with changes in body composition during physiological GH substitution in patients with adult-onset growth hormone deficiency.

    abstract:OBJECTIVE:We examined the effect of GH substitution on adipose tissue-derived hormones and cytokines and sought to identify predictors for changes in body composition during therapy. Long-standing adult-onset GH deficiency (AO-GHD) is associated with increased body fat mass (FM) which, through production of hormones an...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,随机对照试验


    authors: Ueland T,Jørgensen AP,Godang K,Fougner KJ,Aukrust P,Burman P,Bollerslev J

    更新日期:2011-01-01 00:00:00

  • Psychological well-being in patients on 'adequate' doses of l-thyroxine: results of a large, controlled community-based questionnaire study.

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    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

    更新日期:2002-11-01 00:00:00