Studies in constitutionally tall adolescents: somatostatin decrease associated with growth hormone increase after TRH injection.

abstract：OBJECTIVE:The purpose was to investigate whether the function of the pinealocytes is changed in patients with disturbed metabolic rate or in subjects with marked obesity. DESIGN:Venous blood was sampled every second hour between 1800 and 0800 h, and urine collected between 2200 and 0700 h. PATIENTS:Eight patients wit...

journal_title：Clinical endocrinology

authors： Röjdmark S,Berg A,Rössner S,Wetterberg L

更新日期：1991-07-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (PHPT) is an uncommonly diagnosed condition among adolescents and young adults. We review the clinical characteristics of these patients based on our institutional experience. SUBJECTS:Patients aged 12-28 years treated for PHPT at our institution from 1990 to 1996 were evaluated b...

journal_title：Clinical endocrinology

authors： Loh KC,Duh QY,Shoback D,Gee L,Siperstein A,Clark OH

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVES:To optimize the indications for treating girls with idiopathic central precocious puberty with GnRH analogues, since outcomes may vary. DESIGN:Comparison of adult heights with the data at initial evaluation and the target heights. PATIENTS:Group 1 patients (n = 43) were treated with GnRH analogue from 7.9 ...

journal_title：Clinical endocrinology

authors： Adan L,Chemaitilly W,Trivin C,Brauner R

更新日期：2002-03-01 00:00:00

abstract：OBJECTIVE:This case series documents the response of nine individuals with glucocorticoid-refractory Graves' orbitopathy (GO) to B cell depletion therapy with rituximab (RTX). CONTEXT:Graves' disease (GD) is one of the commonest autoimmune conditions and is frequently associated with inflammatory changes around the ey...

journal_title：Clinical endocrinology

authors： Mitchell AL,Gan EH,Morris M,Johnson K,Neoh C,Dickinson AJ,Perros P,Pearce SH

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Some patients with parathyroid carcinoma present with an over-production of nontruncated amino-terminal (NT-N) parathyroid hormone (PTH), a post-transcriptionally modified form of PTH(1-84). This is usually picked up on an elevated whole (W) PTH (third-generation)/total (T) (second-generation) PTH assay ratio...

journal_title：Clinical endocrinology

authors： Caron P,Simonds WF,Maiza JC,Rubin M,Cantor T,Rousseau L,Bilezikian JP,Souberbielle JC,D'Amour P

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...

journal_title：Clinical endocrinology

authors： Li WF,Wang G,Zhao ZB,Liu CA

更新日期：2015-10-01 00:00:00

abstract：:We report six cases of autoimmune thyroid disease associated with chronic urticaria and briefly review the literature, including the histopathological nature of such lesions, and their aetiology and pathogenesis. In view of the prevalence of thyroid disease in patients with chronic urticaria, screening measurements of...

journal_title：Clinical endocrinology

authors： Monge C,Demarco P,Burman KD,Wartofsky L

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:A GH deficiency-like phenotype with normal or high hGH secretion, pathologically low IGF-I serum levels, and catch-up growth under treatment with recombinant hGH is suggestive of the presence of biologically inactive hGH syndrome, whose presumably heterogenous molecular basis is substantially unknown. DESIG...

journal_title：Clinical endocrinology

authors： Binder G,Benz MR,Elmlinger M,Pflaum CD,Strasburger CJ,Ranke MB

更新日期：1999-07-01 00:00:00

abstract：OBJECTIVE:Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in path...

journal_title：Clinical endocrinology

authors： Oflaz H,Sen F,Elitok A,Cimen AO,Onur I,Kasikcioglu E,Korkmaz S,Demirturk M,Kutluturk F,Pamukcu B,Ozbey N

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To define and discuss the changes of important risk factors and TNM staging over the last 40 years in patients operated on for differentiated thyroid carcinoma (DTC), resulting from the introduction of newer sensitive diagnostic procedures in the preoperative evaluation of thyroid nodules. PATIENTS:We review...

journal_title：Clinical endocrinology

authors： Karga H,Mavroudis K,Giagourta I,Triantaphyllopoulou M,Ktena V,Kassi G,Veloutsou H,Papapetrou P

更新日期：2012-02-01 00:00:00

abstract：:Myotonic dystrophy (MyD) is a common genetic neuromuscular disorder in which chromosome 19 gives rise to an abnormal expansion of CTG-trinucleotide repeats. MyD is a highly variable multisystem disorder with muscular and nonmuscular abnormalities. Increasingly, endocrine abnormalities, such as gonadal, pancreatic, and...

journal_title：Clinical endocrinology

authors： Misra D,DeSilva S,Fellerman H,Dufour DR,Streeten DH,Nylen ES

更新日期：2002-02-01 00:00:00

abstract：:Growth hormone release-inhibiting hormone (GHR-IH) was administered to five patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in two patients who had undergone bilateral adrenalectomy because of Cushing's disease; one of them had Nelson's syndrome. Bromocryp...

journal_title：Clinical endocrinology

authors： Benker G,Hackenberg K,Hamburger B,Reinwein D

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the levels of thrombospondin-1 (TSP-1), transforming growth factor-β1 (TGF-β1) and nuclear factor kappaβ (NF-κβ) in polycystic ovarian syndrome (PCOS) patients with and without insulin resistance and after treatment with cyproterone acetate/ethinyloestradiol with o...

journal_title：Clinical endocrinology

authors： Liu M,Gao J,Zhang Y,Li P,Wang H,Ren X,Li C

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves' disease. DESIGN AND MEASUREMENTS:Cultured thyroid cells were ...

journal_title：Clinical endocrinology

authors： Hiromatsu Y,Sato M,Yamada K,Nonaka K

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:The aim was to study the relationship between growth hormone (GH) and insulin-like growth factor-I (IGF-I) in critically ill patients. DESIGN:Case-control study of critically ill patients admitted to the intensive care unit was carried out. PATIENTS:Six critically ill patients (51-78 years) who required ven...

journal_title：Clinical endocrinology

authors： Ross R,Miell J,Freeman E,Jones J,Matthews D,Preece M,Buchanan C

更新日期：1991-07-01 00:00:00

abstract：:The effects of equivalent doses of two inhibitors of the 3-beta-hydroxy steroid dehydrogenase enzyme system--WIN 24540 (trilostane) and WIN 32729--on the secretion of progesterone in early human pregnancy are described. Patients and controls less than 12 weeks pregnant were given a single dose of either drug and the r...

journal_title：Clinical endocrinology

authors： van der Spuy ZM,Jones DL,Wright CS,Piura B,Paintin DB,James VH,Jacobs HS

更新日期：1983-10-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of reduced tissue responsiveness to thyroid hormone usually due to mutations located in the ligand-binding domain and adjacent hinge region of the thyroid hormone receptor beta (TRbeta). In the present report we describe the clinical and l...

journal_title：Clinical endocrinology

authors： Magalhães PK,Rodrigues Dare GL,Rodrigues Dos Santos S,Nogueira CR,de Castro M,Zanini Maciel LM

更新日期：2007-11-01 00:00:00

abstract：:Sixteen consecutive cases of Cushing's disease were treated by radical transphenoidal hypophysectomy. Surgical removal was not possible in two cases. Of the other 14, there was total clinical and biochemical remission of the disease in 13 and partial remission in one. Some form of replacement therapy has been necessar...

journal_title：Clinical endocrinology

authors： Thomas JP,Richards SH

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

journal_title：Clinical endocrinology

authors： Laursen T,Jørgensen JO,Christiansen JS

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies on the cardiovascular risk of progestagen-only contraceptives are rare. With the present study we aimed to investigate the effect of the low-dose etonogestrel-releasing contraceptive implant Implanon on cardiovascular risk factors, including markers of inflammation. DESIGN:Longitudina...

journal_title：Clinical endocrinology

authors： Merki-Feld GS,Imthurn B,Seifert B

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Androgens have paradoxically different effects on hair follicles depending on body site, stimulating beard growth while inducing regression in some areas of the scalp. The mesenchyme derived dermal papilla at the base of the hair follicle regulates many aspects of the growth of follicular epithelium, and is p...

journal_title：Clinical endocrinology

authors： Thornton MJ,Laing I,Hamada K,Messenger AG,Randall VA

更新日期：1993-12-01 00:00:00

abstract：OBJECTIVE:Women with impaired glucose tolerance (IGT) and type 2 diabetes (T2D) are more at risk of cardiovascular disease. The aim of this study was to test the hypothesis that increased visceral adipose tissue (VAT) could explain to a large extent alterations in the cardiovascular disease risk profile of postmenopaus...

journal_title：Clinical endocrinology

authors： Lemieux S,Bédard A,Piché MÈ,Weisnagel SJ,Corneau L,Bergeron J

更新日期：2011-03-01 00:00:00

abstract：:Phaeochromocytomas and paragangliomas (PPGLs) are rare tumours that arise from the adrenal medulla or extra-adrenal sympathetic or parasympathetic paraganglia. Recent advances in genetics have greatly enhanced understanding of the pathogenesis and molecular physiology of PPGL. Concomitantly, advances in molecular imag...

journal_title：Clinical endocrinology

authors： Ryder SJ,Love AJ,Duncan EL,Pattison DA

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

journal_title：Clinical endocrinology

authors： Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

更新日期：2012-01-01 00:00:00

abstract：:The response of plasma immunoreactive met-enkephalin (IR-met-enkephalin) to ethanol (8 g by mouth) after chlorpropamide (250 mg daily for 14 d) was studied in three groups of non-insulin dependent diabetics (a) six diabetics who showed chlorpropamide alcohol flush (CPAF) and in whom the reaction could be blocked by in...

journal_title：Clinical endocrinology

authors： Johnston C,Wiles PG,Medbak S,Bowcock S,Cooke ED,Pyke DA,Rees LH

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 +/- 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Instit...

journal_title：Clinical endocrinology

authors： Rizzo M,Pernice V,Frasheri A,Di Lorenzo G,Rini GB,Spinas GA,Berneis K

更新日期：2009-06-01 00:00:00

abstract：OBJECTIVE:Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with ...

journal_title：Clinical endocrinology

authors： Otsuka F,Noh JY,Chino T,Shimizu T,Mukasa K,Ito K,Ito K,Taniyama M

更新日期：2012-08-01 00:00:00

abstract：:Transdermal oestradiol, 100 micrograms/d, was used to treat 11 women suffering from postmenopausal symptoms. After 3 weeks therapy there was a significant rise in the plasma oestradiol into the premenopausal range and a significant fall in plasma FSH level and symptom score. Bone resorption, assessed by urinary excret...

journal_title：Clinical endocrinology

authors： Selby PL,Peacock M

更新日期：1986-11-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon-like peptide-1 (GLP-1) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP-1 secretion might be ...

journal_title：Clinical endocrinology

authors： Forbes S,Moonan M,Robinson S,Anyaoku V,Patterson M,Murphy KG,Ghatei MA,Bloom SR,Johnston DG

更新日期：2005-01-01 00:00:00

abstract：:In order to investigate the mechanisms by which arginine and L-dopa cause GH release in humans we measured the GH response to GHRH 1-44 (200 micrograms i.v.), arginine (30 g i.v. over 30 min) and L-dopa (500 mg orally) administered alone and 120 minutes following pretreatment with GHRH 1-44 (200 micrograms i.v.) in no...

journal_title：Clinical endocrinology

authors： Page MD,Dieguez C,Valcavi R,Edwards C,Hall R,Scanlon MF

更新日期：1988-05-01 00:00:00