Nocturnal melatonin secretion in thyroid disease and in obesity.

abstract：OBJECTIVE:To study the relationship between the excretion of nephrogenous cyclic AMP (NcAMP) and other blood and urine parameters as an index of PTH-like activity in patients with primary hepatocellular carcinoma. DESIGN:After overnight fast, a double voided urine and a blood sample were collected from each subject fo...

journal_title：Clinical endocrinology

authors： Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

更新日期：1991-12-01 00:00:00

abstract：:Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

journal_title：Clinical endocrinology

authors： Nowak R,McMillen IC,Redman J,Short RV

更新日期：1987-10-01 00:00:00

abstract：BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

journal_title：Clinical endocrinology

authors： Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

更新日期：2014-08-01 00:00:00

abstract：:A young man is reported with an autoimmune polyglandular syndrome (APS) characterized by Addison's disease, primary hypothyroidism, primary hypogonadism, vitiligo, associated with primary empty sella and partial impairment of pituitary hormone secretion. Two years later the patient showed a null cell type acute lympho...

journal_title：Clinical endocrinology

authors： De Rosa G,Della Casa S,Corsello SM,Cecchini L,Callà C

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Durham JA,Kljakovic M,Cooke RR

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Some evidence suggests that dysbiosis of the gut microbiota could be associated with PCOS clinical parameters, but little is known for the association between vaginal microbiome and PCOS. OBJECTIVE:To determine ...

journal_title：Clinical endocrinology

authors： Hong X,Qin P,Huang K,Ding X,Ma J,Xuan Y,Zhu X,Peng D,Wang B

更新日期：2020-07-01 00:00:00

abstract：:The role of endogenous opiate peptides in puerperal hyperprolactinaemia, and in the control of TSH in hypothyroidism, has been investigated. Although exogenous opioids raise prolactin and TSH levels, 16 mg naloxone administered to women on days 2-4 of the puerperium produced no significant change in serum prolactin an...

journal_title：Clinical endocrinology

authors： Grossman A,West S,Williams J,Evans J,Rees LH,Besser GM

更新日期：1982-03-01 00:00:00

abstract：BACKGROUND:Hospital-acquired hyponatraemia is a common and potentially serious condition. Risk factors for hospital-acquired hyponatraemia have not been studied in a controlled fashion. Methods From 1501 patients in whom serum sodium (S(Na)) was determined, 50 cases with hospital-acquired hyponatraemia (in-hospital dec...

journal_title：Clinical endocrinology

authors： Beukhof CM,Hoorn EJ,Lindemans J,Zietse R

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVES:To optimize the indications for treating girls with idiopathic central precocious puberty with GnRH analogues, since outcomes may vary. DESIGN:Comparison of adult heights with the data at initial evaluation and the target heights. PATIENTS:Group 1 patients (n = 43) were treated with GnRH analogue from 7.9 ...

journal_title：Clinical endocrinology

authors： Adan L,Chemaitilly W,Trivin C,Brauner R

更新日期：2002-03-01 00:00:00

abstract：:Six normal adult males were given clonidine and GHRH either separately, or in combination, in random order. The peak serum GH concentrations elicited by clonidine or GHRH were variable but one factor influencing the GH response to GHRH was the GH secretory status in the hour prior to the administration of the GHRH. Pe...

journal_title：Clinical endocrinology

authors： Suri D,Hindmarsh PC,Brain CE,Pringle PJ,Brook CG

更新日期：1990-09-01 00:00:00

abstract：OBJECTIVE:To assess approaches to patients with a potentially malignant thyroid nodule and patients with differentiated thyroid carcinoma and compare them with the European Consensus and Guidelines by the American Thyroid Association. DESIGN:A survey of the 388 active members of the Belgian Thyroid Club. METHODS:A qu...

journal_title：Clinical endocrinology

authors： Van den Bruel A,Moreno-Reyes R,Bex M,Daumerie C,Glinoer D

更新日期：2008-04-01 00:00:00

abstract：:To test whether the administration of sodium fluoride in vivo results in an increase in osteocalcin concentration, we administered sodium fluoride to seven healthy male subjects for a period of 3 weeks. Fasting calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone and osteocalcin were meas...

journal_title：Clinical endocrinology

authors： Dandona P,Coumar A,Gill DS,Bell J,Thomas M

更新日期：1988-10-01 00:00:00

abstract：:A 39-year-old woman presented with amenorrhoea, hyperprolactinaemia and sellar mass. Bromocriptine normalized PRL levels but failed to suppress tumour growth. Subsequently, she developed clinical signs and elevated blood cortisol levels consistent with a diagnosis of Cushing's disease. A pituitary tumour was removed w...

journal_title：Clinical endocrinology

authors： Ikeda H,Yoshimoto T,Kovacs K,Horvath E

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:To examine the association between glycaemic control, insulin resistance and hyperandrogenism on cardiac autonomic function in peripubertal girls with type 1 diabetes. DESIGN:Prospective, clinic-based study of 125 girls with diabetes and 46 age-matched nondiabetic girls. MEASUREMENTS:Heart rate variability ...

journal_title：Clinical endocrinology

authors： Cho YH,Craig ME,Srinivasan S,Benitez-Aguirre P,Mitchell P,Jopling T,Donaghue KC

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:It is generally accepted that there is no clinically significant circadian variation in total insulin-like growth factor (IGF)-I or total IGF-II in healthy subjects. In contrast there is a significant nocturnal decrease in free IGF-I in healthy subjects, corresponding to the nocturnal increase in IGF binding ...

journal_title：Clinical endocrinology

authors： Skjaerbaek C,Frystyk J,Kaal A,Laursen T,Møller J,Weeke J,Jørgensen JO,Sandahl Christiansen J,Orskov H

更新日期：2000-01-01 00:00:00

abstract：OBJECTIVE:To assess the capacity of thyroid follicular cells to function as antigen presenting cells, we have examined their ability to stimulate allogeneic T cells. DESIGN:Thyroid follicular cells were pretreated with interferon-gamma or phorbol myristate acetate, washed thoroughly, and their capacity to induce allog...

journal_title：Clinical endocrinology

authors： Tandon N,Weetman AP

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

journal_title：Clinical endocrinology

authors： Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:The risk of progression of subclinical hypothyroidism (SCH) to clinical dysfunction is one of the factors considered in the decision to treat this condition. This study evaluated the natural history of SCH in women with TSH ≤10 mIU/l. DESIGN:This is a prospective study. PATIENTS:Two hundred and fifty-two wo...

journal_title：Clinical endocrinology

authors： Rosário PW,Carvalho M,Calsolari MR

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Over 1% of the UK population is receiving thyroid hormone replacement with l-thyroxine (T4). However, many patients complain of persistent lethargy and related symptoms on T4 even with normal TSH levels. To date there has been no large study to determine whether this is related to thyroxine replacement or coi...

journal_title：Clinical endocrinology

authors： Saravanan P,Chau WF,Roberts N,Vedhara K,Greenwood R,Dayan CM

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency (21-OHD) is characterized by high androgen levels, ambiguous genitalia or premature pubarche, increased height velocity and skeletal maturation. Considering the possibility of changes in the IGF system components depending on the state of c...

journal_title：Clinical endocrinology

authors： Cunha HM,Elias LL,Camacho-Hübner C,Moreira AC,Martinelli CE Jr

更新日期：2004-07-01 00:00:00

abstract：:Rathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC...

journal_title：Clinical endocrinology

authors： Trifanescu R,Ansorge O,Wass JA,Grossman AB,Karavitaki N

更新日期：2012-02-01 00:00:00

abstract：OBJECTIVE:Serum IGF-I levels are monitored during GH replacement treatment in adults with GH deficiency (GHD) to guide GH dose adjustment and to minimize occurrence of GH-related side-effects. This is not routine practice in children treated with GH. The aim of this study was to evaluate changes in (1) serum IGF-I, IGF...

journal_title：Clinical endocrinology

authors： Tillmann V,Patel L,Gill MS,Whatmore AJ,Price DA,Kibirige MS,Wales JK,Clayton PE

更新日期：2000-09-01 00:00:00

abstract：:Obesity may be characterized by abnormal sex steroid secretion and reduced sex hormone binding globulin (SHBG) which in turn is related to fat distribution and insulin secretion. Recent in-vitro and in-vivo evidence suggests that insulin is the common mechanism regulating the secretion of SHBG and insulin-like growth ...

journal_title：Clinical endocrinology

authors： Weaver JU,Holly JM,Kopelman PG,Noonan K,Giadom CG,White N,Virdee S,Wass JA

更新日期：1990-09-01 00:00:00

abstract：BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

journal_title：Clinical endocrinology

authors： Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

更新日期：2016-04-01 00:00:00

abstract：:1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was ach...

journal_title：Clinical endocrinology

authors： Saratchandran P,Carson ER,Reeve J

更新日期：1976-09-01 00:00:00

abstract：:Plasma cortisol and adrenocorticotrophin hormone (ACTH) profiles were estimated in twelve patients with Addison's disease following randomized oral administration of either cortisone acetate (25 mg) or hydrocortisone (20 mg) alternately, at 0900 h on consecutive days. Normal corticosteroid replacement therapy was disc...

journal_title：Clinical endocrinology

authors： Feek CM,Ratcliffe JG,Seth J,Gray CE,Toft AD,Irvine WJ

更新日期：1981-05-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Nonfunctioning pituitary adenomas (NFPAs) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPAs due to tumour- or treatment-related factors and may increase mortality risk. Here, we analysed the associations of hypopituitarism, hormone replacement and mortality in a...

journal_title：Clinical endocrinology

authors： O'Reilly MW,Reulen RC,Gupta S,Thompson CA,Dineen R,Goulden EL,Bugg G,Pearce H,Toogood AA,Gittoes NJ,Mitchell R,Thompson CJ,Ayuk J

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Growth hormone deficiency (GHD) in adults has been associated with impaired health status and quality of life (QoL) in several studies using generic measures, and in a few studies using recently developed disease-specific measures. Theoretically, disease-specific measures may be more sensitive and succinct th...

journal_title：Clinical endocrinology

authors： Wirén L,Whalley D,McKenna S,Wilhelmsen L

更新日期：2000-02-01 00:00:00

abstract：:A 30-year-old presented in 1984 with a clinically nonfunctional tumour which subsequently developed into a metastatic corticotrophinoma from which he died despite surgery in 1984, 1986 and 1991 and external radiotherapy in 1986. Molecular genetic analysis of tumour and metastatic tissue revealed loss of heterozygosity...

journal_title：Clinical endocrinology

authors： Bates AS,Buckley N,Boggild MD,Bicknell EJ,Perrett CW,Broome JC,Clayton RN

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVES:Patients with type 1 diabetes are at increased risk of cardiovascular disease, which may be related to abnormal lipid metabolism. Secretion and clearance of VLDL apolipoprotein B100 (apoB) are important determinants of plasma lipid concentrations and are known to be influenced by hormones, including insulin ...

journal_title：Clinical endocrinology

authors： Christ ER,Carroll PV,Albany E,Umpleby AM,Lumb PJ,Wierzbicki AS,Simpson HL,Sönksen PH,Russell-Ones DL

更新日期：2001-12-01 00:00:00