Abstract：
:Rathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC do not require surgical intervention, and their natural history is not clear. In series of nonoperated presumed RCCs, 26-94% did not progress during follow-up periods up to 9 years. In symptomatic ones, surgery is indicated, aiming to drain the cyst content and safely remove as much of the capsule as possible. Following surgical intervention, headaches and visual field defects improve or resolve in a significant number of patients (40-100% and 33-100%, respectively) and partial hypopituitarism recovers in 14-50%. Data on relapse rates published in the last 15 years are based on variable follow-up periods and show wide variation (between 0% and 33%). The lowest relapse rates have been described in reports with relatively short mean observation periods (<3 years), whereas in those with longer follow-up the relapse rates increase. Most of the relapses occur within 5-6 years, suggesting that follow-up is required for at least 5 years after surgery. Risk factors for relapse include the presence of squamous metaplasia in the cyst wall, cyst size and the presence of inflammation. Long-term sufficiently powered studies aiming to clarify the natural history of asymptomatic RCCs and of those relapsing postoperatively are required.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Trifanescu R,Ansorge O,Wass JA,Grossman AB,Karavitaki Ndoi
10.1111/j.1365-2265.2011.04235.xsubject
Has Abstractpub_date
2012-02-01 00:00:00pages
151-60issue
2eissn
0300-0664issn
1365-2265journal_volume
76pub_type
杂志文章,评审abstract：OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2011.04080.x
更新日期：2011-09-01 00:00:00
abstract：:Trilostane is a competitive inhibitor of 3 beta-hydroxysteroid dehydrogenase activity in vitro and an orally active inhibitor of steroidogenesis in vivo. A cytochemical section bioassay for this drug (4 alpha, 5-epoxy-17 beta-hydroxy-3-oxo-5 alpha-androstane-2 alpha-carbonitrile) in human plasma has been developed. Th...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1984.tb00131.x
更新日期：1984-07-01 00:00:00
abstract：OBJECTIVE:Data on reference intervals of thyroid functions in Southeast Asia are limited. The aim of this study was to provide reference ranges of thyroid functions and thyroid autoantibodies in Thais. DESIGN AND METHODS:Serum samples from 2545 apparently healthy non-pregnant subjects, aged ≥14 years, from the fourth ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12371
更新日期：2014-05-01 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2007.03145.x
更新日期：2008-07-01 00:00:00
abstract：:The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1986.tb01667.x
更新日期：1986-06-01 00:00:00
abstract：OBJECTIVE AND DESIGN:The immediate early gene locus AP-1, incorporating the cellular oncogenes c-fos and c-jun (and their oncoprotein products Fos and Jun respectively) play a key role in regulating cell growth and differentiation. The myc-gene is also known to promote cell growth. In order to investigate the possible ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1994.tb02453.x
更新日期：1994-01-01 00:00:00
abstract：:The growth hormone (GH) and prolactin (PRL) responses to metoclopramide (MCP) were compared to those with arginine and insulin-induced hypoglycaemia in eight children. While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1980.tb01380.x
更新日期：1980-06-01 00:00:00
abstract：CONTEXT:Hypoparathyroidism is characterized by hypocalcaemia, hyperphosphataemia, and low or inappropriately normal parathyroid hormone (PTH) levels. Idiopathic or genetic drivers are the predominant causes of hypoparathyroidism in paediatric-age patients. OBJECTIVE:This study investigated the aetiology and clinical c...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12944
更新日期：2015-12-01 00:00:00
abstract：:There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1987.tb00798.x
更新日期：1987-04-01 00:00:00
abstract：:Headache is very common in pituitary disease and is reported to be present in more than a third of all patients with pituitary adenomas. Tumour size, cavernous sinus invasion, traction or displacement of intracranial pain-sensitive structures such as blood vessels, cranial nerves and dura mater, and hormonal hypersecr...
journal_title：Clinical endocrinology
pub_type： 杂志文章,评审
doi：10.1111/cen.12314
更新日期：2013-12-01 00:00:00
abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.13168
更新日期：2017-01-01 00:00:00
abstract：OBJECTIVE:We wished to investigate the effects of nicotinamide and 3-aminobenzamide, well known as inhibitors of poly(ADP ribose) synthetase, on interferon-gamma-induced HLA-DR antigen expression using cultured human thyroid cells from patients with Graves' disease. DESIGN AND MEASUREMENTS:Cultured thyroid cells were ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1992.tb02907.x
更新日期：1992-01-01 00:00:00
abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1981.tb00607.x
更新日期：1981-02-01 00:00:00
abstract：OBJECTIVE:Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX. DE...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2011.04265.x
更新日期：2012-05-01 00:00:00
abstract：OBJECTIVE:To assess approaches to patients with a potentially malignant thyroid nodule and patients with differentiated thyroid carcinoma and compare them with the European Consensus and Guidelines by the American Thyroid Association. DESIGN:A survey of the 388 active members of the Belgian Thyroid Club. METHODS:A qu...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2007.03092.x
更新日期：2008-04-01 00:00:00
abstract：OBJECTIVE:To compare the outcome of different treatment options used in several cases of non-islet cell tumour hypoglycaemia (NICTH). PATIENTS:Eight cases of NICTH were referred for diagnosis and monitoring following either surgical or medical treatment. METHODS:Serum samples collected throughout the time-course of e...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.2004.01989.x
更新日期：2004-04-01 00:00:00
abstract：:Normocalcaemic primary hyperparathyroidism is a condition that can present with intermittent hypercalcemia or may evolve into hypercalcemic primary hyperparathyroidism. This milder biochemical entity remains incompletely understood because of a lack of long-term health outcomes regarding both medical and surgical appr...
journal_title：Clinical endocrinology
pub_type： 杂志文章,评审
doi：10.1111/cen.14315
更新日期：2020-11-01 00:00:00
abstract：:Thirty-three samples of follicular fluid (FF) were collected from 14 patients with the polycystic ovary (PCO) syndrome and matched for FF-volume with small follicles collected from subjects with normal ovaries. The median (range) FF concentration of insulin-like growth factor 1 (IGF1) in the group with PCO, 0.42 (0.13...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1990.tb00879.x
更新日期：1990-04-01 00:00:00
abstract：:Raised activity of the LH axis caused by activating mutations of LH receptor gene presents with precocious puberty in boys, analogous to the presentation of LH secreting pituitary adenomas (Faggiano et al., 1983; Ambrosi et al., 1990). LH "hyperactivity' in females appears to have no effect. Hyperactivity of the FSH a...
journal_title：Clinical endocrinology
pub_type： 杂志文章,评审
doi：10.1046/j.1365-2265.1996.8680879.x
更新日期：1996-12-01 00:00:00
abstract：:Infertility with azoospermia requires a diligent search for reversible factors and treatment to restore natural fertility, even though most cases are due to untreatable primary spermatogenic failure and are destined to require consideration of assisted reproductive treatment (ART) options. Complete clinical and diagno...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12026
更新日期：2013-02-01 00:00:00
abstract：:A 25-year-old primigravid woman presented with Cushing's syndrome at 23 weeks gestation; serum cortisol was 1090 nmol/l at 0900 h, 1230 nmol/l at 2200 h; basal urinary free cortisol excretion was 3680 nmol/24 h, and 8830 nmol/24 h after dexamethasone 8 mg daily for 48 hours; plasma ACTH was < 1.1 pmol/l. CT scan of th...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1993.tb02380.x
更新日期：1993-09-01 00:00:00
abstract：OBJECTIVE:There is increasing evidence for the role of cytokines in pituitary differentiated function and tumorigenesis, but the spectrum of cytokines found in the pituitary is unknown. Therefore profiles of cytokine expression were determined in different human anterior pituitary adenoma sub-types. DESIGN:The reverse...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.1996.d01-1554.x
更新日期：1996-08-01 00:00:00
abstract：OBJECTIVE:Hypothyroidism is a common disorder and while the association of overt hypothyroidism with hypercholesterolaemia is clear, the effect upon lipids of the minor abnormalities of thyroid function often found in those receiving T4 replacement therapy is unclear. The aim of the present studies was to define in tho...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1993.tb00339.x
更新日期：1993-05-01 00:00:00
abstract：OBJECTIVE:As only sparse data are available, we aimed to investigate whether needs for activated vitamin D and calcium supplements change in women with hypoparathyroidism during pregnancy and lactation and risk of pregnancy-related complications. DESIGN:Retrospective review of medical records. PATIENTS:Twelve Danish ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.14212
更新日期：2020-09-01 00:00:00
abstract：:A 47-year-old woman was evaluated for congenital dwarfism, primary amenorrhoea due to hypogonadotrophic hypogonadism, severe hyperlipidaemia with pancreatitis, and overt diabetes mellitus associated with severe insulin resistance requiring 2.5-3 units of insulin per kilogram body weight. Chromosomal analysis with tryp...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1995.tb01921.x
更新日期：1995-08-01 00:00:00
abstract：OBJECTIVE:Nonsurgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (PHP) are rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively. Only few studies on Quality of Life (QoL) among patients with Ns-HypoPT and PHP are available. We aimed to investigate the QoL among patients with Ns-Hyp...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.13593
更新日期：2018-06-01 00:00:00
abstract：BACKGROUND:Metadherin (MTDH) protein, also called astrocyte elevated gene-1 (AEG-1) is over expressed in a variety of malignant tumours, and is closely related to tumour invasion and the poor prognosis. OBJECTIVE:This study tries to explore the clinical pathological significance of MTDH expression in a large cohort of...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/cen.12683
更新日期：2015-10-01 00:00:00
abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1046/j.1365-2265.1997.2391059.x
更新日期：1997-09-01 00:00:00
abstract：:The effect of chlorpromazine (CPZ) on prolactin (PRL) secretion was studied in fourteen sexually immature males; nine with idiopathic hypogonadotrophic hypogonadism and five who proved to be normal early pubertal boys. Initially, clinical features and basal levels of testosterone, LH and FSH in serum collected in the ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1982.tb00723.x
更新日期：1982-04-01 00:00:00
abstract：:Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...
journal_title：Clinical endocrinology
pub_type： 杂志文章
doi：10.1111/j.1365-2265.1986.tb03269.x
更新日期：1986-03-01 00:00:00
