Abstract:
OBJECTIVE:Data on reference intervals of thyroid functions in Southeast Asia are limited. The aim of this study was to provide reference ranges of thyroid functions and thyroid autoantibodies in Thais. DESIGN AND METHODS:Serum samples from 2545 apparently healthy non-pregnant subjects, aged ≥14 years, from the fourth Thai National Health Examination Survey were measured for TSH, FT4, antithyroperoxidase (TPO Ab), antithyroglobulin (Tg Ab) and antithyrotrophin receptor antibodies (TRAb). A reference population was selected from the disease-free population by excluding those who had thyroid autoantibodies and TSH > 20 mIU/l. RESULTS:For the total population, median TSH and FT4 levels were 1·94 mIU/l and 1·35 ng/dl, respectively. TSH was higher and FT4 was lower in females than in males. Based on National Academy of Clinical Biochemistry criteria, the reference intervals (2·5th-97·5th percentile) were: TSH, 0·34-5·11 mIU/l; FT4, 0·98-1·79 ng/dl; TPO Ab, 5-84·88 IU/ml; Tg Ab, 10-118·2 IU/ml; and TRAb, 0·3-1·24 IU/l. With the new reference ranges, hypothyroidism was found in 4·16% of the total population (0·78% overt and 3·38% subclinical hypothyroidism) and hyperthyroidism was found in 3·18% (0·94% overt and 2·24% subclinical hyperthyroidism). Positive TPO Ab, Tg Ab and TRAb were found in 8·96%, 12·26% and 5·93%, respectively. The upper normal limit of TSH tended to increase with age, particularly for those aged 80 years and older. CONCLUSIONS:The reference interval for TSH needs to be derived from each specific population. Slightly elevated TSH concentrations in the elderly could be considered acceptable, with no need for thyroxine treatment.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Sriphrapradang C,Pavarangkoon S,Jongjaroenprasert W,Chailurkit LO,Ongphiphadhanakul B,Aekplakorn Wdoi
10.1111/cen.12371subject
Has Abstractpub_date
2014-05-01 00:00:00pages
751-6issue
5eissn
0300-0664issn
1365-2265journal_volume
80pub_type
杂志文章abstract:OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...
journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1994.tb02513.x
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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doi:10.1046/j.1365-2265.2003.01829.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/cen.13268
更新日期:2017-03-01 00:00:00
abstract::The possible relationship between plasma androgenic activity and acne vulgaris was investigated. Plasma testosterone and sex hormone binding globulin (SHBG) levels were determined in healthy girls during different stages of puberty, in healthy adult women and in women with acne vulgaris. Testosterone increase during p...
journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1982.tb00713.x
更新日期:1982-03-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1993.tb01008.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1993.tb02378.x
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doi:10.1111/cen.13329
更新日期:2017-06-01 00:00:00
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更新日期:2012-11-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1994.tb02453.x
更新日期:1994-01-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1995.tb02047.x
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doi:10.1111/j.1365-2265.2004.02030.x
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journal_title:Clinical endocrinology
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doi:10.1111/j.1365-2265.1978.tb02200.x
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更新日期:2013-02-01 00:00:00
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更新日期:2014-05-01 00:00:00
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doi:10.1111/j.1365-2265.1980.tb03399.x
更新日期:1980-10-01 00:00:00
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更新日期:2014-06-01 00:00:00
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doi:10.1111/cen.13548
更新日期:2018-04-01 00:00:00
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更新日期:2020-12-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章,随机对照试验
doi:10.1111/cen.12751
更新日期:2015-10-01 00:00:00
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doi:10.1111/cen.12707
更新日期:2015-06-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1046/j.1365-2265.2000.00876.x
更新日期:2000-01-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1046/j.1365-2265.1997.3461141.x
更新日期:1997-12-01 00:00:00