Isolated combined growth hormone and gonadotrophin deficiency due to hypothalamic dysfunction, associated with insulin resistance.

abstract：BACKGROUND:It has previously been shown that higher serum TSH is associated with increased thyroid cancer incidence and advanced-stage disease. In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for thyroid cancer, it is important to know whether higher TS...

journal_title：Clinical endocrinology

authors： Haymart MR,Glinberg SL,Liu J,Sippel RS,Jaume JC,Chen H

更新日期：2009-09-01 00:00:00

abstract：:The improvement in iodine status among the UK population from the 1930s onwards has been described as an 'accidental public health triumph' despite the lack of any iodine fortification program. However, iodine deficiency in the UK has re-emerged in vulnerable groups and is likely due to a combination of changing farmi...

journal_title：Clinical endocrinology

authors： Woodside JV,Mullan KR

更新日期：2020-11-29 00:00:00

abstract：OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

journal_title：Clinical endocrinology

authors： Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Graves' Ophthalmopathy (GO) is a complex eye and orbital disorder that is uniquely linked to Graves' Hyperthyroidism (GH) and has traditionally been considered a cross-reactive immune response against the thyroid stimulating hormone receptor (TSHR) in orbital tissue. However, because there is no direct evide...

journal_title：Clinical endocrinology

authors： Wescombe L,Lahooti H,Gopinath B,Wall JR

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:The development and progression of sporadic adrenocortical tumours are poorly understood. In autopsy studies adrenocortical tumours are found in between 2 and 9% of the general population. In congenital adrenal hyperplasia (CAH), decreased production of cortisol leads to increased secretion of ACTH from the p...

journal_title：Clinical endocrinology

authors： Kjellman M,Holst M,Bäckdahl M,Larsson C,Farnebo LO,Wedell A

更新日期：1999-03-01 00:00:00

abstract：:We report the case of a male infant who at 10 days of life presented with salt-wasting. Congenital adrenal hyperplasia was excluded on the basis of normal 17 alpha-hydroxy-progesterone plasma levels evaluated before the onset of steroid replacement therapy. The incidental finding of hypertriglyceridaemia led us to sus...

journal_title：Clinical endocrinology

authors： Balducci R,Municchi G,Toscano V,Mangiantini A,Sabatini R,Caiola S,Tedeschi B,Orlandi L,Boscherini B

更新日期：1995-04-01 00:00:00

abstract：CONTEXT:Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover, children with ISS appear to need higher GH doses than children with GH deficiency (GHD) to achieve the same amount of growth and may therefore be at increased risk of adverse events du...

journal_title：Clinical endocrinology

authors： Decker R,Albertsson-Wikland K,Kriström B,Nierop AF,Gustafsson J,Bosaeus I,Fors H,Hochberg Z,Dahlgren J

更新日期：2010-09-01 00:00:00

abstract：:Two main types of RET/PTC oncogene, named RET/PTC-1 and 3, occur in papillary thyroid carcinomas especially in those from Belarus children after the Chernobyl nuclear accident. Several variants of RET/PTC-3 have also been found, having different break points with respect to the classical RET/PTC-3. To our knowledge, n...

journal_title：Clinical endocrinology

authors： Elisei R,Romei C,Soldatenko PP,Cosci B,Vorontsova T,Vivaldi A,Basolo F,Cherstvoy ED,Pinchera A,Pacini F

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Adults with GH deficiency (GHD) exhibit changes in body composition. Studies of the effects of GH substitution on body composition have been short-term or not adequately controlled. The purpose of this study was to evaluate the long-term effects of GH on soft tissue using dual-energy X-ray absorptiometry (DEX...

journal_title：Clinical endocrinology

authors： Hansen TB,Vahl N,Jørgensen JO,Christiansen JS,Hagen C

更新日期：1995-12-01 00:00:00

abstract：OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

journal_title：Clinical endocrinology

authors： Ip MS,Tan KC,Peh WC,Lam KS

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Androgen insensitivity syndromes (AIS) in subjects with 46, XY karyotype and normal or even elevated androgen blood levels are characterized by various aberrations in male differentiation and virilization. AIS is often accompanied by a broad spectrum of abnormal binding characteristics of the androgen recepto...

journal_title：Clinical endocrinology

authors： Weidemann W,Linck B,Haupt H,Mentrup B,Romalo G,Stockklauser K,Brinkmann AO,Schweikert HU,Spindler KD

更新日期：1996-12-01 00:00:00

abstract：:The adrenolytic agent, 2,2-bis[2-chlorophenyl-4-chlorophenyl] 1,1 dichloroethane (o,p'-DDD), was used over a 20-month period following surgery in a 2 3/12-year-old girl for treatment of adrenocortical carcinoma. The child remained free of disease and was maintained on glucocorticoid and mineralo-corticoid supplements ...

journal_title：Clinical endocrinology

authors： Greig F,Oberfield SE,Levine LS,Ghavimi F,Pang S,New MI

更新日期：1984-04-01 00:00:00

abstract：:Diagnosis of XY pure gonadal dysgenesis was established in a patient of female phenotype, with female internal genitalia, but with a chromosomal constitution of 46 XY. Streak gonads had undergone neoplastic transformation--gonadoblastoma and dysgerminoma. Before operation the concentrations of gonadotrophins in plasma...

journal_title：Clinical endocrinology

authors： Wilson SC,Oakey RE,Scott JS

更新日期：1988-11-01 00:00:00

abstract：BACKGROUND:It is still difficult to differentiate pituitary adenoma remnants from postradiotherapy fibrosis by computed tomography (CT) or magnetic resonance imaging (MRI), especially in patients with clinically nonfunctioning pituitary adenomas (NFA), lacking circulating markers to follow disease progression or cure. ...

journal_title：Clinical endocrinology

authors： Colao A,Ferone D,Lombardi G,Lastoria S

更新日期：2002-06-01 00:00:00

abstract：:Two patients with profound hypocalcaemia due to uraemia and hypoparathyroidism respectively presented with alterations of mental state as their dominant symptom. 1-Alpha-hydroxycholecalciferol (1-alpha-OHD3) was chosen as the principal therapy because of its potency and rapid action. In both patients the plasma calciu...

journal_title：Clinical endocrinology

authors： Gertner JM,Hodsman AB,Neuberger JN

更新日期：1976-09-01 00:00:00

abstract：:Normocalcaemic primary hyperparathyroidism is a condition that can present with intermittent hypercalcemia or may evolve into hypercalcemic primary hyperparathyroidism. This milder biochemical entity remains incompletely understood because of a lack of long-term health outcomes regarding both medical and surgical appr...

journal_title：Clinical endocrinology

authors： Dawood NB,Yan KL,Shieh A,Livhits MJ,Yeh MW,Leung AM

更新日期：2020-11-01 00:00:00

abstract：BACKGROUND:The prognostic value of the telomerase reverse transcriptase (TERT) promoter mutation, resulting in poor clinical outcomes of papillary thyroid carcinoma (PTC), has been generally confirmed. To data, there is no high-level evidence approving the association of TERT promoter mutation and aggressive clinical b...

journal_title：Clinical endocrinology

authors： Yin DT,Yu K,Lu RQ,Li X,Xu J,Lei M,Li H,Wang Y,Liu Z

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:Pregnancy and lactation comprise a critical window spanning all seasons during which maternal vitamin D status potentially may influence the long-term health of the newborn. Women typically receive calcium/vitamin D supplementation through antenatal vitamins, but there has been limited serial evaluation of m...

journal_title：Clinical endocrinology

authors： Kramer CK,Ye C,Swaminathan B,Hanley AJ,Connelly PW,Sermer M,Zinman B,Retnakaran R

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is associated with a varied clinical presentation. The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes. DESIGN:An obser...

journal_title：Clinical endocrinology

authors： Owen PJ,Chatterjee VK,John R,Halsall D,Lazarus JH

更新日期：2009-04-01 00:00:00

abstract：OBJECTIVE:The relationship between growth hormone (GH) therapy and malignancy, including leukaemias, remains controversial. In order to study this possible relationship further, we have investigated whether GH treatment induces chromosomal abnormalities in peripheral blood lymphocytes. DESIGN:Open, prospective study i...

journal_title：Clinical endocrinology

authors： Bozzola M,Tettoni K,Severi F,Capra E,Danesino C,Scappaticci S

更新日期：1997-09-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Parathyroid hormone-related protein (PTHrP) produced by cancers has a central role as a humoral mediator of hypercalcaemia in patients with malignancy. Since the prevalences of hypercalcaemia of malignancy and parathyroid disease reflect the population studied, hypercalcaemic patients from a di...

journal_title：Clinical endocrinology

authors： Walls J,Ratcliffe WA,Howell A,Bundred NJ

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

journal_title：Clinical endocrinology

authors： Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Final adult height is determined by both childhood and pubertal growth. The later is a function of growth velocity and bone maturation, and both are regulated by growth hormone. In a study of the safety and efficacy of GH therapy, we analysed the impact of age on bone maturation and predicted adult height. P...

journal_title：Clinical endocrinology

authors： Hochberg Z,Leiberman E,Landau H,Koren R,Zadik Z

更新日期：1994-09-01 00:00:00

abstract：:The thyroid functional parameters of 102 children with protein-calorie malnutrition (PCM) classified as undernourished, marasmic, kwashiorkor and marasmic-kwashiorkor were studied by measuring the serum T4, T3, T3 percentage uptake (T3%UT), free thyroxine index (FTI), and (in a few subjects) TSH. Total plasma proteins...

journal_title：Clinical endocrinology

authors： Onuora C,Maharajan G,Singh A,Etta KM

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002. DESIGN:Descriptive epidemiological study. METHODS:Thyroid cancer registratio...

journal_title：Clinical endocrinology

authors： Reynolds RM,Weir J,Stockton DL,Brewster DH,Sandeep TC,Strachan MW

更新日期：2005-02-01 00:00:00

abstract：:The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

journal_title：Clinical endocrinology

authors： Lamberts SW,Verleun T,Hofland L,Del Pozo E

更新日期：1987-07-01 00:00:00

abstract：INTRODUCTION:Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West ...

journal_title：Clinical endocrinology

authors： Knight BA,Shields BM,He X,Pearce EN,Braverman LE,Sturley R,Vaidya B

更新日期：2017-03-01 00:00:00

abstract：:Endocrine autoimmunity is known to be characterized by the presence of specific autoantibodies and from the histopathological point of view by lymphocytic infiltration in the target tissue. The presence of mononuclear cell infiltrates is the pathological hallmark of most endocrine diseases characterized by an autoimmu...

journal_title：Clinical endocrinology

authors： Pozzilli P,Carotenuto P,Delitala G

更新日期：1994-11-01 00:00:00

abstract：:We describe a 40-year-old male with acromegaly, multiple and recurrent cutaneous myxomas, spotty cutaneous pigmentation, a mammary myxoma, a large-cell calcifying Sertoli cell tumour of the testis, and an unusual calcifying pigmented neuroectodermal tumour. He presented a combination of clinical and histological featu...

journal_title：Clinical endocrinology

authors： Leedman PJ,Cohen AK,Matz LR

更新日期：1986-11-01 00:00:00

abstract：OBJECTIVE:Our clinical practice has been to offer treatment with cyclical disodium etidronate and high dose calcium supplements (1500-1600 mg/day) to all female patients with osteoporosis who are unable or unwilling to take hormone replacement therapy (HRT), and male osteoporotics. In a retrospective study we compared ...

journal_title：Clinical endocrinology

authors： Orme SM,Simpson M,Stewart SP,Oldroyd B,Westmacott CF,Smith MA,Belchetz PE

更新日期：1994-08-01 00:00:00