Does growth hormone treatment increase chromosomal abnormalities?

abstract：OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

journal_title：Clinical endocrinology

authors： Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

更新日期：1998-12-01 00:00:00

abstract：:Twenty-three endemic goitrous subjects (goitre grade: III and IV) that were living in a chronic iodine-deficient area (iodine intake: less than 40 micrograms I/d) were submitted to clinical and laboratory evaluation within 3-8 weeks of arrival at the metropolitan area of São Paulo, where daily iodine intake is estimat...

journal_title：Clinical endocrinology

authors： Lima N,Medeiros-Neto G

更新日期：1984-12-01 00:00:00

abstract：:Immunoreactive calcitonin was found in extracts of seven out of eight consecutive breast carcinomas and four selected lung carcinomas, but not in extracts of benign breast lesions or normal tissues. This suggests that the high plasma calcitonin levels observed in patients with a wide variety of cancers reflect ectopic...

journal_title：Clinical endocrinology

authors： Hillyard CJ,Coombes RC,Greenberg PB,Galante LS,MacIntyre I

更新日期：1976-01-01 00:00:00

abstract：BACKGROUND:Distinguishing malignant thyroid nodules in patients with follicular cytology by fine-needle aspiration (FNA) remains problematic. The large majority of thyroid nodules (> 85%) are overtreated. Therefore, a clear need exists to develop more accurate initial diagnostic tests for follicular thyroid nodules. Ga...

journal_title：Clinical endocrinology

authors： Hooft L,van der Veldt AA,Hoekstra OS,Boers M,Molthoff CF,van Diest PJ

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:There are currently no sensitive and specific assays for activin B that could be utilized to study human biological fluids. The aim of this project was to develop and validate a 'total' activin B ELISA for use with human biological fluids and establish concentrations of activin B in the circula...

journal_title：Clinical endocrinology

authors： Ludlow H,Phillips DJ,Myers M,McLachlan RI,de Kretser DM,Allan CA,Anderson RA,Groome NP,Hyvönen M,Duncan WC,Muttukrishna S

更新日期：2009-12-01 00:00:00

abstract：:1 alpha, 25-Dihydroxycholecalciferol (1,25-(OH)2D3) has been measured in human serum by radioimmunoassay. The assay uses a high titre antiserum raised in sheep against 1,25-(OH)2D3-25-hemisuccinate, conjugated to bovine serum albumin. The sensitivity of the assay is 10 pg/tube. Other hydroxylated forms of vitamin D3 c...

journal_title：Clinical endocrinology

authors： Clemens TL,Hendy GN,Papapoulos SE,Fraher LJ,Care AD,O'Riordan JL

更新日期：1979-01-01 00:00:00

abstract：OBJECTIVE:Serum thyroglobulin (Tg) has been associated with a number of thyroid disorders and has been proposed as an indicator of iodine deficiency in a population. However, few studies have addressed the epidemiology of Tg in a population-based setting or in the context of exposure to radioactive iodine-131 (I-131). ...

journal_title：Clinical endocrinology

authors： Cahoon EK,Rozhko A,Hatch M,Polyanskaya O,Ostroumova E,Tang M,Nadirov E,Yauseyenka V,Savasteeva I,McConnell RJ,Pfeiffer RM,Brenner AV

更新日期：2013-07-01 00:00:00

abstract：OBJECTIVE:We aimed to elucidate the accuracy and limitations of [(18)F]-fluoro-L-dihydroxyphenylalanine ([(18) F]DOPA) positron emission tomography (PET) for Japanese patients with congenital hyperinsulinism. Although [(18)F]DOPA PET is reported to be useful for precisely localizing the focal form of congenital hyperin...

journal_title：Clinical endocrinology

authors： Masue M,Nishibori H,Fukuyama S,Yoshizawa A,Okamoto S,Doi R,Uemoto S,Tokumi T,Kasai T,Yorifuji T

更新日期：2011-09-01 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：:In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid-luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterecto...

journal_title：Clinical endocrinology

authors： Bäckström T,Smith S,Lothian H,Baird DT

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

journal_title：Clinical endocrinology

authors： Ip MS,Tan KC,Peh WC,Lam KS

更新日期：2001-10-01 00:00:00

abstract：:Two main types of RET/PTC oncogene, named RET/PTC-1 and 3, occur in papillary thyroid carcinomas especially in those from Belarus children after the Chernobyl nuclear accident. Several variants of RET/PTC-3 have also been found, having different break points with respect to the classical RET/PTC-3. To our knowledge, n...

journal_title：Clinical endocrinology

authors： Elisei R,Romei C,Soldatenko PP,Cosci B,Vorontsova T,Vivaldi A,Basolo F,Cherstvoy ED,Pinchera A,Pacini F

更新日期：2000-07-01 00:00:00

abstract：UNLABELLED:Objective To evaluate the effect of strontium ranelate (SR) on bone turnover markers in women with established osteoporosis previously treated with teriparatide (TPTD--recombinant human PTH 1-34). DESIGN PATIENTS: Twenty-two postmenopausal Caucasian women (aged 65.7 +/- 1.7 years) with established osteoporos...

journal_title：Clinical endocrinology

authors： Anastasilakis AD,Goulis DG,Polyzos SA,Gerou S,Ballaouri I,Efstathiadou Z,Kita M,Avramidis A

更新日期：2009-04-01 00:00:00

abstract：:A 39-year-old woman presented with secondary amenorrhoea in the absence of galactorrhoea, hirsutism or virilization. Investigation revealed a strikingly elevated serum testosterone, dihydrotesterone, free testosterone and LH level. At laparotomy a large granulosa cell tumour was encountered and totally removed. Analys...

journal_title：Clinical endocrinology

authors： Taylor HC,Velasco ME,Flores SG,Berg G,Brown TR

更新日期：1982-12-01 00:00:00

abstract：:Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The ...

journal_title：Clinical endocrinology

authors： Fraioli F,Cappa M,Fabbri A,Gnessi L,Moretti C,Borrelli P,Isidori A

更新日期：1984-03-01 00:00:00

abstract：BACKGROUND:Graves' Ophthalmopathy (GO) is a complex eye and orbital disorder that is uniquely linked to Graves' Hyperthyroidism (GH) and has traditionally been considered a cross-reactive immune response against the thyroid stimulating hormone receptor (TSHR) in orbital tissue. However, because there is no direct evide...

journal_title：Clinical endocrinology

authors： Wescombe L,Lahooti H,Gopinath B,Wall JR

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The rarity of pituitary apoplexy renders it a difficult subject for audit; hence there are no evidence-based standards of optimum care for such patients. The key controversy in management relates to the role of acute neurosurgical intervention. In recent years we have adopted a relatively conse...

journal_title：Clinical endocrinology

authors： Ayuk J,McGregor EJ,Mitchell RD,Gittoes NJ

更新日期：2004-12-01 00:00:00

abstract：:It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

journal_title：Clinical endocrinology

authors： Thompson CJ,White MC,Baylis PH

更新日期：1989-05-01 00:00:00

abstract：OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

journal_title：Clinical endocrinology

authors： Vilar L,Burke CW

更新日期：1994-12-01 00:00:00

abstract：OBJECTIVE:Non-tumour causes of hyperprolactinaemia, including prolactin-elevating drugs, must be excluded. There is a general view that such drugs are unlikely to raise serum PRL above 3000 mU/I, but the literature is confusing. We report 8 patients receiving treatment with neuroleptic drugs, whose serum PRL concentrat...

journal_title：Clinical endocrinology

authors： Pollock A,McLaren EH

更新日期：1998-10-01 00:00:00

abstract：OBJECTIVE:The 2017 revised Bethesda System for Reporting Thyroid Cytopathology (BSRTC) included new malignancy rates for each category as well as new management recommendations. Here, we evaluate the malignancy rate and test performance for BSRTC categories in a middle-sized institution outside the United States (US). ...

journal_title：Clinical endocrinology

authors： Avior G,Dagan O,Shochat I,Frenkel Y,Tessler I,Meir A,Jaffe A,Cohen O

更新日期：2020-09-27 00:00:00

abstract：OBJECTIVE:Insulin resistance has been linked to intrauterine growth restriction; adiponectin is a strong determinant of insulin sensitivity. We aimed at studying the contributions of birthweight and insulin sensitivity to circulating adiponectin in children born small for gestational age (SGA). DESIGN:Cross-sectional,...

journal_title：Clinical endocrinology

authors： López-Bermejo A,Casano-Sancho P,Fernández-Real JM,Kihara S,Funahashi T,Rodríguez-Hierro F,Ricart W,Ibañez L

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:SRY-negative 46,XX testicular and ovotesticular disorders/differences of sex development (T/OTDSD) represent a very rare and unique DSD condition where testicular tissue develops in the absence of a Y chromosome. To date, very few studies have described the phenotype, clinical and surgical management and long...

journal_title：Clinical endocrinology

authors： Lambert S,Peycelon M,Samara-Boustani D,Hyon C,Dumeige L,Peuchmaur M,Fiot E,Léger J,Simon D,Paye-Jaouen A,Bouligand J,Siffroi JP,Carel JC,McElreavey K,El Ghoneimi A,Brachet C,Bouvattier C,Martinerie L

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains u...

journal_title：Clinical endocrinology

authors： Tang Y,Qiao P,Qu X,Bao Y,Li Y,Liao Y,Ying H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Turner syndrome (TS) is characterized by growth retardation, hypogonadism and a high risk of cardiovascular complications and atherosclerosis; case reports suggest that thrombo-embolic complications may be present. DESIGN:Cross-sectional study. PATIENTS:Sixty women with TS. MEASUREMENTS:We characterized th...

journal_title：Clinical endocrinology

authors： Gravholt CH,Mortensen KH,Andersen NH,Ibsen L,Ingerslev J,Hjerrild BE

更新日期：2012-05-01 00:00:00

abstract：:The citric acid cycle, also known as the Krebs cycle, plays an integral role in cellular metabolism and aerobic respiration. Mutations in genes encoding the citric acid cycle enzymes succinate dehydrogenase, fumarate hydratase and malate dehydrogenase all predispose to hereditary tumour syndromes. The succinate dehydr...

journal_title：Clinical endocrinology

authors： MacFarlane J,Seong KC,Bisambar C,Madhu B,Allinson K,Marker A,Warren A,Park SM,Giger O,Challis BG,Maher ER,Casey RT

更新日期：2020-11-01 00:00:00

abstract：:Twenty women, who had been randomly selected from women with subclinical hypothyroidism identified in a population study were treated with L-thyroxine and placebo in a double-blind cross-over design during 2 x 6 months. Three women did not complete the study, one because she moved to another part of the country, and t...

journal_title：Clinical endocrinology

authors： Nyström E,Caidahl K,Fager G,Wikkelsö C,Lundberg PA,Lindstedt G

更新日期：1988-07-01 00:00:00

abstract：:The effect of pretreatment with biosynthetic methionyl human GH (hGH) on the GH response to GHRH has been studied in normal subjects. Eight volunteers were given either 4 IU hGH or placebo s.c. 12-hourly for 72 h before a GHRH test, or a single s.c. dose of 4 IU hGH 12 h before a GHRH test. Somatomedin-C (Sm-C) levels...

journal_title：Clinical endocrinology

authors： Ross RJ,Borges F,Grossman A,Smith R,Ngahfoong L,Rees LH,Savage MO,Besser GM

更新日期：1987-01-01 00:00:00

abstract：BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

journal_title：Clinical endocrinology

authors： Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:Our clinical practice has been to offer treatment with cyclical disodium etidronate and high dose calcium supplements (1500-1600 mg/day) to all female patients with osteoporosis who are unable or unwilling to take hormone replacement therapy (HRT), and male osteoporotics. In a retrospective study we compared ...

journal_title：Clinical endocrinology

authors： Orme SM,Simpson M,Stewart SP,Oldroyd B,Westmacott CF,Smith MA,Belchetz PE

更新日期：1994-08-01 00:00:00