Effect of Sandostatin LAR on sleep apnoea in acromegaly: correlation with computerized tomographic cephalometry and hormonal activity.

Abstract:

OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS:Fourteen subjects with acromegaly were recruited. MEASUREMENTS:Subjects were assessed at baseline and those with apnoea-hypopnoea index (AHI) > or = 5 were reassessed after 6 months of treatment with Sandostatin LAR 20-30 mg IMI 4-weekly. Biochemical activity was assessed with levels of GH and IGF-1. Sleep disordered breathing was assessed with overnight polysomnography. Upper airway anatomic profile was defined with computerized tomographic cephalometry. RESULTS:Of 14 subjects (age 42.0 +/- 8.1 years, mean +/- SD; 11 men) at baseline, there was a positive correlation between GH and tongue length (VT; P = 0.004), and between AHI and cephalometric indices: length of soft palate (PMU; P = 0.002); mandibular plane-hyoid bone distance (MPH; P = 0.017), maximum thickness of soft palate (Max-SP; P = 0.018) and VT (P = 0.027). Eight patients had sleep disordered breathing (AHI > or = 5) which was predominantly obstructive in nature (AHI = 29.4 +/- 22.6). After treatment, there were significant improvements in hormonal profile: GH, mU/l (before, 51.5 +/- 27.8; after, 8.0 +/- 7.4; P = 0.017) and IGF-1, nmol/l (before, 95.5 +/- 23.4; after, 35.0 +/- 12.4; P = 0.012); sleep-disordered breathing: AHI (before, 29.4 +/- 22.6; after, 13.4 +/- 11.12; P = 0.025), snoring episodes (before, 486 +/- 240; after, 165 +/- 170; P = 0.05); cephalometric indices, mm: MPH (before, 18.8 +/- 12.1; after, 14.8 +/- 8.4; P = 0.018), VT (before, 72.3 +/- 4.4; after, 69.7 +/- 4.3; P = 0.05). There was a positive correlation between the reduction in GH and AHI (r = 0.738, P = 0.037). CONCLUSIONS:The findings demonstrated that there was correlation between sleep apnoea severity and soft tissue overgrowth at the upper airway region in acromegaly. They also suggest that Sandostatin LAR improved obstructive sleep apnoea in acromegaly, and the effect might be partly mediated via a reduction in upper airway soft tissue, in particular that of the tongue, concomitant with a reduction in GH levels.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Ip MS,Tan KC,Peh WC,Lam KS

doi

10.1046/j.1365-2265.2001.01358.x

keywords:

subject

Has Abstract

pub_date

2001-10-01 00:00:00

pages

477-83

issue

4

eissn

0300-0664

issn

1365-2265

pii

1358

journal_volume

55

pub_type

杂志文章
  • The pharmacokinetics, safety and endocrine effects of authentic biosynthetic human growth hormone in normal subjects.

    abstract::The pharmacokinetics, safety and endocrine effects of an authentic human growth hormone (bio-hGH), produced by the expression of genomic hGH in a mammalian cell line, were studied in six healthy young men who were administered 0.2 U/kg/day subcutaneously for five consecutive days. Changes in sodium balance and in thyr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1989.tb00431.x

    authors: Ho KY,Weissberger AJ,Stuart MC,Day RO,Lazarus L

    更新日期:1989-04-01 00:00:00

  • Seladin-1/DHCR24 expression in normal ovary, ovarian epithelial and granulosa tumours.

    abstract:OBJECTIVE:The human DIMINUTO/DWARF1 homolog seladin-1/DHCR24 has been recently reported to be up-regulated in adrenocortical adenomas. Seladin-1 expression has been reported in the normal ovary. Granulosa cell tumours of the ovary (GCT) as with adrenocortical adenomas arise from a steroidogenic tissue, respond to pitui...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02308.x

    authors: Fuller PJ,Alexiadis M,Jobling T,McNeilage J

    更新日期:2005-07-01 00:00:00

  • Exploring the spectrum of 3-M syndrome, a primordial short stature disorder of disrupted ubiquitination.

    abstract::3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2265.2012.04428.x

    authors: Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

    更新日期:2012-09-01 00:00:00

  • Increasing thyroid cancer incidence in Queensland, Australia 1982-2008 - true increase or overdiagnosis?

    abstract:BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12724

    authors: Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

    更新日期:2016-02-01 00:00:00

  • The role of endogenous opioids in the chlorpropamide alcohol flush.

    abstract::The response of plasma immunoreactive met-enkephalin (IR-met-enkephalin) to ethanol (8 g by mouth) after chlorpropamide (250 mg daily for 14 d) was studied in three groups of non-insulin dependent diabetics (a) six diabetics who showed chlorpropamide alcohol flush (CPAF) and in whom the reaction could be blocked by in...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1984.tb01386.x

    authors: Johnston C,Wiles PG,Medbak S,Bowcock S,Cooke ED,Pyke DA,Rees LH

    更新日期:1984-11-01 00:00:00

  • Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.

    abstract:OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1994.tb02554.x

    authors: Laursen T,Jørgensen JO,Christiansen JS

    更新日期:1994-09-01 00:00:00

  • Longitudinal evaluation of adrenocorticotrophin and beta-lipotrophin plasma levels following bilateral adrenalectomy in patients with Cushing's disease.

    abstract:OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1993.tb01756.x

    authors: Moreira AC,Castro M,Machado HR

    更新日期:1993-07-01 00:00:00

  • Effects of increasing levothyroxine on pregnancy outcomes in women with uncontrolled hypothyroidism.

    abstract:OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13168

    authors: Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

    更新日期:2017-01-01 00:00:00

  • Nonalcoholic fatty liver disease and age are strong indicators for atherosclerosis in morbid obesity.

    abstract:OBJECTIVE:Whether nonalcoholic fatty liver disease (NAFLD) can predict atherosclerosis in obese patients remains unclear. The aim of our study was to investigate the usefulness of NAFLD and other cardiometabolic parameters in predicting subclinical atherosclerosis in obese patients. DESIGN, PATIENTS AND MEASUREMENTS:W...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12698

    authors: Puig J,Blasco G,Daunis-I-Estadella J,Loshuertos E,Codina J,Cuba V,Ortiz R,Xifra G,Ricart W,Pedraza S,Federici M,Fernández-Real JM

    更新日期:2015-08-01 00:00:00

  • MRI-based abnormalities in young adults at risk of adverse bone health due to childhood-onset metabolic & endocrine conditions.

    abstract:OBJECTIVE:Traditional methods of bone densitometry may not provide a comprehensive assessment of bone health. We aimed to assess bone micro-architecture and bone marrow adiposity (BMA) by MRI in adults with osteogenesis imperfecta (OI) and endocrinopathy including GH deficiency and/or hypogonadism. MEASUREMENTS:High-r...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12367

    authors: McComb C,Harpur A,Yacoubian C,Leddy C,Anderson G,Shepherd S,Perry C,Shaikh MG,Foster J,Ahmed SF

    更新日期:2014-06-01 00:00:00

  • Percutaneous coronary intervention increases leptin and decreases adiponectin levels.

    abstract:OBJECTIVE:The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabol...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02654.x

    authors: Azar RR,Sarkis A,Salameh E,Gannagé-Yared MH,Amm-Azar M,Badaoui G,Germanos M,Kassab R

    更新日期:2006-12-01 00:00:00

  • Biochemical and clinical effects of fenclofenac in thyrotoxicosis.

    abstract::Administration of the anti-inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 +/- 8.6 (SEM) nmol/l before therapy was normalized to 70 +/- 6.4 nmol/l after administration of the drug...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2265.1982.tb00729.x

    authors: Pearson DW,Ratcliffe WA,Thomson JA,Ratcliffe JG

    更新日期:1982-04-01 00:00:00

  • Strong association between serum levels of leptin and testosterone in men.

    abstract:OBJECTIVE:Leptin serves as a hormonal signal linking food intake and energy expenditure to fat mass. As significant effects of testosterone administration on body composition and adipose tissue have been described recently, we examined a possible association between serum levels of leptin and testosterone which has not...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1997.2681067.x

    authors: Behre HM,Simoni M,Nieschlag E

    更新日期:1997-08-01 00:00:00

  • Radiofrequency ablation for the management of thyroid nodules: A critical appraisal of the literature.

    abstract::The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1111/cen.13422

    authors: Cesareo R,Palermo A,Pasqualini V,Cianni R,Gaspa G,Manfrini S,Pacella CM

    更新日期:2017-12-01 00:00:00

  • A receptor assay for the measurement of TSH receptor antibodies in unextracted serum.

    abstract::A receptor assay for TSH receptor antibodies is described in which unextracted serum, detergent solubilised TSH receptors and 125I-labelled TSH are used. The assay was rapid and reproducible with coefficients of inter-assay variation of 12.3%, 2.1 and 2.6% at mean inhibition of TSH binding values of 11, 53, and 79 res...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1984.tb00102.x

    authors: Southgate K,Creagh F,Teece M,Kingswood C,Rees Smith B

    更新日期:1984-05-01 00:00:00

  • Gene expression profiles of phaeochromocytomas with ERBB2 overexpression reveal a new molecular mechanism tumourigenicity.

    abstract:OBJECTIVE:Phaeochromocytomas (PHEO) and functional paragangliomas (PGLs) are catecholamine-secreting neuroendocrine tumours. Although most PHEO/PGLs are benign, 10-35% present as (or develop into) malignant tumours with a poor prognosis. Overexpression of ERBB2 (v-erb-b2 erythroblastic leukaemia viral oncogene homologu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2012.04388.x

    authors: Qi Y,Su T,Zhang X,Jiang Y,Yuan W,Wang W,Cui B,Ning G

    更新日期:2012-09-01 00:00:00

  • Parafibromin mutations in hereditary hyperparathyroidism syndromes and parathyroid tumours.

    abstract:OBJECTIVE:To investigate two patients with the hyperparathyroidism-jaw tumour (HPT-JT) syndrome and three patients with familial isolated hyperparathyroidism (FIHP), together with 31 parathyroid tumours (2 HPT-JT, 2 FIHP and 27 sporadic) for HRPT2 mutations. The HPT-JT syndrome and FIHP are autosomal dominant disorders...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2006.02460.x

    authors: Bradley KJ,Cavaco BM,Bowl MR,Harding B,Cranston T,Fratter C,Besser GM,Conceição Pereira M,Davie MW,Dudley N,Leite V,Sadler GP,Seller A,Thakker RV

    更新日期:2006-03-01 00:00:00

  • Serum and follicular fluid insulin like growth factors I and II during growth hormone co-treatment for in-vitro fertilization and embryo transfer.

    abstract:OBJECTIVE:We wished to assess the changes in serum IGF-I and IGF-II concentrations during gonadotrophin treatment alone or with additional GH treatment and to compare follicular fluid IGF-I and IGF-II concentrations in the two treatment groups. DESIGN:We performed an open study of co-treatment with GH and subsequently...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1991.tb03544.x

    authors: Owen EJ,Torresani T,West C,Mason BA,Jacobs HS

    更新日期:1991-10-01 00:00:00

  • The effect of a continuous infusion of a somatostatin analogue (octreotide) for two years on growth hormone secretion and height prediction in tall children.

    abstract:OBJECTIVE:Strategies to limit the final height of tall children have centred on the use of high doses of sex steroids to advance skeletal maturation. This limits therapy to the peripubertal years whereas the greatest gain in height is in the prepubertal years. Prepubertal growth is largely GH dependent and previous wor...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2265.1995.tb02670.x

    authors: Hindmarsh PC,Pringle PJ,Stanhope R,Brook CG

    更新日期:1995-05-01 00:00:00

  • Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.

    abstract:OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1046/j.1365-2265.1996.7760786.x

    authors: Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

    更新日期:1996-09-01 00:00:00

  • Modulation of glucocorticoid metabolism by the growth hormone - IGF-1 axis.

    abstract::The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1365-2265.2007.02763.x

    authors: Agha A,Monson JP

    更新日期:2007-04-01 00:00:00

  • Normal long-term health-related quality of life can be achieved in patients with functional pituitary adenomas having surgery as primary treatment.

    abstract:BACKGROUND:Previous studies report impaired health-related quality of life (HRQoL) in patients with functional pituitary adenomas (FPA). We assessed HRQoL in FPA patients having undergone surgery at our University Central Hospital between 2000 and 2010, with combined adjuvant treatment given to achieve strict hormonal ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.12550

    authors: Ritvonen E,Karppinen A,Sintonen H,Vehkavaara S,Kivipelto L,Roine RP,Niemelä M,Schalin-Jäntti C

    更新日期:2015-03-01 00:00:00

  • No correlation between BRAFV600E mutation and clinicopathological features of papillary thyroid carcinomas in Taiwan.

    abstract:OBJECTIVE:Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have been identified in human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a numbe...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.2005.02367.x

    authors: Liu RT,Chen YJ,Chou FF,Li CL,Wu WL,Tsai PC,Huang CC,Cheng JT

    更新日期:2005-10-01 00:00:00

  • Changes in heart valve structure and function in patients treated with dopamine agonists for prolactinomas, a 2-year follow-up study.

    abstract:OBJECTIVE:The use of ergot-derived dopamine agonists (DA) to treat patients with prolactinomas has not been associated with an increased risk of significant heart valve dysfunction. Accordingly, the present study evaluated whether the long-term use of DA for hyperprolactinaemia may be associated with increased risk of ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1111/j.1365-2265.2011.04326.x

    authors: Delgado V,Biermasz NR,van Thiel SW,Ewe SH,Marsan NA,Holman ER,Feelders RA,Smit JW,Bax JJ,Pereira AM

    更新日期:2012-07-01 00:00:00

  • Growth hormone (GH) enhances anaerobic capacity: impact on physical function and quality of life in adults with GH deficiency.

    abstract:CONTEXT:Anaerobic capacity is impaired in adults with GH deficiency (GHD), adversely affecting physical function and quality of life (QoL). OBJECTIVE:To investigate whether GH replacement improves anaerobic capacity, physical function and QoL in adults with GHD. DESIGN:One-month double-blind placebo-controlled crosso...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13147

    authors: Chikani V,Cuneo RC,Hickman I,Ho KK

    更新日期:2016-10-01 00:00:00

  • Growth hormone treatment improves body composition in adults with Prader-Willi syndrome.

    abstract:OBJECTIVE:Low growth hormone (GH) secretion and hypogonadism are common in patients with Prader-Willi syndrome (PWS). In this study we present the effects of GH treatment on body composition and metabolism in adults with PWS. PATIENTS AND MEASUREMENTS:Nineteen patients with clinical PWS were recruited, 13 had PWS geno...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1046/j.1365-2265.2003.01769.x

    authors: Höybye C,Hilding A,Jacobsson H,Thorén M

    更新日期:2003-05-01 00:00:00

  • Absorption and tolerability of taste-masked hydrocortisone granules in neonates, infants and children under 6 years of age with adrenal insufficiency.

    abstract:OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/cen.13447

    authors: Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

    更新日期:2018-01-01 00:00:00

  • Pyridostigmine fails to increase either spontaneous or GHRH-stimulated GH secretion during day or night in growth hormone-insufficient children.

    abstract::OBJECTIVE The aim of the study was to investigate whether pyridostigmine, a cholinesterase inhibitor which is thought to act at the hypothalamus to inhibit somatostatin secretion, would augment spontaneous or GHRH-stimulated serum GH levels in patients with GH-insufficiency. DESIGN Oral pyridostigmine 60 mg or placebo...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1111/j.1365-2265.1991.tb00313.x

    authors: Kirk JM,Ross RJ,Trainer PJ,Froud AL,Davies SC,Savage MO,Besser GM

    更新日期:1991-05-01 00:00:00

  • Binding of immunoglobulin-G from patients with thyroid autoimmune disease to normal T lymphocytes.

    abstract::Sera from patients with Graves' disease and Hashimoto's thyroiditis were reacted with normal T lymphocyte preparations in an attempt to detect binding of immunoglobulin G (IgG) to T cells. Sera from normal subjects and patients with toxic adenomas served as controls. Each serum was reacted with at least three differen...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章

    doi:10.1111/j.1365-2265.1983.tb00739.x

    authors: Pacini F,Sridama V,Pressendo J,DeGroot LJ,Medof ME

    更新日期:1983-07-01 00:00:00

  • Effects of insulin and glucocorticoids on the leptin system are mediated through free leptin.

    abstract:OBJECTIVE:Insulin and glucocorticoids are known to increase total leptin levels. However, the effects of insulin and glucocorticoids on the components of the leptin system - free leptin (FL), bound leptin (BL) and soluble leptin receptor (SR) - have not been elucidated. The aim of this study was to determine if there i...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章

    doi:10.1046/j.1365-2265.2001.01243.x

    authors: Lewandowski K,Randeva HS,O'Callaghan CJ,Horn R,Medley GF,Hillhouse EW,Brabant G,O'Hare P

    更新日期:2001-04-01 00:00:00