Detection of autoantibodies to recombinant human thyroid peroxidase by sensitive enzyme immunoassay.

abstract：OBJECTIVE:Given the important role of the beta2-adrenoceptor (beta2-AR) in lipid mobilization and the lack of studies in Southern European countries, the aim of this study was to investigate the role of the glutamine 27 glutamic acid (Gln27Glu) beta2-AR polymorphism in the susceptibility to obesity and its metabolic co...

journal_title：Clinical endocrinology

authors： González Sánchez JL,Proenza AM,Martínez Larrad MT,Ramis JM,Fernández Pérez C,Palou A,Serrano Ríos M

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether, in the absence of gonads, GH could bring forward the age of neuroendocrine activation resulting in onset of puberty. DESIGN:In girls with Turner's syndrome, we evaluated the effects of GH therapy on developmental changes in FSH serum concentrations used as an indicator of ...

journal_title：Clinical endocrinology

authors： Bourguignon JP,Gérard A,Deby-Dupont G,Franchimont P

更新日期：1993-07-01 00:00:00

abstract：:3-M syndrome is an autosomal recessive primordial growth disorder characterized by small birth size and post-natal growth restriction associated with a spectrum of minor anomalies (including a triangular-shaped face, flat cheeks, full lips, short chest and prominent fleshy heels). Unlike many other primordial short st...

journal_title：Clinical endocrinology

authors： Clayton PE,Hanson D,Magee L,Murray PG,Saunders E,Abu-Amero SN,Moore GE,Black GC

更新日期：2012-09-01 00:00:00

abstract：:High gastrin levels were found in twenty-one out of fifty-six consecutive patients (38%) with thyrotoxicosis. Following return to euthyroidism gastrin levels generally fell, but twelve patients (21%) remained hypergastrinaemic. Six of these patients (11%) had achlorhydria indicating atrophic gastritis of the antrum sp...

journal_title：Clinical endocrinology

authors： Dahlberg PA,Karlsson FA,Lundqvist G

更新日期：1981-02-01 00:00:00

abstract：:An ornithine infusion test was performed in fifty-four children with constitutional short stature. The ornithine infusion induced an elevated level of GH at 45 min (mean value = 873 pmol/l) and a similar rise of cortisol levels (mean value = 544 nmol/l). An important peak of ACTH appeared 15 min before the increase of...

journal_title：Clinical endocrinology

authors： Evain-Brion D,Donnadieu M,Roger M,Job JC

更新日期：1982-08-01 00:00:00

abstract：:Familial neurohypophysial diabetes insipidus (FNDI) is a rare autosomal dominant syndrome stemming from the absence of arginine vasopressin (AVP). More than thirty-five different germline mutations in the arginine vasopressin-neurophysin II gene have been reported. These mutations are either in the signal peptide or s...

journal_title：Clinical endocrinology

authors： Boson WL,Sarubi JC,d'Alva CB,Friedman E,Faria D,De Marco L,Wajchenberg B

更新日期：2003-01-01 00:00:00

abstract：:Objective African-Americans have been shown to have low prevalence of hypothyroidism. Brazil has a high ethnic admixture allowing further exploration into whether environmental factors can explain the ethnic differences. Design A survey, representative of the population of Rio de Janeiro, a large metropolitan city in ...

journal_title：Clinical endocrinology

authors： Sichieri R,Baima J,Marante T,de Vasconcellos MT,Moura AS,Vaisman M

更新日期：2007-06-01 00:00:00

abstract：:The 'basal' plasma glucose, defined as the stable overnight concentration, has been assessed as an index of diabetes control by comparison with plasma glucose measurements during 24-h profiles in diet-treated maturity-onset diabetic patients and normal subjects. The basal plasma glucose correlated with the total (r=0....

journal_title：Clinical endocrinology

authors： Holman RR,Turner RC

更新日期：1981-03-01 00:00:00

abstract：:The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These oscillating levels are also seen at the level of tissues such as the brain and trigger pulses of gene activation and downstream signallin...

journal_title：Clinical endocrinology

authors： Russell GM,Durant C,Ataya A,Papastathi C,Bhake R,Woltersdorf W,Lightman S

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence for the role of cytokines in pituitary differentiated function and tumorigenesis, but the spectrum of cytokines found in the pituitary is unknown. Therefore profiles of cytokine expression were determined in different human anterior pituitary adenoma sub-types. DESIGN:The reverse...

journal_title：Clinical endocrinology

authors： Green VL,Atkin SL,Speirs V,Jeffreys RV,Landolt AM,Mathew B,Hipkin L,White MC

更新日期：1996-08-01 00:00:00

abstract：OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

journal_title：Clinical endocrinology

authors： Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

更新日期：2019-12-01 00:00:00

abstract：:We designed a systematic study of patients with Cushing's disease to compare the results of acute experiments with cyproheptadine, sodium valproate and bromocriptine with the results of chronic treatment with sodium valproate. In 13 patients the plasma cortisol response to single doses of 2.5 mg bromocriptine, 6 mg cy...

journal_title：Clinical endocrinology

authors： Koppeschaar HP,Croughs RJ,Thijssen JH,Schwarz F

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism and calcium supplementation have been linked to cardiovascular outcomes. The study objective was to examine plasma calcium as a predictor of cardiovascular disease in the general population, as results from previous cohort studies are conflicting. DESIGN, PARTICIPANTS AND MEASUREM...

journal_title：Clinical endocrinology

authors： Walsh JP,Divitini ML,Knuiman MW

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Mutations in the melanocortin-4 receptor gene (MC4R) are the most common monogenic form of human obesity. However, the contribution of MC4R mutations to obesity in Chinese has not been investigated. We studied the frequency of MC4R mutations in an obese southern Chinese population and the functional consequen...

journal_title：Clinical endocrinology

authors： Rong R,Tao YX,Cheung BM,Xu A,Cheung GC,Lam KS

更新日期：2006-08-01 00:00:00

abstract：OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

journal_title：Clinical endocrinology

authors： Moreira AC,Castro M,Machado HR

更新日期：1993-07-01 00:00:00

abstract：:Malignant insulinomas are very rare endocrine tumours with a variable clinical course. We describe a 51-year-old man who had two large insulinomas resected from the body of the pancreas and 19 years later, having again become symptomatic, was found to have hepatic metastases. Medical treatment with diazoxide and octre...

journal_title：Clinical endocrinology

authors： Scott A,Hinwood D,Donnelly R

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:No single histological or molecular marker is diagnostic for malignant phaeochromocytomas and paragangliomas (PPGLs). This study aimed to establish and evaluate a prognostic nomogram to improve the prediction of metastatic probability in individual PPGL patients. METHODS:Three hundred and 47 consecutive PPGL...

journal_title：Clinical endocrinology

authors： Zhong X,Ye L,Su T,Xie J,Zhou W,Jiang Y,Jiang L,Ning G,Wang W

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:It has previously been shown that higher serum TSH is associated with increased thyroid cancer incidence and advanced-stage disease. In the healthy adult population, mean TSH increases with age. As age over 45 years is a known prognostic indicator for thyroid cancer, it is important to know whether higher TS...

journal_title：Clinical endocrinology

authors： Haymart MR,Glinberg SL,Liu J,Sippel RS,Jaume JC,Chen H

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to observe the changes in bone and mineral metabolism and to confirm the regulation of fibroblast growth factor-23 (FGF-23) in untreated Graves' disease. PATIENTS AND MEASUREMENTS:The study comprised 39 patients, with or without Graves' disease. The Graves' disease group was made up...

journal_title：Clinical endocrinology

authors： Park SE,Cho MA,Kim SH,Rhee Y,Kang ES,Ahn CW,Cha BS,Lee EJ,Kim KR,Lee HC,Lim SK

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:Women with Turner's syndrome (TS) have recently been shown to be at an increased risk of developing chronic liver disease. There has been some concern that oestrogen replacement therapy may exacerbate hepatic dysfunction. The aim of this study was to assess hepatic function in women with TS and to determine t...

journal_title：Clinical endocrinology

authors： Elsheikh M,Hodgson HJ,Wass JA,Conway GS

更新日期：2001-08-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：:A review of the genetics of male undermasculinization must encompass a description of the embryology of the genital system. The dimorphism of sex development consequent upon the formation of a testis and the subsequent secretion of hormones to impose a male phenotype is highlighted. Thus, an understanding of the cause...

journal_title：Clinical endocrinology

authors： Ahmed SF,Hughes IA

更新日期：2002-01-01 00:00:00

abstract：OBJECTIVE:To identify predictors of hypothalamic-pituitary-adrenal (HPA) axis recovery interval and severity of glucocorticoid withdrawal symptoms (GWS) in patients undergoing adrenalectomy for corticotropin-independent cortisol excess. DESIGN:This is a retrospective study of patients with mild autonomous cortisol exc...

journal_title：Clinical endocrinology

authors： Hurtado MD,Cortes T,Natt N,Young WF Jr,Bancos I

更新日期：2018-12-01 00:00:00

abstract：:Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

journal_title：Clinical endocrinology

authors： Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:PCOS is associated with obesity and insulin resistance. Efforts have focused on whether an abnormal energy homeostasis contributes to the development of obesity in these patients. There are conflicting results in the literature regarding whether women with PCOS have an altered basal metabolic rate (BMR), ther...

journal_title：Clinical endocrinology

authors： Churchill SJ,Wang ET,Bhasin G,Alexander C,Bresee C,Pall M,Azziz R,Mathur R,Pisarska MD

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to develop an assay for the measurement of thyroid blocking antibodies (TBAb), based on the ability of patient serum to inhibit TSH stimulated 3H-cAMP production following incubation of FRTL-5 or JPO9 cells with 3H-adenine. The assay was then used to evaluate a child born with neonat...

journal_title：Clinical endocrinology

authors： Michelangeli VP,Poon CW,Arnus EE,Frauman AG,Connelly J,Colman PG

更新日期：1995-01-01 00:00:00

abstract：:We report six cases of autoimmune thyroid disease associated with chronic urticaria and briefly review the literature, including the histopathological nature of such lesions, and their aetiology and pathogenesis. In view of the prevalence of thyroid disease in patients with chronic urticaria, screening measurements of...

journal_title：Clinical endocrinology

authors： Monge C,Demarco P,Burman KD,Wartofsky L

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Primary hyperparathyroidism (PHPT) is an uncommonly diagnosed condition among adolescents and young adults. We review the clinical characteristics of these patients based on our institutional experience. SUBJECTS:Patients aged 12-28 years treated for PHPT at our institution from 1990 to 1996 were evaluated b...

journal_title：Clinical endocrinology

authors： Loh KC,Duh QY,Shoback D,Gee L,Siperstein A,Clark OH

更新日期：1998-04-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin re...

journal_title：Clinical endocrinology

authors： Cuatrecasas G,Granada ML,Formiguera X,Rull M,Alastrué A,Remesar X,Alemany M,Foz M

更新日期：1998-02-01 00:00:00