Low prevalence of hypothyroidism among black and Mulatto people in a population-based study of Brazilian women.

abstract：:A late rise in serum GH occurs 3-5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses...

journal_title：Clinical endocrinology

authors： Valcavi R,Zini M,Dieguez C,Portioli I,Scanlon MF

更新日期：1990-05-01 00:00:00

abstract：:Non-endocrine tumours are capable of production of ectopic hormones, precursor molecules subunits and hormone-related fragments. The measurement of these may provide biochemical markers of malignancy, allowing presymptomatic diagnosis which may lead ultimately to an improved prognosis for the patient. The study of ect...

journal_title：Clinical endocrinology

authors： Rees LH

更新日期：1976-01-01 00:00:00

abstract：OBJECTIVE:To compare biochemical variables, renal function and calcium and vitamin D intakes in euparathyroid and hyperparathyroid patients with primary osteoporosis and osteopenia and describe the measures necessary to normalize serum PTH in the patients with secondary hyperparathyroidism. DESIGN AND PATIENTS:We revi...

journal_title：Clinical endocrinology

authors： Yendt ER,Kovacs KA,Jones G

更新日期：2008-12-01 00:00:00

abstract：DESIGN:Prevalence of type 2 diabetes and glucose intolerance increase with age. It has been demonstrated that beta cell function declines at about 1% per year in glucose tolerant Caucasians. However, this relationship is not known to exist in other ethnic groups. SUBJECTS AND MEASUREMENTS:We investigated the relations...

journal_title：Clinical endocrinology

authors： Chiu KC,Martinez DS,Chu A

更新日期：2005-03-01 00:00:00

abstract：BACKGROUND:Whether subclinical hypothyroidism adversely impacts pregnancy outcomes is inconclusive, and limited data are available on the optimal TSH range in women planning pregnancy. OBJECTIVE:To investigate the association between maternal preconception TSH levels and pregnancy outcomes. DESIGN:Population-based co...

journal_title：Clinical endocrinology

authors： Chen S,Zhou X,Zhu H,Yang H,Gong F,Wang L,Zhang M,Jiang Y,Yan C,Li J,Wang Q,Zhang S,Pan H

更新日期：2017-06-01 00:00:00

abstract：BACKGROUND:Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion. OBJECTIVE:To investigate the clinical characteristics and accurate management of aromatase-deficient children. PATIENTS AND METHOD...

journal_title：Clinical endocrinology

authors： Fan L,Zhang B,Li L,Gong C

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

journal_title：Clinical endocrinology

authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Traditionally, acromegaly evaded diagnosis until in its clinically obvious later stages when treatment is more difficult. Over the last 25 years diagnostic tests have improved, but whether clinical disease detection also improved was unknown, so we tested if disease severity at diagnosis had changed from 198...

journal_title：Clinical endocrinology

authors： Reid TJ,Post KD,Bruce JN,Nabi Kanibir M,Reyes-Vidal CM,Freda PU

更新日期：2010-02-01 00:00:00

abstract：:A 16-year-old female patient with an adrenal tumour was studied. Clinically she had progressive hirsutism, showed high urinary 17-oxosteroid excretion with normal plasma cortisol. Plasma C19-steroids, both unconjugated (including testosterone) and sulphate-conjugated, were greatly elevated. On surgical exploration an ...

journal_title：Clinical endocrinology

authors： Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

更新日期：1978-04-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) is contraindicated in a proportion of patients with suspected ACTH deficiency. The aim of this study was to investigate the diagnostic accuracy of the glucagon stress test (GST) compared with the overnight metyrapone test (OMT) in patients with contraindications to ITT. DESIG...

journal_title：Clinical endocrinology

authors： Cegla J,Jones B,Seyani L,Papadoulou D,Wynne K,Martin NM,Meeran K,Chapman R,Donaldson M,Goldstone AP,Tan T

更新日期：2013-05-01 00:00:00

abstract：OBJECTIVE:We have investigated plasma potassium changes during insulin-induced hypoglycaemia (IIH) in adult patients with growth hormone deficiency (GHD) who have low total body potassium and may also have a vulnerable myocardium due to an increased prevalence of atherosclerosis. DESIGN:Hypoglycaemia was induced throu...

journal_title：Clinical endocrinology

authors： Davies JS,Hinds NP,Millward EM,McDowell I,Scanlon MF

更新日期：1998-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Growth hormone treatment in children with idiopathic short stature (ISS) leads to growth acceleration in the first years, but the effect on final height is still poorly documented. We therefore studied the long-term effect of GH therapy in children with idiopathic short stature. DESIGN:We have...

journal_title：Clinical endocrinology

authors： Wit JM,Boersma B,de Muinck Keizer-Schrama SM,Nienhuis HE,Oostdijk W,Otten BJ,Delemarre-Van de Waal HA,Reeser M,Waelkens JJ,Rikken B

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVE:The somatostatin analogue octreotide (Sandostatin, Novartis, Basie) significantly improves the syndromes suffered by most patients with neuroendocrine tumours (NETs). The use of [111In-DTPA-D-Phe1]-octreotide scintigraphy ([111In]-pentetreotide) to predict the response to octreotide treatment has been describ...

journal_title：Clinical endocrinology

authors： Shi W,Buchanan KD,Johnston CF,Larkin C,Ong YL,Ferguson R,Laird J

更新日期：1998-03-01 00:00:00

abstract：:Administration of the anti-inflammatory drug fenclofenac (600 mg bd) for 28 days to four females with thyrotoxicosis resulted in a rapid decline in thyroid hormone levels. The mean total thyroxine (T4) level of 173 +/- 8.6 (SEM) nmol/l before therapy was normalized to 70 +/- 6.4 nmol/l after administration of the drug...

journal_title：Clinical endocrinology

authors： Pearson DW,Ratcliffe WA,Thomson JA,Ratcliffe JG

更新日期：1982-04-01 00:00:00

abstract：OBJECTIVES:Loss of E-cadherin is an important marker of epithelial tumour progression. The aims of this study were to explore whether E-cadherin expression and localization correlate to corticotroph tumour progression, relate the expression of the E-cadherin gene (CDH1) to immunohistochemical E-cadherin staining patter...

journal_title：Clinical endocrinology

authors： Evang JA,Berg JP,Casar-Borota O,Lekva T,Kringen MK,Ramm-Pettersen J,Bollerslev J

更新日期：2011-12-01 00:00:00

abstract：:Prolactin secretion and biological activity have been investigated in 20 females with persistent idiopathic galactorrhoea who had normal resting serum prolactin levels at presentation. Results were compared with those in 34 normal controls. Hyperprolactinaemia, which was persistent in one and intermittent in the other...

journal_title：Clinical endocrinology

authors： Johnston DG,Haigh J,Prescott RW,Heaton A,Kendall-Taylor P,Baylis P,Alberti KG,Rowe R,Friesen H,Cook D

更新日期：1985-05-01 00:00:00

abstract：OBJECTIVE:Complications of childhood cirrhosis include abnormal growth and malnutrition, associated with abnormalities in circulating IGFs and IGFBPs. Controlled studies suggest that intensive enteral feeding enhances nutritional status. The aim was to ascertain whether nasogastric feeding improves nutritional status i...

journal_title：Clinical endocrinology

authors： Holt RI,Miell JP,Jones JS,Mieli-Vergani G,Baker AJ

更新日期：2000-02-01 00:00:00

abstract：OBJECTIVE:GH deficiency, either in children or in adults, is a clinically relevant problem. The diagnosis is based on dynamic tests of GH secretion, which are clear cut on a group basis but highly problematic for individual diagnosis. The controversy surrounding the diagnosis of GH deficiency reflects the absence of a ...

journal_title：Clinical endocrinology

authors： Micic D,Popovic V,Kendereski A,Peino R,Dieguez C,Casanueva FF

更新日期：1996-11-01 00:00:00

abstract：:Human liver contains components in both cytosol and nucleosol which bind the synthetic testosterone derivative, mibolerone, with a high affinity, moderate capacity and a high specificity for androgens. Gel filtration chromatography shows two binding components, a high molecular weight component (mol wt. 250 000) prese...

journal_title：Clinical endocrinology

authors： Bannister P,Sheridan P,Losowsky MS

更新日期：1985-11-01 00:00:00

abstract：:The effect of surgical stress on the secretions of LH, FSH, testosterone (T) and oestradiol (E2) were studied in twelve male patients. During surgery LH rose significantly; post-operatively, LH fell but remained persistently elevated a week after operation. However, T and E2 fell progressively to a nadir on the second...

journal_title：Clinical endocrinology

authors： Wang C,Chan V,Yeung RT

更新日期：1978-09-01 00:00:00

abstract：OBJECTIVE:Hypercortisolaemia is associated with an increased risk of cardiovascular disease (CVD), either through a direct action on the myocardium or by increased traditional cardiovascular risk factors. The aim of this study was to investigate whether the alterations in the ECG in Cushing's disease (CD) are predictab...

journal_title：Clinical endocrinology

authors： Alexandraki KI,Kaltsas GA,Vouliotis AI,Papaioannou TG,Trisk L,Zilos A,Korbonits M,Besser GM,Anastasakis A,Grossman AB

更新日期：2011-05-01 00:00:00

abstract：OBJECTIVE:Ghrelin and obestatin have apparent opposite orexigenic and anorexigenic effects, although the latter has not been firmly demonstrated in humans. So far, little data have been reported in relation to its potential association with metabolic syndrome (MS). The objective was to study obestatin concentrations in...

journal_title：Clinical endocrinology

authors： Mora M,Granada ML,Roca M,Palomera E,Puig R,Serra-Prat M,Puig-Domingo M

更新日期：2013-06-01 00:00:00

abstract：OBJECTIVE:Hyperinsulinaemia has a role in the development of hyperandrogenism and polycystic ovary syndrome in women of normal weight. Polycystic ovaries are common in women with bulimia nervosa and this study aimed to determine whether women with bulimia nervosa are insulin resistant and to examine the relation betwee...

journal_title：Clinical endocrinology

authors： Raphael FJ,Rodin DA,Peattie A,Bano G,Kent A,Nussey SS,Lacey JH

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVE:Abnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen the severity of the abnormal serum liver biochemistries. There is a wide range of the incidence of these abnormalities in the published literature...

journal_title：Clinical endocrinology

authors： Lin TY,Shekar AO,Li N,Yeh MW,Saab S,Wilson M,Leung AM

更新日期：2017-05-01 00:00:00

abstract：:The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion. Blood sugar nadir occurred at the onset of symptoms (t...

journal_title：Clinical endocrinology

authors： Nussey SS,Page SR,Ang VT,Jenkins JS,White A

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVES:Patients undergoing abdominal surgery often suffer from morbidity associated with increased protein catabolism. Therapeutic recombinant human insulin-like growth factor (rhIGF)-I has been proposed as a means of reversing this process. As IGFBPs modulate the bioavailability of the IGFs, we have studied the ch...

journal_title：Clinical endocrinology

authors： Cotterill AM,Mendel P,Holly JM,Timmins AG,Camacho-Hübner C,Hughes SC,Ross RM,Blum WF,Langford RM

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The study was designed to examine the effect of percutaneous coronary intervention (PCI) on adiponectin and leptin levels. We have previously demonstrated that PCI triggers a systemic inflammatory response. We hypothesized that inflammation participates in the pathogenesis of diabetes mellitus and the metabol...

journal_title：Clinical endocrinology

authors： Azar RR,Sarkis A,Salameh E,Gannagé-Yared MH,Amm-Azar M,Badaoui G,Germanos M,Kassab R

更新日期：2006-12-01 00:00:00

abstract：:Phospholipase C activity was measured in human endometrium using an assay based on the release of total labelled water soluble products (inositol, inositol phosphates) from L-3-phosphatidyl-[2-3H] inositol. The enzyme was shown to be calcium dependent and to have an optimum pH of 5.5. There was no difference between p...

journal_title：Clinical endocrinology

authors： Bonney RC,Franks S

更新日期：1987-09-01 00:00:00

abstract：:A new model has been established for the perfused in situ rat lung. During perfusion with glucose at 4 mmol/l, physiological concentrations of insulin (50 mu/l) caused an initial 1.5 fold increase in lactate production; the increase being sustained at 30% for the 4 h of perfusion. The observation that the lung respond...

journal_title：Clinical endocrinology

authors： Stubbs WA,Morgan I,Lloyd B,Alberti KG

更新日期：1977-09-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00