Abstract:
BACKGROUND AND OBJECTIVE:Growth hormone treatment in children with idiopathic short stature (ISS) leads to growth acceleration in the first years, but the effect on final height is still poorly documented. We therefore studied the long-term effect of GH therapy in children with idiopathic short stature. DESIGN:We have treated 27 prepubertal children with ISS with recombinant human GH (rhGH) in an initial dosage of 2 IU/m2 body surface/day subcutaneously, which was doubled either after the first year if the height velocity increment was less than 2 cm/year, or thereafter if height velocity fell below the P50 for bone age. Growth and bone maturation of the treatment group (ISS group, n = 21) were compared to those of an untreated control group with ISS (ISS controls, n = 27) and of a group of rhGH treated children with isolated GH deficiency (GHD group, n = 7). RESULTS:In 9 patients of the ISS group still on treatment, height standard deviation score (HSDS) for chronological age increased from -3.8 +/- 0.7 to -2.3 +/- 0.9 (mean +/- standard deviation) over 6 years, while in matched ISS controls HSDS for age did not change. HSDS for age in the GHD group increased from -3.9 +/- 0.6 to -1.8 +/- 0.7 after 4 years, significantly more than the ISS group. Bone maturation was accelerated in the ISS and GHD groups. HSDS for bone age and predicted adult height did not change in either group. Final height in 12 children of the ISS group was -2.6 +/- 1.0 SDS. In the untreated controls final height was similar. A low integrated GH concentration over 24 hours, a low GH peak to provocative stimuli, and minimal initial BA delay predicted a favourable outcome. CONCLUSION:rhGH treatment in this group of children with idiopathic short stature did not increase average final height. Part of the heterogeneity of the response can be attributed to the variation in endogenous GH secretion and initial bone age delay.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Wit JM,Boersma B,de Muinck Keizer-Schrama SM,Nienhuis HE,Oostdijk W,Otten BJ,Delemarre-Van de Waal HA,Reeser M,Waelkens JJ,Rikken Bdoi
10.1111/j.1365-2265.1995.tb02644.xsubject
Has Abstract,Author List Incompletepub_date
1995-04-01 00:00:00pages
365-72issue
4eissn
0300-0664issn
1365-2265journal_volume
42pub_type
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1990.tb00507.x
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1994.tb03782.x
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journal_title:Clinical endocrinology
pub_type: 临床试验,杂志文章
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pub_type: 杂志文章,meta分析
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journal_title:Clinical endocrinology
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pub_type: 杂志文章
doi:10.1046/j.1365-2265.1999.00632.x
更新日期:1999-02-01 00:00:00
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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更新日期:1986-07-01 00:00:00
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journal_title:Clinical endocrinology
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journal_title:Clinical endocrinology
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doi:10.1046/j.1365-2265.1999.00878.x
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更新日期:2017-01-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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更新日期:2018-12-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
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更新日期:1979-03-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/cen.12639
更新日期:2015-02-01 00:00:00