Intrauterine growth restriction (IUGR) is associated with increased leptin synthesis and binding capability in neonates.


OBJECTIVE:Animal studies suggest pathological foetal programming of hypothalamic circuits regulating food intake in the setting of leptin deficiency and intrauterine growth restriction (IUGR). We aimed to compare placental leptin synthesis and leptin-binding capability in venous cord blood between IUGR newborns and neonates born appropriate for gestational age (AGA). DESIGN:Prospective controlled multicentre study. PATIENTS:Twenty-one ultrasound-proven IUGR and 33 AGA neonates. MEASUREMENTS:The concentration of leptin and soluble leptin receptor (sOB-R) in venous cord blood at birth was determined. Moreover, placental gene and protein expression of leptin and placental mRNA expression of functional and total leptin receptor isoforms were measured. RESULTS:Whereas log-leptin concentration in venous cord blood did not differ between IUGR and AGA newborns, the concentration of log-sOB-R was elevated in IUGR neonates (p(confounder adjusted)=0·009). Placental leptin protein synthesis as well as leptin mRNA was significantly higher in IUGR than in AGA infants (log-transformed, relative gene expression, p(confounder adjusted)=0·004). Analysis of gene expression of functional and total leptin receptor isoforms did not show any difference between both groups. CONCLUSIONS:Leptin-binding capability in venous cord blood is increased in IUGR newborns. Thus, via foetal programming, reduced biologically active leptin levels might contribute to a perturbed regulation of appetite.


Clin Endocrinol (Oxf)


Clinical endocrinology


Tzschoppe A,Struwe E,Rascher W,Dörr HG,Schild RL,Goecke TW,Beckmann MW,Hofner B,Kratzsch J,Dötsch J




Has Abstract


2011-04-01 00:00:00












  • Increased thyrotrophin secretion induced by sulpiride in man.

    abstract::100 mg i.m. sulpiride (a dopamine-receptor-blocking drug) led to a significant rise in plasma TSH in normal womem, in female patients with galactorrhoea, and, to a much more marked degree, in male and female patients with primary hypothyroidism. In the hypothyroid patients, there was a significant positive correlation...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Massara F,Camanni F,Belforte L,Vergano V,Molinatti GM

    更新日期:1978-11-01 00:00:00

  • Reciprocal changes of serum thyroglobulin and TSH in residents of a moderate endemic goitre area.

    abstract::Subjects living in iodine deficient areas were reported to have elevated serum thyroglobulin (Tg) concentrations. This finding was interpreted as related to thyroid stimulation. Discrepant results, however, were found when serum Tg concentrations were correlated either with serum TSH or with goitre size. In this study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Fenzi GF,Ceccarelli C,Macchia E,Monzani F,Bartalena L,Giani C,Ceccarelli P,Lippi F,Baschieri L,Pinchera A

    更新日期:1985-08-01 00:00:00

  • A new germline VHL gene mutation in three patients with apparently sporadic pheochromocytoma.

    abstract:CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

    更新日期:2013-03-01 00:00:00

  • The effects of oestrogen exposure on bone mass in male to female transsexuals.

    abstract:OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

    更新日期:1998-12-01 00:00:00

  • Efficacy of lanreotide Autogel administered every 4-8 weeks in patients with acromegaly previously responsive to lanreotide microparticles 30 mg: a phase III trial.

    abstract:OBJECTIVE AND DESIGN:Depot somatostatin analogues are well accepted as either adjuvant or primary therapy for acromegaly, and their long dosage intervals facilitate adherence to treatment. Our objective was to evaluate whether lanreotide Autogel 120 mg, every 4-8 weeks, was as effective in controlling acromegaly as lan...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Lucas T,Astorga R,Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly.

    更新日期:2006-09-01 00:00:00

  • Subcutaneous pulsatile glucocorticoid replacement therapy.

    abstract::The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These oscillating levels are also seen at the level of tissues such as the brain and trigger pulses of gene activation and downstream signallin...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章


    authors: Russell GM,Durant C,Ataya A,Papastathi C,Bhake R,Woltersdorf W,Lightman S

    更新日期:2014-08-01 00:00:00

  • Eating, sleeping and sexual function disorders in women with polycystic ovary syndrome (PCOS): A systematic review and meta-analysis.

    abstract:PURPOSE:We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. METHODS:A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reportin...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Thannickal A,Brutocao C,Alsawas M,Morrow A,Zaiem F,Murad MH,Javed Chattha A

    更新日期:2020-04-01 00:00:00

  • Assessment of cure after transsphenoidal surgery for Cushing's disease.

    abstract::The best long-term results of transsphenoidal surgery appear to be in those patients who have unmeasurable serum cortisol levels in the immediate post-operative period. This appears to be due to isolated ACTH deficiency in the remaining normal pituitary gland. In our experience, however, long-term clinical remission m...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: McCance DR,Besser M,Atkinson AB

    更新日期:1996-01-01 00:00:00

  • Insulin sensitivity in growth hormone-deficient children: influence of replacement treatment.

    abstract:OBJECTIVE:In adults, excessive GH secretion may lead to secondary diabetes mellitus, while prolonged GH treatment may accelerate the onset of type 2 diabetes mellitus in predisposed children. The aim of the study was to evaluate insulin sensitivity (IS) and glucose tolerance (GT) in a group of GH-deficient children tre...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Radetti G,Pasquino B,Gottardi E,Contadin IB,Rigon F,Aimaretti G

    更新日期:2004-10-01 00:00:00

  • The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome.

    abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Amato MC,Galluzzo A,Finocchiaro S,Criscimanna A,Giordano C

    更新日期:2008-07-01 00:00:00

  • Isolated growth hormone (GH) deficiency due to compound heterozygosity for two new mutations in the GH-releasing hormone receptor gene.

    abstract:OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

    更新日期:2001-05-01 00:00:00

  • Serum free cortisol as an ancillary tool in the interpretation of the low-dose 1-μg ACTH test.

    abstract:OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

    更新日期:2011-09-01 00:00:00

  • Leydig cell failure with testicular radiation doses

    abstract:OBJECTIVE:Testosterone replacement is generally considered likely to be required only at testicular radiation doses in excess of 20Gy. Long-term data are not available for patients receiving 9-14.4Gy as part of Total Body Irradiation in childhood. DESIGN:Retrospective cohort study. DATA COLLECTION:notes review, labor...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Taneja S,Rao A,Nussey S,Leiper A

    更新日期:2019-11-01 00:00:00

  • Increased IGF-I : IGFBP-3 ratio in patients with hepatocellular carcinoma.

    abstract:BACKGROUND:The development of hepatocellular carcinoma in liver cirrhosis is associated with altered synthesis and secretion of several growth factors. AIM:The aim of this prospective study was to investigate the potential implication of IGF-I and its major binding protein (IGFBP-3) in the development of hepatocellula...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mattera D,Capuano G,Colao A,Pivonello R,Manguso F,Puzziello A,D'Agostino L

    更新日期:2003-12-01 00:00:00

  • The nature of human chorionic gonadotrophin glycoforms in gestational thyrotoxicosis.

    abstract:OBJECTIVE:We examined the charge heterogeneity and carbohydrate complexity of hCG in healthy pregnant Asian subjects and Asian women with gestational thyrotoxicosis to assess whether particular glycoforms of hCG are associated with the thyrotoxicosis of pregnancy. DESIGN:Blood was taken at 8-16 weeks of gestation from...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Talbot JA,Lambert A,Anobile CJ,McLoughlin JD,Price A,Weetman AP,Robertson WR

    更新日期:2001-07-01 00:00:00

  • Diagnostic performance of HMGA2 gene expression for differentiation of malignant thyroid nodules: A systematic review and meta-analysis.

    abstract:OBJECTIVE:The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN:The MEDLINE/PubMed and EMBASE database, from the earliest available date of i...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,meta分析


    authors: Kim BH,Kim SJ,Kim M,Lee SW,Jeong SY,Pak K,Kim K,Kim IJ

    更新日期:2018-12-01 00:00:00

  • Effects of growth hormone release-inhibiting hormone and bromocryptine (CB 154) in states of abnormal pituitary-adrenal function.

    abstract::Growth hormone release-inhibiting hormone (GHR-IH) was administered to five patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in two patients who had undergone bilateral adrenalectomy because of Cushing's disease; one of them had Nelson's syndrome. Bromocryp...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Benker G,Hackenberg K,Hamburger B,Reinwein D

    更新日期:1976-03-01 00:00:00

  • Reproductive hormones during pubertal transition in girls with transient Thelarche.

    abstract:CONTEXT:Transient thelarche (TT), that is, the appearance, regression and subsequent reappearance of breast buds, is a frequent phenomenon, but little is known about pubertal transition in these girls. OBJECTIVE:To describe pubertal progression, growth, genotypes, reproductive hormones and growth factors in girls with...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Soto J,Pereira A,Busch AS,Almstrup K,Corvalan C,Iñiguez G,Juul A,Mericq V

    更新日期:2020-09-01 00:00:00

  • HDAC2 expression and variable number of repeats in exon 1 of the HDAC2 gene in corticotroph adenomas.

    abstract:OBJECTIVES:Alterations in protein expression of histone deacetylase 2 (HDAC2) have been demonstrated in various neoplasms, and lack of nuclear expression of HDAC2 has previously been shown in some human and canine corticotroph adenomas. This study aimed to examine HDAC2 expression in a Norwegian cohort of corticotroph ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Evang JA,Borota OC,Melum E,Holm R,Ramm-Pettersen J,Bollerslev J,Berg JP

    更新日期:2010-08-01 00:00:00

  • Comparison of high intensity focused ultrasound and radioiodine for treating toxic thyroid nodules.

    abstract:PURPOSE:We compared the effectiveness of high intensity focused ultrasound (HIFU) and radioiodine (RAI) to treat patients carrying toxic thyroid nodule (TTN). Normalization of serum thyrotropin (TSH) 1 year after treatment was the primary end-point; concurrent changes in nodules' volume and scintigraphic pattern were a...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Giovanella L,Piccardo A,Pezzoli C,Bini F,Ricci R,Ruberto T,Trimboli P

    更新日期:2018-08-01 00:00:00

  • ACTH and gonadotropin deficiencies predict mortality in patients treated for nonfunctioning pituitary adenoma: long-term follow-up of 519 patients in two large European centres.

    abstract:CONTEXT AND OBJECTIVE:Nonfunctioning pituitary adenomas (NFPAs) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPAs due to tumour- or treatment-related factors and may increase mortality risk. Here, we analysed the associations of hypopituitarism, hormone replacement and mortality in a...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: O'Reilly MW,Reulen RC,Gupta S,Thompson CA,Dineen R,Goulden EL,Bugg G,Pearce H,Toogood AA,Gittoes NJ,Mitchell R,Thompson CJ,Ayuk J

    更新日期:2016-11-01 00:00:00

  • A relook at the 8th edition of the AJCC TNM staging system of anaplastic thyroid carcinoma: A SEER-based study.

    abstract:OBJECTIVE:In the 8th edition American Joint Committee on Cancer (AJCC) tumour-node-metastasis (TNM) staging system (TNM-8), changes have been made regarding anaplastic thyroid carcinoma (ATC) compared with the 7th edition (TNM-7). The major changes are that anaplastic ATC now has the same T stage definitions as differe...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Xiang J,Wang Z,Sun W,Zhang H

    更新日期:2020-12-26 00:00:00

  • Small, dense low-density lipoproteins (LDL) are predictors of cardio- and cerebro-vascular events in subjects with the metabolic syndrome.

    abstract:OBJECTIVE:Small, dense low-density lipoproteins (LDL) are a feature of the metabolic syndrome (MS) but their predictive role still remains to be established. We performed a 2-year follow-up study in 124 subjects with MS (63 +/- 6 years), as defined by the American Heart Association/National Heart, Lung and Blood Instit...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Rizzo M,Pernice V,Frasheri A,Di Lorenzo G,Rini GB,Spinas GA,Berneis K

    更新日期:2009-06-01 00:00:00

  • Association between habitual physical activity and brown adipose tissue activity in individuals undergoing PET-CT scan.

    abstract:OBJECTIVE:Augmented brown adipose tissue (BAT) mass and activity lead to higher basic metabolic rate which is beneficial against obesity. Our aim was to investigate whether habitual (i.e. usual weekly participation) physical activity is linked with BAT activity and mass in humans, in a group of patients undergoing (18)...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Dinas PC,Nikaki A,Jamurtas AZ,Prassopoulos V,Efthymiadou R,Koutedakis Y,Georgoulias P,Flouris AD

    更新日期:2015-01-01 00:00:00

  • Which parameters predict the beneficial effect of GnRHa treatment on height in girls with central precocious puberty?

    abstract:OBJECTIVE:Data about GnRHa on adult height in girls with central precocious puberty(CPP) have shown variable results, ranging from improvement of growth prognosis to lack of any benefit.This study was designed to delineate the criteria to decide which girls with idiopathic CPP(iCPP) will have a height benefit from GnRH...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vuralli D,Gonc EN,Ozon ZA,Kandemir N,Alikasifoglu A

    更新日期:2021-01-18 00:00:00

  • Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.

    abstract:OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Laursen T,Jørgensen JO,Christiansen JS

    更新日期:1994-09-01 00:00:00

  • Comparison of the overnight metyrapone and glucagon stimulation tests in the assessment of secondary hypoadrenalism.

    abstract:OBJECTIVE:The insulin tolerance test (ITT) is contraindicated in a proportion of patients with suspected ACTH deficiency. The aim of this study was to investigate the diagnostic accuracy of the glucagon stress test (GST) compared with the overnight metyrapone test (OMT) in patients with contraindications to ITT. DESIG...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cegla J,Jones B,Seyani L,Papadoulou D,Wynne K,Martin NM,Meeran K,Chapman R,Donaldson M,Goldstone AP,Tan T

    更新日期:2013-05-01 00:00:00

  • New breakpoints in both the H4 and RET genes create a variant of PTC-1 in a post-Chernobyl papillary thyroid carcinoma.

    abstract::Two main types of RET/PTC oncogene, named RET/PTC-1 and 3, occur in papillary thyroid carcinomas especially in those from Belarus children after the Chernobyl nuclear accident. Several variants of RET/PTC-3 have also been found, having different break points with respect to the classical RET/PTC-3. To our knowledge, n...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Elisei R,Romei C,Soldatenko PP,Cosci B,Vorontsova T,Vivaldi A,Basolo F,Cherstvoy ED,Pinchera A,Pacini F

    更新日期:2000-07-01 00:00:00

  • Effects of peroral and transdermal oestrogen replacement therapy on glucose and insulin metabolism.

    abstract:OBJECTIVE:Conflicting data have been reported previously on the effects of oestrogen replacement therapy on glucose tolerance, and the effects on glycosylated haemoglobin GHbA(1c) have been studied only among diabetics. The objective of this study was to evaluate the effects on glucose and insulin metabolism among nond...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Karjalainen A,Paassilta M,Heikkinen J,Bäckström AC,Savolainen M,Kesäniemi YA

    更新日期:2001-02-01 00:00:00

  • Growth deficiency in polytransfused beta-thalassaemia patients is not growth hormone dependent.

    abstract:OBJECTIVE:Growth deficiency is commonly seen in polytransfused beta-thalassaemia patients, especially in adolescence. It is not completely dependent on the lack of their pubertal growth spurt. GH impairment at different levels (hypothalamic or pituitary) and/or a reduced IGF-1 synthesis have been suggested the main cau...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cavallo L,Gurrado R,Gallo F,Zacchino C,De Mattia D,Tatò L

    更新日期:1997-06-01 00:00:00