Insulin resistance and the metabolic syndrome in obese French children.

abstract：BACKGROUND:GH and IGF-I affect cardiac structure and performance. In the general population, low IGF-I has been associated with higher prevalence of ischaemic heart disease and mortality. Both in GH deficiency (GHD) and excess life expectancy has been reported to be reduced because of cardiovascular disease. OBJECTIVE...

journal_title：Clinical endocrinology

authors： Colao A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Adult onset GH deficiency (GHD) is characterized by abnormalities of serum lipoprotein profiles and GH replacement results in favourable alterations in serum total and low density lipoprotein (LDL)-cholesterol. Preliminary evidence has indicated that the effect of GH replacement in this respect may be additiv...

journal_title：Clinical endocrinology

authors： Monson JP,Jönsson P,Koltowska-Häggström M,Kourides I

更新日期：2007-10-01 00:00:00

abstract：:1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was ach...

journal_title：Clinical endocrinology

authors： Saratchandran P,Carson ER,Reeve J

更新日期：1976-09-01 00:00:00

abstract：OBJECTIVE:The optimal treatment regimen with thionamide drugs remains a matter for debate. We have investigated whether high doses of carbimazole, when compared with low doses, reduce relapse rates of Graves' disease. DESIGN:In an open label, randomized, prospective trial of treatment of Graves' disease we compared hi...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Ford HC,Fagerström JN,Cordwell DP,Delahunt JW,Toomath RJ

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:Sex steroid hormones influence bone mineral density (BMD) in women, but are less well-studied in men. We evaluated the association of serum total and free sex steroid hormones and SHBG with osteopaenia in a nationally representative sample of men aged 20-90 years. DESIGN:BMD and sex steroid hormones were mea...

journal_title：Clinical endocrinology

authors： Paller CJ,Shiels MS,Rohrmann S,Basaria S,Rifai N,Nelson W,Platz EA,Dobs A

更新日期：2009-01-01 00:00:00

abstract：:Sera from patients with Graves' disease and Hashimoto's thyroiditis were reacted with normal T lymphocyte preparations in an attempt to detect binding of immunoglobulin G (IgG) to T cells. Sera from normal subjects and patients with toxic adenomas served as controls. Each serum was reacted with at least three differen...

journal_title：Clinical endocrinology

authors： Pacini F,Sridama V,Pressendo J,DeGroot LJ,Medof ME

更新日期：1983-07-01 00:00:00

abstract：:Recombinant human TSH (rhTSH) has revolutionized the care of patients with differentiated thyroid cancer. Since its approval for clinical use in 2001 in Europe (1998 in the USA), rhTSH has greatly enhanced the surveillance of these patients by allowing the avoidance of hypothyroidism for TSH stimulation. Previously, a...

journal_title：Clinical endocrinology

authors： Woodmansee WW,Haugen BR

更新日期：2004-08-01 00:00:00

abstract：UNLABELLED:Objective To evaluate the effect of strontium ranelate (SR) on bone turnover markers in women with established osteoporosis previously treated with teriparatide (TPTD--recombinant human PTH 1-34). DESIGN PATIENTS: Twenty-two postmenopausal Caucasian women (aged 65.7 +/- 1.7 years) with established osteoporos...

journal_title：Clinical endocrinology

authors： Anastasilakis AD,Goulis DG,Polyzos SA,Gerou S,Ballaouri I,Efstathiadou Z,Kita M,Avramidis A

更新日期：2009-04-01 00:00:00

abstract：:In 44 patients with acromegaly treated by transsphenoidal pituitary microsurgery, the relationship between changes in pre- and post-operative GH dynamics and postoperative fasting plasma GH levels was examined to clarify which is the optimal approach for evaluating postoperative removal of the tumour. TRH, LHRH and br...

journal_title：Clinical endocrinology

authors： Karashima T,Kato K,Nawata H,Ikuyama S,Ibayashi H,Nakagaki H,Kitamura K

更新日期：1986-08-01 00:00:00

abstract：BACKGROUND:Aromatase deficiency (AD) caused by cytochrome P450 family 19 subfamily A polypeptide 1 (CYP19A1) variants is characterized by a deficiency in androgen-to-oestrogen conversion. OBJECTIVE:To investigate the clinical characteristics and accurate management of aromatase-deficient children. PATIENTS AND METHOD...

journal_title：Clinical endocrinology

authors： Fan L,Zhang B,Li L,Gong C

更新日期：2020-12-01 00:00:00

abstract：CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective...

journal_title：Clinical endocrinology

authors： Celi FS,Zemskova M,Linderman JD,Babar NI,Skarulis MC,Csako G,Wesley R,Costello R,Penzak SR,Pucino F

更新日期：2010-05-01 00:00:00

abstract：:Growth hormone release-inhibiting hormone (GHR-IH) was administered to five patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in two patients who had undergone bilateral adrenalectomy because of Cushing's disease; one of them had Nelson's syndrome. Bromocryp...

journal_title：Clinical endocrinology

authors： Benker G,Hackenberg K,Hamburger B,Reinwein D

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:Here we use a novel ELISA that is specific for full-length visfatin (PBEF/NAMPT), compare it with the existing C-terminal based assay and use it to investigate associations of visfatin with metabolic parameters. DESIGN, PATIENTS AND MEASUREMENTS:We established the specificity and effectiveness of the new ELI...

journal_title：Clinical endocrinology

authors： Retnakaran R,Youn BS,Liu Y,Hanley AJ,Lee NS,Park JW,Song ES,Vu V,Kim W,Tungtrongchitr R,Havel PJ,Swarbrick MM,Shaw C,Sweeney G

更新日期：2008-12-01 00:00:00

abstract：:A radioimmunoassay (RIA) procedure was devised for the estimation of PRL in eluates of dried whole blood from filter paper. Levels of PRL were measured in newborn blood obtained during the first week of life from 530 infants of normal birthweight (greater than 2500 g) with normal T4 values, 114 infants of normal birth...

journal_title：Clinical endocrinology

authors： Mitchell ML,Hermos RJ,Bennett JE,McKenna JJ,Mitchell EL

更新日期：1986-01-01 00:00:00

abstract：:The response of serum calcium, PTH, CT and gastrin to an infusion of secretin (3 CU/kg/h) over a period of 90 min was studied in ten healthy males and two female patients with hypoparathyroidism. In the healthy males serum calcium, after a transient fall, significantly increased at 45 min after the onset of the infusi...

journal_title：Clinical endocrinology

authors： Lo Cascio V,Piubello W,Cominacini L,Vantini I,Galvanini G,Ederle A,Cavallini G,Scuro LA

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:There has been a rapid shift from open to laparoscopic approaches in adrenal surgery, but the safety and efficacy of bilateral laparoscopic adrenalectomy (BLA) in patients with corticotrophin (ACTH)-dependent Cushing's syndrome continues to be defined. OBJECTIVE:Review outcomes in the largest series of pati...

journal_title：Clinical endocrinology

authors： Chow JT,Thompson GB,Grant CS,Farley DR,Richards ML,Young WF Jr

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to group patients with MODY (maturity-onset diabetes of the young) according to the genetic alterations underlying the disease and to investigate their clinical characteristics. PATIENTS AND METHODS:Molecular analysis of GCK (MODY2), HNF-1alpha (MODY3), HNF-4alpha (MODY1) and HNF-1b...

journal_title：Clinical endocrinology

authors： Estalella I,Rica I,Perez de Nanclares G,Bilbao JR,Vazquez JA,San Pedro JI,Busturia MA,Castaño L,Spanish MODY Group.

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVE:Insulin resistance and subclinical inflammation are characteristics in the development of type 2 diabetes mellitus (T2DM). The adipokine chemerin has been associated with both factors. The aim of this study was to analyse whether chemerin predicts T2DM. DESIGN:Blood samples of 440 participants of the Metabol...

journal_title：Clinical endocrinology

authors： Bobbert T,Schwarz F,Fischer-Rosinsky A,Maurer L,Möhlig M,Pfeiffer AF,Mai K,Spranger J

更新日期：2015-06-01 00:00:00

abstract：:In order to evaluate simultaneously in thyrotoxic subjects the relative contributions of insulin secretion, insulin-sensitivity (SI) and glucose-mediated (SG) glucose disposal to overall glucose tolerance, seven non-obese patients with thyrotoxicosis were studied by the minimal model analysis of the frequently sampled...

journal_title：Clinical endocrinology

authors： Pestell R,Alford F,Ramos R,Sawyer S,Best J,Ward G

更新日期：1990-10-01 00:00:00

abstract：OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

journal_title：Clinical endocrinology

authors： Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To define and discuss the changes of important risk factors and TNM staging over the last 40 years in patients operated on for differentiated thyroid carcinoma (DTC), resulting from the introduction of newer sensitive diagnostic procedures in the preoperative evaluation of thyroid nodules. PATIENTS:We review...

journal_title：Clinical endocrinology

authors： Karga H,Mavroudis K,Giagourta I,Triantaphyllopoulou M,Ktena V,Kassi G,Veloutsou H,Papapetrou P

更新日期：2012-02-01 00:00:00

abstract：CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoi...

journal_title：Clinical endocrinology

authors： Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVE:It has been postulated that a decrease in thyroid size can be achieved by thyroxine treatment in patients with goitrous Hashimoto's thyroiditis but no objective data are available. We have therefore investigated the influence of thyroxine treatment on ultrasonically determined thyroid size. We also measured s...

journal_title：Clinical endocrinology

authors： Hegedüs L,Hansen JM,Feldt-Rasmussen U,Hansen BM,Høier-Madsen M

更新日期：1991-09-01 00:00:00

abstract：CONTEXT:Teriparatide (TPTD) therapy has been proposed as a potential treatment strategy in severe cases of pregnancy- and lactation-associated osteoporosis (PLO) characterized by the occurrence of fragility fractures in the third trimester or early postpartum. OBJECTIVE:To investigate the changes in bone mineral densi...

journal_title：Clinical endocrinology

authors： Hong N,Kim JE,Lee SJ,Kim SH,Rhee Y

更新日期：2018-05-01 00:00:00

abstract：:Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

journal_title：Clinical endocrinology

authors： Napier C,Pearce SH

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patient...

journal_title：Clinical endocrinology

authors： Riss P,Kammer M,Selberherr A,Bichler C,Kaderli R,Scheuba C,Niederle B

更新日期：2016-08-01 00:00:00

abstract：CONTEXT:Steroid 5α-reductase type 2 deficiency (5α-RD2) is a male-limited, autosomal recessive inherited disease. Affected 46, XY individuals usually present with ambiguous genitalia at birth. An early and precise diagnosis is of great value to the long-term prognosis of the disease. OBJECTIVE:To describe the clinical...

journal_title：Clinical endocrinology

authors： Zhu H,Liu W,Han B,Fan M,Zhao S,Wang H,Lu Y,Pan C,Chen F,Chen M,Song H,Cheng K,Qiao J

更新日期：2014-11-01 00:00:00

abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

journal_title：Clinical endocrinology

authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

更新日期：1993-02-01 00:00:00

abstract：BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Charmandari E

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to determine the levels of thrombospondin-1 (TSP-1), transforming growth factor-β1 (TGF-β1) and nuclear factor kappaβ (NF-κβ) in polycystic ovarian syndrome (PCOS) patients with and without insulin resistance and after treatment with cyproterone acetate/ethinyloestradiol with o...

journal_title：Clinical endocrinology

authors： Liu M,Gao J,Zhang Y,Li P,Wang H,Ren X,Li C

更新日期：2015-12-01 00:00:00