Bilateral laparoscopic adrenalectomy for corticotrophin-dependent Cushing's syndrome: a review of the Mayo Clinic experience.

abstract：OBJECTIVE:Little is known about the dose-response relationship of potential, unwanted, effects of inhaled beclomethasone (BDP) on the hypothalamo-pituitary-adrenal (HPA) axis, particularly in nonspecialist clinic settings. The purpose of our study was to investigate the dose-response relationship of inhaled BDP on the ...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Durham JA,Kljakovic M,Cooke RR

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To study the reproducibility of 24-h serum growth hormone (GH) concentration profiles in adults. DESIGN:24-h serum GH concentrations were constructed by drawing blood samples at 20-min intervals. Four study occasions over a period of 1 year were chosen to assess the reproducibility. SUBJECTS:Six healthy adu...

journal_title：Clinical endocrinology

authors： Saini S,Hindmarsh PC,Matthews DR,Pringle PJ,Jones J,Preece MA,Brook CG

更新日期：1991-06-01 00:00:00

abstract：:Sixteen consecutive cases of Cushing's disease were treated by radical transphenoidal hypophysectomy. Surgical removal was not possible in two cases. Of the other 14, there was total clinical and biochemical remission of the disease in 13 and partial remission in one. Some form of replacement therapy has been necessar...

journal_title：Clinical endocrinology

authors： Thomas JP,Richards SH

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：BACKGROUND:There is little information available about any link between the levels of adiponectin, intercellular adhesion molecule-1 (ICAM-1), tumour necrosis factor-alpha (TNF-alpha) and heart-type fatty acid-binding protein (H-FABP) in coronary atherosclerotic plaque specimens. AIM:To analyse tissue levels of adipon...

journal_title：Clinical endocrinology

authors： Karaduman M,Sengul A,Oktenli C,Pekel A,Yesilova Z,Musabak U,Sanisoglu SY,Gunay C,Baysan O,Kocar IH,Tatar H,Ozata M

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:Relationship between adult growth hormone deficiency (AGHD) and increased cardiovascular disease risk is very well known in hypopituitary patients treated with conventional hormone replacement therapy other than growth hormone (GH) administration. Endothelial dysfunction, an early and reversible event in path...

journal_title：Clinical endocrinology

authors： Oflaz H,Sen F,Elitok A,Cimen AO,Onur I,Kasikcioglu E,Korkmaz S,Demirturk M,Kutluturk F,Pamukcu B,Ozbey N

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

journal_title：Clinical endocrinology

authors： Polderman KH,Gooren LJ,van der Veen EA

更新日期：1994-05-01 00:00:00

abstract：BACKGROUND:Adrenal vein sampling (AVS) failure is mainly due to right adrenal vein unavailability. Multinomial regression modelling (MRM) and left adrenal vein-to-peripheral vein ratio (LAV/PV) were proposed to predict the lateralization index without the right AVS. OBJECTIVE:To assess external validity of MRM and LAV...

journal_title：Clinical endocrinology

authors： Bouchard-Bellavance R,Perrault F,Soulez G,Chagnon M,Kline GA,Bourdeau I,Lacroix A,So B,Therasse E

更新日期：2020-12-01 00:00:00

abstract：:Malignant insulinomas are very rare endocrine tumours with a variable clinical course. We describe a 51-year-old man who had two large insulinomas resected from the body of the pancreas and 19 years later, having again become symptomatic, was found to have hepatic metastases. Medical treatment with diazoxide and octre...

journal_title：Clinical endocrinology

authors： Scott A,Hinwood D,Donnelly R

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:Appropriate replacement doses of glucocorticoid are important to determine in primary and secondary adrenal deficiency in children, both to avoid the risks of hypoglycaemia and adrenal crisis associated with undertreatment, and to avoid growth suppression and reduced final height potential associated with ste...

journal_title：Clinical endocrinology

authors： DeVile CJ,Stanhope R

更新日期：1997-07-01 00:00:00

abstract：:OBJECTIVE The aim of the study was to investigate whether pyridostigmine, a cholinesterase inhibitor which is thought to act at the hypothalamus to inhibit somatostatin secretion, would augment spontaneous or GHRH-stimulated serum GH levels in patients with GH-insufficiency. DESIGN Oral pyridostigmine 60 mg or placebo...

journal_title：Clinical endocrinology

authors： Kirk JM,Ross RJ,Trainer PJ,Froud AL,Davies SC,Savage MO,Besser GM

更新日期：1991-05-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Polycystic ovary syndrome (PCOS) is a heterogeneous disorder characterized by chronic anovulation, hyperandrogenism, polycystic ovary morphology (PCOM) and metabolic disturbances including insulin resistance and type 2 diabetes mellitus. Although insulin resistance could be associated with PCOM, r...

journal_title：Clinical endocrinology

authors： Hong SH,Sung YA,Hong YS,Jeong K,Chung H,Lee H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Previous studies have suggested that chronic fatigue syndrome (CFS) is associated with changes in appetite and weight, and also with mild hypocortisolism. Because both of these features may be related to leptin metabolism, we undertook a study of leptin in CFS. DESIGN:(i) A comparison of morning leptin conce...

journal_title：Clinical endocrinology

authors： Cleare AJ,O'Keane V,Miell J

更新日期：2001-07-01 00:00:00

abstract：OBJECTIVE:SRY-negative 46,XX testicular and ovotesticular disorders/differences of sex development (T/OTDSD) represent a very rare and unique DSD condition where testicular tissue develops in the absence of a Y chromosome. To date, very few studies have described the phenotype, clinical and surgical management and long...

journal_title：Clinical endocrinology

authors： Lambert S,Peycelon M,Samara-Boustani D,Hyon C,Dumeige L,Peuchmaur M,Fiot E,Léger J,Simon D,Paye-Jaouen A,Bouligand J,Siffroi JP,Carel JC,McElreavey K,El Ghoneimi A,Brachet C,Bouvattier C,Martinerie L

更新日期：2020-12-09 00:00:00

abstract：OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

journal_title：Clinical endocrinology

authors： Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

更新日期：2013-02-01 00:00:00

abstract：OBJECTIVE:Patients on long-term dialysis may develop secondary hyperparathyroidism (SHPT), which causes varying degrees of bone mass loss. This condition is treated with parathyroidectomy (PTX). We investigated whether serial serum bone turnover markers could predict changes in bone mineral density (BMD) after PTX. DE...

journal_title：Clinical endocrinology

authors： Lu KC,Ma WY,Yu JC,Wu CC,Chu P

更新日期：2012-05-01 00:00:00

abstract：:We describe a patient with multiple endocrine adenomatosis Type I, characterized by pituitary-dependent Cushing's Syndrome, marked hyperprolactinaemia, primary hyperparathyroidism and hyperinsulinism leading to hypoglycaemia. The patient subsequently developed an exocrine pancreatic carcinoma at the age of 32 years fr...

journal_title：Clinical endocrinology

authors： Oliver MH,Drury PL,Van't Hoff W

更新日期：1983-05-01 00:00:00

abstract：BACKGROUND:Traditionally, acromegaly evaded diagnosis until in its clinically obvious later stages when treatment is more difficult. Over the last 25 years diagnostic tests have improved, but whether clinical disease detection also improved was unknown, so we tested if disease severity at diagnosis had changed from 198...

journal_title：Clinical endocrinology

authors： Reid TJ,Post KD,Bruce JN,Nabi Kanibir M,Reyes-Vidal CM,Freda PU

更新日期：2010-02-01 00:00:00

abstract：:The fundamental question in assessing an older man with a slightly low total testosterone and normal gonadotrophin levels is to determine whether or not he has clinical hypogonadism. Hypogonadism is defined as a clinical syndrome complex, which comprises both symptoms as well as biochemical testosterone deficiency. As...

journal_title：Clinical endocrinology

authors： Hugh Jones T

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Traumatic brain injury (TBI) has been associated with hypopituitarism and GH deficiency. However, TBI-mediated hypopituitarism may be more frequent than previously thought. The present work, performed in patients with severe TBI at least 1 year before, had three aims: (i) to evaluate the prevalence of hypopit...

journal_title：Clinical endocrinology

authors： Leal-Cerro A,Flores JM,Rincon M,Murillo F,Pujol M,Garcia-Pesquera F,Dieguez C,Casanueva FF

更新日期：2005-05-01 00:00:00

abstract：BACKGROUND:GH and IGF-I affect cardiac structure and performance. In the general population, low IGF-I has been associated with higher prevalence of ischaemic heart disease and mortality. Both in GH deficiency (GHD) and excess life expectancy has been reported to be reduced because of cardiovascular disease. OBJECTIVE...

journal_title：Clinical endocrinology

authors： Colao A

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

journal_title：Clinical endocrinology

authors： Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

更新日期：2010-02-01 00:00:00

abstract：:Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

journal_title：Clinical endocrinology

authors： Armitage M,Nooney J,Evans S

更新日期：2003-08-01 00:00:00

abstract：INTRODUCTION:Confirmation of monogenic diabetes caused by glucokinase mutations (GCK-MODY) allows pharmacogenetic intervention in the form of insulin discontinuation. This is especially important among paediatric and young adult populations where GCK-MODY is most prevalent. METHODS:The study evaluated the utility of l...

journal_title：Clinical endocrinology

authors： Fendler W,Borowiec M,Antosik K,Szadkowska A,Deja G,Jarosz-Chobot P,Mysliwiec M,Wyka K,Pietrzak I,Skupien J,Malecki MT,Mlynarski W

更新日期：2011-09-01 00:00:00

abstract：BACKGROUND:Mutations in CYP21A2 lead to deficiency of 21-hydroxylase and can have either severe or moderate effects on phenotype, which can be prevented by early treatment. We studied long-term effects of this deficiency on phenotype in patients who had not been treated for prolonged periods and correlated these phenot...

journal_title：Clinical endocrinology

authors： Goossens K,Juniarto AZ,Timmerman MA,Faradz SM,Wolffenbuttel KP,Drop SL,de Jong FH

更新日期：2009-11-01 00:00:00

abstract：:The responses of plasma adrenocorticotrophin (ACTH), cortisol, growth hormone (GH) and prolactin to insulin-induced hypoglycaemia were studied in six lean male subjects (age 22-29 years). Intravenous insulin tests were performed with and without oxytocin infusion. Blood sugar nadir occurred at the onset of symptoms (t...

journal_title：Clinical endocrinology

authors： Nussey SS,Page SR,Ang VT,Jenkins JS,White A

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:The best method for determining hydrocortisone replacement therapy is not well defined. This study aimed to assess interindividual variability in cortisol pharmacokinetics and to investigate whether measurement of salivary cortisol provides a useful alternative to plasma concentration measurements. DESIGN:In...

journal_title：Clinical endocrinology

authors： Thomson AH,Devers MC,Wallace AM,Grant D,Campbell K,Freel M,Connell JM

更新日期：2007-06-01 00:00:00

abstract：:An oestrogen provocation test was performed in five healthy women during chronic intranasal treatment with 400 or 600 micrograms of the superactive LHRH agonist D-Ser(TBU)6-EA10-LHRH daily. Oestradiol benzoate 2.5 mg was administered intramuscularly after at least 3 months of LHRH agonist treatment. The serum levels o...

journal_title：Clinical endocrinology

authors： Bergquist C,Nillius SJ,Wide L

更新日期：1982-02-01 00:00:00

abstract：OBJECTIVE:We wished to develop optimal criteria for interpreting the single-dose overnight metyrapone test and to compare the diagnostic efficiency of the overnight and the standard 6-dose metyrapone tests for the differential diagnosis of ACTH-dependent Cushing's syndrome. DESIGN:Retrospective pilot study based on al...

journal_title：Clinical endocrinology

authors： Avgerinos PC,Nieman LK,Oldfield EH,Cutler GB Jr

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

journal_title：Clinical endocrinology

authors： Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

更新日期：2003-07-01 00:00:00