Growth hormone secretory pattern and response to treatment in children with short stature followed to adult height.


OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnormal growth rates and short stature, defined as a height of more than 2SD below the mean for age and sex. The patients were classified according to their pattern of findings on baseline pharmacological GH stimulation tests and a 12-h assay of nocturnal spontaneous GH secretion. Twenty-eight patients (24%) had normal hormone levels by both methods (group I); 14 (12%) had normal levels by stimulation tests but subnormal levels by the physiological assay (group II); 48 (41%) had subnormal levels on pharmacological stimulation, with normal physiologic levels (group III); and 26 (22%) had subnormal levels by both methods (group IV). All children in groups II and IV, and 27 in group III, designated IIIb, were treated with recombinant GH at 0.7 U (0.23 mg/kg) of body weight per week. GH secretory patterns were related to final height SD scores and other growth parameters, after the patients had attained their adult stature 6.7 +/- 2.2 years (SD) after GH evaluation. RESULTS:The five groups were similar with respect to mean baseline height SD scores for chronological as well as bone age. Whether assessed as absolute or parentally adjusted (relative) values, mean gains in height SD scores were significantly greater in treated patients with physiological hormone deficiency (groups II and IV) than in those with normal hormone levels (group I, untreated controls). Relative height gains were 1.03 +/- 1.45 cm (6.6 +/- 9.28 cm) and 1.85 +/- 1.21 cm (SDS; 11.8 +/- 7.74 cm) in groups II and IV respectively, compared with only 0.11 +/- 0.42 cm (0.7 +/- 2.68 cm) in group I (P < 0.01 and P < 0.001). GH treatment failed to improve either the absolute or parentally adjusted final height of patients with GH deficiency by stimulation tests but normal levels by physiological assay. CONCLUSION:Long-term administration of GH to short children with normal spontaneous GH secretion is not associated with an appreciable increase in adult height.


Clin Endocrinol (Oxf)


Clinical endocrinology


Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M





Has Abstract


2003-07-01 00:00:00














  • Insulin secretion and insulin-like growth factor-I levels in active and controlled acromegaly.

    abstract:OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Hopkins KD,Holdaway IM

    更新日期:1992-01-01 00:00:00

  • The IGF-I receptor sub-membrane domain is intact in GH-secreting pituitary tumours.

    abstract:BACKGROUND AND OBJECTIVE:Clinical acromegaly is characterized by dysregulation of somatotroph GH secretion in the presence of high circulating serum IGF-I levels. Physiologically, IGF-I exerts a negative feedback on GH secretion at both the hypothalamic and the pituitary levels. We have previously shown that the 943 an...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Greenman Y,Prager D,Melmed S

    更新日期:1995-02-01 00:00:00

  • Identification of the first germline HRPT2 whole-gene deletion in a patient with primary hyperparathyroidism.

    abstract:OBJECTIVE:Germline mutations in the HRPT2 gene are associated with the hereditary hyperparathyroidism-jaw tumour syndrome (HPT-JT) and a subset of familial isolated hyperparathyroidism (FIHP). Somatic HRPT2 mutations are detected in sporadic parathyroid carcinomas and less frequently in cystic adenomas. The purpose of ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Domingues R,Tomaz RA,Martins C,Nunes C,Bugalho MJ,Cavaco BM

    更新日期:2012-01-01 00:00:00

  • Determination of adrenal volume by MRI in healthy children: associations with age, body size, pubertal stage and serum levels of adrenal androgens.

    abstract:BACKGROUND:Adrenal disorders such as congenital adrenal hyperplasia result in abnormal adrenal size and morphology, but little is known about the clinical value of magnetic resonance imaging (MRI) in determining adrenal volume. OBJECTIVE:To evaluate the potential usefulness of MR methodology, to estimate adrenal size ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Mouritsen A,Johansen ML,Wohlfahrt-Veje C,Hagen CP,Tinggaard J,Mieritz MG,Tefre de Renzy-Martin K,Soeborg T,Fallentin E,Juul A,Main KM

    更新日期:2014-08-01 00:00:00

  • Pulsatile, nyctohemeral and entropic characteristics of GH secretion in adult GH-deficient patients: selectively decreased pulsatile release and increased secretory disorderliness with preservation of diurnal timing and gender distinctions.

    abstract:INTRODUCTION:The present clinical investigation uses a high-precision GH immunofluorometric assay to examine the postulate that principally the amplitude mode of GH secretory control is disrupted in adults with GH deficiency. PATIENTS AND METHODS:To this end, we investigated GH secretory dynamics in a cohort of 19 adu...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Roelfsema F,Biermasz NR,Veldhuis JD

    更新日期:2002-01-01 00:00:00

  • Addison's disease with polyglandular autoimmunity carries a more than 2·5-fold risk for adrenal crises: German Health insurance data 2010-2013.

    abstract:OBJECTIVE:Adrenal crises are potentially life-threatening complications in patients with adrenal insufficiency (AI). Our objective was to investigate the frequency of adrenal crises in different forms of AI. DESIGN/PATIENTS:The Statutory Health Insurance (SHI) database of the Techniker Krankenkasse - covering more tha...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Meyer G,Badenhoop K,Linder R

    更新日期:2016-09-01 00:00:00

  • Effect of Sandostatin LAR on sleep apnoea in acromegaly: correlation with computerized tomographic cephalometry and hormonal activity.

    abstract:OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ip MS,Tan KC,Peh WC,Lam KS

    更新日期:2001-10-01 00:00:00

  • Renal leak of calcium in post-menopausal osteoporosis.

    abstract:BACKGROUND:Urine calcium after an overnight fast is higher in osteoporotic than in normal post-menopausal women. The question is whether this is the cause or effect of the bone-losing state. OBJECTIVE:To establish whether the elevated obligatory calcium loss in osteoporotic women is due to a raised filtered load of ca...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Nordin BE,Horowitz M,Need A,Morris HA

    更新日期:1994-07-01 00:00:00

  • Intron polymorphism in the KIAA0350 gene is reproducibly associated with susceptibility to type 1 diabetes (T1D) in the Han Chinese population.

    abstract:OBJECTIVE:Three independent genome-wide association studies in white populations have reported that single nucleotide polymorphisms (SNPs) in the KIAA0350 gene are associated with susceptibility to type 1 diabetes (T1D). The gene product of KIAA0350 is predicted to be a sugar binding C-type lectin. In the present study...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Wu X,Zhu X,Wang X,Ma J,Zhu S,Li J,Liu Y

    更新日期:2009-07-01 00:00:00

  • Metabolic effects of growth hormone administered subcutaneously once or twice daily to growth hormone deficient adults.

    abstract:OBJECTIVE:The aim of this study was to compare the metabolic effects of GH administered subcutaneously either once or twice daily. The actions of GH might depend upon a pulsatile pattern of serum GH. Pulsatile and continuous intravenous delivery of GH, however, induce similar short-term metabolic effects in GH deficien...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Laursen T,Jørgensen JO,Christiansen JS

    更新日期:1994-09-01 00:00:00

  • Quantification and regulation of adipsin in human cerebrospinal fluid (CSF).

    abstract:CONTEXT:Data on quantification and regulation of adipsin in human cerebrospinal fluid (CSF) are sparse, and the physiological role of adipsin as an adipokine crossing the blood-brain barrier (BBB) is uncertain. OBJECTIVES:This study quantified adipsin concentrations in paired serum and CSF samples of patients undergoi...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Schmid A,Hochberg A,Berghoff M,Schlegel J,Karrasch T,Kaps M,Schäffler A

    更新日期:2016-02-01 00:00:00

  • Persistence of Müllerian ducts in male pseudohermaphroditism, and its relationship to cryptorchidism.

    abstract::Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

    更新日期:1983-08-01 00:00:00

  • Isolated growth hormone (GH) deficiency due to compound heterozygosity for two new mutations in the GH-releasing hormone receptor gene.

    abstract:OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

    更新日期:2001-05-01 00:00:00

  • Administration of human recombinant insulin-like growth factor-I to patients following major gastrointestinal surgery.

    abstract:OBJECTIVE:The aim was to study the pharmacokinetic parameters and biological activity of a single dose of human recombinant IGF-I (rhIGF-I) administered to patients following major gastrointestinal surgery. DESIGN:A double blind placebo controlled externally randomized study of 30 patients; the study commencing 24 hou...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Miell JP,Taylor AM,Jones J,Buchanan CR,Rennie J,Sherwood R,Leicester R,Ross RJ

    更新日期:1992-12-01 00:00:00

  • Twin models of environmental and genetic influences on pubertal development, salivary testosterone, and estradiol in adolescence.

    abstract:OBJECTIVE:Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol, and pubertal status, into genetic and environmental components. DESIGN:A sample of male and female adolescent twins from the greater Austin ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Grotzinger AD,Mann FD,Patterson MW,Herzhoff K,Tackett JL,Tucker-Drob EM,Paige Harden K

    更新日期:2018-02-01 00:00:00

  • Serum thyroglobulin concentrations and 131I whole body scans in the diagnosis of metastases from differentiated thyroid carcinoma (after thyroidectomy).

    abstract::Measurements of circulating thyroglobulin (hTg) and 131I whole body scan were performed in 101 patients with differentiated thyroid carcinoma who had been subjected to surgical thyroidectomy and 131I ablation of remaining thyroid tissue. All 45 patients with positive scans (i.e. functioning metastases) had elevated hT...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Pacini F,Pinchera A,Giani C,Grasso L,Baschieri L

    更新日期:1980-07-01 00:00:00

  • Pseudodominant inheritance in a family with nonautoimmune hypothyroidism due to biallelic DUOX2 mutations.

    abstract:OBJECTIVES:Mutations in the dual oxidase 2 gene (DUOX2) is the most common genetic cause of congenital hypothyroidism (CH) in Japan. All previously described DUOX2 mutation-carrying families have followed autosomal recessive inheritance. We report a nonconsanguineous Japanese family harbouring biallelic DUOX2 mutations...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Abe K,Narumi S,Suwanai AS,Hamajima T,Hasegawa T

    更新日期:2015-09-01 00:00:00

  • Do growth hormone (GH) serial sampling, insulin-like growth factor-I (IGF-I) or auxological measurements have an advantage over GH stimulation testing in predicting the linear growth response to GH therapy?

    abstract:OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究


    authors: Rogol AD,Blethen SL,Sy JP,Veldhuis JD

    更新日期:2003-02-01 00:00:00

  • Blockage of the positive feedback effect of oestradiol during prolonged administration of clomiphene citrate to normal women.

    abstract::The effect of clomiphene citrate on the occurrence and timing of the endogenous LH surge in superovulated cycles is unclear. To study further this event, five normally ovulating women were treated with clomiphene citrate 100 mg per day in two different cycles, that is, for 5 days in one cycle (days 2 to 6, CC-5) and f...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Messinis IE,Templeton A

    更新日期:1988-11-01 00:00:00

  • The evaluation of metabolic parameters and insulin sensitivity for a more robust diagnosis of the polycystic ovary syndrome.

    abstract:BACKGROUND:Polycystic ovary syndrome (PCOS) is considered predominantly as a hyperandrogenetic syndrome and the evaluation of metabolic parameters and insulin sensitivity is not mandatory. CONTEXT:PCOS diagnostic criteria [National Institute of Health (NIH), Rotterdam Consensus (ROT), Androgen Excess Society (AES)] ar...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Amato MC,Galluzzo A,Finocchiaro S,Criscimanna A,Giordano C

    更新日期:2008-07-01 00:00:00

  • Cardiovascular risk factors in children and adolescents with congenital adrenal hyperplasia due to 21-hydroxylase deficiency.

    abstract:OBJECTIVE:The prevalence of cardiovascular risk factors in congenital adrenal hyperplasia (CAH) varies widely. In the light of recent changes in treatment regimens, we have reassessed the prevalence of these risk factors in our current cohort of patients with CAH due to P450c21 deficiency. METHODS:A retrospective cros...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Subbarayan A,Dattani MT,Peters CJ,Hindmarsh PC

    更新日期:2014-04-01 00:00:00

  • A longitudinal study on bone mineral density until adulthood in girls with Turner's syndrome participating in a growth hormone injection frequency-response trial.

    abstract:OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

    更新日期:2000-05-01 00:00:00

  • The loss of circadian rhythm for intact parathyroid hormone and nephrogenous cyclic AMP in patients with primary hyperparathyroidism.

    abstract::The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h period has shown the existence of a circadian rhythm in normal males which is absent in patients with primary hyperparathyroidism. The physiological significance of this observation is reflected in the presence of parallel changes in nephroge...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Logue FC,Fraser WD,Gallacher SJ,Cameron DA,O'Reilly DS,Beastall GH,Patel U,Boyle IT

    更新日期:1990-04-01 00:00:00

  • Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.

    abstract:OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

    更新日期:1996-09-01 00:00:00

  • Prevalence of coeliac disease in idiopathic hypoparathyroidism and effect of gluten-free diet on calcaemic control.

    abstract:BACKGROUND:Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1-α-(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium/vitamin D malabsorption. OBJECTIVE:We assessed t...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Saha S,Saini S,Makharia GK,Datta Gupta S,Goswami R

    更新日期:2016-04-01 00:00:00

  • Iodine deficiency amongst pregnant women in South-West England.

    abstract:INTRODUCTION:Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Knight BA,Shields BM,He X,Pearce EN,Braverman LE,Sturley R,Vaidya B

    更新日期:2017-03-01 00:00:00

  • Acute endocrine profile of sulpiride in the human.

    abstract::Normal men and normally menstruating women received i.m. injections of 0.1 to 4.0 mg/kg sulpiride. This psychotropic drug induced a very rapid (already significant after 5 minutes) and sustained (still significant after 7 hours) elevation of prolactin (PRL) concentrations in all subjects with no consistent modificatio...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: L'Hermite M,Denayer P,Golstein J,Virasoro E,Vanhaelst L,Copinschi G,Robyn C

    更新日期:1978-09-01 00:00:00

  • The effects of dithiothreitol on thyroid stimulation in vitro.

    abstract::There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ginsberg J,Rafter DJ,von Westarp C,Murray PG

    更新日期:1987-04-01 00:00:00

  • Polymorphisms in the interferon-induced helicase (IFIH1) locus and susceptibility to Addison's disease.

    abstract:OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

    更新日期:2013-02-01 00:00:00

  • Atrial natriuretic factor reduces vasopressin and angiotensin II but not the ACTH response to acute hypoglycaemic stress in normal men.

    abstract:OBJECTIVE:We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN:Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Wittert GA,Espiner EA,Richards AM,Donald RA,Livesey JH,Yandle TG

    更新日期:1993-02-01 00:00:00