Growth failure in a child showing characteristics of Seckel syndrome: possible effects of IGF-I and endogenous IGFBP-3.

abstract：OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

journal_title：Clinical endocrinology

authors： Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

更新日期：2019-12-01 00:00:00

abstract：OBJECTIVE:The somatostatin analogue octreotide (Sandostatin, Novartis, Basie) significantly improves the syndromes suffered by most patients with neuroendocrine tumours (NETs). The use of [111In-DTPA-D-Phe1]-octreotide scintigraphy ([111In]-pentetreotide) to predict the response to octreotide treatment has been describ...

journal_title：Clinical endocrinology

authors： Shi W,Buchanan KD,Johnston CF,Larkin C,Ong YL,Ferguson R,Laird J

更新日期：1998-03-01 00:00:00

abstract：OBJECTIVE:The level of growth hormone (GH), growth hormone secretogogue (GHS) and GHS receptor (GHSR) messenger ribonucleic acid (mRNA) expression has been reported as being higher in GH-producing pituitary adenomas than in other types of pituitary adenomas. Recently, ghrelin, an endogenous ligand specific for GHSR, wa...

journal_title：Clinical endocrinology

authors： Kim K,Arai K,Sanno N,Osamura RY,Teramoto A,Shibasaki T

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:High overnight plasma growth hormone (GH) levels in insulin-dependent diabetes mellitus (IDDM) are reflected in both an increase in the GH pulse amplitude and elevated baseline GH concentrations. To determine whether these are a result of an increase in GH secretory episodes, we undertook deconvolution analys...

journal_title：Clinical endocrinology

authors： Pal BR,Matthews DR,Edge JA,Mullis PE,Hindmarsh PC,Dunger DB

更新日期：1993-01-01 00:00:00

abstract：:The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

journal_title：Clinical endocrinology

authors： Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

更新日期：1988-09-01 00:00:00

abstract：:A late rise in serum GH occurs 3-5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses...

journal_title：Clinical endocrinology

authors： Valcavi R,Zini M,Dieguez C,Portioli I,Scanlon MF

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late-maturing adolescents grow slower than postulated by age-related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity refe...

journal_title：Clinical endocrinology

authors： Binder G,Lehrian TJ,Hoffmann E,Blumenstock G,Rahmaoui A,Trzaskoma B,Reinehr T

更新日期：2021-02-01 00:00:00

abstract：OBJECTIVE:Strategies to limit the final height of tall children have centred on the use of high doses of sex steroids to advance skeletal maturation. This limits therapy to the peripubertal years whereas the greatest gain in height is in the prepubertal years. Prepubertal growth is largely GH dependent and previous wor...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Pringle PJ,Stanhope R,Brook CG

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. DESIGN:In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated th...

journal_title：Clinical endocrinology

authors： Burman P,Hetta J,Wide L,Månsson JE,Ekman R,Karlsson FA

更新日期：1996-03-01 00:00:00

abstract：:Twenty-two cases of male pseudohermaphroditism with persistence of Müllerian duct derivatives were reviewed. In 12 cases of mixed gonadal dysgenesis and five cases of dysgenetic male pseudohermaphroditism, testosterone-dependent steps of sex differentiation were also impaired, and testicular dysgenesis was prominent, ...

journal_title：Clinical endocrinology

authors： Josso N,Fekete C,Cachin O,Nezelof C,Rappaport R

更新日期：1983-08-01 00:00:00

abstract：OBJECTIVE:Nonsurgical hypoparathyroidism (NS-HypoPT) and pseudohypoparathyroidism (PHP) are rare diseases, with a prevalence of 2/100.000 and 1/100.000, respectively. Only few studies on Quality of Life (QoL) among patients with Ns-HypoPT and PHP are available. We aimed to investigate the QoL among patients with Ns-Hyp...

journal_title：Clinical endocrinology

authors： Underbjerg L,Sikjaer T,Rejnmark L

更新日期：2018-06-01 00:00:00

abstract：:We have studied the effects of dopamine on the secretion of TSH and its subunits in vivo and in vitro. Four normal controls, seven patients with primary hypothyroidism, two patients with peripheral resistance to thyroid hormone (PRTH), and two patients with alpha-secreting pituitary tumours underwent a 3-h dopamine in...

journal_title：Clinical endocrinology

authors： Cooper DS,Klibanski A,Ridgway EC

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：PURPOSE:We aim to evaluate the association of PCOS with eating, sleeping and sexual function disorders. METHODS:A comprehensive search including MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus through 01 August 2018 was conducted for studies reportin...

journal_title：Clinical endocrinology

authors： Thannickal A,Brutocao C,Alsawas M,Morrow A,Zaiem F,Murad MH,Javed Chattha A

更新日期：2020-04-01 00:00:00

abstract：OBJECTIVE:The use of thyrotropin (TSH) in the initial assessment of thyroid nodules is inefficient and leads to unnecessary assessment costs. We compared the total costs of thyroid nodule assessment with or without the use of TSH in the initial assessment. METHODS:A total of 1808 patients with thyroid nodules received...

journal_title：Clinical endocrinology

authors： Cai H,Qiao Y,Xi H,Luo Q,Yuan X,Yang Y,Lv Z

更新日期：2017-02-01 00:00:00

abstract：:Two female patients with functioning adrenocortical carcinomas had plasma ACTH detectable by RIA at presentation. In both patients there was evidence for biological activity of ACTH. There was no evidence for an ectopic source of ACTH, nor for a pituitary tumour. Urinary steroid analysis showed patterns of multiple ho...

journal_title：Clinical endocrinology

authors： Law A,Hague WM,Daly JG,Honour JW,Taylor N,Jeffcoate SL,Himsworth RL,Joplin GF

更新日期：1988-07-01 00:00:00

abstract：:The response of serum calcium, PTH, CT and gastrin to an infusion of secretin (3 CU/kg/h) over a period of 90 min was studied in ten healthy males and two female patients with hypoparathyroidism. In the healthy males serum calcium, after a transient fall, significantly increased at 45 min after the onset of the infusi...

journal_title：Clinical endocrinology

authors： Lo Cascio V,Piubello W,Cominacini L,Vantini I,Galvanini G,Ederle A,Cavallini G,Scuro LA

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

journal_title：Clinical endocrinology

authors： Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:The diagnostic impact of chromogranin A (CgA) measurement has been studied in various neuroendocrine tumours (NET) such as pheochromocytomas, gastrinomas and neuroblastomas. Clinically nonfunctioning pituitary adenomas (NFPA) are generally diagnosed on tumoural symptoms or hypopituitarism and, except for gona...

journal_title：Clinical endocrinology

authors： Gussi IL,Young J,Baudin E,Bidart JM,Chanson P

更新日期：2003-11-01 00:00:00

abstract：:The measurement of serum intact parathyroid hormone (PTH) (1-84) over a 24-h period has shown the existence of a circadian rhythm in normal males which is absent in patients with primary hyperparathyroidism. The physiological significance of this observation is reflected in the presence of parallel changes in nephroge...

journal_title：Clinical endocrinology

authors： Logue FC,Fraser WD,Gallacher SJ,Cameron DA,O'Reilly DS,Beastall GH,Patel U,Boyle IT

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:To study the reproducibility of 24-h serum growth hormone (GH) concentration profiles in adults. DESIGN:24-h serum GH concentrations were constructed by drawing blood samples at 20-min intervals. Four study occasions over a period of 1 year were chosen to assess the reproducibility. SUBJECTS:Six healthy adu...

journal_title：Clinical endocrinology

authors： Saini S,Hindmarsh PC,Matthews DR,Pringle PJ,Jones J,Preece MA,Brook CG

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVES:The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta-analysis of placebo-controlled studies publ...

journal_title：Clinical endocrinology

authors： Isidori AM,Giannetta E,Gianfrilli D,Greco EA,Bonifacio V,Aversa A,Isidori A,Fabbri A,Lenzi A

更新日期：2005-10-01 00:00:00

abstract：:Plasma cortisol and adrenocorticotrophin hormone (ACTH) profiles were estimated in twelve patients with Addison's disease following randomized oral administration of either cortisone acetate (25 mg) or hydrocortisone (20 mg) alternately, at 0900 h on consecutive days. Normal corticosteroid replacement therapy was disc...

journal_title：Clinical endocrinology

authors： Feek CM,Ratcliffe JG,Seth J,Gray CE,Toft AD,Irvine WJ

更新日期：1981-05-01 00:00:00

abstract：OBJECTIVE:Stimulation with corticotropin-releasing hormone (CRH) is one of principal tools for the differential diagnosis of ACTH-dependent Cushing's syndrome. However, different dosages and species of CRH may be employed; further, ACTH levels can be measured by radioimmunoassay (RIA) or immunoradiometric assay (IRMA)....

journal_title：Clinical endocrinology

authors： Pecori Giraldi F,Invitti C,Cavagnini F,Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-pituitary-adrenal axis.

更新日期：2001-05-01 00:00:00

abstract：:Serum thyroxine was consistently unmeasurable by radioimmunoassay in an elderly patient with myxoedema after successful treatment with oral thyroxine. Abnormal binding of thyroxine was suspected and shown to be due to the presence in serum of antibodies of the IgG variety. The characteristics of these antibodies with ...

journal_title：Clinical endocrinology

authors： Pearce CJ,Byfield PG,Edmonds CJ,Lalloz MR,Himsworth RL

更新日期：1981-07-01 00:00:00

abstract：:We studied the circadian rhythm and the response of the hypothalamic-pituitary-adrenal (HPA) axis to ovine corticotrophin releasing hormone (oCRH) stimulation and dexamethasone suppression in 32 children with grade II-III marasmus. Children were studied prior to and after nutritional rehabilitation. Mean baseline plas...

journal_title：Clinical endocrinology

authors： Malozowski S,Muzzo S,Burrows R,Leiva L,Loriaux L,Chrousos G,Winterer J,Cassorla F

更新日期：1990-04-01 00:00:00

abstract：BACKGROUND:Subjects with non-functioning pituitary adenomas (NFAs) frequently develop GH deficiency due to tumour expansion or as a consequence of tumour therapy. The safety of GH replacement (GHR) in these individuals remains unclear. OBJECTIVE:To assess the effect of GHR on tumour recurrence in patients with NFAs so...

journal_title：Clinical endocrinology

authors： Arnold JR,Arnold DF,Marland A,Karavitaki N,Wass JA

更新日期：2009-03-01 00:00:00

abstract：OBJECTIVE:Fractures are related to falling. Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures and has been considered as a syndrome of early ageing. The aim was to study whether fine motor function (FM) and body balance (BB) were impaired and related to genotype, fractures, metabolic vari...

journal_title：Clinical endocrinology

authors： El-Mansoury M,Barrenäs ML,Bryman I,Hanson C,Landin-Wilhelmsen K

更新日期：2009-08-01 00:00:00

abstract：:The in-vivo reaction of the plasma GH concentration to the administration of the somatostatin analogue SMS 201-995, bromocriptine and their combination were compared with the in-vitro effects of both compounds and their combination on GH release and the GH tumour cell content of 9 acromegalic patients. Exposure of cul...

journal_title：Clinical endocrinology

authors： Lamberts SW,Verleun T,Hofland L,Del Pozo E

更新日期：1987-07-01 00:00:00

abstract：OBJECTIVE:Congenital adrenal hyperplasia (CAH) is an autosomal recessive inherited disorder resulting in lack of cortisol and often aldosterone and overproduction of androgens. Raised levels of androgens can lead to increased mass in the laryngeal tissues, which may lower the fundamental frequency (F0) of the voice. D...

journal_title：Clinical endocrinology

authors： Nygren U,Södersten M,Falhammar H,Thorén M,Hagenfeldt K,Nordenskjöld A

更新日期：2009-01-01 00:00:00