The hypothalamic-pituitary-adrenal axis in infantile malnutrition.

abstract：:Serum immunoreactive melatonin was measured in thirty-three male subjects with delayed puberty, thirty of whom had simple (idiopathic) delayed puberty (SDP) and three of whom were GH deficient. The results were compared with a control population of twenty-six subjects. Significantly elevated values of serum melatonin ...

journal_title：Clinical endocrinology

authors： Cohen HN,Hay ID,Annesley TM,Beastall GH,Wallace AM,Spooner R,Thomson JA,Eastwold P,Klee GG

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:Constitutional delay of growth and puberty (CDGP) is a tempo variant with a good prognosis. Healthy late-maturing adolescents grow slower than postulated by age-related references, and therefore, CDGP is frequently confused with growth hormone deficiency (GHD). For differential diagnosis, height velocity refe...

journal_title：Clinical endocrinology

authors： Binder G,Lehrian TJ,Hoffmann E,Blumenstock G,Rahmaoui A,Trzaskoma B,Reinehr T

更新日期：2021-02-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Growth hormone treatment in children with idiopathic short stature (ISS) leads to growth acceleration in the first years, but the effect on final height is still poorly documented. We therefore studied the long-term effect of GH therapy in children with idiopathic short stature. DESIGN:We have...

journal_title：Clinical endocrinology

authors： Wit JM,Boersma B,de Muinck Keizer-Schrama SM,Nienhuis HE,Oostdijk W,Otten BJ,Delemarre-Van de Waal HA,Reeser M,Waelkens JJ,Rikken B

更新日期：1995-04-01 00:00:00

abstract：:In an attempt to obtain further information on the aetiology of premenstrual syndrome (PMS), the endocrine changes following enucleation of the corpus luteum in the mid-luteal phase of the cycle were studied in seven patients with PMS, and the results compared to details of seven control patients undergoing hysterecto...

journal_title：Clinical endocrinology

authors： Bäckström T,Smith S,Lothian H,Baird DT

更新日期：1985-06-01 00:00:00

abstract：INTRODUCTION:The present clinical investigation uses a high-precision GH immunofluorometric assay to examine the postulate that principally the amplitude mode of GH secretory control is disrupted in adults with GH deficiency. PATIENTS AND METHODS:To this end, we investigated GH secretory dynamics in a cohort of 19 adu...

journal_title：Clinical endocrinology

authors： Roelfsema F,Biermasz NR,Veldhuis JD

更新日期：2002-01-01 00:00:00

abstract：:Six girls and one boy with precocious puberty were treated with a superactive LHRH analogue (D-TRP6-LHRH) for periods ranging from 1 year to 2 years and 3 months. In the first phase of the treatment it was administered in combination with cyproterone acetate (CyA) to counteract an early stimulatory effect until inhibi...

journal_title：Clinical endocrinology

authors： Kauli R,Pertzelan A,Ben-Zeev Z,Lewin RP,Kaufman H,Schally AM,Schally AV,Laron Z

更新日期：1984-04-01 00:00:00

abstract：:We studied variables known to change with thyroid hormone status in 18 patients with subclinical hypothyroidism before and during treatment with thyroxine in a dose sufficient to restore the plasma TSH response to TRH to normal. There was an associated increase in both plasma total T4 and free T4 within the normal ran...

journal_title：Clinical endocrinology

authors： Bell GM,Todd WT,Forfar JC,Martyn C,Wathen CG,Gow S,Riemersma R,Toft AD

更新日期：1985-01-01 00:00:00

abstract：OBJECTIVE:Cranial irradiation frequently results in growth hormone (GH) deficiency. Patients with radiation-induced GH deficiency usually remain responsive to exogenous growth hormone releasing hormone, implying radiation damages the hypothalamus rather than the pituitary. Little is known about the effect of cranial ir...

journal_title：Clinical endocrinology

authors： Ogilvy-Stuart AL,Wallace WH,Shalet SM

更新日期：1994-08-01 00:00:00

abstract：:A gonadotrophin response testosterone producing adrenal cortical adenoma in a 61-year-old woman is described. Oophorectomy was performed before adrenalectomy as at first an ovarian origin of excess and androgen production was suspected. The hypophyseal gonadal feedback system was studied after oophorectomy using LHRH ...

journal_title：Clinical endocrinology

authors： de Lange WE,Pratt JJ,Doorenbos H

更新日期：1980-01-01 00:00:00

abstract：OBJECTIVE:Diagnosing thyroid nodules preoperatively using traditional diagnostic tools - ultrasonography (US) and cytology - still carries a considerable degree of uncertainty, and surgery is recommended for a far from negligible number of patients simply for diagnostic purposes. Thyroid elastosonography (USE) and BRAF...

journal_title：Clinical endocrinology

authors： Nacamulli D,Nico L,Barollo S,Zambonin L,Pennelli G,Girelli ME,Casal Ide E,Pelizzo MR,Vianello F,Negro I,Watutantrige-Fernando S,Mantero F,Rugge M,Mian C

更新日期：2012-10-01 00:00:00

abstract：OBJECTIVE:To examine the factors influencing the levels of sex hormone-binding globulin (SHBG) in normal postmenopausal women by assessing the relationship between SHBG and measured anthropometric, metabolic and hormonal variables. DESIGN:Cross-sectional, observational study. SUBJECTS AND METHODS:Seventy normal postm...

journal_title：Clinical endocrinology

authors： Wu F,Ames R,Evans MC,France JT,Reid IR

更新日期：2001-01-01 00:00:00

abstract：CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

journal_title：Clinical endocrinology

authors： Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

更新日期：2009-11-01 00:00:00

abstract：:The majority of benign thyroid nodules are asymptomatic, remain stable in size and do not require treatment. However, a minority of patients with growing nodules may have local symptoms or cosmetic concerns, and thus demand surgical therapy. The timely use of ultrasound-guided, minimally invasive thermal therapies has...

journal_title：Clinical endocrinology

authors： Cesareo R,Palermo A,Pasqualini V,Cianni R,Gaspa G,Manfrini S,Pacella CM

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:We examined the contributions of growth hormone (GH) and insulin-like growth factor-I (IGF-I) to insulin sensitivity and beta-cell function in acromegaly. DESIGN:A cross-sectional study was used with continuous infusion of glucose with model assessment to determine insulin sensitivity and beta-cell function....

journal_title：Clinical endocrinology

authors： Hopkins KD,Holdaway IM

更新日期：1992-01-01 00:00:00

abstract：OBJECTIVE:Genotype and phenotype heterogeneity in patients with GH insensitivity syndrome suggests that partial defects exist in the GH receptor. Children with partial GH resistance would be expected to have short stature, elevated GH levels and relatively low levels of IGF-I and IGFBP-3. Provocation tests of the GH-IG...

journal_title：Clinical endocrinology

authors： Cotterill AM,Camacho-Hübner C,Duquesnoy P,Savage MO

更新日期：1998-06-01 00:00:00

abstract：:The role of bromocriptine in the treatment of non-functioning pituitary tumours is not yet defined. Patients with these tumours who present with visual field defects usually undergo immediate surgery. Three consecutive patients are reported: each had rapid improvement in their visual field defects following bromocript...

journal_title：Clinical endocrinology

authors： D'Emden MC,Harrison LC

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVE:Binding sites specific for growth hormone have been identified in the brain, but the action of GH on the central nervous system is still poorly understood. DESIGN:In a double-blind, placebo-controlled 21-month trial with a cross-over design, with each treatment period lasting for 9 months, we investigated th...

journal_title：Clinical endocrinology

authors： Burman P,Hetta J,Wide L,Månsson JE,Ekman R,Karlsson FA

更新日期：1996-03-01 00:00:00

abstract：OBJECTIVES:Loss of E-cadherin is an important marker of epithelial tumour progression. The aims of this study were to explore whether E-cadherin expression and localization correlate to corticotroph tumour progression, relate the expression of the E-cadherin gene (CDH1) to immunohistochemical E-cadherin staining patter...

journal_title：Clinical endocrinology

authors： Evang JA,Berg JP,Casar-Borota O,Lekva T,Kringen MK,Ramm-Pettersen J,Bollerslev J

更新日期：2011-12-01 00:00:00

abstract：:We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid s...

journal_title：Clinical endocrinology

authors： Nicholls MG,Julius S,Zweifler AJ

更新日期：1981-09-01 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：OBJECTIVE:High overnight plasma growth hormone (GH) levels in insulin-dependent diabetes mellitus (IDDM) are reflected in both an increase in the GH pulse amplitude and elevated baseline GH concentrations. To determine whether these are a result of an increase in GH secretory episodes, we undertook deconvolution analys...

journal_title：Clinical endocrinology

authors： Pal BR,Matthews DR,Edge JA,Mullis PE,Hindmarsh PC,Dunger DB

更新日期：1993-01-01 00:00:00

abstract：OBJECTIVE:To estimate the frequency of the metabolic syndrome (MS) and of the insulin resistance syndrome (IRS) in overweight or obese French children and to determine the risk factors. DESIGN, PATIENTS AND METHODS:A total of 308 overweight and obese children [166 girls, 142 boys, aged 7-17 years; median body mass ind...

journal_title：Clinical endocrinology

authors： Druet C,Dabbas M,Baltakse V,Payen C,Jouret B,Baud C,Chevenne D,Ricour C,Tauber M,Polak M,Alberti C,Levy-Marchal C

更新日期：2006-06-01 00:00:00

abstract：:Pituitary-dependent Cushing's syndrome is rare in childhood. Two patients are reported who had unsuccessful transsphenoidal microadenomectomy and therefore underwent pituitary radiotherapy. In both patients there was progressive normalization of hypothalamo-pituitary-adrenal function and at 8 and 10 years after radiot...

journal_title：Clinical endocrinology

authors： Johnston LB,Grossmann AB,Plowman PN,Besser GM,Savage MO

更新日期：1998-05-01 00:00:00

abstract：:In order to investigate the mechanism of GIP secretion and the role of endogenous GIP in the enteroinsular axis in duodenal ulcer patients, we have compared plasma GIP, insulin, and blood glucose responses to oral glucose ingestion in 10 duodenal ulcer patients, 5 patients with total gastrectomy, and 20 normal subject...

journal_title：Clinical endocrinology

authors： Takemura J,Seino Y,Yamamura T,Yoshiya K,Ishikawa Y,Itoh N,Imura H

更新日期：1983-09-01 00:00:00

abstract：BACKGROUND:Proton magnetic resonance spectroscopy ((1) H-MRS) is a sensitive, noninvasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing's syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochem...

journal_title：Clinical endocrinology

authors： Resmini E,Santos A,Gómez-Anson B,López-Mourelo O,Pires P,Vives-Gilabert Y,Crespo I,Portella MJ,de Juan-Delago M,Webb SM

更新日期：2013-11-01 00:00:00

abstract：CONTEXT:Unlike pituitary macroadenomas, microadenomas (micros) are not commonly associated with hypopituitarism. In clinical practice, we have observed that patients with ACTH-secreting micros have a higher than expected prevalence of central hypothyroidism (HT), and we speculated that this effect might be because of g...

journal_title：Clinical endocrinology

authors： Mathioudakis N,Thapa S,Wand GS,Salvatori R

更新日期：2012-12-01 00:00:00

abstract：OBJECTIVE:Gitelman's syndrome, recognized as a variant of Bartter's syndrome, is characterized by hypokalaemic metabolic alkalosis in combination with hypomagnesaemia and hypocalciuria. Overlapping biochemical features in Gitelman's syndrome and Bartter's syndrome has been observed. Here, we investigated the clinical, ...

journal_title：Clinical endocrinology

authors： Nakamura A,Shimizu C,Nagai S,Yoshida M,Aoki K,Kondo T,Miyoshi H,Wada N,Tajima T,Terauchi Y,Yoshioka N,Koike T

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To study the relationship between the excretion of nephrogenous cyclic AMP (NcAMP) and other blood and urine parameters as an index of PTH-like activity in patients with primary hepatocellular carcinoma. DESIGN:After overnight fast, a double voided urine and a blood sample were collected from each subject fo...

journal_title：Clinical endocrinology

authors： Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

更新日期：1991-12-01 00:00:00

abstract：OBJECTIVE:It is known that growth hormone can induce accelerated bone turnover in GH deficient people as well as healthy elderly people. In this study we examined the effect of recombinant human GH (rhGH) on bone mineral mass and bone turnover in the presence of the bone resorption inhibiting agent, pamidronate. Effect...

journal_title：Clinical endocrinology

authors： Erdtsieck RJ,Pols HA,Valk NK,van Ouwerkerk BM,Lamberts SW,Mulder P,Birkenhäger JC

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:Microprolactinomas have been reported to resolve spontaneously after pregnancy and there have been suggestions that oestrogen therapy increases the size of microprolactinomas. Little is known, however, about the effect of the menopause in patients previously known to be hyperprolactinaemic. The aim of this st...

journal_title：Clinical endocrinology

authors： Karunakaran S,Page RC,Wass JA

更新日期：2001-03-01 00:00:00