Evidence for a hypothalamic alteration of catecholamine metabolism in polycystic ovary syndrome.

abstract：:A 16-year-old female patient with an adrenal tumour was studied. Clinically she had progressive hirsutism, showed high urinary 17-oxosteroid excretion with normal plasma cortisol. Plasma C19-steroids, both unconjugated (including testosterone) and sulphate-conjugated, were greatly elevated. On surgical exploration an ...

journal_title：Clinical endocrinology

authors： Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

更新日期：1978-04-01 00:00:00

abstract：OBJECTIVE:This case series documents the response of nine individuals with glucocorticoid-refractory Graves' orbitopathy (GO) to B cell depletion therapy with rituximab (RTX). CONTEXT:Graves' disease (GD) is one of the commonest autoimmune conditions and is frequently associated with inflammatory changes around the ey...

journal_title：Clinical endocrinology

authors： Mitchell AL,Gan EH,Morris M,Johnson K,Neoh C,Dickinson AJ,Perros P,Pearce SH

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To report and explore potential reasons for undetectable or low-normal serum intact PTH levels in patients with surgically verified primary hyperparathyroidism with parathyroid adenomas, review the relevant literature, and offer suggestions for management of such patients occasionally encountered in clinical...

journal_title：Clinical endocrinology

authors： Bhadada SK,Cardenas M,Bhansali A,Mittal BR,Behera A,Chanukya GV,Nahar U,Rao DS

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patient...

journal_title：Clinical endocrinology

authors： Riss P,Kammer M,Selberherr A,Bichler C,Kaderli R,Scheuba C,Niederle B

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Genotype and phenotype heterogeneity in patients with GH insensitivity syndrome suggests that partial defects exist in the GH receptor. Children with partial GH resistance would be expected to have short stature, elevated GH levels and relatively low levels of IGF-I and IGFBP-3. Provocation tests of the GH-IG...

journal_title：Clinical endocrinology

authors： Cotterill AM,Camacho-Hübner C,Duquesnoy P,Savage MO

更新日期：1998-06-01 00:00:00

abstract：:Three different forms of testosterone (T) replacement therapy were compared; they were the intramuscular injection of mixed testosterone esters 250 mg; the subcutaneous implantation of 6 X 100 mg pellets of fused testosterone; and the oral administration of testosterone undecanoate (TU) 80 mg twice daily. Six hypogona...

journal_title：Clinical endocrinology

authors： Cantrill JA,Dewis P,Large DM,Newman M,Anderson DC

更新日期：1984-08-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:Women with previous gestational diabetes (pGDM) are at risk of developing Type 2 diabetes. Glucagon-like peptide-1 (GLP-1) potentiates the insulin response to oral glucose, and its secretion is diminished in Type 2 diabetes. The aim of the study was to see if decreased GLP-1 secretion might be ...

journal_title：Clinical endocrinology

authors： Forbes S,Moonan M,Robinson S,Anyaoku V,Patterson M,Murphy KG,Ghatei MA,Bloom SR,Johnston DG

更新日期：2005-01-01 00:00:00

abstract：:The present study concerns eighteen chronic alcoholics with minimal liver damage. A significant reduction in total serum T4 with an accompanying drop in circulating TBG was observed in these otherwise euthyroid patients. During alcohol withdrawal, we observed a rapid increase in T4 and TBG into the normal range. We su...

journal_title：Clinical endocrinology

authors： Geurts J,Demeester-Mirkine N,Glinoer D,Prigogine T,Fernandez-Deville M,Corvilain J

更新日期：1981-02-01 00:00:00

abstract：OBJECTIVE:Strategies to limit the final height of tall children have centred on the use of high doses of sex steroids to advance skeletal maturation. This limits therapy to the peripubertal years whereas the greatest gain in height is in the prepubertal years. Prepubertal growth is largely GH dependent and previous wor...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Pringle PJ,Stanhope R,Brook CG

更新日期：1995-05-01 00:00:00

abstract：OBJECTIVE:To assess the effect of nutritional supplementation on growth and puberty in constitutionally delayed children. PATIENTS:One hundred and two boys, 13.6-15.5 years of age, who were referred because of short stature and delayed puberty. METHODS:The boys were randomly allocated to one of the following treatmen...

journal_title：Clinical endocrinology

authors： Zadik Z,Sinai T,Zung A,Reifen R

更新日期：2004-06-01 00:00:00

abstract：:A single fasting level of serum prolactin was measured in each of sixty control subjects and eighty-three psychiatric patients of both sexes who had been on neuroleptic therapy for 2-4 weeks (acute treatment) or at least 5 years (chronic treatment) and who were aged either 17-45 or 48-85 years. All groups of patients ...

journal_title：Clinical endocrinology

authors： Rivera JL,Lal S,Ettigi P,Hontela S,Muller HF,Friesen HG

更新日期：1976-05-01 00:00:00

abstract：OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

journal_title：Clinical endocrinology

authors： Moreira AC,Castro M,Machado HR

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:The objective of the present study was to elucidate the parathyroid responsiveness by measurements of blood ionized calcium and serum intact parathyroid hormone (PTH) concentrations, before and during trisodium citrate induced hypocalcaemia. PATIENTS AND CONTROLS:Sixteen patients with primary hyperparathyroi...

journal_title：Clinical endocrinology

authors： Schwarz P,Sørensen HA,Momsen G,McNair P,Transbøl I

更新日期：1992-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Although the physiology of minipuberty are well-established, it is not fully explained why it occurs. It has been suggested that minipuberty contributes to the development of reproductive organs, somatic growth, cognitive/behavioral, and sex-specific brain development. Given the well-known trade-of...

journal_title：Clinical endocrinology

authors： Karaoglan M,Nacarkahya G

更新日期：2020-12-05 00:00:00

abstract：OBJECTIVE:To study the effects of thyroxine on orocaecal transit time in a group of elderly hypothyroid patients on long-term thyroxine replacement therapy. DESIGN:Measurement of the effect of withdrawal and subsequent replacement of thyroxine replacement therapy on orocaecal transit time. PATIENTS:Fifteen elderly, p...

journal_title：Clinical endocrinology

authors： Rahman Q,Haboubi NY,Hudson PR,Lee GS,Shah IU

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVE:Thyroid cancer is the most common malignant endocrine tumour, and its incidence has continuously increased worldwide over the past three decades. We focused on the association of multifocal papillary thyroid carcinoma (PTC) with messenger RNA (mRNA) expression to characterize how molecular and histopathologic...

journal_title：Clinical endocrinology

authors： Pak K,Suh S,Goh TS,Kim SJ,Oh SO,Seok JW,Kim IJ,Kim YH

更新日期：2019-04-01 00:00:00

abstract：OBJECTIVES:There is growing evidence for the association between bone mineral density (BMD) and vascular calcification, which is related to cardiovascular disease. Coronary multidetector row computed tomography (MDCT) is a noninvasive tool developed to evaluate coronary status precisely. We used MDCT to evaluate this a...

journal_title：Clinical endocrinology

authors： Choi SH,An JH,Lim S,Koo BK,Park SE,Chang HJ,Choi SI,Park YJ,Park KS,Jang HC,Shin CS

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:We assessed the relationship between serum IGFBP-3 levels with IGF-I and quantitative GH secretory status in poorly growing children. DESIGN:We studied the relationship between 24-hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF-I and the IGFBP-3 serum levels. PATIENT...

journal_title：Clinical endocrinology

authors： Phillip M,Chalew SA,Kowarski AA,Stene MA

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:Growth deficiency is commonly seen in polytransfused beta-thalassaemia patients, especially in adolescence. It is not completely dependent on the lack of their pubertal growth spurt. GH impairment at different levels (hypothalamic or pituitary) and/or a reduced IGF-1 synthesis have been suggested the main cau...

journal_title：Clinical endocrinology

authors： Cavallo L,Gurrado R,Gallo F,Zacchino C,De Mattia D,Tatò L

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Although autoantibody production is a key feature of autoimmunity, it is not known whether variation in autoantibody production and clearance pathways is involved in disease susceptibility. The Fc Gamma Receptor IIa (FcGRIIa) molecule is involved in the clearance of autoantibodies and a functional single nucl...

journal_title：Clinical endocrinology

authors： Yesmin K,Hargreaves C,Newby PR,Brand OJ,Heward JM,Franklyn JA,Gough SC,Simmonds MJ

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN meta...

journal_title：Clinical endocrinology

authors： Jeon MJ,Chung MS,Kwon H,Kim M,Park S,Baek JH,Song DE,Sung TY,Hong SJ,Kim TY,Kim WB,Shong YK,Lee JH,Kim WG

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:To audit the efficacy of quinagolide (CV205-502, Norprolac, Sandoz) in lowering prolactin, and its tolerability, in patients with bromocriptine resistance (BCR) or bromocriptine intolerance (BCI), in view of the paucity of results published in patients specifically with BCR or BCI, by collating results in our...

journal_title：Clinical endocrinology

authors： Vilar L,Burke CW

更新日期：1994-12-01 00:00:00

abstract：:Plasma concentrations of FSH, LH, testosterone and prolactin have been studied in seventeen men, aged 19 to 38 years, with traumatic paraplegia. Plasma testosterone, FSH and LH values were normal in all patients. The median LH concentration in patients was significantly higher (P less than 0.05) than in controls but t...

journal_title：Clinical endocrinology

authors： Young RJ,Strachan RK,Seth J,Nicol K,Frier BM,Corrall RJ

更新日期：1982-09-01 00:00:00

abstract：OBJECTIVE AND DESIGN:Depot somatostatin analogues are well accepted as either adjuvant or primary therapy for acromegaly, and their long dosage intervals facilitate adherence to treatment. Our objective was to evaluate whether lanreotide Autogel 120 mg, every 4-8 weeks, was as effective in controlling acromegaly as lan...

journal_title：Clinical endocrinology

authors： Lucas T,Astorga R,Spanish-Portuguese Multicentre Autogel Study Group on Acromegaly.

更新日期：2006-09-01 00:00:00

abstract：:The demonstration that the incretin hormone glucagon-like peptide 1 can improve glycaemic control in patients with type 2 diabetes has led to the rapid development during the last decade of promising new classes of agent for the management of type 2 diabetes. These agents possess a range of physiological effects that ...

journal_title：Clinical endocrinology

authors： Barnett AH

更新日期：2009-03-01 00:00:00

abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in acromegaly. Left ventricular mass (LVM) is an important parameter measured to detect LVH, but the relationship with body size should be considered by correcting LVM to body surface area (BSA), height or height2.7. All trials concern...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Pivonello R,Spinelli L,Ciccarelli A,de Divitiis O,Lombardi G,Colao A

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVE:Cadmium (Cd) has been shown to impair pubertal development in experimental animals. However, no data are available for male adolescents with increased urinary cadmium levels. DESIGN:The aim of this cross-sectional study was to evaluate pubertal onset and pituitary-gonadal axis hormones in male adolescents wi...

journal_title：Clinical endocrinology

authors： Interdonato M,Pizzino G,Bitto A,Galfo F,Irrera N,Mecchio A,Pallio G,Ramistella V,De Luca F,Santamaria A,Minutoli L,Marini H,Squadrito F,Altavilla D

更新日期：2015-09-01 00:00:00

abstract：:The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of st...

journal_title：Clinical endocrinology

authors： Ellemann K,Thorsteinsson B,Fugleberg S,Feldt-Rasmussen B,Andersen OO,Grønbaek P,Binder C

更新日期：1987-05-01 00:00:00

abstract：:Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The ...

journal_title：Clinical endocrinology

authors： Fraioli F,Cappa M,Fabbri A,Gnessi L,Moretti C,Borrelli P,Isidori A

更新日期：1984-03-01 00:00:00

abstract：:Hyperthyroidism is a well recognized complication of gestational trophoblastic tumours (GTT) and may be due to high circulating concentrations of human chorionic gonadotrophin (hCG) or its variants. We have studied 24 clinically euthyroid women with GTT. Eight were biochemically hyperthyroid with low or undetectable s...

journal_title：Clinical endocrinology

authors： Kennedy RL,Sheridan E,Darne J,Griffiths H,Davies R,Price A,Cohn M

更新日期：1990-08-01 00:00:00