Percutaneous ethanol injection treatment of autonomous thyroid adenoma: hormonal and clinical evaluation.

abstract：:Pituitary-dependent Cushing's syndrome is rare in childhood. Two patients are reported who had unsuccessful transsphenoidal microadenomectomy and therefore underwent pituitary radiotherapy. In both patients there was progressive normalization of hypothalamo-pituitary-adrenal function and at 8 and 10 years after radiot...

journal_title：Clinical endocrinology

authors： Johnston LB,Grossmann AB,Plowman PN,Besser GM,Savage MO

更新日期：1998-05-01 00:00:00

abstract：:The 'basal' plasma glucose, defined as the stable overnight concentration, has been assessed as an index of diabetes control by comparison with plasma glucose measurements during 24-h profiles in diet-treated maturity-onset diabetic patients and normal subjects. The basal plasma glucose correlated with the total (r=0....

journal_title：Clinical endocrinology

authors： Holman RR,Turner RC

更新日期：1981-03-01 00:00:00

abstract：OBJECTIVE:To study the relationship between the excretion of nephrogenous cyclic AMP (NcAMP) and other blood and urine parameters as an index of PTH-like activity in patients with primary hepatocellular carcinoma. DESIGN:After overnight fast, a double voided urine and a blood sample were collected from each subject fo...

journal_title：Clinical endocrinology

authors： Panesar NS,Au KM,Leung NW,Shek CC,Swaminathan R

更新日期：1991-12-01 00:00:00

abstract：BACKGROUND:Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and ...

journal_title：Clinical endocrinology

authors： Mitchell AL,Hickey J,Vaidya B,Mason R,Ajjan R,Zammitt N,Perros P,Dayan C,TEAMeD.

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVES:To report and explore potential reasons for undetectable or low-normal serum intact PTH levels in patients with surgically verified primary hyperparathyroidism with parathyroid adenomas, review the relevant literature, and offer suggestions for management of such patients occasionally encountered in clinical...

journal_title：Clinical endocrinology

authors： Bhadada SK,Cardenas M,Bhansali A,Mittal BR,Behera A,Chanukya GV,Nahar U,Rao DS

更新日期：2008-09-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：:A convenient, sensitive radioimmunoassay of free thyroxine in serum dialysates is described. The method utilizes a solid phase separation system (pre-formed double antibody) and a relatively short incubation period (220 min) with a staggered addition of tracer. Blanks were low and consistent. The normal range for non-...

journal_title：Clinical endocrinology

authors： Giles AF

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with ...

journal_title：Clinical endocrinology

authors： Otsuka F,Noh JY,Chino T,Shimizu T,Mukasa K,Ito K,Ito K,Taniyama M

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVE:Thyroid dysfunction and obesity during pregnancy have been associated with negative neonatal and obstetric outcomes. Thyroid hormone reference ranges have not been established for the pregnant Hispanic population. This study defines thyroid hormone reference ranges during early pregnancy in Chilean women and ...

journal_title：Clinical endocrinology

authors： Mosso L,Martínez A,Rojas MP,Latorre G,Margozzini P,Lyng T,Carvajal J,Campusano C,Arteaga E,Boucai L

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Although the physiology of minipuberty are well-established, it is not fully explained why it occurs. It has been suggested that minipuberty contributes to the development of reproductive organs, somatic growth, cognitive/behavioral, and sex-specific brain development. Given the well-known trade-of...

journal_title：Clinical endocrinology

authors： Karaoglan M,Nacarkahya G

更新日期：2020-12-05 00:00:00

abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

journal_title：Clinical endocrinology

authors： Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

更新日期：2017-01-01 00:00:00

abstract：:Urinary immunoreactive PGA and PGE, plasma and urinary aldosterone, and plasma renin activity (PRA) were determined in eleven control subjects and four patients with diabetic hyporeninaemic hypoaldosteronism (HH) before and during 4 days of sodium chloride restriction and frusemide administration. Aldosterone and PRA ...

journal_title：Clinical endocrinology

authors： Farese RV,Rodriguez-Colomé M,O'Malley BC

更新日期：1980-11-01 00:00:00

abstract：:The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

journal_title：Clinical endocrinology

authors： Zahedi A,Booth GL,Smyth HS,Farrell WE,Clayton RN,Asa SL,Ezzat S

更新日期：2001-10-01 00:00:00

abstract：:The adrenolytic agent, 2,2-bis[2-chlorophenyl-4-chlorophenyl] 1,1 dichloroethane (o,p'-DDD), was used over a 20-month period following surgery in a 2 3/12-year-old girl for treatment of adrenocortical carcinoma. The child remained free of disease and was maintained on glucocorticoid and mineralo-corticoid supplements ...

journal_title：Clinical endocrinology

authors： Greig F,Oberfield SE,Levine LS,Ghavimi F,Pang S,New MI

更新日期：1984-04-01 00:00:00

abstract：:The antigenicity of HCG was tested in twenty-three young healthy men receiving two different HCG preparations (A and B). Each subject received 5000 i.u. HCG intramuscularly daily for three consecutive days, followed by another course, 3 weeks later, of 5000 i.u. HCG injections daily for 3 days. Two of the fifteen subj...

journal_title：Clinical endocrinology

authors： Nieschlag E,Bernitz S,Töpert M

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVE:The diagnosis of the nonclassical form of 21-hydroxylase (NC-21OH) deficiency, established before molecular studies, is based on basal 17OH-progesterone (17OH-P) values > 15 nmol/l or ACTH-stimulated 17OH-P values > 30 nmol/l. This disease is caused by mutations in the structural gene that can be grouped into...

journal_title：Clinical endocrinology

authors： Bachega TA,Billerbeck AE,Marcondes JA,Madureira G,Arnhold IJ,Mendonca BB

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:Hypercortisolism is associated with impaired glucose tolerance and insulin resistance. For many years hydrocortisone 30 mg was the standard total daily replacement dose in adult hypopituitarism. The use of this conventional dose has now been shown to result in mild biochemical hypercortisolism and might contr...

journal_title：Clinical endocrinology

authors： McConnell EM,Bell PM,Ennis C,Hadden DR,McCance DR,Sheridan B,Atkinson AB

更新日期：2002-02-01 00:00:00

abstract：:The growth hormone (GH) and prolactin (PRL) responses to metoclopramide (MCP) were compared to those with arginine and insulin-induced hypoglycaemia in eight children. While a significant rise in GH release after stimulation with arginine and insulin occurred in all subjects (P less than 0.05), no significant increase...

journal_title：Clinical endocrinology

authors： Ijaiya K,Roth B,Schwenk A

更新日期：1980-06-01 00:00:00

abstract：CONTEXT:Peroxisome proliferator-activated receptor gamma (PPAR-gamma) agonists such as thiazolidinediones (TZDs) improve insulin sensitivity in type 2 diabetes mellitus (T2DM) through effects on fat metabolism whereas GH stimulates lipolysis and induces insulin resistance. OBJECTIVE:To evaluate the impact of TZDs on f...

journal_title：Clinical endocrinology

authors： Krag MB,Nielsen S,Guo Z,Pedersen SB,Schmitz O,Christiansen JS,Jørgensen JO

更新日期：2008-09-01 00:00:00

abstract：PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

journal_title：Clinical endocrinology

authors： Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

更新日期：2010-06-01 00:00:00

abstract：:We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid s...

journal_title：Clinical endocrinology

authors： Nicholls MG,Julius S,Zweifler AJ

更新日期：1981-09-01 00:00:00

abstract：BACKGROUND:A GH deficiency-like phenotype with normal or high hGH secretion, pathologically low IGF-I serum levels, and catch-up growth under treatment with recombinant hGH is suggestive of the presence of biologically inactive hGH syndrome, whose presumably heterogenous molecular basis is substantially unknown. DESIG...

journal_title：Clinical endocrinology

authors： Binder G,Benz MR,Elmlinger M,Pflaum CD,Strasburger CJ,Ranke MB

更新日期：1999-07-01 00:00:00

abstract：CONTEXT:The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective...

journal_title：Clinical endocrinology

authors： Celi FS,Zemskova M,Linderman JD,Babar NI,Skarulis MC,Csako G,Wesley R,Costello R,Penzak SR,Pucino F

更新日期：2010-05-01 00:00:00

abstract：OBJECTIVE:Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making. DESIGN AND PATIENTS:We identified 728 RET533 Brazilian relatives, spread out over 7 generati...

journal_title：Clinical endocrinology

authors： Signorini PS,França MI,Camacho CP,Lindsey SC,Valente FO,Kasamatsu TS,Machado AL,Salim CP,Delcelo R,Hoff AO,Cerutti JM,Dias-da-Silva MR,Maciel RM

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:GH deficiency, either in children or in adults, is a clinically relevant problem. The diagnosis is based on dynamic tests of GH secretion, which are clear cut on a group basis but highly problematic for individual diagnosis. The controversy surrounding the diagnosis of GH deficiency reflects the absence of a ...

journal_title：Clinical endocrinology

authors： Micic D,Popovic V,Kendereski A,Peino R,Dieguez C,Casanueva FF

更新日期：1996-11-01 00:00:00

abstract：:The effect of clomiphene citrate on the occurrence and timing of the endogenous LH surge in superovulated cycles is unclear. To study further this event, five normally ovulating women were treated with clomiphene citrate 100 mg per day in two different cycles, that is, for 5 days in one cycle (days 2 to 6, CC-5) and f...

journal_title：Clinical endocrinology

authors： Messinis IE,Templeton A

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

journal_title：Clinical endocrinology

authors： Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Little is known about the relationships of dietary factors, physical activity and sedentary behaviour to dehydroepiandrosterone sulphate (DHEAS) and insulin-like growth factor-1 (IGF-1) concentrations among prepubertal children. Therefore, we studied the associations of these lifestyle factors with serum DHEA...

journal_title：Clinical endocrinology

authors： Mäntyselkä A,Jääskeläinen J,Eloranta AM,Väistö J,Voutilainen R,Ong K,Brage S,Lakka TA,Lindi V

更新日期：2018-02-01 00:00:00

abstract：:We have investigated the role of endogenous opioid peptides in the release of oxytocin (OT) in response to breast feeding and breast stimulation in humans. Five breast feeding women were studied on two separate occasions within 4 weeks of delivery. Saline or naloxone, 4 mg bolus and 6 mg/h, was administered intravenou...

journal_title：Clinical endocrinology

authors： Johnson MR,Andrews MA,Seckl JR,Lightman SL

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:The present study was performed to characterize the molecular heterogeneity of serum FSH in normal males and to investigate the possible influence of testosterone on serum FSH in androgen-deficient men before and during testosterone administration. DESIGN AND PATIENTS:Serum samples were taken at 10-minute in...

journal_title：Clinical endocrinology

authors： Harsch IA,Simoni M,Nieschlag E

更新日期：1993-08-01 00:00:00