Peroxisome proliferator-activated receptor gamma agonism modifies the effects of growth hormone on lipolysis and insulin sensitivity.

abstract：:A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

journal_title：Clinical endocrinology

authors： Nabarro JD

更新日期：1987-04-01 00:00:00

abstract：:The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

journal_title：Clinical endocrinology

authors： Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

更新日期：1988-09-01 00:00:00

abstract：OBJECTIVE:Vascular dysfunction and accelerated atherosclerosis are prominent features of hypothyroidism. The relative roles of thyroid hormone (TH) deficiency and the associated vascular risk conditions are still unclear. We studied the impact of acute and chronic hypothyroidism on vascular reactivity. PATIENTS:We stu...

journal_title：Clinical endocrinology

authors： Napoli R,Guardasole V,Zarra E,D'Anna C,De Sena A,Lupoli GA,Oliviero U,Matarazzo M,Lupoli G,Saccà L

更新日期：2010-01-01 00:00:00

abstract：OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

journal_title：Clinical endocrinology

authors： Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

更新日期：2018-09-01 00:00:00

abstract：:The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...

journal_title：Clinical endocrinology

authors： Howlett TA,Drury PL,Perry L,Doniach I,Rees LH,Besser GM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Traditionally, acromegaly evaded diagnosis until in its clinically obvious later stages when treatment is more difficult. Over the last 25 years diagnostic tests have improved, but whether clinical disease detection also improved was unknown, so we tested if disease severity at diagnosis had changed from 198...

journal_title：Clinical endocrinology

authors： Reid TJ,Post KD,Bruce JN,Nabi Kanibir M,Reyes-Vidal CM,Freda PU

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:Use of the antithyroid drugs (ATDs) thiamazole (MMI) and propylthiouracil (PTU) is associated with a high frequency of side effects. When patients experience side effects with one (the 1st) ATD, it is usually discontinued and another is administered (the 2nd ATD). We investigated side effects associated with ...

journal_title：Clinical endocrinology

authors： Otsuka F,Noh JY,Chino T,Shimizu T,Mukasa K,Ito K,Ito K,Taniyama M

更新日期：2012-08-01 00:00:00

abstract：:Autoantibodies to thyroid peroxidase (TPO), the thyroid 'microsomal' antigen, are widely utilized in the diagnosis of human autoimmune thyroid disease. Crude human thyroid preparations of TPO are of differing potency, contain residual thyroglobulin (Tg) and other human membrane antigens, and are available in only limi...

journal_title：Clinical endocrinology

authors： Kendler DL,Martin A,Magnusson RP,Davies TF

更新日期：1990-12-01 00:00:00

abstract：OBJECTIVE:Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have been identified in human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a numbe...

journal_title：Clinical endocrinology

authors： Liu RT,Chen YJ,Chou FF,Li CL,Wu WL,Tsai PC,Huang CC,Cheng JT

更新日期：2005-10-01 00:00:00

abstract：:In nine patients with thyrotoxicosis (three patients with ophthalmopathy, one patient with T3 thyrotoxicosis) we followed plasma levels of triiodothyronine (T3) and thyroxine (T4) and the TRH induced TSH release before and under treatment with propythiouracil (PTU), carbimazole or methimazol. The patients were observe...

journal_title：Clinical endocrinology

authors： von zur Mühlen A,Hesch RD,Köbberling J

更新日期：1975-03-01 00:00:00

abstract：OBJECTIVES:Bilateral adrenalectomy may be indicated in patients with Cushing's disease in whom hypercortisolism is not resolved after pituitary microsurgery. However, Nelson's syndrome is a major long-term complication of such therapy. We have carried out a longitudinal study on patients with Cushing's disease who unde...

journal_title：Clinical endocrinology

authors： Moreira AC,Castro M,Machado HR

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVES:There is no licensed, dose-appropriate formulation of hydrocortisone for children with adrenal insufficiency (AI) and patients rely on compounded adult medication. The aim of this study was to evaluate the absorption, palatability and safety of Infacort® , an immediate-release, granule formulation of hydroco...

journal_title：Clinical endocrinology

authors： Neumann U,Whitaker MJ,Wiegand S,Krude H,Porter J,Davies M,Digweed D,Voet B,Ross RJ,Blankenstein O

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:To define the symptoms, signs and treatment outcomes in a population of older patients with Cushing's disease (CD). METHODS:We analysed the clinical presentation and treatment outcomes in 45 CD patients older than 60 years, in comparison with 90 CD patients younger than 60, and a control group of 45 older p...

journal_title：Clinical endocrinology

authors： Qiao N,Swearingen B,Tritos NA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS:A mul...

journal_title：Clinical endocrinology

authors： Lemos MC,Gomes L,Bastos M,Leite V,Limbert E,Carvalho D,Bacelar C,Monteiro M,Fonseca F,Agapito A,Castro JJ,Regateiro FJ,Carvalheiro M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Genotype and phenotype heterogeneity in patients with GH insensitivity syndrome suggests that partial defects exist in the GH receptor. Children with partial GH resistance would be expected to have short stature, elevated GH levels and relatively low levels of IGF-I and IGFBP-3. Provocation tests of the GH-IG...

journal_title：Clinical endocrinology

authors： Cotterill AM,Camacho-Hübner C,Duquesnoy P,Savage MO

更新日期：1998-06-01 00:00:00

abstract：:Twenty-one patients with hyperthyroid Graves' disease were treated with carbimazole 30 mg daily, given as a single dose. Propranolol was also given for the first 3 weeks. All became clinically euthyroid with normal serum thyroxine (T4) levels, usually within 1-3 months. Patients with large goitres and raised serum alk...

journal_title：Clinical endocrinology

authors： MacFarlane IA,Davies D,Longson D,Shalet SM,Beardwell CG

更新日期：1983-06-01 00:00:00

abstract：:Pituitary-dependent Cushing's syndrome is rare in childhood. Two patients are reported who had unsuccessful transsphenoidal microadenomectomy and therefore underwent pituitary radiotherapy. In both patients there was progressive normalization of hypothalamo-pituitary-adrenal function and at 8 and 10 years after radiot...

journal_title：Clinical endocrinology

authors： Johnston LB,Grossmann AB,Plowman PN,Besser GM,Savage MO

更新日期：1998-05-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

journal_title：Clinical endocrinology

authors： Rogol AD,Blethen SL,Sy JP,Veldhuis JD

更新日期：2003-02-01 00:00:00

abstract：:Renin-angiotensin-aldosterone system (RAAS) plays a crucial role in maintaining water and electrolytes homoeostasis, and its deregulation contributes to the development of arterial hypertension. Since the historical description of the "classical" RAAS, a dramatic increase in our understanding of the molecular mechanis...

journal_title：Clinical endocrinology

authors： Monticone S,Losano I,Tetti M,Buffolo F,Veglio F,Mulatero P

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To study the effects of long-term growth hormone (GH) treatment on lipid metabolism and carbohydrate tolerance in GH-deficient adults. DESIGN:Open trial of GH treatment for 4 years. GH dose was (median, range) 0.025 (0.010-0.050) IU/kg daily. PATIENTS:Thirteen GH-deficient hypopituitary adults (seven men, s...

journal_title：Clinical endocrinology

authors： al-Shoumer KA,Gray R,Anyaoku V,Hughes C,Beshyah S,Richmond W,Johnston DG

更新日期：1998-06-01 00:00:00

abstract：BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

journal_title：Clinical endocrinology

authors： Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

更新日期：2014-08-01 00:00:00

abstract：OBJECTIVE:A retrospective study was conducted in order to elucidate the clinicopathological significance of fibrous bodies, a hallmark of the sparsely granulated variant of GH-producing pituitary adenomas. METHODS:A total of 37 acromegalic patients, 14 men and 23 women, with pure GH adenomas were studied. Immunohistoc...

journal_title：Clinical endocrinology

authors： Nishioka H,Haraoka J,Akada K

更新日期：2003-12-01 00:00:00

abstract：OBJECTIVE:The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN:The MEDLINE/PubMed and EMBASE database, from the earliest available date of i...

journal_title：Clinical endocrinology

authors： Kim BH,Kim SJ,Kim M,Lee SW,Jeong SY,Pak K,Kim K,Kim IJ

更新日期：2018-12-01 00:00:00

abstract：:Only five cases of growth hormone secreting pituitary carcinoma have been documented. We present a 49-year-old West Indian male with grossly elevated plasma growth hormone (760-10,400 mU/l), and a large aggressive pituitary tumour that continued to grow despite repeated pituitary surgery, radiotherapy and medical ther...

journal_title：Clinical endocrinology

authors： Stewart PM,Carey MP,Graham CT,Wright AD,London DR

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

journal_title：Clinical endocrinology

authors： Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:Pubertal gynaecomastia is a very common condition. Although the underlying aetiology is poorly understood, it is generally accepted that excess of oestrogens and deficit of androgens are involved in the pathogenesis. Furthermore, adiposity as well as the GH/IGF-I axis may play a role. In this study, we elucid...

journal_title：Clinical endocrinology

authors： Mieritz MG,Sorensen K,Aksglaede L,Mouritsen A,Hagen CP,Hilsted L,Andersson AM,Juul A

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore, we investigated the adi...

journal_title：Clinical endocrinology

authors： Wagenmakers M,Roerink S,Gil L,Plantinga T,Smit J,Netea-Maier R,Hermus A

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To determine whether maternal vitamin D supplementation, in the vitamin D deficient mother, prevents neonatal vitamin D deficiency. DESIGN:Open-label randomized controlled trial. SETTING:Metropolitan Melbourne, Australia, tertiary hospital routine antenatal outpatient clinic. PARTICIPANTS:Seventy-eight wom...

journal_title：Clinical endocrinology

authors： Rodda CP,Benson JE,Vincent AJ,Whitehead CL,Polykov A,Vollenhoven B

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:Hypopituitarism, including severe GH deficiency, is an almost inevitable outcome of craniopharyngioma. However, some GH deficient children with this tumour may grow normally or even have accelerated growth postoperatively. To study this phenomenon we have investigated the endocrine status, including IGF-1 and...

journal_title：Clinical endocrinology

authors： Tiulpakov AN,Mazerkina NA,Brook CG,Hindmarsh PC,Peterkova VA,Gorelyshev SK

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:The optimal treatment regimen with thionamide drugs remains a matter for debate. We have investigated whether high doses of carbimazole, when compared with low doses, reduce relapse rates of Graves' disease. DESIGN:In an open label, randomized, prospective trial of treatment of Graves' disease we compared hi...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Ford HC,Fagerström JN,Cordwell DP,Delahunt JW,Toomath RJ

更新日期：1998-05-01 00:00:00