Abstract:
OBJECTIVE:A retrospective study was conducted in order to elucidate the clinicopathological significance of fibrous bodies, a hallmark of the sparsely granulated variant of GH-producing pituitary adenomas. METHODS:A total of 37 acromegalic patients, 14 men and 23 women, with pure GH adenomas were studied. Immunohistochemistry was performed with antibodies specific for cytokeratin 8 and 18 (CAM5.2), GH, prolactin and E-cadherin. The tumour volume was estimated with high-resolution magnetic resonance imaging. RESULTS:The percentages of adenoma cells with dot-like immunoreactivity for CAM5.2, fibrous bodies, were variable, ranging continuously from 0 to 100%. An increased percentage was associated with a lower basal GH level per unit tumour volume, a lower GH response to a bromocriptine suppression test, decreased immunoreactivities for GH and prolactin, and a decreased expression of E-cadherin immunoreactivity. CONCLUSION:GH adenomas could not be distinctly separated into those with or without fibrous bodies. Decreased expression of E-cadherin may be involved in formation of fibrous bodies and result in lower GH production.
journal_name
Clin Endocrinol (Oxf)journal_title
Clinical endocrinologyauthors
Nishioka H,Haraoka J,Akada Kdoi
10.1046/j.1365-2265.2003.01921.xkeywords:
subject
Has Abstractpub_date
2003-12-01 00:00:00pages
768-72issue
6eissn
0300-0664issn
1365-2265pii
CEN1921journal_volume
59pub_type
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journal_title:Clinical endocrinology
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更新日期:1997-10-01 00:00:00
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abstract:OBJECTIVE:Serum IGF-I levels are monitored during GH replacement treatment in adults with GH deficiency (GHD) to guide GH dose adjustment and to minimize occurrence of GH-related side-effects. This is not routine practice in children treated with GH. The aim of this study was to evaluate changes in (1) serum IGF-I, IGF...
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1994.tb02524.x
更新日期:1994-08-01 00:00:00
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journal_title:Clinical endocrinology
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更新日期:1980-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/cen.12593
更新日期:2015-01-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1046/j.1365-2265.2001.01322.x
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pub_type: 杂志文章,评审
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更新日期:2014-12-01 00:00:00
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journal_title:Clinical endocrinology
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doi:10.1046/j.1365-2265.1999.00612.x
更新日期:1999-01-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章,meta分析
doi:10.1111/j.1365-2265.2010.03902.x
更新日期:2011-02-01 00:00:00
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journal_title:Clinical endocrinology
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pub_type: 临床试验,杂志文章
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更新日期:2002-08-01 00:00:00
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pub_type: 杂志文章
doi:10.1046/j.1365-2265.2000.00902.x
更新日期:2000-03-01 00:00:00
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更新日期:2013-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1365-2265.1978.tb02773.x
更新日期:1978-04-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1990.tb00487.x
更新日期:1990-08-01 00:00:00
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pub_type: 杂志文章,实务指引
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更新日期:2007-06-01 00:00:00
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更新日期:2001-04-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/j.1365-2265.1979.tb01360.x
更新日期:1979-02-01 00:00:00
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journal_title:Clinical endocrinology
pub_type: 杂志文章
doi:10.1111/cen.13557
更新日期:2018-05-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2008-09-01 00:00:00