Abnormal pubertal development in primary hypothyroidism.

abstract：:A late rise in serum GH occurs 3-5 h following oral glucose in man. In order to investigate the mechanisms through which this occurs we have studied the late GH rise after oral glucose during administration of a supramaximal dose of GHRH. In eight normal subjects, oral glucose (100 g) greatly enhanced the GH responses...

journal_title：Clinical endocrinology

authors： Valcavi R,Zini M,Dieguez C,Portioli I,Scanlon MF

更新日期：1990-05-01 00:00:00

abstract：OBJECTIVE:The aim was to investigate whether, in the absence of gonads, GH could bring forward the age of neuroendocrine activation resulting in onset of puberty. DESIGN:In girls with Turner's syndrome, we evaluated the effects of GH therapy on developmental changes in FSH serum concentrations used as an indicator of ...

journal_title：Clinical endocrinology

authors： Bourguignon JP,Gérard A,Deby-Dupont G,Franchimont P

更新日期：1993-07-01 00:00:00

abstract：OBJECTIVE:TSH suppression therapy has been reported to be effective in some cases of papillary carcinoma of the thyroid. However, there has been little information regarding the status of expression of TSH-R mRNA in papillary carcinomas. Therefore, we examined the expression of TSH receptor (TSH-R) mRNA in thyroid tumo...

journal_title：Clinical endocrinology

authors： Tanaka K,Inoue H,Miki H,Komaki K,Monden Y

更新日期：1996-03-01 00:00:00

abstract：:delta 5 and delta 4 steroid levels were studied in the plasma and cyst fluid of women with gross cystic breast disease (GCBD). In luteal phase a significant increase in plasma levels (mean +/- SEM) of DHA (11.2 +/- 2.4 ng/ml), DHAS (1.45 +/- 0.6 micrograms/ml) and cortisol 277 +/- 15.7 ng/ml) was found; in follicular ...

journal_title：Clinical endocrinology

authors： Inaudi P,Bernabei A,Gioffré W,Franchi F,Mazzullo G,De Leo V,D'Antona N

更新日期：1987-12-01 00:00:00

abstract：OBJECTIVE:Adequate uterine growth is an essential component of pubertal induction with exogenous oestradiol in those with hypogonadism. Poor uterine development will render the individual vulnerable in the context of fertility. We assessed uterine size using ultrasound in those who had undergone pubertal induction trea...

journal_title：Clinical endocrinology

authors： Burt E,Davies MC,Yasmin E,Cameron-Pimblett A,Mavrelos D,Talaulikar V,Conway GS

更新日期：2019-12-01 00:00:00

abstract：:Serum immunoreactive melatonin was measured in thirty-three male subjects with delayed puberty, thirty of whom had simple (idiopathic) delayed puberty (SDP) and three of whom were GH deficient. The results were compared with a control population of twenty-six subjects. Significantly elevated values of serum melatonin ...

journal_title：Clinical endocrinology

authors： Cohen HN,Hay ID,Annesley TM,Beastall GH,Wallace AM,Spooner R,Thomson JA,Eastwold P,Klee GG

更新日期：1982-11-01 00:00:00

abstract：:We have employed a syngeneic system utilizing thyroid cell monolayers initiated following thyroid surgery co-cultured with autologous T cells to demonstrate T cell autosensitization in patients with Graves' disease. Antigen-induced blastogenesis was monitored using 24 h [3H]thymidine uptake. Control experiments with 5...

journal_title：Clinical endocrinology

authors： Davies TF,Bermas B,Platzer M,Roman SH

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Centripetal obesity is associated with systemic low-grade inflammation and an increased cardiovascular risk. Patients in long-term remission of Cushing's syndrome (CS) report persisting abdominal fat accumulation. However, this has previously not been adequately objectified. Therefore, we investigated the adi...

journal_title：Clinical endocrinology

authors： Wagenmakers M,Roerink S,Gil L,Plantinga T,Smit J,Netea-Maier R,Hermus A

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:We evaluated pulsatile and circadian TSH secretion in primary hypothyroidism. DESIGN:In a prospective study, blood was sampled every 10 minutes during 24 hours for assay of TSH (IRMA). Thyroid hormones and TSH responsiveness to TRH were then measured. SUBJECTS:Nine patients with overt primary hypothyroidism...

journal_title：Clinical endocrinology

authors： Adriaanse R,Brabant G,Prank K,Endert E,Wiersinga WM

更新日期：1992-12-01 00:00:00

abstract：BACKGROUND:Thyroid cancer incidence has been increasing worldwide. Some suggest greater ascertainment of indolent tumours is the only driver, but others suggest there has been a true increase. Increases in Australia appear to have been among the largest in the world, so we investigated incidence trends in the Australia...

journal_title：Clinical endocrinology

authors： Pandeya N,McLeod DS,Balasubramaniam K,Baade PD,Youl PH,Bain CJ,Allison R,Jordan SJ

更新日期：2016-02-01 00:00:00

abstract：:Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

journal_title：Clinical endocrinology

authors： Napier C,Pearce SH

更新日期：2015-04-01 00:00:00

abstract：:The human population which lives and works in polar environments has been increasing steadily over the last 15 years. Very little is known about how these residents adjust to their environment. Cold adaptation in man is a poorly understood phenomenon. Euthermic mammals maintain body temperature during cold exposure vi...

journal_title：Clinical endocrinology

authors： Reed HL,Burman KD,Shakir KM,O'Brian JT

更新日期：1986-07-01 00:00:00

abstract：:Although there is a circadian rhythm in blood melatonin concentrations in humans, the problems associated with frequent blood collection limit the use of this rhythm in the investigation of the circadian system and in the diagnosis and treatment of chronobiological disorders. Therefore, to establish a convenient, non-...

journal_title：Clinical endocrinology

authors： Nowak R,McMillen IC,Redman J,Short RV

更新日期：1987-10-01 00:00:00

abstract：:Severe pituitary Cushing's disease of sudden onset after 18 years of unsuccessful treatment for a previously non-functioning chromophobe adenoma is described in a middle-aged woman. Initial presentation with symptoms of optic nerve compression had been preceded by two years of amenorrhoea. Transfrontal resection of a ...

journal_title：Clinical endocrinology

authors： Vaughan NJ,Laroche CM,Goodman I,Davies MJ,Jenkins JS

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:With increasing use of computed tomography and magnetic resonance imaging, pituitary adenomas are being discovered incidentally with increasing frequency. However, limited data are available concerning the clinical importance and natural history of such 'incicentalomas'. We have undertaken a prospective study...

journal_title：Clinical endocrinology

authors： Feldkamp J,Santen R,Harms E,Aulich A,Mödder U,Scherbaum WA

更新日期：1999-07-01 00:00:00

abstract：:There is evidence that the porcine TSH receptor contains essential disulphide bridge(s) which can be disrupted by dithiothreitol (DTT). The aim of the present study was to determine whether exposure of intact thyroid cells to DTT leads to altered thyroid stimulation. TSH-stimulated iodine organification in cultured po...

journal_title：Clinical endocrinology

authors： Ginsberg J,Rafter DJ,von Westarp C,Murray PG

更新日期：1987-04-01 00:00:00

abstract：INTRODUCTION:Guidelines do not currently recommend routine systematic hormonal screening for pheochromocytoma (PHEO) in all/normotensive patients with neurofibromatosis type 1 (NF1), in contrast to other PHEO-predisposing genetic syndromes such as Von Hippel-Lindau syndrome and multiple endocrine neoplasia type 2. OBJ...

journal_title：Clinical endocrinology

authors： Moramarco J,El Ghorayeb N,Dumas N,Nolet S,Boulanger L,Burnichon N,Lacroix A,Elhaffaf Z,Gimenez Roqueplo AP,Hamet P,Bourdeau I

更新日期：2017-03-01 00:00:00

abstract：:Measurements of circulating thyroglobulin (hTg) and 131I whole body scan were performed in 101 patients with differentiated thyroid carcinoma who had been subjected to surgical thyroidectomy and 131I ablation of remaining thyroid tissue. All 45 patients with positive scans (i.e. functioning metastases) had elevated hT...

journal_title：Clinical endocrinology

authors： Pacini F,Pinchera A,Giani C,Grasso L,Baschieri L

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVE:Hypothalamic-pituitary-adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid ...

journal_title：Clinical endocrinology

authors： Stirrat LI,Walker JJ,Stryjakowska K,Jones N,Homer NZM,Andrew R,Norman JE,Lightman SL,Reynolds RM

更新日期：2018-04-01 00:00:00

abstract：OBJECTIVES:The Asp727Glu polymorphism in the TSH receptor (TSHR) gene is associated with serum TSH levels. However, the proportion of genetic variation accounted for by this polymorphism is unknown. In this study, we (1) examined the association of the Asp727Glu polymorphism with thyroid size, serum levels of TSH, thyr...

journal_title：Clinical endocrinology

authors： Hansen PS,van der Deure WM,Peeters RP,Iachine I,Fenger M,Sørensen TI,Kyvik KO,Visser TJ,Hegedüs L

更新日期：2007-06-01 00:00:00

abstract：OBJECTIVE:The development and progression of sporadic adrenocortical tumours are poorly understood. In autopsy studies adrenocortical tumours are found in between 2 and 9% of the general population. In congenital adrenal hyperplasia (CAH), decreased production of cortisol leads to increased secretion of ACTH from the p...

journal_title：Clinical endocrinology

authors： Kjellman M,Holst M,Bäckdahl M,Larsson C,Farnebo LO,Wedell A

更新日期：1999-03-01 00:00:00

abstract：:Five patients with Bloom's syndrome aged from 2 8/12 to 27 years, all of whom had hypogonadism, were subjected to an i.v. LHRH test and two of them to an i.m. HCG test. There was increased responsiveness of plasma LH and FSH, indicating that the hypogonadism is primary in nature and of early development. The tubular e...

journal_title：Clinical endocrinology

authors： Kauli R,Prager-lewin R,Kaufman H,Laron Z

更新日期：1977-04-01 00:00:00

abstract：:Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold diffe...

journal_title：Clinical endocrinology

authors： Andersen AN,Hertz J,Kjer JJ,Eskildsen PC,Larsen PS,Svenstrup B,Nielsen J,Arends J

更新日期：1980-08-01 00:00:00

abstract：OBJECTIVE:The purpose of the current study was to investigate the diagnostic performance of high mobility group A2 (HMGA2) gene expression for differentiation of malignant thyroid nodules through a systematic review and meta-analysis. DESIGN:The MEDLINE/PubMed and EMBASE database, from the earliest available date of i...

journal_title：Clinical endocrinology

authors： Kim BH,Kim SJ,Kim M,Lee SW,Jeong SY,Pak K,Kim K,Kim IJ

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Growth deficiency is commonly seen in polytransfused beta-thalassaemia patients, especially in adolescence. It is not completely dependent on the lack of their pubertal growth spurt. GH impairment at different levels (hypothalamic or pituitary) and/or a reduced IGF-1 synthesis have been suggested the main cau...

journal_title：Clinical endocrinology

authors： Cavallo L,Gurrado R,Gallo F,Zacchino C,De Mattia D,Tatò L

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVE:Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS:A mul...

journal_title：Clinical endocrinology

authors： Lemos MC,Gomes L,Bastos M,Leite V,Limbert E,Carvalho D,Bacelar C,Monteiro M,Fonseca F,Agapito A,Castro JJ,Regateiro FJ,Carvalheiro M

更新日期：2006-10-01 00:00:00

abstract：:Patients with Congenital adrenal hyperplasia due to partial deficiency in the enzyme 21-hydroxylase can present in childhood or adolescence with signs of adrenal androgen excess. Strategies to reduce the impact of androgen excess in females include cosmetic measures as well as antiandrogens and agents such as the comb...

journal_title：Clinical endocrinology

authors： Matthews D,Cheetham T

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH stimulation tests and assays of spontaneous GH secretion as predictors of change in height standard deviation score at the end of GH treatment in children with short stature. PATIENTS AND METHODS:We retrospectively studied 116 children (67 boys and 49 girls) with subnorm...

journal_title：Clinical endocrinology

authors： Radetti G,Buzi F,Cassar W,Paganini C,Stacul E,Maghnie M

更新日期：2003-07-01 00:00:00

abstract：OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN...

journal_title：Clinical endocrinology

authors： Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

更新日期：2017-01-01 00:00:00

abstract：OBJECTIVE:The interferon-induced helicase C domain-containing protein 1 (IFIH1) gene encodes a sensor for double-stranded RNA that initiates antiviral activity against enteroviruses. Previous investigations have indicated a role for IFIH1 in autoimmunity, as common and rare polymorphisms in this gene have been associat...

journal_title：Clinical endocrinology

authors： Zurawek M,Fichna M,Januszkiewicz D,Fichna P,Nowak J

更新日期：2013-02-01 00:00:00