当前位置： SCI文献检索 > CLINICAL ENDOCRINOLOGY期刊下所有文献 > Effects of increasing levothyroxine on pregnancy outcomes in women with uncontrolled hypothyroidism.

Effects of increasing levothyroxine on pregnancy outcomes in women with uncontrolled hypothyroidism.

Abstract：

OBJECTIVE:Uncontrolled hypothyroidism has been associated with an increased risk of adverse pregnancy outcomes. We aimed to assess the effectiveness of increasing levothyroxine (LT4) dose on reducing the risk of adverse outcomes for pregnant women with TSH level greater than the recommended 1st trimester limit. DESIGN, PATIENTS, MEASUREMENTS:We reviewed the electronic medical records of pregnant women evaluated from January 2011 to December 2013, who had history of LT4-treated hypothyroidism and were found to have TSH > 2·5 mIU/l in 1st trimester. Women were divided into two groups: group A - LT4 dose was increased within two weeks from the TSH test, group B - LT4 dose remained stable. We compared the frequency of pregnancy loss (primary outcome) and other prespecified pregnancy-related adverse outcomes between groups. RESULTS:There were 85 women in group A (median TSH: 5·0, interquartile range 3·8-6·8 mIU/l) and 11 women in group B (median TSH: 4·5, interquartile range 3·2-4·9 mIU/l). The groups were not different in baseline clinical and socioeconomic characteristics. The mean interval between TSH test and LT4 dose increase was 4·5 (SD 4·6) days. Pregnancy loss was significantly lower in group A (2/85, 2·4%) vs group B (4/11, 36·4%) (P = 0·001). Other pregnancy-related adverse outcomes were similar between groups. CONCLUSIONS:Increasing LT4 dose for women with uncontrolled hypothyroidism in the 1st trimester of pregnancy was associated with a decreased risk of pregnancy loss. Given the limitations of our study, this association awaits further confirmation from larger studies.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Maraka S,Singh Ospina NM,O'Keeffe DT,Rodriguez-Gutierrez R,Espinosa De Ycaza AE,Wi CI,Juhn YJ,Coddington CC 3rd,Montori VM

doi

10.1111/cen.13168

subject

Has Abstract

pub_date

2017-01-01 00:00:00

pages

150-155

issue

1

eissn

0300-0664

issn

1365-2265

journal_volume

86

pub_type

杂志文章

相关文献

CLINICAL ENDOCRINOLOGY文献大全
  • Pegvisomant-primed GH stimulation test.

    abstract：OBJECTIVE:Provocative stimulation tests for GH assessment have poor reproducibility and can often elicit false positive results in normal children. The aim of our study was to evaluate the capability of pegvisomant, as an enhancer of GH secretion, in unmasking false-positive results in short children undergoing GH test...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2007.03132.x

    authors： Radetti G,Wu Z,Elsedfy HH,El Kholy M,Bozzola M,Strasburger CJ

    更新日期：2008-06-01 00:00:00

  • Resting and exercise energy use in Antarctica: effect of 50% restriction in temperate climate energy requirements.

    abstract：OBJECTIVE:To determine the impact of energy restriction (ER) upon the previously reported increased resting and exercise-related oxygen utilization, reduced body temperature, increased serum TSH, and reduced serum free T3 concentrations found during Antarctic residence (AR). DESIGN:Prospective, intervention with both ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2006.02588.x

    authors： Case HS,Reed HL,Palinkas LA,Reedy KR,Van Do N,Finney NS,Seip R

    更新日期：2006-08-01 00:00:00

  • Cortisol metabolism, postnatal depression and weight changes in the first 12 months postpartum.

    abstract：BACKGROUND & OBJECTIVES:Postnatal depression correlates with postpartum weight retention, and dysregulated cortisol metabolism is evident in depressed individuals. Cortisol metabolism, BMI and metabolic phenotype are robustly associated, but the role of cortisol metabolism in postnatal mental health and weight loss has...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.13150

    authors： Rogers SL,Hughes BA,Tomlinson JW,Blissett J

    更新日期：2016-12-01 00:00:00

  • The effect of oral glucose on the leucocyte sodium pump in normal and obese subjects.

    abstract：:The effect of oral glucose (40 g/m2 body surface area) on the leucocyte 22Na efflux rate constants (ERC) was studied in 13 normal weight and 10 obese subjects. The ouabain-sensitive 22Na ERC was higher in leucocytes isolated from fasting obese subjects (median [range] for obese 2.77 [2.33-3.11] vs normals 1.91 [1.57-2...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1987.tb01161.x

    authors： Ng LL,Hockaday TD

    更新日期：1987-09-01 00:00:00

  • MicroRNA signature in massive macronodular adrenocortical disease and implications for adrenocortical tumourigenesis.

    abstract：PURPOSE:Massive macronodular adrenocortical disease (MMAD) may be caused by aberrant microRNA expression. To determine the microRNA profile in MMAD and identify putative microRNA-gene target pairs involved in adrenal tumourigenesis. EXPERIMENTAL DESIGN:We performed microRNA microarray analysis in 10 patients with ACTH...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2009.03725.x

    authors： Bimpaki EI,Iliopoulos D,Moraitis A,Stratakis CA

    更新日期：2010-06-01 00:00:00

  • Growth hormone administration stimulates energy expenditure and extrathyroidal conversion of thyroxine to triiodothyronine in a dose-dependent manner and suppresses circadian thyrotrophin levels: studies in GH-deficient adults.

    abstract：OBJECTIVE:The impact of exogenous GH on thyroid function remains controversial although most data add support to a stimulation of peripheral T4 to T3 conversion. For further elucidation we evaluated iodothyronine and circadian TSH levels in GH-deficient patients as part of a GH dose-response study. PATIENTS:Eight GH-d...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1994.tb01826.x

    authors： Jørgensen JO,Møller J,Laursen T,Orskov H,Christiansen JS,Weeke J

    更新日期：1994-11-01 00:00:00

  • Decreased sex hormone binding globulin (SHBG) and insulin-like growth factor binding protein (IGFBP-1) in extreme obesity.

    abstract：:Obesity may be characterized by abnormal sex steroid secretion and reduced sex hormone binding globulin (SHBG) which in turn is related to fat distribution and insulin secretion. Recent in-vitro and in-vivo evidence suggests that insulin is the common mechanism regulating the secretion of SHBG and insulin-like growth ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1990.tb00507.x

    authors： Weaver JU,Holly JM,Kopelman PG,Noonan K,Giadom CG,White N,Virdee S,Wass JA

    更新日期：1990-09-01 00:00:00

  • Central cervical lymph node metastases in papillary thyroid cancer: a systematic review of imaging-guided and prophylactic removal of the central compartment.

    abstract：BACKGROUND:Papillary thyroid cancer (PTC) is a common endocrine cancer and commonly presents with lymph node (LN) metastases. The role of surgical removal of the central cervical LN compartment is poorly defined. There are no prospective randomized controlled trials addressing the relevance to the extent of the initial...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,meta分析,评审

    doi：10.1111/j.1365-2265.2011.04162.x

    authors： Mulla M,Schulte KM

    更新日期：2012-01-01 00:00:00

  • Novel melanocortin 4 receptor gene mutations in severely obese children.

    abstract：OBJECTIVE:Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. The significance of MC4R mutations in Asian obese populations has not been adequately examined. The objective of this study was to determine the role of MC4R mutations in severely obese Asian children. DESIGN:We screened 22...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2007.03071.x

    authors： Lee YS,Poh LK,Kek BL,Loke KY

    更新日期：2008-04-01 00:00:00

  • Clinical features and genetic analysis of four Brazilian kindreds with resistance to thyroid hormone.

    abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of reduced tissue responsiveness to thyroid hormone usually due to mutations located in the ligand-binding domain and adjacent hinge region of the thyroid hormone receptor beta (TRbeta). In the present report we describe the clinical and l...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2007.02956.x

    authors： Magalhães PK,Rodrigues Dare GL,Rodrigues Dos Santos S,Nogueira CR,de Castro M,Zanini Maciel LM

    更新日期：2007-11-01 00:00:00

  • Clinical and biochemical effects of incremental doses of the long-acting somatostatin analogue SMS 201-995 in ten acromegalic patients.

    abstract：:Ten patients (seven women, three men) with active acromegaly, five previously treated and five newly diagnosed, were included in an open-label prospective trial of 3 daily subcutaneous injections of the long-acting somatostatin analogue SMS 201-995 (Sandostatin) at increasing doses in order to obtain maximum growth ho...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1990.tb00916.x

    authors： Shi YF,Harris AG,Zhu XF,Deng JY

    更新日期：1990-06-01 00:00:00

  • Thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues.

    abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2265.1997.3371118.x

    authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

    更新日期：1997-11-01 00:00:00

  • Fasting plasma free fatty acid concentrations and Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma2 gene in healthy individuals.

    abstract：BACKGROUND:The Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR) gamma gene has been associated in some, but not all, studies with lower body mass index (BMI) and improved insulin sensitivity; how an altered transcriptional activity of PPARgamma2 could influence insulin sensitivity is curre...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.2002.01618.x

    authors： Vaccaro O,Mancini FP,Ruffa G,Sabatino L,Iovine C,Masulli M,Colantuoni V,Riccardi G

    更新日期：2002-10-01 00:00:00

  • The geographical distribution of thyrotoxicosis in England according to the presence or absence of TSH-receptor antibodies.

    abstract：:In a prospective study of the incidence of thyrotoxicosis sera from 216 thyrotoxic patients in seven English towns were assayed for TSH-receptor antibodies. The incidence of antibody negative thyrotoxicosis correlated closely with the previous prevalence of endemic goitre in the towns (r = 0.9) indicating a high curre...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1985.tb00225.x

    authors： Phillips DI,Barker DJ,Rees Smith B,Didcote S,Morgan D

    更新日期：1985-09-01 00:00:00

  • Rethinking antithyroid drugs in pregnancy.

    abstract：:Uncontrolled hyperthyroidism in pregnancy poses a risk to both mother and foetus, and the optimal treatment strategy in this setting remains elusive. Instigation of pharmacological therapy or an alternative intervention during pregnancy requires careful consideration, and the evidence that has underpinned our choice o...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/cen.12577

    authors： Napier C,Pearce SH

    更新日期：2015-04-01 00:00:00

  • Glycoprotein hormone alpha-subunit and prolactin release by cultured pituitary adenoma cells from acromegalic patients: correlation with GH release.

    abstract：:In-vitro data of pituitary adenoma cells from 28 acromegalic patients were evaluated. In addition to GH, PRL was produced by 16 adenomas (57%) and alpha-subunit by 15 adenomas (54%) while there was a significantly higher incidence of tumours producing PRL and alpha-subunit simultaneously. From 26 pituitary adenomas en...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1989.tb00264.x

    authors： Hofland LJ,van Koetsveld PM,Verleun TM,Lamberts SW

    更新日期：1989-06-01 00:00:00

  • Identification and management of poor response to growth-promoting therapy in children with short stature.

    abstract：:Growth hormone (GH) is widely prescribed for children with short stature across a range of growth disorders. Recombinant human (rh) insulin-like growth factor-1 (rhIGF-1) therapy is approved for severe primary IGF-I deficiency - a state of severe GH resistance. Evidence is increasing for an unacceptably high rate of p...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1365-2265.2012.04420.x

    authors： Bang P,Ahmed SF,Argente J,Backeljauw P,Bettendorf M,Bona G,Coutant R,Rosenfeld RG,Walenkamp MJ,Savage MO

    更新日期：2012-08-01 00:00:00

  • Insulin treatment normalizes reduced free insulin-like growth factor-I concentrations in diabetic children.

    abstract：OBJECTIVE:We have recently demonstrated multiple aberrations in the GH-IGF axis in the sera of children with untreated insulin-dependent diabetes mellitus (IDDM) which were restored after insulin replacement. However, the net result of these alterations in the IGF system on the concentrations of free/biologically avail...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1996.7760786.x

    authors： Bereket A,Lang CH,Blethen SL,Ng LC,Wilson TA

    更新日期：1996-09-01 00:00:00

  • A new less-invasive and more informative low-dose ACTH test: salivary steroids in response to intramuscular corticotrophin.

    abstract：OBJECTIVE:The intravenous low-dose ACTH test has been proposed as a sensitive tool to assess adrenal function through circulating steroids. The aims of this study were to: (a) find the minimal intramuscular ACTH dose that induced serum and salivary cortisol and aldosterone responses equivalent to those obtained after a...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2004.02144.x

    authors： Contreras LN,Arregger AL,Persi GG,Gonzalez NS,Cardoso EM

    更新日期：2004-12-01 00:00:00

  • Maternal hypothyroxinemia and effects on cognitive functioning in childhood: how and why?

    abstract：:Exposure to maternal hypothyroxinemia during pregnancy, which is characterized by low free T4 but normal thyroid-stimulating hormone (TSH) levels, can negatively affect the foetus. This review provides an overview of present findings concerning the association between maternal hypothyroxinemia during pregnancy and chi...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章,评审

    doi：10.1111/cen.12227

    authors： Henrichs J,Ghassabian A,Peeters RP,Tiemeier H

    更新日期：2013-08-01 00:00:00

  • Response of sex hormone binding globulin and insulin-like growth factor binding protein-1 to an oral glucose tolerance test in obese women with polycystic ovary syndrome before and after calorie restriction.

    abstract：OBJECTIVE:We determined the relationship of short-term changes in circulating insulin concentrations, resulting from an oral glucose load, to those in both sex hormone binding globulin (SHBG) and insulin-like growth factor binding protein 1 (IGFBP-1) and assessed the effect of a short-term low calorie diet on the level...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1993.tb02378.x

    authors： Hamilton-Fairley D,Kiddy D,Anyaoku V,Koistinen R,Seppälä M,Franks S

    更新日期：1993-09-01 00:00:00

  • 17 beta-oestradiol counteracts the formation of the more acidic isoforms of follicle-stimulating hormone and luteinizing hormone after menopause.

    abstract：OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.1994.tb02513.x

    authors： Wide L,Naessén T

    更新日期：1994-06-01 00:00:00

  • Associations between visceral adipose tissue, inflammation and sex steroid concentrations in men.

    abstract：CONTEXT:In men, obesity and the metabolic syndrome are accompanied by decreased testosterone levels, but little is known about the associations between visceral adipose tissue (VAT), VAT-related inflammation and sex steroids. OBJECTIVE:To examine the relative impact of VAT, abdominal subcutaneous adipose tissue (SAT) ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2012.04401.x

    authors： Gautier A,Bonnet F,Dubois S,Massart C,Grosheny C,Bachelot A,Aubé C,Balkau B,Ducluzeau PH

    更新日期：2013-03-01 00:00:00

  • Biochemical and hormonal changes induced by one week of administration of rIGF-I to patients with Laron type dwarfism.

    abstract：OBJECTIVE:The purpose of this investigation was to evaluate the effectiveness of short-term administration of recombinant biosynthetic IGF-I on patients with an hereditary inability to generate this hormone. DESIGN AND PATIENTS:Ten patients with Laron type dwarfism (LTD) (4 males, six females) aged 3 1/2 to 37 3/4 yea...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2265.1991.tb03513.x

    authors： Laron Z,Klinger B,Jensen LT,Erster B

    更新日期：1991-08-01 00:00:00

  • Changing trends in incidence and mortality of thyroid cancer in Scotland.

    abstract：OBJECTIVE:The incidence of thyroid cancer is increasing in several countries. The aim was to investigate trends in the incidence and mortality of thyroid cancer in Scotland, where thyroid cancer is relatively uncommon, between 1960 and 2002. DESIGN:Descriptive epidemiological study. METHODS:Thyroid cancer registratio...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2004.02187.x

    authors： Reynolds RM,Weir J,Stockton DL,Brewster DH,Sandeep TC,Strachan MW

    更新日期：2005-02-01 00:00:00

  • Circulating IGF-I levels are associated with increased biventricular contractility in top-level rowers.

    abstract：BACKGROUND:The intensive physical activity is often associated with cardiac changes. OBJECTIVES:(i) To evaluate the IGF-I system and myocardial structure and function by standard Doppler echocardiography and Tissue Doppler in athletes and sedentary controls; and (ii) to determine any relationship between IGF-I system ...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2008.03177.x

    authors： Vitale G,Galderisi M,Colao A,Innelli P,Guerra G,Guerra E,Dini FL,Orio F Jr,Soscia A,De Divitiis O,Lombardi G

    更新日期：2008-08-01 00:00:00

  • Thyroid function in short children born small-for-gestational age (SGA) before and during GH treatment.

    abstract：CONTEXT:Disturbances in thyroid function have been described in small-for-gestational age (SGA) children but the influence of prematurity is unclear. In addition, the effect of GH treatment on thyroid function has not been studied in short SGA children. OBJECTIVES:To determine whether short SGA children have higher TS...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2008.03195.x

    authors： de Kort SW,Willemsen RH,van der Kaay DC,van Dijk M,Visser TJ,Hokken-Koelega AC

    更新日期：2008-08-01 00:00:00

  • No association of the codon 55 methionine to valine polymorphism in the SUMO4 gene with Graves' disease.

    abstract：OBJECTIVE:A functional polymorphism at codon 55 of the small ubiquitin-like modifier-4 (SUMO4) gene (methionine to valine; M55V) has recently been associated with type 1 diabetes mellitus (T1D). We aimed to establish whether this locus also contributes towards the genetic susceptibility to Graves' disease (GD) and auto...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2265.2005.02224.x

    authors： Jennings CE,Owen CJ,Wilson V,Pearce SH

    更新日期：2005-03-01 00:00:00

  • A longitudinal study on bone mineral density until adulthood in girls with Turner's syndrome participating in a growth hormone injection frequency-response trial.

    abstract：OBJECTIVE:The aim of this study was to assess the volumetric bone mineral density (BMD) in girls with Turner's syndrome (TS) before and during growth hormone (GH) treatment in combination with low dose oestrogens as well as three years after discontinuation of GH treatment. DESIGN:In a prospective, randomized injectio...

    journal_title：Clinical endocrinology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1046/j.1365-2265.2000.00963.x

    authors： Sass TC,De Muinck Keizer-Schrama SM,Stijnen T,Asarfi A,Van Leeuwen WJ,Van Teunenbroek A,Van Rijn RR,Drop SL

    更新日期：2000-05-01 00:00:00

  • Thyroid dysfunction in patients with amyloid goitre.

    abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

    journal_title：Clinical endocrinology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2265.1997.1841000.x

    authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

    更新日期：1997-06-01 00:00:00