Identification and management of poor response to growth-promoting therapy in children with short stature.

abstract：:The opiate control of the pituitary-adrenal axis has been investigated in normal subjects. The infusion of 1 mg of the met-enkephalin analogue, DAMME, led to a fall in circulating cortisol in spite of a fall in blood pressure. Conversley, 16 mg of the opiate antagonist, naloxone led to brisk and pronounced elevations ...

journal_title：Clinical endocrinology

authors： Grossman A,Gaillard RC,McCartney P,Rees LH,Besser GM

更新日期：1982-09-01 00:00:00

abstract：:We describe here two patients with hypothyroidism due to pituitary-hypothalamic disease in whom basal thyrotrophin (TSH) levels measured by radioimmunoassay (RIA) were elevated yet when measured by a cytochemical bioassay (CBA) were found to be normal. This finding and the absence of the normal rise of thyroid hormone...

journal_title：Clinical endocrinology

authors： Petersen VB,McGregor AM,Belchetz PE,Elkeles RS,Hall R

更新日期：1978-05-01 00:00:00

abstract：:An LHRH test was performed on twenty-eight regularly menstruating females during follicular phase of their cycles. Twenty-four were then given an intramuscular injection of progesterone in oil and retested with LHRH 20 or 44 h later, the remaining four received no pretreatment and acted as controls. The twelve subject...

journal_title：Clinical endocrinology

authors： Shaw RW,Butt WR,London DR

更新日期：1975-09-01 00:00:00

abstract：OBJECTIVE:Therapy with GHRH in patients with mild GH insufficiency appears to be more effective than in those with severe insufficiency. We, therefore, studied the clinical response of children with idiopathic short stature to treatment with GHRH(1-29)NH2 (GHRHa) for a period of 12 months. DESIGN:Eighteen short pre-pu...

journal_title：Clinical endocrinology

authors： Kirk JM,Trainer PJ,Majrowski WH,Murphy J,Savage MO,Besser GM

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:Genotype and phenotype heterogeneity in patients with GH insensitivity syndrome suggests that partial defects exist in the GH receptor. Children with partial GH resistance would be expected to have short stature, elevated GH levels and relatively low levels of IGF-I and IGFBP-3. Provocation tests of the GH-IG...

journal_title：Clinical endocrinology

authors： Cotterill AM,Camacho-Hübner C,Duquesnoy P,Savage MO

更新日期：1998-06-01 00:00:00

abstract：OBJECTIVE:This study was designed in order to evaluate bone turnover with bone formation and resorption markers in hyperthyroidism and its possible relationship with serum cytokines interleukin 6 (IL-6) and tumour necrosis-alpha (TNF-alpha), levels of thyroid hormones and thyroid autoantibodies. DESIGN AND PATIENTS:Tw...

journal_title：Clinical endocrinology

authors： Akalin A,Colak O,Alatas O,Efe B

更新日期：2002-07-01 00:00:00

abstract：BACKGROUND:Whether subclinical hypothyroidism adversely impacts pregnancy outcomes is inconclusive, and limited data are available on the optimal TSH range in women planning pregnancy. OBJECTIVE:To investigate the association between maternal preconception TSH levels and pregnancy outcomes. DESIGN:Population-based co...

journal_title：Clinical endocrinology

authors： Chen S,Zhou X,Zhu H,Yang H,Gong F,Wang L,Zhang M,Jiang Y,Yan C,Li J,Wang Q,Zhang S,Pan H

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Our clinical practice has been to offer treatment with cyclical disodium etidronate and high dose calcium supplements (1500-1600 mg/day) to all female patients with osteoporosis who are unable or unwilling to take hormone replacement therapy (HRT), and male osteoporotics. In a retrospective study we compared ...

journal_title：Clinical endocrinology

authors： Orme SM,Simpson M,Stewart SP,Oldroyd B,Westmacott CF,Smith MA,Belchetz PE

更新日期：1994-08-01 00:00:00

abstract：OBJECTIVE:We have investigated plasma potassium changes during insulin-induced hypoglycaemia (IIH) in adult patients with growth hormone deficiency (GHD) who have low total body potassium and may also have a vulnerable myocardium due to an increased prevalence of atherosclerosis. DESIGN:Hypoglycaemia was induced throu...

journal_title：Clinical endocrinology

authors： Davies JS,Hinds NP,Millward EM,McDowell I,Scanlon MF

更新日期：1998-08-01 00:00:00

abstract：:We have investigated the role of endogenous opioid peptides in the release of oxytocin (OT) in response to breast feeding and breast stimulation in humans. Five breast feeding women were studied on two separate occasions within 4 weeks of delivery. Saline or naloxone, 4 mg bolus and 6 mg/h, was administered intravenou...

journal_title：Clinical endocrinology

authors： Johnson MR,Andrews MA,Seckl JR,Lightman SL

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVE:A new protocol for postoperative calcium management was developed with the aim of achieving an increase in the proportion of patients being safely discharged on the first postoperative day. We present our experience with the first 50 patients treated under this new protocol. PATIENTS AND DESIGN:A cohort stud...

journal_title：Clinical endocrinology

authors： Grodski S,Lundgren CI,Sidhu S,Sywak M,Delbridge L

更新日期：2009-02-01 00:00:00

abstract：:A modified short ACTH test for the detection of heterozygote carriers of 21-hydroxylase deficiency (21-OHD) was applied to twenty-one controls and fourteen parents of children with 21-OHD. The following modifications were introduced: (1) Endogenous ACTH was suppressed by dexamethasone administration prior to the test,...

journal_title：Clinical endocrinology

authors： Lejeune-Lenain C,Cantraine F,Dufrasnes M,Prevot F,Wolter R,Franckson JR

更新日期：1980-06-01 00:00:00

abstract：:A A 23-year-old man with secondary hypogonadism was also found to be thyrotoxic. Results of thyroid function tests were in the hyperthyroid range but the serum TSH was inappropriately high. A pituitary tumour was demonstrated and following hypophysectomy he became biochemically hypothyroid. Evidence is presented and d...

journal_title：Clinical endocrinology

authors： Baylis PH

更新日期：1976-03-01 00:00:00

abstract：:Raised activity of the LH axis caused by activating mutations of LH receptor gene presents with precocious puberty in boys, analogous to the presentation of LH secreting pituitary adenomas (Faggiano et al., 1983; Ambrosi et al., 1990). LH "hyperactivity' in females appears to have no effect. Hyperactivity of the FSH a...

journal_title：Clinical endocrinology

authors： Conway GS

更新日期：1996-12-01 00:00:00

abstract：OBJECTIVE:The aim of this investigation was to assess the insulin cleavage capacity in obese humans. Increased insulin degradation by visceral adipose tissue has previously been demonstrated in obese rats and could be interpreted as a physiological response to hyperinsulinaemia. The recent characterization of leptin re...

journal_title：Clinical endocrinology

authors： Cuatrecasas G,Granada ML,Formiguera X,Rull M,Alastrué A,Remesar X,Alemany M,Foz M

更新日期：1998-02-01 00:00:00

abstract：CONTEXT:Two main forms of amiodarone-induced thyrotoxicosis (AIT) exist. Type 1 AIT is a form of iodine-induced hyperthyroidism. Its management is complex and includes thionamides, potassium perchlorate and, occasionally, thyroidectomy. Type 2 AIT is a destructive thyroiditis, responds to glucocorticoids, and usually d...

journal_title：Clinical endocrinology

authors： Bogazzi F,Bartalena L,Dell'Unto E,Tomisti L,Rossi G,Pepe P,Tanda ML,Grasso L,Macchia E,Aghini-Lombardi F,Pinchera A,Martino E

更新日期：2007-10-01 00:00:00

abstract：:It has been suggested that abnormalities of thirst and vasopressin secretion commonly coexist with Kallmann's syndrome. Out-patient plasma osmolality, plasma sodium and 24-hour urine volume were similar in 10 patients with Kallmann's syndrome and 10 matched controls. Six patients underwent dynamic testing of osmoregul...

journal_title：Clinical endocrinology

authors： Thompson CJ,White MC,Baylis PH

更新日期：1989-05-01 00:00:00

abstract：:Serum prolactin concentrations were measured in nine untreated hypothyroid infants and 23 euthyroid controls. In the former group the serum prolactin concentrations were tenfold higher than the controls (352 vs 34 micrograms/l), declining gradually upon treatment. Although serum prolactin concentrations can be mildly ...

journal_title：Clinical endocrinology

authors： McCormick KL

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:The relationship of quantitative GH secretion to height, growth velocity and puberty is complex and has been the subject of extensive study in children. This study was designed to relate quantitative GH secretion to final height. SUBJECTS:Twenty tall (> 183 cm, 90th centile for adult height) and 20 short (< ...

journal_title：Clinical endocrinology

authors： Trainer PJ,Palermo M,Kirk JM,Fanciulli G,Perry LH,Delitala G,Besser GM

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:To elucidate the interaction between insulin and dehydroepi-androsterone (DHEA) concentrations, we evaluated serum DHEA and DHEA-sulphate (DHEA-S) levels in diabetic patients with hyperinsulinaemia. PATIENTS AND DESIGN:Twenty-four subjects with non-insulin dependent diabetes mellitus, 12 hyperinsulinaemic su...

journal_title：Clinical endocrinology

authors： Yamaguchi Y,Tanaka S,Yamakawa T,Kimura M,Ukawa K,Yamada Y,Ishihara M,Sekihara H

更新日期：1998-09-01 00:00:00

abstract：OBJECTIVE:We compared IGF-1 and IGFBP3 concentrations in a group of adults treated for brain tumours in childhood with those of matched controls, and investigated the relationship between the GH secretory pattern and IGF-1/IGFBP3 concentrations in the entire group. DESIGN:We performed 24 h serum GH profiles using 20 m...

journal_title：Clinical endocrinology

authors： Achermann JC,Hindmarsh PC,Brook CG

更新日期：1998-11-01 00:00:00

abstract：OBJECTIVE:The newly discovered vasoactive peptides, endothelin 1, 2 and 3, and their receptors are widely distributed in various non-vascular tissues. Recent studies have suggested the presence, as well as possible regulatory roles, of endothelins at several levels of the pituitary-gonadal axis. We determined the level...

journal_title：Clinical endocrinology

authors： Hammami MM,Haq A,AlSedairy S

更新日期：1994-03-01 00:00:00

abstract：OBJECTIVE:The effects of thiazide medication in patients with primary hyperparathyroidism (PHPT) have so far not been elucidated. The aim of this study was to analyse the extent to which the administration of thiazides may influence biochemical parameters and therefore the diagnosis of PHPT in a large cohort of patient...

journal_title：Clinical endocrinology

authors： Riss P,Kammer M,Selberherr A,Bichler C,Kaderli R,Scheuba C,Niederle B

更新日期：2016-08-01 00:00:00

abstract：BACKGROUND:GH may be beneficial in treating patients with end-stage renal disease (ESRD). However, the efficacy and safety of GH could be compromised by the potential for accumulation in the circulation. OBJECTIVE:The objective was to investigate the pharmacokinetics and safety of GH treatment in ESRD patients. DESIG...

journal_title：Clinical endocrinology

authors： Langbakke IH,Nielsen JN,Skettrup MP,Harper A,Klitgaard T,Weil A,Engelhardt E,Lange M

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:To study circulating adiponectin concentrations in relation to diabetes duration and endogenous insulin secretion in patients with type 1 diabetes. PATIENTS:Patients with haemoglobin A1c (HbA1c) < 6% (reference range 3.6-5.4%) were selected for the study. Twenty-two men and 24 women [age 41.3 +/- 13.8 years ...

journal_title：Clinical endocrinology

authors： Lindström T,Frystyk J,Hedman CA,Flyvbjerg A,Arnqvist HJ

更新日期：2006-12-01 00:00:00

abstract：BACKGROUND:Hospital-acquired hyponatraemia is a common and potentially serious condition. Risk factors for hospital-acquired hyponatraemia have not been studied in a controlled fashion. Methods From 1501 patients in whom serum sodium (S(Na)) was determined, 50 cases with hospital-acquired hyponatraemia (in-hospital dec...

journal_title：Clinical endocrinology

authors： Beukhof CM,Hoorn EJ,Lindemans J,Zietse R

更新日期：2007-03-01 00:00:00

abstract：CONTEXT:The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts. OBJECTIVE:To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel. DESIGN:A population-based coh...

journal_title：Clinical endocrinology

authors： Libruder C,Blumenfeld O,Dichtiar R,Laron Z,Zadik Z,Shohat T,Afek A

更新日期：2016-11-01 00:00:00

abstract：OBJECTIVE:Calcium absorption is an important determinant of calcium retention and bone metabolism. However, most methods of measuring calcium absorption, including the well-established dual stable isotope method, are costly and cumbersome to implement. We evaluated whether an oral calcium tolerance test (OCTT), which i...

journal_title：Clinical endocrinology

authors： Ceglia L,Abrams SA,Harris SS,Rasmussen HM,Dallal GE,Dawson-Hughes B

更新日期：2010-01-01 00:00:00

abstract：INTRODUCTION:The present clinical investigation uses a high-precision GH immunofluorometric assay to examine the postulate that principally the amplitude mode of GH secretory control is disrupted in adults with GH deficiency. PATIENTS AND METHODS:To this end, we investigated GH secretory dynamics in a cohort of 19 adu...

journal_title：Clinical endocrinology

authors： Roelfsema F,Biermasz NR,Veldhuis JD

更新日期：2002-01-01 00:00:00

abstract：:The age-dependent decline of the gonadal and somatotopic axis has been causally linked to frailty in the elderly by their effects on muscle mass and bone mineral density. However, for healthy men data on serum oestrogens and androgens, as well as IGF-1, as a common outcome measure covering the whole adult age range ar...

journal_title：Clinical endocrinology

authors： Leifke E,Gorenoi V,Wichers C,Von Zur Mühlen A,Von Büren E,Brabant G

更新日期：2000-12-01 00:00:00