Reduced serum dehydroepiandrosterone levels in diabetic patients with hyperinsulinaemia.

abstract：:Twenty women with secondary hypogonadism and four normal women in the early follicular phase of the cycle were treated for 7 days with 10, 50 or 100 micrograms synthetic LHRH administered intramuscularly at 4 h intervals. Concentrations of pituitary and ovarian hormones in plasma were measured at intervals during the ...

journal_title：Clinical endocrinology

authors： Vaughan Williams CA,McNeilly AS,Baird DT

更新日期：1983-07-01 00:00:00

abstract：OBJECTIVE:Results from studies on the effect of glucocorticosteroids on protein turnover in both rat and man have been conflicting. The aim of this study was to investigate the primary cause of muscle wasting in patients with Cushing's syndrome. DESIGN:Studies of whole body 1(-14)C-leucine turnover in patients with Cu...

journal_title：Clinical endocrinology

authors： Bowes SB,Benn JJ,Scobie IN,Umpleby AM,Lowy C,Sönksen PH

更新日期：1993-11-01 00:00:00

abstract：:Malignant insulinomas are very rare endocrine tumours with a variable clinical course. We describe a 51-year-old man who had two large insulinomas resected from the body of the pancreas and 19 years later, having again become symptomatic, was found to have hepatic metastases. Medical treatment with diazoxide and octre...

journal_title：Clinical endocrinology

authors： Scott A,Hinwood D,Donnelly R

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:TSH suppression therapy has been reported to be effective in some cases of papillary carcinoma of the thyroid. However, there has been little information regarding the status of expression of TSH-R mRNA in papillary carcinomas. Therefore, we examined the expression of TSH receptor (TSH-R) mRNA in thyroid tumo...

journal_title：Clinical endocrinology

authors： Tanaka K,Inoue H,Miki H,Komaki K,Monden Y

更新日期：1996-03-01 00:00:00

abstract：:A new radioreceptor assay for insulin-like growth factor-II (IGF-II), using receptors on ovine placental membranes, is described. Half-maximal displacement of specifically bound radioiodinated human IGF-II tracer was seen at 1.0 ng/tube of unlabelled IGF-II. The cross-reactivity of IGF-I was 1%, and insulin was entire...

journal_title：Clinical endocrinology

authors： Baxter RC,de Mellow JS

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:Controversial data on ghrelin concentration during exercise in human subjects have been published. We tested the hypothesis that exercise could affect acylated ghrelin (AG) and unacylated ghrelin (UAG), which could partly explain the previously reported inconsistent findings on the association of exercise wit...

journal_title：Clinical endocrinology

authors： Kim HJ,Lee S,Kim TW,Kim HH,Jeon TY,Yoon YS,Oh SW,Kwak H,Lee JG

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:When the gonadotrophin levels increase at midcycle, more basic isoforms of FSH and LH appear in the circulation. However, when these gonadotrophins increase at menopause more acidic forms appear. The present study was done to see whether chronic 17 beta-oestradiol (E2) administration to post-menopausal women ...

journal_title：Clinical endocrinology

authors： Wide L,Naessén T

更新日期：1994-06-01 00:00:00

abstract：:Vasoactive intestinal peptide (VIP) is a highly basic 28 amino-acid peptide which was first isolated from porcine small intestine (Said & Mutt, 1970). It is related to several other peptides including PHI (peptide with N-terminal histidine and C-terminal isoleucine amide), secretin, glucagon, and has some sequences si...

journal_title：Clinical endocrinology

authors： Prysor-Jones RA,Jenkins JS

更新日期：1988-12-01 00:00:00

abstract：BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Charmandari E

更新日期：2015-04-01 00:00:00

abstract：:A receptor assay for TSH receptor antibodies is described in which unextracted serum, detergent solubilised TSH receptors and 125I-labelled TSH are used. The assay was rapid and reproducible with coefficients of inter-assay variation of 12.3%, 2.1 and 2.6% at mean inhibition of TSH binding values of 11, 53, and 79 res...

journal_title：Clinical endocrinology

authors： Southgate K,Creagh F,Teece M,Kingswood C,Rees Smith B

更新日期：1984-05-01 00:00:00

abstract：OBJECTIVE:Recent studies have shown that a relatively high number of diabetic patients may have unsuspected Cushing's syndrome (CS). The aim of the present study was to screen for CS in adult patients with newly diagnosed diabetes mellitus who were not selected for clinical characteristics, such as poor control and obe...

journal_title：Clinical endocrinology

authors： Reimondo G,Pia A,Allasino B,Tassone F,Bovio S,Borretta G,Angeli A,Terzolo M

更新日期：2007-08-01 00:00:00

abstract：:We have investigated the role of endogenous opioid peptides in the release of oxytocin (OT) in response to breast feeding and breast stimulation in humans. Five breast feeding women were studied on two separate occasions within 4 weeks of delivery. Saline or naloxone, 4 mg bolus and 6 mg/h, was administered intravenou...

journal_title：Clinical endocrinology

authors： Johnson MR,Andrews MA,Seckl JR,Lightman SL

更新日期：1990-07-01 00:00:00

abstract：OBJECTIVES:Widespread amyloid deposition in the thyroid gland causes diffuse, clinically apparent enlargement of the thyroid (amyloid goitre: AG). The aim of this study was to clarify the abnormalities of thyroid function in patients with AG. DESIGN:Thirty patients with secondary amyloidosis were retrospectively analy...

journal_title：Clinical endocrinology

authors： Kimura H,Yamashita S,Ashizawa K,Yokoyama N,Nagataki S

更新日期：1997-06-01 00:00:00

abstract：OBJECTIVES:Patients with type 1 diabetes are at increased risk of cardiovascular disease, which may be related to abnormal lipid metabolism. Secretion and clearance of VLDL apolipoprotein B100 (apoB) are important determinants of plasma lipid concentrations and are known to be influenced by hormones, including insulin ...

journal_title：Clinical endocrinology

authors： Christ ER,Carroll PV,Albany E,Umpleby AM,Lumb PJ,Wierzbicki AS,Simpson HL,Sönksen PH,Russell-Ones DL

更新日期：2001-12-01 00:00:00

abstract：OBJECTIVE:The protein-tyrosine-phosphate nonreceptor 22 gene (PTPN22) has recently been identified as a susceptibility locus for a number of autoimmune diseases including Graves' disease (GD). PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-...

journal_title：Clinical endocrinology

authors： Zeitlin AA,Heward JM,Brand OJ,Newby PR,Franklyn JA,Gough SC,Simmonds MJ

更新日期：2006-09-01 00:00:00

abstract：:Plasma aldosterone (PA), plasma renin activity (PRA), extracellular fluid volume (EFV) and hepatic blood flow were measured in forty-four patients with sustained essential hypertension and compared with forty-two normotensive controls of same age and sex. All patient had inulin clearances within the normal range and b...

journal_title：Clinical endocrinology

authors： Safar ME,Simon AC,Dard SA,Parlier HR,Pauleau NE,Vincent ML,Sassard JE

更新日期：1982-01-01 00:00:00

abstract：BACKGROUND:Classical congenital adrenal hyperplasia (CAH) is characterized by a defect in cortisol and aldosterone secretion, adrenal hyperandrogenism, impaired adrenal medullary function and insulin insensitivity. The latter along with the increased tendency towards obesity raises questions whether other cardiovascula...

journal_title：Clinical endocrinology

authors： Roche EF,Charmandari E,Dattani MT,Hindmarsh PC

更新日期：2003-05-01 00:00:00

abstract：:In order to investigate the endocrine requirements for induction of follicle maturation, ovulation and luteal function we have measured plasma LH and FSH concentrations in 109 cycles induced by treatment with LHRH in 25 women with amenorrhoea of diverse aetiology. The major clinical and endocrine subgroupings were pol...

journal_title：Clinical endocrinology

authors： Abdulwahid NA,Adams J,van der Spuy ZM,Jacobs HS

更新日期：1985-12-01 00:00:00

abstract：:The excretion of FSH, LH, oestrogens and pregnanediol was monitored once weekly in urine samples collected from eight peri-menopausal women aged 44-55 years (median, 52 years). Observations were commenced between 5 and 15 weeks before the menopause and were continued for 22-30 weeks after final menstruation. Amenorrho...

journal_title：Clinical endocrinology

authors： Metcalf MG,Donald RA,Livesey JH

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVE:The importance of oestrogen on bone mineral density (BMD) in males was suggested by reports of patients with oestrogen resistance and aromatase deficiency who demonstrated osteoporosis and epiphyseal plate maturation defect despite high testosterone levels. In the present study, we examined the effects of oes...

journal_title：Clinical endocrinology

authors： Reutrakul S,Ongphiphadhanakul B,Piaseu N,Krittiyawong S,Chanprasertyothin S,Bunnag P,Rajatanavin R

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:Cushing's syndrome (CS) is a well recognized cause of bone loss. Although many previous studies have shown decreased bone mineral density (BMD) in the lumbar spina and proximal femur of patients with endogenous CS, so far, the data estimating BMD in their peripheral skeleton are sparse. The aim of the present...

journal_title：Clinical endocrinology

authors： Karavitaki N,Ioannidis G,Giannakopoulos F,Mavrokefalos P,Thalassinos N

更新日期：2004-02-01 00:00:00

abstract：CONTEXT:Subjects with nonalcoholic fatty liver disease (NAFLD) have a high risk of developing type 2 diabetes and cardiovascular diseases. Low serum potassium concentration or low dietary potassium intake can result in metabolic disorders. OBJECTIVE:Our objective was to evaluate the association between low serum potas...

journal_title：Clinical endocrinology

authors： Sun K,Lu J,Jiang Y,Xu M,Xu Y,Zhang J,Xu B,Sun J,Sun W,Ren C,Liu J,Wang W,Bi Y,Ning G

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:To investigate the risk of pregnancy complications in women with and without polycystic ovary syndrome after consideration of lifestyle factors. DESIGN:Prospective cohort. PATIENTS AND MEASUREMENTS:Participants (n = 5628) were apparently healthy nulliparous women with singleton pregnancies from the Screeni...

journal_title：Clinical endocrinology

authors： Bahri Khomami M,Moran LJ,Kenny L,Grieger JA,Myers J,Poston L,McCowan L,Walker J,Dekker G,Norman R,Roberts CT

更新日期：2019-06-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to investigate the diagnostic performance of pre-operative staging ultrasound (US) according to body mass index (BMI) in patients with papillary thyroid carcinoma (PTC) PATIENTS AND METHODS: This retrospective study included 625 patients with PTC who underwent pre-operative staging U...

journal_title：Clinical endocrinology

authors： Choi JS,Lee HS,Kim EK,Moon HJ,Kwak JY

更新日期：2015-10-01 00:00:00

abstract：BACKGROUND:22q11.2 deletion syndrome (22q11.2DS) is a relatively common yet under-recognized genetic syndrome that may present with endocrine features. We aimed to address the factors that contribute to the high prevalence of hypocalcaemia. METHODS:We investigated hypocalcaemia in a well-characterized sample of 138 ad...

journal_title：Clinical endocrinology

authors： Cheung EN,George SR,Costain GA,Andrade DM,Chow EW,Silversides CK,Bassett AS

更新日期：2014-08-01 00:00:00

abstract：BACKGROUND:Postsurgical regrowth or recurrence of nonfunctioning pituitary adenomas (NFAs) is not uncommon and often requires further surgery or radiotherapy (DXT). Routine postoperative DXT increases the incidence of hypopituitarism, which is associated with increased morbidity and mortality. Identification of genetic...

journal_title：Clinical endocrinology

authors： Buch HN,Raskauskiene D,Bahar A,Bicknell EJ,Farrell WE,Clayton RN

更新日期：2004-07-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The resistance of macroprolactinomas to dopamine agonist (DA) therapy, whether defined as an absence of PRL normalization or the lack of significant tumour shrinkage after prolonged treatment at high doses, is usually regarded as unpredictable. The aim of this retrospective study, conducted in a te...

journal_title：Clinical endocrinology

authors： Delgrange E,Duprez T,Maiter D

更新日期：2006-04-01 00:00:00

abstract：CONTEXT:Besides medullary thyroid carcinoma and other endocrinopathies, people with Multiple Endocrine Neoplasia Type 2 (MEN2) are at risk of gastrointestinal (GI) symptoms. OBJECTIVE:To investigate the impact of GI symptoms on the daily lives of patients with MEN2. DESIGN:An online survey was conducted among patient...

journal_title：Clinical endocrinology

authors： Goncharova M,Grey J,Druce M

更新日期：2020-11-10 00:00:00

abstract：OBJECTIVE:The metabolic syndrome has been associated with increased mortality in some Caucasian populations, but data in Asian populations are not available. We present data describing the association of the metabolic syndrome with mortality. METHODS:The impact of the US National Cholesterol Education Program Adult Tr...

journal_title：Clinical endocrinology

authors： Thomas GN,Schooling CM,McGhee SM,Ho SY,Cheung BM,Wat NM,Janus ED,Lam KS,Lam TH,Hong Kong Cardiovascular Risk Factor Prevalence Study Steering Committee.

更新日期：2007-05-01 00:00:00