Low serum potassium level is associated with nonalcoholic fatty liver disease and its related metabolic disorders.

abstract：OBJECTIVE:Mutations in the GH releasing hormone receptor (GHRH-R) have recently been shown to cause autosomal recessive isolated GH deficiency (IGHD). Patients who are homozygous for GHRH-R mutations have a subnormal GH response to pharmacological agents that stimulate GH secretion and an appropriate response to exogen...

journal_title：Clinical endocrinology

authors： Salvatori R,Fan X,Phillips JA 3rd,Prince M,Levine MA

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Persistent elevation of urinary albumin excretion (UAE), even within normal range, is an independent predictor for cardiovascular disease. Accumulating research suggests that low levels of vitamin D and high levels of parathyroid hormone (PTH) also increase cardiovascular disease risk. This study is intended ...

journal_title：Clinical endocrinology

authors： Kim HW,Park H,Cho KH,Han K,Ko BJ

更新日期：2014-01-01 00:00:00

abstract：OBJECTIVE:The mechanisms leading to higher bone mineral density (BMD) in hirsute patients than in healthy controls have seldom been examined. We compared the metabolic, hormonal and bone metabolic parameters in hirsute patients and female controls and correlated BMD and bone metabolic parameters with testosterone, oest...

journal_title：Clinical endocrinology

authors： Glintborg D,Andersen M,Hagen C,Hermann AP

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:Genetic alterations in four oncogenes, namely RAS point mutations, RET rearrangements (RET/PTC), NTRK1 rearrangements (TRK) and BRAF point mutations have been identified in human papillary thyroid carcinomas (PTCs). These oncogenes act along the RET/PTC(TRK)-RAS-BRAF-MEK-MAPK kinase pathway, mediating a numbe...

journal_title：Clinical endocrinology

authors： Liu RT,Chen YJ,Chou FF,Li CL,Wu WL,Tsai PC,Huang CC,Cheng JT

更新日期：2005-10-01 00:00:00

abstract：:The pathogenetic mechanisms underlying pituitary tumorigenesis are largely unknown. Previous reports have suggested that aggressive pituitary adenomas and/or carcinomas may be associated with genetic alterations that are distinct from those responsible for the more common and less aggressive pituitary adenomas. Here, ...

journal_title：Clinical endocrinology

authors： Zahedi A,Booth GL,Smyth HS,Farrell WE,Clayton RN,Asa SL,Ezzat S

更新日期：2001-10-01 00:00:00

abstract：:Radioiodine has been in use for over 60 years as a treatment for hyperthyroidism. Major changes in clinical practice have occurred with the realization that accurate dosimetry is incapable of avoiding the risks of hypothyroidism, while more accurate assessment of the risks of other adverse effects of radioiodine such ...

journal_title：Clinical endocrinology

authors： Weetman AP

更新日期：2007-06-01 00:00:00

abstract：:Eight patients with treated Addison's disease were studied whilst receiving different doses of fludrocortisone together with a constant intake of glucocorticoid. Plasma renin activity (PRA), blood pressure, pulse rate and plasma potassium and urea concentrations were measured after 2-week periods on each dose. In two ...

journal_title：Clinical endocrinology

authors： Thompson DG,Mason AS,Goodwin FJ

更新日期：1979-05-01 00:00:00

abstract：OBJECTIVES:Papillary thyroid microcarcinoma (PTMC) has an excellent prognosis with an indolent disease course. However, some PTMCs have an aggressive course with lateral cervical lymph node (LCLN) metastasis or distant metastasis. This study aimed to evaluate the pre-operative features of PTMC associated with LCLN meta...

journal_title：Clinical endocrinology

authors： Jeon MJ,Chung MS,Kwon H,Kim M,Park S,Baek JH,Song DE,Sung TY,Hong SJ,Kim TY,Kim WB,Shong YK,Lee JH,Kim WG

更新日期：2017-06-01 00:00:00

abstract：OBJECTIVE:Skewed X chromosome inactivation (XCI) was associated with female predominance in adult autoimmune thyroid disease (ATD). In normal females, skewed XCI is increased with age. Whether early-onset skewed XCI is associated with childhood ATD remains unknown. This study aimed to determine XCI skewing in paediatri...

journal_title：Clinical endocrinology

authors： Santiwatana S,Mahachoklertwattana P,Limwongse C,Khlairit P,Pongratanakul S,Roothumnong E,Prangphan K,Choubtum L,Songdej D,Poomthavorn P

更新日期：2018-12-01 00:00:00

abstract：:Rathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC...

journal_title：Clinical endocrinology

authors： Trifanescu R,Ansorge O,Wass JA,Grossman AB,Karavitaki N

更新日期：2012-02-01 00:00:00

abstract：:Twenty-seven healthy females referred for legal abortion between the sixth and ninth week of pregnancy were treated for 1 week with either bromocriptine, metoclopramide or placebo. Serum prolactin was significantly (P < 0.01) elevated by metoclopramide and suppressed by bromocriptine. Despite a more than tenfold diffe...

journal_title：Clinical endocrinology

authors： Andersen AN,Hertz J,Kjer JJ,Eskildsen PC,Larsen PS,Svenstrup B,Nielsen J,Arends J

更新日期：1980-08-01 00:00:00

abstract：:A 25-year-old primigravid woman presented with Cushing's syndrome at 23 weeks gestation; serum cortisol was 1090 nmol/l at 0900 h, 1230 nmol/l at 2200 h; basal urinary free cortisol excretion was 3680 nmol/24 h, and 8830 nmol/24 h after dexamethasone 8 mg daily for 48 hours; plasma ACTH was < 1.1 pmol/l. CT scan of th...

journal_title：Clinical endocrinology

authors： Close CF,Mann MC,Watts JF,Taylor KG

更新日期：1993-09-01 00:00:00

abstract：OBJECTIVE:Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. DESIGN AND PATIENTS:We conducted a ...

journal_title：Clinical endocrinology

authors： Xu JY,Sham PC,Xu A,Tso AW,Wat NM,Cheng KY,Fong CH,Janus ED,Lam KS

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVE:Results from studies on the effect of glucocorticosteroids on protein turnover in both rat and man have been conflicting. The aim of this study was to investigate the primary cause of muscle wasting in patients with Cushing's syndrome. DESIGN:Studies of whole body 1(-14)C-leucine turnover in patients with Cu...

journal_title：Clinical endocrinology

authors： Bowes SB,Benn JJ,Scobie IN,Umpleby AM,Lowy C,Sönksen PH

更新日期：1993-11-01 00:00:00

abstract：OBJECTIVES:The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta-analysis of placebo-controlled studies publ...

journal_title：Clinical endocrinology

authors： Isidori AM,Giannetta E,Gianfrilli D,Greco EA,Bonifacio V,Aversa A,Isidori A,Fabbri A,Lenzi A

更新日期：2005-10-01 00:00:00

abstract：OBJECTIVE:Obesity is a major risk factor for coronary heart disease, and surgical treatment of obese patients as part of a multidisciplinary approach seems to provide faster results than diet therapy. The aim of this study was to evaluate the effect of dermolipectomy on insulin action and inflammatory markers in 20 obe...

journal_title：Clinical endocrinology

authors： Rizzo MR,Paolisso G,Grella R,Barbieri M,Grella E,Ragno E,Grella R,Nicoletti G,D'Andrea F

更新日期：2005-09-01 00:00:00

abstract：OBJECTIVE:The present study was performed to characterize the molecular heterogeneity of serum FSH in normal males and to investigate the possible influence of testosterone on serum FSH in androgen-deficient men before and during testosterone administration. DESIGN AND PATIENTS:Serum samples were taken at 10-minute in...

journal_title：Clinical endocrinology

authors： Harsch IA,Simoni M,Nieschlag E

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:The aetiology of non-insulin dependent diabetes is unknown, but defective insulin secretion is a feature. The disease also has a strong genetic basis and first-degree relatives of patients have an increased risk of future diabetes. To investigate whether beta-cell dysfunction is an early feature of the diseas...

journal_title：Clinical endocrinology

authors： Gelding SV,Andres C,Niththyananthan R,Gray IP,Mather H,Johnston DG

更新日期：1995-03-01 00:00:00

abstract：CONTEXT:It has been suggested that patients with papillary thyroid cancer (PTC) harbouring the BRAF(V600E) mutation have a worse prognosis. We showed in PTC that high levels of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) inversely correlate with disease-free interval (DFI). OBJECTIVES:To inv...

journal_title：Clinical endocrinology

authors： Ulisse S,Baldini E,Sorrenti S,Barollo S,Prinzi N,Catania A,Nesca A,Gnessi L,Pelizzo MR,Mian C,De Vito C,Calvanese A,Palermo S,Persechino S,De Antoni E,D'Armiento M

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVE:There are no consistent data on the prevalence and bone status of normocalcaemic hypoparathyroidism (NHYPO) as defined by normal adjusted calcium and low PTH level. Our aim was to determine the prevalence and the metabolic bone profile of NHYPO in older women, assessing its evolution over time. The second obj...

journal_title：Clinical endocrinology

authors： Palermo A,Jacques R,Gossiel F,Reid DM,Roux C,Felsenberg D,Glueer CC,Eastell R

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:Disturbances in the GH/IGF-I axis are reported in 25-60% of short children born small for gestational age (SGA). We hypothesized that these abnormalities might be related to abnormalities in the pituitary region. Therefore, the results of magnetic resonance imaging (MRI) of short SGA children were compared t...

journal_title：Clinical endocrinology

authors： Arends NJ,V d Lip W,Robben SG,Hokken-Koelega AC

更新日期：2002-12-01 00:00:00

abstract：OBJECTIVE:Data in women regarding the role of OT in LH secretion during the LH surge are conflicting. As in previous studies blood samples for LH measurements were taken infrequently, we re-examined this matter in women with a fully characterized midcycle LH surge. DESIGN:Normal women were studied over two cycles. Whe...

journal_title：Clinical endocrinology

authors： Vanakara P,Dafopoulos K,Papastergiopoulou L,Kallitsaris A,Papageorgiou I,Messinis IE

更新日期：2009-07-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:There is compelling evidence that insulin resistance may play a pivotal role in the development of pregnancy complications including pre-eclampsia and intrauterine growth restriction (IUGR). As dysregulation of visfatin and adiponectin is found in insulin resistance, both adipokines might contribute to pregna...

journal_title：Clinical endocrinology

authors： Fasshauer M,Blüher M,Stumvoll M,Tönessen P,Faber R,Stepan H

更新日期：2007-03-01 00:00:00

abstract：OBJECTIVE:Growth hormone release in response to all known stimuli of GH secretion is blunted in obese subjects. Several studies, using d,l-fenfluramine (d,l-FF) as a serotoninergic tool, suggest that brain serotonin plays a role in the pathogenesis of this phenomenon. However, the effect of d,l-FF appears to be depende...

journal_title：Clinical endocrinology

authors： Kars ME,Pijl H,Cohen AF,Frölich M,Schoemaker HC,Brandenburg HC,Meinders AE

更新日期：1996-05-01 00:00:00

abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

journal_title：Clinical endocrinology

authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

更新日期：1997-11-01 00:00:00

abstract：OBJECTIVES:The aim of the study was to review our long-term use of subcutaneous oestradiol (E2) implant therapy for the treatment of climacteric symptoms in post-menopausal women. On the grounds that the aim is to restore premenopausal serum E2 levels, our declared clinical policy is not to repeat implants even in the ...

journal_title：Clinical endocrinology

authors： Buckler HM,Kalsi PK,Cantrill JA,Anderson DC

更新日期：1995-05-01 00:00:00

abstract：:We have studied the effects of dopamine on the secretion of TSH and its subunits in vivo and in vitro. Four normal controls, seven patients with primary hypothyroidism, two patients with peripheral resistance to thyroid hormone (PRTH), and two patients with alpha-secreting pituitary tumours underwent a 3-h dopamine in...

journal_title：Clinical endocrinology

authors： Cooper DS,Klibanski A,Ridgway EC

更新日期：1983-03-01 00:00:00

abstract：OBJECTIVE:We compared IGF-1 and IGFBP3 concentrations in a group of adults treated for brain tumours in childhood with those of matched controls, and investigated the relationship between the GH secretory pattern and IGF-1/IGFBP3 concentrations in the entire group. DESIGN:We performed 24 h serum GH profiles using 20 m...

journal_title：Clinical endocrinology

authors： Achermann JC,Hindmarsh PC,Brook CG

更新日期：1998-11-01 00:00:00