Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.

abstract：OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

journal_title：Clinical endocrinology

authors： McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) has been suggested as the gold standard for diagnosing GH deficiency (GHD). The ITT is, however, potentially hazardous. Glucose monitoring during the ITT varies between centres and there is surprisingly little information on the actual level of blood glucose nadir and the dura...

journal_title：Clinical endocrinology

authors： Holmer H,Link K,Erfurth EM

更新日期：2006-02-01 00:00:00

abstract：OBJECTIVE:To evaluate the effect of hyperprolactinaemia and its treatment with dopamine-agonists on bone mass and turnover in adolescent patients compared to adults. PATIENTS:Forty patients with hyperprolactinaemia (20 with disease onset during adolescence and 20 during adulthood) and 40 healthy control subjects. DES...

journal_title：Clinical endocrinology

authors： Colao A,Di Somma C,Loche S,Di Sarno A,Klain M,Pivonello R,Pietrosante M,Salvatore M,Lombardi G

更新日期：2000-03-01 00:00:00

abstract：INTRODUCTION:Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West ...

journal_title：Clinical endocrinology

authors： Knight BA,Shields BM,He X,Pearce EN,Braverman LE,Sturley R,Vaidya B

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00

abstract：:Rathke's cleft cysts (RCCs) are benign, sellar and/or suprasellar lesions originating from the remnants of Rathke's pouch. Although a common finding in routine autopsies (12-33% of normal pituitary glands), symptomatic cases are rare and comprise 5-15% of all surgically resected sellar lesions. Small, asymptomatic RCC...

journal_title：Clinical endocrinology

authors： Trifanescu R,Ansorge O,Wass JA,Grossman AB,Karavitaki N

更新日期：2012-02-01 00:00:00

abstract：:Sleep history and pituitary function were studied and sleep polygraphy performed in 11 acromegalic patients before and after pituitary surgery. Excessive daytime sleepiness or habitual snoring or both together, as well as an elevated fasting level of serum GH occurred in all the patients. In five men but in none of th...

journal_title：Clinical endocrinology

authors： Pekkarinen T,Partinen M,Pelkonen R,Iivanainen M

更新日期：1987-12-01 00:00:00

abstract：CONTEXT:Disturbances in thyroid function have been described in small-for-gestational age (SGA) children but the influence of prematurity is unclear. In addition, the effect of GH treatment on thyroid function has not been studied in short SGA children. OBJECTIVES:To determine whether short SGA children have higher TS...

journal_title：Clinical endocrinology

authors： de Kort SW,Willemsen RH,van der Kaay DC,van Dijk M,Visser TJ,Hokken-Koelega AC

更新日期：2008-08-01 00:00:00

abstract：:The growth hormone-insulin-like growth factor 1 (GH-IGF-1) axis plays an important role in modulating the peripheral metabolism of glucocorticoids mainly through its effect on the isoenzyme 11 beta-hydroxysteroid dehydrogenase 1 (11beta-HSD1) which, in vivo, functions as a reductase catalysing the conversion of cortis...

journal_title：Clinical endocrinology

authors： Agha A,Monson JP

更新日期：2007-04-01 00:00:00

abstract：OBJECTIVE:To compare the relative utility of GH secretion via pharmacological stimulation, overnight serial sampling, IGF-I levels and auxological variables as predictors of change in height standard deviation score (deltaHt SDS) during GH treatment. DESIGN:A multicentre observational study. PATIENTS:Prepubertal chil...

journal_title：Clinical endocrinology

authors： Rogol AD,Blethen SL,Sy JP,Veldhuis JD

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVE:Circulating testosterone declines during male ageing, and low testosterone may predispose to ill health. We sought to determine whether greater participation in healthy behaviours predicted reduced risk of subsequent lower circulating testosterone in older men. DESIGN:Cross-sectional analysis of a population...

journal_title：Clinical endocrinology

authors： Yeap BB,Almeida OP,Hyde Z,Norman PE,Chubb SA,Jamrozik K,Hankey GJ,Flicker L

更新日期：2009-03-01 00:00:00

abstract：:The effect of glucocorticoid excess on insulin disappearance from plasma was examined in eight normal men during cortisone treatment (50 mg orally twice daily for 4 d) and in the absence of any medication (control) in random order. Constant infusion of insulin (1-5 mU/kg/min) was used to achieve different levels of st...

journal_title：Clinical endocrinology

authors： Ellemann K,Thorsteinsson B,Fugleberg S,Feldt-Rasmussen B,Andersen OO,Grønbaek P,Binder C

更新日期：1987-05-01 00:00:00

abstract：:Seckel syndrome is an autosomal-recessive disorder with a frequency of less than 1/10 000 births in which there are multiple malformations including severe short stature. We report on a patient with Seckel syndrome with a current body height of -7.5 SDS. Laboratory investigations at the age of 19 months revealed high ...

journal_title：Clinical endocrinology

authors： Schmidt A,Chakravarty A,Brommer E,Fenne BD,Siebler T,De Meyts P,Kiess W

更新日期：2002-08-01 00:00:00

abstract：:Plasma aldosterone (PA), plasma renin activity (PRA), extracellular fluid volume (EFV) and hepatic blood flow were measured in forty-four patients with sustained essential hypertension and compared with forty-two normotensive controls of same age and sex. All patient had inulin clearances within the normal range and b...

journal_title：Clinical endocrinology

authors： Safar ME,Simon AC,Dard SA,Parlier HR,Pauleau NE,Vincent ML,Sassard JE

更新日期：1982-01-01 00:00:00

abstract：OBJECTIVE:The euglycemic-hyperinsulinemic clamp is the gold standard to evaluate insulin resistance (IR), but there are only a few studies on the prevalence of IR in Chinese Han women with polycystic ovary syndrome (PCOS). This study investigated: (a) the prevalence of IR in Chinese Han women with PCOS by clamp, (b) th...

journal_title：Clinical endocrinology

authors： Li W,Chen Q,Xie Y,Hu J,Yang S,Lin M

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:Stimulation with corticotropin-releasing hormone (CRH) is one of principal tools for the differential diagnosis of ACTH-dependent Cushing's syndrome. However, different dosages and species of CRH may be employed; further, ACTH levels can be measured by radioimmunoassay (RIA) or immunoradiometric assay (IRMA)....

journal_title：Clinical endocrinology

authors： Pecori Giraldi F,Invitti C,Cavagnini F,Study Group of the Italian Society of Endocrinology on the Pathophysiology of the Hypothalamic-pituitary-adrenal axis.

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Fractures are related to falling. Turner syndrome (TS) is associated with hypogonadism, osteoporosis and fractures and has been considered as a syndrome of early ageing. The aim was to study whether fine motor function (FM) and body balance (BB) were impaired and related to genotype, fractures, metabolic vari...

journal_title：Clinical endocrinology

authors： El-Mansoury M,Barrenäs ML,Bryman I,Hanson C,Landin-Wilhelmsen K

更新日期：2009-08-01 00:00:00

abstract：OBJECTIVE:Growth deficiency is commonly seen in polytransfused beta-thalassaemia patients, especially in adolescence. It is not completely dependent on the lack of their pubertal growth spurt. GH impairment at different levels (hypothalamic or pituitary) and/or a reduced IGF-1 synthesis have been suggested the main cau...

journal_title：Clinical endocrinology

authors： Cavallo L,Gurrado R,Gallo F,Zacchino C,De Mattia D,Tatò L

更新日期：1997-06-01 00:00:00

abstract：:The role of brain catecholamine (CA) activity in the neuroendocrine regulation of the GnRH-LH system in polycystic ovary syndrome (PCO) was investigated by high-performance liquid chromatography (HPLC) with electrochemical detector. We measured urinary dopamine (DA), noradrenaline (NA), adrenaline (A), vanillylmandeli...

journal_title：Clinical endocrinology

authors： Paradisi R,Grossi G,Venturoli S,Capelli M,Porcu E,Fabbri R,Pasquali R,Flamigni C

更新日期：1988-09-01 00:00:00

abstract：CONTEXT:Germline mutations in four genes (RET, VHL, SDHB and SDHD) are detected in about 17% of patients with apparently sporadic pheochromocytoma. Thus, genetic screening of all patients with this disease is suggested for a rational diagnostic approach and management. OBJECTIVE:To report the clinical, biochemical and...

journal_title：Clinical endocrinology

authors： D'Elia AV,Grimaldi F,Pizzolitto S,De Maglio G,Bregant E,Passon N,Franzoni A,Verrienti A,Tamburrano G,Durante C,Filetti S,Fogolari F,Russo D,Damante G

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Clinically significant Graves' orbitopathy (GO) develops in about 25% of those with Graves' disease (GD); most cases of GD in the UK are managed by endocrinologists. Despite this, patients report significant delays before a diagnosis of GO is made. Measures to increase awareness of the early signs of GO and ...

journal_title：Clinical endocrinology

authors： Mitchell AL,Hickey J,Vaidya B,Mason R,Ajjan R,Zammitt N,Perros P,Dayan C,TEAMeD.

更新日期：2017-12-01 00:00:00

abstract：CONTEXT AND OBJECTIVE:Nonfunctioning pituitary adenomas (NFPAs) are the most common subtype of pituitary tumour. Hypopituitarism is observed in NFPAs due to tumour- or treatment-related factors and may increase mortality risk. Here, we analysed the associations of hypopituitarism, hormone replacement and mortality in a...

journal_title：Clinical endocrinology

authors： O'Reilly MW,Reulen RC,Gupta S,Thompson CA,Dineen R,Goulden EL,Bugg G,Pearce H,Toogood AA,Gittoes NJ,Mitchell R,Thompson CJ,Ayuk J

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

journal_title：Clinical endocrinology

authors： Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

更新日期：2009-11-01 00:00:00

abstract：OBJECTIVE:Androgens have paradoxically different effects on hair follicles depending on body site, stimulating beard growth while inducing regression in some areas of the scalp. The mesenchyme derived dermal papilla at the base of the hair follicle regulates many aspects of the growth of follicular epithelium, and is p...

journal_title：Clinical endocrinology

authors： Thornton MJ,Laing I,Hamada K,Messenger AG,Randall VA

更新日期：1993-12-01 00:00:00

abstract：:1,24,25-trihydroxyvitamin D3 has been detected in human serum using a sensitive radioimmunoassay. Tritiated 1,24,25-trihydroxyvitamin D3 was synthesized biologically and used as tracer to monitor the recovery of endogenous metabolite during isolation from serum. Circulating 1,24,25(OH)3D3 in normal subjects ranged fro...

journal_title：Clinical endocrinology

authors： Clemens TL,Fraher LJ,Sandler LM,O'Riordan JL

更新日期：1982-04-01 00:00:00

abstract：BACKGROUND AND OBJECTIVE:The differentiation of benign from malignant phaeochromocytoma is difficult. We have examined whether the use of flow cytometric determination of nuclear DNA content would be useful as a predictor of malignant behaviour in patients with phaeochromocytoma as some previous studies had suggested t...

journal_title：Clinical endocrinology

authors： Heaney AP,O'Rourke D,Arthur K,Beatty OL,Russell CF,Sloan JM,Hamilton P,Atkinson AB

更新日期：1996-02-01 00:00:00

abstract：:1. A mathematical model has been constructed of human thyroid hormone regulation by the anterior pituitary gland, which takes account of most of the currently available experimental data. 2. Successful simulation of data on the stimulation of thyrotrophin (TSH) secretion by thyrotrophin releasing hormone (TRH) was ach...

journal_title：Clinical endocrinology

authors： Saratchandran P,Carson ER,Reeve J

更新日期：1976-09-01 00:00:00

abstract：BACKGROUND AND AIMS:Autoimmune thyroiditis is one of the most common autoimmune disorders. Autoantibodies against the thyroid gland, with thyroid peroxidase antibody (TPO-Ab) and thyroglobulin antibody (Tg-Ab) as the most common autoantibodies, can often be demonstrated in serum in population surveys. In the present st...

journal_title：Clinical endocrinology

authors： Pedersen IB,Knudsen N,Jørgensen T,Perrild H,Ovesen L,Laurberg P

更新日期：2003-01-01 00:00:00

abstract：BACKGROUND:Left ventricular hypertrophy (LVH) is the most common cardiac abnormality in acromegaly. Left ventricular mass (LVM) is an important parameter measured to detect LVH, but the relationship with body size should be considered by correcting LVM to body surface area (BSA), height or height2.7. All trials concern...

journal_title：Clinical endocrinology

authors： Vitale G,Galderisi M,Pivonello R,Spinelli L,Ciccarelli A,de Divitiis O,Lombardi G,Colao A

更新日期：2004-03-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:Although the physiology of minipuberty are well-established, it is not fully explained why it occurs. It has been suggested that minipuberty contributes to the development of reproductive organs, somatic growth, cognitive/behavioral, and sex-specific brain development. Given the well-known trade-of...

journal_title：Clinical endocrinology

authors： Karaoglan M,Nacarkahya G

更新日期：2020-12-05 00:00:00