Healthier lifestyle predicts higher circulating testosterone in older men: the Health In Men Study.

abstract：BACKGROUND:Peroxisomal proliferator-activated receptors (PPAR)- gamma are expressed abundantly in ACTH-secreting pituitary tumours. The PPAR-gamma activator rosiglitazone has been shown to suppress ACTH secretion in human adrenocorticotroph tumour cells in vitro, and prevent and reduce adrenocorticotroph tumour develop...

journal_title：Clinical endocrinology

authors： Mullan KR,Leslie H,McCance DR,Sheridan B,Atkinson AB

更新日期：2006-05-01 00:00:00

abstract：:Delayed puberty is defined arbitrarily on the basis of statistical consideration, when no signs of puberty have occurred at 2.0 SD (13.4 years in girls and 13.8 in boys) above the mean chronological age for the onset of puberty. The vast majority of these patients have no endocrine abnormality and their pubertal devel...

journal_title：Clinical endocrinology

authors： Albanese A,Stanhope R

更新日期：1995-07-01 00:00:00

abstract：INTRODUCTION:Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. OBJECTIVE:To assess if PCOS increases CV risk independently in young obese women by examining carotid intima-media wal...

journal_title：Clinical endocrinology

authors： Kahal H,Aburima A,Ungvari T,Rigby AS,Dawson AJ,Coady AM,Vince RV,Ajjan RA,Kilpatrick ES,Naseem KM,Atkin SL

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is associated with a varied clinical presentation. The cardiac effects of RTH have been described but vascular function has yet to be fully evaluated in this condition. We have measured the arterial function of those with RTH to assess any vascular changes. DESIGN:An obser...

journal_title：Clinical endocrinology

authors： Owen PJ,Chatterjee VK,John R,Halsall D,Lazarus JH

更新日期：2009-04-01 00:00:00

abstract：CONTEXT:Carney complex (CNC) is an autosomal dominant multiple endocrine neoplasia syndrome (OMIM 160980). About 70% of cases are familiar; most have mutations of the PRKAR1A gene on chromosome 17q22-24. There is little phenotype-genotype correlation known to date. OBJECTIVE:To study the genotype-phenotype correlation...

journal_title：Clinical endocrinology

authors： Gennari M,Stratakis CA,Hovarth A,Pirazzoli P,Cicognani A

更新日期：2008-11-01 00:00:00

abstract：BACKGROUND:In patients with acromegaly serum IGF-I is increasingly used as a marker of disease activity. As a result, the relationship between serum GH and IGF-I is of profound interest. Healthy females secrete three times more GH than males but have broadly similar serum IGF-I levels, and women with GH deficiency requ...

journal_title：Clinical endocrinology

authors： Parkinson C,Renehan AG,Ryder WD,O'Dwyer ST,Shalet SM,Trainer PJ

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:Poorly differentiated thyroid cancer (PDTC) is a rare, but aggressive thyroid cancer (TC) and a main cause of death from non-anaplastic follicular cell-derived TC. Assessing the risk of PDTC-related death and the risk of recurrence is important for clinicians. The recent American Thyroid Association (ATA) 201...

journal_title：Clinical endocrinology

authors： Walczyk A,Kopczyński J,Gąsior-Perczak D,Pałyga I,Kowalik A,Chrapek M,Hejnold M,Góźdź S,Kowalska A

更新日期：2019-08-01 00:00:00

abstract：:The clinical features, diagnosis and management of 16 consecutive patients with ectopic ACTH production are described and biochemical data are compared with those of 48 consecutive patients with pituitary-dependent Cushing's disease. In 10 cases the ectopic ACTH secreting tumour was completely occult to routine clinic...

journal_title：Clinical endocrinology

authors： Howlett TA,Drury PL,Perry L,Doniach I,Rees LH,Besser GM

更新日期：1986-06-01 00:00:00

abstract：BACKGROUND:Polycystic ovary syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Some evidence suggests that dysbiosis of the gut microbiota could be associated with PCOS clinical parameters, but little is known for the association between vaginal microbiome and PCOS. OBJECTIVE:To determine ...

journal_title：Clinical endocrinology

authors： Hong X,Qin P,Huang K,Ding X,Ma J,Xuan Y,Zhu X,Peng D,Wang B

更新日期：2020-07-01 00:00:00

abstract：OBJECTIVE:To compare effectiveness and tolerability of quinagolide (CV 205-502) and cabergoline (CAB) treatments in 39 patients with prolactinoma. STUDY DESIGN:All 39 patients were treated first with quinagolide for 12 months and then with cabergoline for 12 months. A wash-out period was performed in all patients afte...

journal_title：Clinical endocrinology

authors： Di Sarno A,Landi ML,Marzullo P,Di Somma C,Pivonello R,Cerbone G,Lombardi G,Colao A

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:We explored the possibility of a genetic anomaly in the sex determining region of the Y chromosome, SRY gene, known to be equated to the testis determining region. PATIENTS:Four patients with bilateral congenital anorchia, absence of testicular tissue, elevated FSH and a lack of testosterone response to huma...

journal_title：Clinical endocrinology

authors： Lobaccaro JM,Medlej R,Berta P,Belon C,Galifer RB,Guthmann JP,Chevalier C,Czernichow P,Dumas R,Sultan C

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:The prevalence of clinically silent corticotroph macroadenomas is unknown. Our aim was to determine the prevalence of clinically silent corticotroph macroadenomas among all pituitary macroadenomas. DESIGN:Patients scheduled to have transsphenoidal surgery for any sellar mass were prospectively evaluated clin...

journal_title：Clinical endocrinology

authors： Guttenberg KB,Mayson SE,Sawan C,Kharlip J,Lee JY,Martinez-Lage M,Loevner LA,Ewanichak J,Grady MS,Snyder PJ

更新日期：2016-12-01 00:00:00

abstract：:Uncorrected thyroid dysfunction in pregnancy has well-recognized deleterious effects on foetal and maternal health. The early gestation period is one of the critical foetal vulnerability during which maternal thyroid dysfunction may have lasting repercussions. Accordingly, a pragmatic preconception strategy is key for...

journal_title：Clinical endocrinology

authors： Okosieme OE,Khan I,Taylor PN

更新日期：2018-09-01 00:00:00

abstract：:The possibility of differences in glucocorticoid sensitivity between normal and cystic fibrosis fibroblasts was studied in cultured cells derived from forearm skin biopsies. Both normal and cystic fibrosis cells bound tritiated dexamethasone with high affinity (Kd 37 degrees C approximately equal to 10 nmol/1) to a li...

journal_title：Clinical endocrinology

authors： Khalid BA,Gyorki S,Warne GL,Funder JW

更新日期：1983-04-01 00:00:00

abstract：OBJECTIVE:Abnormal serum liver function tests are common in patients with untreated thyrotoxicosis, even prior to the initiation of antithyroidal medications that may worsen the severity of the abnormal serum liver biochemistries. There is a wide range of the incidence of these abnormalities in the published literature...

journal_title：Clinical endocrinology

authors： Lin TY,Shekar AO,Li N,Yeh MW,Saab S,Wilson M,Leung AM

更新日期：2017-05-01 00:00:00

abstract：OBJECTIVES:Mutations in the dual oxidase 2 gene (DUOX2) is the most common genetic cause of congenital hypothyroidism (CH) in Japan. All previously described DUOX2 mutation-carrying families have followed autosomal recessive inheritance. We report a nonconsanguineous Japanese family harbouring biallelic DUOX2 mutations...

journal_title：Clinical endocrinology

authors： Abe K,Narumi S,Suwanai AS,Hamajima T,Hasegawa T

更新日期：2015-09-01 00:00:00

abstract：:Infertility with azoospermia requires a diligent search for reversible factors and treatment to restore natural fertility, even though most cases are due to untreatable primary spermatogenic failure and are destined to require consideration of assisted reproductive treatment (ART) options. Complete clinical and diagno...

journal_title：Clinical endocrinology

authors： McLachlan RI

更新日期：2013-02-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Acylation-stimulating protein (ASP) is an adipose tissue-derived hormone, which stimulates glucose and free fatty acid (FFA) uptake into adipocytes. Changes in ASP metabolism are associated with alterations in lipid metabolism. As postnatal catch-up growth has been associated with dyslipidaemia in...

journal_title：Clinical endocrinology

authors： Leunissen RW,Gao Y,Cianflone K,Stijnen T,Hokken-Koelega AC

更新日期：2010-06-01 00:00:00

abstract：:The results obtained with a new test of prolactin (PRL) release in six panhypopituitary patients as compared to fourteen normal subjects (eight females and six males) are presented. The test consists of the i.m. administration of 100 mg of sulpiride and the measurement of plasma PRL by a double antibody radioimmunoass...

journal_title：Clinical endocrinology

authors： Batrinos ML,Pavlou SN,Pitoulis SA,Sfikaki AP,Alexandrides TK,Piaditis GP

更新日期：1978-03-01 00:00:00

abstract：OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

journal_title：Clinical endocrinology

authors： Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:Little is known of the hormone environment of the developing early human embryo. We have therefore measured selected steroids in the intrauterine fluids of early pregnancy. DESIGN:Measurement of progesterone, 17 alpha-hydroxyprogesterone, oestradiol-17 beta, testosterone, androstenedione, cortisol and dehydr...

journal_title：Clinical endocrinology

authors： Atkinson G,Campbell DJ,Cawood ML,Oakey RE

更新日期：1996-04-01 00:00:00

abstract：OBJECTIVE:The insulin tolerance test (ITT) is contraindicated in a proportion of patients with suspected ACTH deficiency. The aim of this study was to investigate the diagnostic accuracy of the glucagon stress test (GST) compared with the overnight metyrapone test (OMT) in patients with contraindications to ITT. DESIG...

journal_title：Clinical endocrinology

authors： Cegla J,Jones B,Seyani L,Papadoulou D,Wynne K,Martin NM,Meeran K,Chapman R,Donaldson M,Goldstone AP,Tan T

更新日期：2013-05-01 00:00:00

abstract：INTRODUCTION:Iodine deficiency in pregnancy may impair foetal neurological development. The UK population is generally thought to be iodine sufficient; however, recent studies have questioned this assumption. Our study aimed to explore the prevalence of iodine deficiency in a cohort of pregnant mothers from South-West ...

journal_title：Clinical endocrinology

authors： Knight BA,Shields BM,He X,Pearce EN,Braverman LE,Sturley R,Vaidya B

更新日期：2017-03-01 00:00:00

abstract：OBJECTIVE:Scalp hair loss is often encountered in clinical practice in Japan after successful surgery for acromegaly. However, this intriguing issue has not been addressed in the literature. The aim of this study was to examine scalp hair loss after surgery for acromegaly. METHODS:Postoperative scalp hair loss was sur...

journal_title：Clinical endocrinology

authors： Yamada S,Fukuhara N,Nishioka H,Yamaguchi-Okada M,Takeshita A,Takeuchi Y

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVE:We have evaluated the efficacy of percutaneous ethanol injection as an alternative to surgery and iodine-131 treatment in solitary autonomous thyroid adenoma. DESIGN:Percutaneous ethanol injection (0.5-2.8 ml ethanol/ml nodular tissue) was performed under sonographic guidance in 3-5 (1-2 weekly) sessions; a ...

journal_title：Clinical endocrinology

authors： Monzani F,Goletti O,Caraccio N,Del Guerra P,Ferdeghini M,Pucci E,Baschieri L

更新日期：1992-05-01 00:00:00

abstract：:A 39-year-old woman presented with amenorrhoea, hyperprolactinaemia and sellar mass. Bromocriptine normalized PRL levels but failed to suppress tumour growth. Subsequently, she developed clinical signs and elevated blood cortisol levels consistent with a diagnosis of Cushing's disease. A pituitary tumour was removed w...

journal_title：Clinical endocrinology

authors： Ikeda H,Yoshimoto T,Kovacs K,Horvath E

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:The optimal treatment regimen with thionamide drugs remains a matter for debate. We have investigated whether high doses of carbimazole, when compared with low doses, reduce relapse rates of Graves' disease. DESIGN:In an open label, randomized, prospective trial of treatment of Graves' disease we compared hi...

journal_title：Clinical endocrinology

authors： Grebe SK,Feek CM,Ford HC,Fagerström JN,Cordwell DP,Delahunt JW,Toomath RJ

更新日期：1998-05-01 00:00:00

abstract：:Thyroid function and exposure to dietary goitrogenic factors (iodine deficiency and thiocyanate overload) were studied at birth and from birth to 7 years in 200 neonates and 347 children living in the severe endemic goitre area of Ubangi, Northern Zaire. Serum T4 was at the lower limit of normal at birth (104 +/- 4 nm...

journal_title：Clinical endocrinology

authors： Vanderpas J,Bourdoux P,Lagasse R,Rivera M,Dramaix M,Lody D,Nelson G,Delange F,Ermans AM,Thilly CH

更新日期：1984-03-01 00:00:00

abstract：:A A 23-year-old man with secondary hypogonadism was also found to be thyrotoxic. Results of thyroid function tests were in the hyperthyroid range but the serum TSH was inappropriately high. A pituitary tumour was demonstrated and following hypophysectomy he became biochemically hypothyroid. Evidence is presented and d...

journal_title：Clinical endocrinology

authors： Baylis PH

更新日期：1976-03-01 00:00:00

abstract：BACKGROUND:Hydrocortisone therapy should be individualized in congenital adrenal hyperplasia (CAH) patients to avoid over and under replacement. We have assessed how differences in absorption and half-life of cortisol influence glucocorticoid exposure. PATIENTS AND METHODS:Forty-eight patients (21 M) aged between 6·1 ...

journal_title：Clinical endocrinology

authors： Hindmarsh PC,Charmandari E

更新日期：2015-04-01 00:00:00