Pituitary-ovarian function before, during and after the menopause: a longitudinal study.

abstract：OBJECTIVE:Glucocorticoid excess is commonly related to neuropsychiatric and neurological disorders, with memory impairment typically found among these disorders. The objective of this study is to offer a clinical profile of memory deficits resulting from exposure to chronic stress-level elevations of endogenous glucoco...

journal_title：Clinical endocrinology

authors： León-Carrión J,Atutxa AM,Mangas MA,Soto-Moreno A,Pumar A,Leon-Justel A,Martín-Rodriguez JF,Venegas E,Domínguez-Morales MR,Leal-Cerro A

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:Identification of the novel endocrine role of osteocalcin (OC) and its receptor GPRC6A has given rise to a new branch of research in OC/GPRC6A axis related to glucose metabolism. GPRC6A- and OC-deficient mice share features of the metabolic syndrome, in addition to male infertility. Recently, the polymorphism...

journal_title：Clinical endocrinology

authors： Di Nisio A,Rocca MS,Fadini GP,De Toni L,Marcuzzo G,Marescotti MC,Sanna M,Plebani M,Vettor R,Avogaro A,Foresta C

更新日期：2017-02-01 00:00:00

abstract：:In 44 patients with acromegaly treated by transsphenoidal pituitary microsurgery, the relationship between changes in pre- and post-operative GH dynamics and postoperative fasting plasma GH levels was examined to clarify which is the optimal approach for evaluating postoperative removal of the tumour. TRH, LHRH and br...

journal_title：Clinical endocrinology

authors： Karashima T,Kato K,Nawata H,Ikuyama S,Ibayashi H,Nakagaki H,Kitamura K

更新日期：1986-08-01 00:00:00

abstract：:A new radioreceptor assay for insulin-like growth factor-II (IGF-II), using receptors on ovine placental membranes, is described. Half-maximal displacement of specifically bound radioiodinated human IGF-II tracer was seen at 1.0 ng/tube of unlabelled IGF-II. The cross-reactivity of IGF-I was 1%, and insulin was entire...

journal_title：Clinical endocrinology

authors： Baxter RC,de Mellow JS

更新日期：1986-03-01 00:00:00

abstract：OBJECTIVE:The purpose was to investigate whether the function of the pinealocytes is changed in patients with disturbed metabolic rate or in subjects with marked obesity. DESIGN:Venous blood was sampled every second hour between 1800 and 0800 h, and urine collected between 2200 and 0700 h. PATIENTS:Eight patients wit...

journal_title：Clinical endocrinology

authors： Röjdmark S,Berg A,Rössner S,Wetterberg L

更新日期：1991-07-01 00:00:00

abstract：:A 42-year-old woman had galactorrhoea and amenorrhoea. Four years previously she complained of sensory disturbance of her legs, with galt disturbance. Serum PRL level was 1408 mU/l. Magnetic resonance imaging showed a spindle-shaped mass in the spinal canal at the level of the ninth thoracic vertebra. The tumour was r...

journal_title：Clinical endocrinology

authors： Katsuren E,Ishikawa S,Honda K,Saito T

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:We aimed to investigate the impact of a long-acting somatostatin analogue, octreotide, on glucose tolerance and on insulin sensitivity in acromegaly. DESIGN:We performed a non-randomized controlled trial. PATIENTS:Seven patients with active acromegaly were assessed before and during octreotide therapy given...

journal_title：Clinical endocrinology

authors： Ho KK,Jenkins AB,Furler SM,Borkman M,Chisholm DJ

更新日期：1992-03-01 00:00:00

abstract：:We have recently reported an impaired growth hormone (GH) response to a single i.v. bolus dose of growth hormone releasing factor (1 microgram/kg body weight) in obese women. We have now investigated whether the i.v. administration of low dose GHRF(1-29)NH2 (0.33 microgram/kg/h) by 15 min pulsed injections for 3 h fol...

journal_title：Clinical endocrinology

authors： Kopelman PG,Noonan K

更新日期：1986-02-01 00:00:00

abstract：:We were able to observe the effect of withdrawal of endogenous sympathetic drive in a hypertensive patient with an aldosterone-secreting adrenal adenoma. Acute stimulation of both carotid sinus nerves lowered blood pressure to normotensive or hypotensive levels by reducing peripheral resistance. When chronic carotid s...

journal_title：Clinical endocrinology

authors： Nicholls MG,Julius S,Zweifler AJ

更新日期：1981-09-01 00:00:00

abstract：OBJECTIVE:Parathyroid carcinoma remains difficult to diagnose. Recently, it has been shown that mutations in the HRPT2 gene (encoding parafibromin) are associated with the development of parathyroid carcinoma. Although MEN1 is not typically thought to be involved in carcinoma formation, parathyroid carcinoma may be an ...

journal_title：Clinical endocrinology

authors： Haven CJ,van Puijenbroek M,Tan MH,Teh BT,Fleuren GJ,van Wezel T,Morreau H

更新日期：2007-09-01 00:00:00

abstract：BACKGROUND:Assessment of the hypothalamic-pituitary-adrenal (HPA) axis after pituitary surgery is important for appropriate decision making regarding replacement therapy. The synacthen test is often used but is questioned, as time has to elapse for adrenal atrophy to develop. OBJECTIVE:To audit the use of the 250 micr...

journal_title：Clinical endocrinology

authors： Klose M,Lange M,Kosteljanetz M,Poulsgaard L,Feldt-Rasmussen U

更新日期：2005-11-01 00:00:00

abstract：:Although vasomotor instability or hot flushes are a well-known occurrence in women with natural or artificially-induced menopause, they have not previously been described in children. We report three children in different stages of puberty who developed vasomotor instability following surgery involving the hypothalami...

journal_title：Clinical endocrinology

authors： Witt MF,Blethen SL

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVE:We determined the effects of physiological (non-hypotensive) increments of plasma atrial natriuretic factor (ANF) on the vasopressin and hypothalamic-pituitary-adrenal response to insulin induced hypoglycaemia. DESIGN:Single blind, placebo controlled, randomized study of the effect of vehicle alone or ANF (2...

journal_title：Clinical endocrinology

authors： Wittert GA,Espiner EA,Richards AM,Donald RA,Livesey JH,Yandle TG

更新日期：1993-02-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy and safety of prenatal dexamethasone treatment in offspring at risk for congenital adrenal hyperplasia. METHODS:MEDLINE, EMBASE, the Cochrane Library, the clinicaltrials.gov website databases were systematically searched from inception through March 2019. WMD and SMD with 95%CIs were c...

journal_title：Clinical endocrinology

authors： Xu L,Lin W,Cai L,Huang H,Liang J,Li L,Zong L,Wang N,Wen J,Chen G

更新日期：2020-02-01 00:00:00

abstract：:Twenty-four hyperprolactinaemic women were treated for 6 months with the new, non-ergot, long-acting dopamine agonist, CV 205-502. The treatment resulted in normalization of PRL secretion in 17 of the 24 women at once-daily doses of 0.05 to 0.15 mg of the drug. Sixteen of these women as well as 4 of those who remained...

journal_title：Clinical endocrinology

authors： Rasmussen C,Bergh T,Wide L,Brownell J

更新日期：1988-09-01 00:00:00

abstract：:Growth hormone release-inhibiting hormone (GHR-IH) was administered to five patients with abnormal pituitary-adrenal function. There was immediate suppression by about 50% of ACTH levels in two patients who had undergone bilateral adrenalectomy because of Cushing's disease; one of them had Nelson's syndrome. Bromocryp...

journal_title：Clinical endocrinology

authors： Benker G,Hackenberg K,Hamburger B,Reinwein D

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:Vasopressin (AVP) is reported to be an important factor for regulating cortisol secretion in patients with Cushing's syndrome due to ACTH-independent macronodular adrenocortical hyperplasia (AIMAH). Recently, there have been several case reports of subclinical Cushing's syndrome due to AIMAH, in which the pat...

journal_title：Clinical endocrinology

authors： Tatsuno I,Uchida D,Tanaka T,Koide H,Shigeta A,Ichikawa T,Sasano H,Saito Y

更新日期：2004-02-01 00:00:00

abstract：:We have studied three patients (1M, 2F), age range 10.9 to 15.5 years, who had abnormal sexual maturation secondary to primary hypothyroidism. The boy had inappropriately large testes for his stage of puberty, the girls had isolated breast development and there was absence of pubertal growth acceleration. FSH, LH, TSH...

journal_title：Clinical endocrinology

authors： Pringle PJ,Stanhope R,Hindmarsh P,Brook CG

更新日期：1988-05-01 00:00:00

abstract：:A single-dose study was performed to examine the pharmacokinetics of subcutaneous octreotide in acromegalic patients and to investigate the relationship between growth hormone and the elimination half-life of the drug. Fourteen acromegalic patients (six men and eight women; age range 35-59 years) who had previously re...

journal_title：Clinical endocrinology

authors： Nicholls J,Wynick D,Domin J,Sandler LM,Bloom SR

更新日期：1990-05-01 00:00:00

abstract：:We have previously reported that L-thyroxine treated patients may often have elevated serum T4 concentrations and yet show no clinical signs of hyperthyroidism. We found that such patients had normal serum T3 concentrations. The present study explored the relationship between serum T3 and T4 and dosage of L-thyroxine....

journal_title：Clinical endocrinology

authors： Rendell M,Salmon D

更新日期：1985-06-01 00:00:00

abstract：BACKGROUND:Mutations in PROP1, HESX1 and LHX3 are associated with combined pituitary hormone deficiency (CPHD) and orthotopic posterior pituitary lobe (OPP). OBJECTIVE:To identify mutations in PROP1, HESX1 and LHX3 in a large cohort of patients with CPHD and OPP (35 Brazilian, two Argentinian). DESIGN AND METHODS:We ...

journal_title：Clinical endocrinology

authors： Madeira JL,Nishi MY,Nakaguma M,Benedetti AF,Biscotto IP,Fernandes T,Pequeno T,Figueiredo T,Franca MM,Correa FA,Otto AP,Abrão M,Miras MB,Santos S,Jorge AA,Costalonga EF,Mendonca BB,Arnhold IJ,Carvalho LR

更新日期：2017-12-01 00:00:00

abstract：OBJECTIVE:Treatment by octreotide has been suggested in medullary thyroid carcinoma patients with post-surgery metastases. The purpose of this study was to evaluate if the tumoral regression could be improved by a high dose and by prolonged octreotide treatment. DESIGN:Fourteen thyroidectomized patients were studied. ...

journal_title：Clinical endocrinology

authors： Modigliani E,Cohen R,Joannidis S,Siame-Mourot C,Guliana JM,Charpentier G,Cassuto D,Bentata Pessayre M,Tabarin A,Roger P

更新日期：1992-02-01 00:00:00

abstract：CONTEXT:Carney complex (CNC) is an autosomal dominant multiple endocrine neoplasia syndrome (OMIM 160980). About 70% of cases are familiar; most have mutations of the PRKAR1A gene on chromosome 17q22-24. There is little phenotype-genotype correlation known to date. OBJECTIVE:To study the genotype-phenotype correlation...

journal_title：Clinical endocrinology

authors： Gennari M,Stratakis CA,Hovarth A,Pirazzoli P,Cicognani A

更新日期：2008-11-01 00:00:00

abstract：CONTEXT:Endothelial progenitor cells (EPCs) are bone marrow-derived cells required for endothelial repair. Circulating EPC concentration is low in conditions characterized by endothelial dysfunction but their number can be increased by treatment with phosphodiesterase-5 (PDE5) inhibitors. EPCs are also reduced in hypog...

journal_title：Clinical endocrinology

authors： Foresta C,Di Mambro A,Caretta N,De Toni L,Zuccarello D,Ferlin A

更新日期：2009-09-01 00:00:00

abstract：OBJECTIVE:Pituitary responsiveness to GnRH varies throughout the normal menstrual cycle. We have investigated whether there are differences in the ovarian mechanisms which regulate gonadotrophin secretion between the follicular and the luteal phase of the cycle. DESIGN:Normally ovulating women were studied during the ...

journal_title：Clinical endocrinology

authors： Alexandris E,Milingos S,Kollios G,Seferiadis K,Lolis D,Messinis IE

更新日期：1997-12-01 00:00:00

abstract：BACKGROUND:Iodide organification defects are frequently but not always associated with mutations in the thyroid peroxidase (TPO) gene and characterized by a positive perchlorate discharge test. These mutations phenotypically produce a congenital goitrous hypothyroidism, with an autosomal recessive mode of inheritance. ...

journal_title：Clinical endocrinology

authors： Rivolta CM,Louis-Tisserand M,Varela V,Gruñeiro-Papendieck L,Chiesa A,González-Sarmiento R,Targovnik HM

更新日期：2007-08-01 00:00:00

abstract：:In order to evaluate the possible influence of GABAergic neurotransmission on the arginine vasopressin (AVP) response to osmotic and pressure volumetric stimuli, the GABAergic drug sodium valproate was administered by mouth (200 or 400 mg 16 h, 8 h and just before tests) to eight normal men before osmotic (i.v. infusi...

journal_title：Clinical endocrinology

authors： Chiodera P,Gnudi A,Volpi R,Marchesi C,Marchesi M,Davoli D,Capretti L,Coiro V

更新日期：1989-04-01 00:00:00

abstract：OBJECTIVES:Alterations in protein expression of histone deacetylase 2 (HDAC2) have been demonstrated in various neoplasms, and lack of nuclear expression of HDAC2 has previously been shown in some human and canine corticotroph adenomas. This study aimed to examine HDAC2 expression in a Norwegian cohort of corticotroph ...

journal_title：Clinical endocrinology

authors： Evang JA,Borota OC,Melum E,Holm R,Ramm-Pettersen J,Bollerslev J,Berg JP

更新日期：2010-08-01 00:00:00

abstract：OBJECTIVE:Mutations of the PROP1 gene lead to combined pituitary hormone deficiency (CPHD), which is characterized by a deficiency of GH, TSH, LH/FSH, PRL and, less frequently, ACTH. This study was undertaken to investigate the molecular defect in a cohort of patients with CPHD. DESIGN, PATIENTS AND MEASUREMENTS:A mul...

journal_title：Clinical endocrinology

authors： Lemos MC,Gomes L,Bastos M,Leite V,Limbert E,Carvalho D,Bacelar C,Monteiro M,Fonseca F,Agapito A,Castro JJ,Regateiro FJ,Carvalheiro M

更新日期：2006-10-01 00:00:00

abstract：OBJECTIVE:Polymorphisms in the thyroid transcription factor forkhead factor E1 (FOXE1) gene have been implicated in the genetic susceptibility to differentiated thyroid cancer, but little is known about their effect on tumour characteristics. The objective of this study was to determine the contribution of the FOXE1 po...

journal_title：Clinical endocrinology

authors： Raimundo J,Alvelos MI,Azevedo T,Martins T,Rodrigues FJ,Lemos MC

更新日期：2017-02-01 00:00:00