Association of FOXE1 polyalanine repeat region with thyroid cancer is dependent on tumour size.

abstract：OBJECTIVE:Reviewing the clinical outcomes of a large kindred with a RET p.Gly533Cys mutation, 10 years after the first description of this kindred, has provided an important set of clinical data for healthcare decision-making. DESIGN AND PATIENTS:We identified 728 RET533 Brazilian relatives, spread out over 7 generati...

journal_title：Clinical endocrinology

authors： Signorini PS,França MI,Camacho CP,Lindsey SC,Valente FO,Kasamatsu TS,Machado AL,Salim CP,Delcelo R,Hoff AO,Cerutti JM,Dias-da-Silva MR,Maciel RM

更新日期：2014-02-01 00:00:00

abstract：:Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The ...

journal_title：Clinical endocrinology

authors： Fraioli F,Cappa M,Fabbri A,Gnessi L,Moretti C,Borrelli P,Isidori A

更新日期：1984-03-01 00:00:00

abstract：OBJECTIVES:Sleep apnoea has been reported to occur in subjects with acromegaly. This study evaluates the relationship among biochemical activity, sleep apnoeic activity and upper airway anatomic profile in acromegaly, and the effect of Sandostatin LAR, a long-acting somatostatin analogue, on these parameters. PATIENTS...

journal_title：Clinical endocrinology

authors： Ip MS,Tan KC,Peh WC,Lam KS

更新日期：2001-10-01 00:00:00

abstract：OBJECTIVE:Human resistin gene (RETN) polymorphisms have been found to be associated with type 2 diabetes (T2DM), insulin resistance and/or obesity. We evaluated, in a 5-year prospective study, whether RETN polymorphisms could predict the progression of glycaemia in southern Chinese. DESIGN AND PATIENTS:We conducted a ...

journal_title：Clinical endocrinology

authors： Xu JY,Sham PC,Xu A,Tso AW,Wat NM,Cheng KY,Fong CH,Janus ED,Lam KS

更新日期：2007-02-01 00:00:00

abstract：:The response of plasma immunoreactive met-enkephalin (IR-met-enkephalin) to ethanol (8 g by mouth) after chlorpropamide (250 mg daily for 14 d) was studied in three groups of non-insulin dependent diabetics (a) six diabetics who showed chlorpropamide alcohol flush (CPAF) and in whom the reaction could be blocked by in...

journal_title：Clinical endocrinology

authors： Johnston C,Wiles PG,Medbak S,Bowcock S,Cooke ED,Pyke DA,Rees LH

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:We assessed the relationship between serum IGFBP-3 levels with IGF-I and quantitative GH secretory status in poorly growing children. DESIGN:We studied the relationship between 24-hour integrated concentration of GH, peak GH to paired sequential stimulation tests, IGF-I and the IGFBP-3 serum levels. PATIENT...

journal_title：Clinical endocrinology

authors： Phillip M,Chalew SA,Kowarski AA,Stene MA

更新日期：1993-10-01 00:00:00

abstract：OBJECTIVE:Vaspin is associated with metabolic parameters and insulin resistance. However, the expression of vaspin in visceral adipose tissue (VAT) in pregnant women with gestational diabetes mellitus (GDM) has not been fully explored, and the contribution of vaspin to the biological mechanisms underlying GDM remains u...

journal_title：Clinical endocrinology

authors： Tang Y,Qiao P,Qu X,Bao Y,Li Y,Liao Y,Ying H

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:Some patients with parathyroid carcinoma present with an over-production of nontruncated amino-terminal (NT-N) parathyroid hormone (PTH), a post-transcriptionally modified form of PTH(1-84). This is usually picked up on an elevated whole (W) PTH (third-generation)/total (T) (second-generation) PTH assay ratio...

journal_title：Clinical endocrinology

authors： Caron P,Simonds WF,Maiza JC,Rubin M,Cantor T,Rousseau L,Bilezikian JP,Souberbielle JC,D'Amour P

更新日期：2011-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to evaluate the overall ultrasonographic features and clinical factors that contribute to inadequate sampling in ultrasound-guided fine-needle aspiration biopsy (US-FNAB) of thyroid nodules. MATERIALS AND METHODS:From April 2008 to December 2008, 4077 US-FNABs in 3767 consecutive pati...

journal_title：Clinical endocrinology

authors： Choi SH,Han KH,Yoon JH,Moon HJ,Son EJ,Youk JH,Kim EK,Kwak JY

更新日期：2011-06-01 00:00:00

abstract：OBJECTIVE:Osteocalcin is a bone-specific protein secreted by osteoblasts and often used as a bone formation biomarker. Rodent studies have reported a hormonal role of osteocalcin on glucose metabolism, increasing insulin secretion and sensitivity and increasing energy expenditure. However, it is unknown whether osteoca...

journal_title：Clinical endocrinology

authors： Rochefort GY,Rocher E,Aveline PC,Garnero P,Bab I,Chappard C,Jaffré C,Benhamou CL

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:Pseudohypoparathyroidism type Ia (PHP-Ia) is a hereditary disorder characterized by resistance to multiple hormones that work via cAMP such as PTH and TSH, accompanied by typical skeletal features including short stature and brachydactyly, termed Albright hereditary osteodystrophy (AHO). In affected kindreds,...

journal_title：Clinical endocrinology

authors： Mouallem M,Shaharabany M,Weintrob N,Shalitin S,Nagelberg N,Shapira H,Zadik Z,Farfel Z

更新日期：2008-02-01 00:00:00

abstract：OBJECTIVE:Epidemiological studies on the cardiovascular risk of progestagen-only contraceptives are rare. With the present study we aimed to investigate the effect of the low-dose etonogestrel-releasing contraceptive implant Implanon on cardiovascular risk factors, including markers of inflammation. DESIGN:Longitudina...

journal_title：Clinical endocrinology

authors： Merki-Feld GS,Imthurn B,Seifert B

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:Infusion of GH secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted GH secretion associated with a substantial IGF-I rise. Here we report the dynamic characteristics of spontaneous nightly TSH and PRL secre...

journal_title：Clinical endocrinology

authors： Van den Berghe G,de Zegher F,Veldhuis JD,Wouters P,Gouwy S,Stockman W,Weekers F,Schetz M,Lauwers P,Bouillon R,Bowers CY

更新日期：1997-11-01 00:00:00

abstract：BACKGROUND:Traditionally, acromegaly evaded diagnosis until in its clinically obvious later stages when treatment is more difficult. Over the last 25 years diagnostic tests have improved, but whether clinical disease detection also improved was unknown, so we tested if disease severity at diagnosis had changed from 198...

journal_title：Clinical endocrinology

authors： Reid TJ,Post KD,Bruce JN,Nabi Kanibir M,Reyes-Vidal CM,Freda PU

更新日期：2010-02-01 00:00:00

abstract：:The thyroid functional parameters of 102 children with protein-calorie malnutrition (PCM) classified as undernourished, marasmic, kwashiorkor and marasmic-kwashiorkor were studied by measuring the serum T4, T3, T3 percentage uptake (T3%UT), free thyroxine index (FTI), and (in a few subjects) TSH. Total plasma proteins...

journal_title：Clinical endocrinology

authors： Onuora C,Maharajan G,Singh A,Etta KM

更新日期：1983-01-01 00:00:00

abstract：OBJECTIVE:There is increasing evidence that antenatal stress has long-lasting effects on child development, but there is less accord on the mechanisms and the gestational window of susceptibility. One possible mechanism is by foetal exposure to maternal cortisol. To explore this, we investigated the relationship betwee...

journal_title：Clinical endocrinology

authors： Sarkar P,Bergman K,Fisk NM,O'Connor TG,Glover V

更新日期：2007-05-01 00:00:00

abstract：:In order to evaluate the effect of alpha-1 adrenoreceptor regulation of ACTH release during insulin-induced hypoglycaemia, we studied the response to hypoglycaemia with and without prazosin premedication in eight normal men. Prazosin pretreatment did not affect basal or peak plasma ACTH, cortisol or GH during hypoglyc...

journal_title：Clinical endocrinology

authors： Cuneo RC,Livesey JH,Nicholls MG,Espiner EA,Donald RA

更新日期：1987-01-01 00:00:00

abstract：:We have studied the inositol phospholipid turnover response to thyrotrophin-releasing hormone (TRH) gonadotrophin-releasing hormone (GnRH) and arginine vasopressin (AVP) in five corticotroph and six somatotroph pituitary adenomas. GnRH (100 nM) increased inositol phospholipid turnover in five of five somatotroph adeno...

journal_title：Clinical endocrinology

authors： Levy A,Lightman SL,Hoyland J,Mason WT

更新日期：1990-07-01 00:00:00

abstract：INTRODUCTION:Previous studies investigating cardiovascular (CV) risk in obese women with polycystic ovary syndrome (PCOS) have been potentially confounded by not adequately accounting for body weight. OBJECTIVE:To assess if PCOS increases CV risk independently in young obese women by examining carotid intima-media wal...

journal_title：Clinical endocrinology

authors： Kahal H,Aburima A,Ungvari T,Rigby AS,Dawson AJ,Coady AM,Vince RV,Ajjan RA,Kilpatrick ES,Naseem KM,Atkin SL

更新日期：2013-08-01 00:00:00

abstract：OBJECTIVE:Nonuniformity in suppression of spermatogenesis induced by various hormones or hormone combinations has impeded the development of an effective hormonal male contraceptive. The basis for this heterogeneity in response remained unresolved to date; however, the presence of ethnic differences points to an involv...

journal_title：Clinical endocrinology

authors： Eckardstein SV,Schmidt A,Kamischke A,Simoni M,Gromoll J,Nieschlag E

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVE:Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. The significance of MC4R mutations in Asian obese populations has not been adequately examined. The objective of this study was to determine the role of MC4R mutations in severely obese Asian children. DESIGN:We screened 22...

journal_title：Clinical endocrinology

authors： Lee YS,Poh LK,Kek BL,Loke KY

更新日期：2008-04-01 00:00:00

abstract：INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and s...

journal_title：Clinical endocrinology

authors： Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

更新日期：2014-09-01 00:00:00

abstract：OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

journal_title：Clinical endocrinology

authors： Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

更新日期：2018-09-01 00:00:00

abstract：OBJECTIVE:Both severe growth hormone (GH) deficiency in hypopituitary adults and physiological ageing are associated with an increase in fat mass, dyslipidaemia, and an increased incidence of cardiovascular disease. Ageing is also associated with a physiological decrease in spontaneous as well as stimulated GH secretio...

journal_title：Clinical endocrinology

authors： Vahl N,Klausen I,Christiansen JS,Jørgensen JO

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND:Disturbances in the GH/IGF-I axis are reported in 25-60% of short children born small for gestational age (SGA). We hypothesized that these abnormalities might be related to abnormalities in the pituitary region. Therefore, the results of magnetic resonance imaging (MRI) of short SGA children were compared t...

journal_title：Clinical endocrinology

authors： Arends NJ,V d Lip W,Robben SG,Hokken-Koelega AC

更新日期：2002-12-01 00:00:00

abstract：BACKGROUND:Efficacy of the GH-receptor antagonist pegvisomant (PEG) has differed between preclinical and observational studies mainly due to dose adjustment and IGF-I normalization criteria. An escape phenomenon has also been described, but its definition and underlying causes have not been fully established. OBJECTIV...

journal_title：Clinical endocrinology

authors： Ramos-Leví AM,Bernabeu I,Álvarez-Escolá C,Aller J,Lucas T,de Miguel P,Rodríguez-Cañete L,Sampedro-Núñez MA,Halperin I,Puig-Domingo M,Marazuela M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:To analyse the effectiveness of age on HbA1c as a criterion for the diagnosis of diabetes in Chinese different age subjects. METHODS:This retrospective study enrolled a total of 1147 outpatients with untreated newly diagnosed diabetes (aged 18-80 years, 42·55% women) from the Fujian Province, China, and 427 ...

journal_title：Clinical endocrinology

authors： Yang L,Shen X,Yan S,Xu F,Wu P

更新日期：2015-02-01 00:00:00

abstract：OBJECTIVE:To examine the association between glycaemic control, insulin resistance and hyperandrogenism on cardiac autonomic function in peripubertal girls with type 1 diabetes. DESIGN:Prospective, clinic-based study of 125 girls with diabetes and 46 age-matched nondiabetic girls. MEASUREMENTS:Heart rate variability ...

journal_title：Clinical endocrinology

authors： Cho YH,Craig ME,Srinivasan S,Benitez-Aguirre P,Mitchell P,Jopling T,Donaghue KC

更新日期：2014-06-01 00:00:00

abstract：OBJECTIVE:Malignant phaeochromocytomas are rare and highly aggressive tumours. This retrospective study evaluated the outcome of combined chemotherapy with cyclophosphamide, vincristine and dacarbazine (also known as CVD regimen). METHODS:Patients with histologically and radiologically confirmed malignant phaeochromoc...

journal_title：Clinical endocrinology

authors： Deutschbein T,Fassnacht M,Weismann D,Reincke M,Mann K,Petersenn S

更新日期：2015-01-01 00:00:00

abstract：:The glucocorticoid hormone cortisol is released in pulses resulting in a complex and dynamic ultradian rhythm of plasma cortisol that underlies the classical circadian rhythm. These oscillating levels are also seen at the level of tissues such as the brain and trigger pulses of gene activation and downstream signallin...

journal_title：Clinical endocrinology

authors： Russell GM,Durant C,Ataya A,Papastathi C,Bhake R,Woltersdorf W,Lightman S

更新日期：2014-08-01 00:00:00