Thyroid status in various degrees of protein-calorie malnutrition in children.

abstract：OBJECTIVE:Recovery of thyroid function in patients following hypothyroidism induced by 131I therapy for Graves' disease has been described, but only a few detailed clinical and biochemical studies of this phenomenon (transient hypothyroidism) have been published. The prevalence, mechanism, and final outcome of transien...

journal_title：Clinical endocrinology

authors： Aizawa Y,Yoshida K,Kaise N,Fukazawa H,Kiso Y,Sayama N,Hori H,Abe K

更新日期：1997-01-01 00:00:00

abstract：INTRODUCTION:Diagnostic I-123 scans have been shown to underestimate the disease burden in differentiated thyroid cancer (DTC) when compared to I-131 post-treatment scans, especially in children and patients who have had prior radioiodine (RAI) therapy and/or distant metastasis. I-124 PET/CT has been shown to be highly...

journal_title：Clinical endocrinology

authors： Santhanam P,Taieb D,Solnes L,Marashdeh W,Ladenson PW

更新日期：2017-05-01 00:00:00

abstract：:The role of endogenous opiate peptides in puerperal hyperprolactinaemia, and in the control of TSH in hypothyroidism, has been investigated. Although exogenous opioids raise prolactin and TSH levels, 16 mg naloxone administered to women on days 2-4 of the puerperium produced no significant change in serum prolactin an...

journal_title：Clinical endocrinology

authors： Grossman A,West S,Williams J,Evans J,Rees LH,Besser GM

更新日期：1982-03-01 00:00:00

abstract：OBJECTIVE:Research on sources of variation in adolescent's gonadal hormone levels is limited. We sought to decompose individual differences in adolescent testosterone, estradiol, and pubertal status, into genetic and environmental components. DESIGN:A sample of male and female adolescent twins from the greater Austin ...

journal_title：Clinical endocrinology

authors： Grotzinger AD,Mann FD,Patterson MW,Herzhoff K,Tackett JL,Tucker-Drob EM,Paige Harden K

更新日期：2018-02-01 00:00:00

abstract：:The uterine cross-sectional area (UXA) of women with polycystic (PCO) or multifollicular ovaries (MFO) is significantly larger and smaller, respectively, than those of normal women during the early-mid-follicular phase of the menstrual cycle. In the present study the distribution of oestradiol in plasma from normal wo...

journal_title：Clinical endocrinology

authors： Polson DW,Franks S,Reed MJ,Cheng RW,Adams J,James VH

更新日期：1987-05-01 00:00:00

abstract：OBJECTIVE:Resistance to thyroid hormone (RTH) is a dominantly inherited syndrome of reduced tissue responsiveness to thyroid hormone usually due to mutations located in the ligand-binding domain and adjacent hinge region of the thyroid hormone receptor beta (TRbeta). In the present report we describe the clinical and l...

journal_title：Clinical endocrinology

authors： Magalhães PK,Rodrigues Dare GL,Rodrigues Dos Santos S,Nogueira CR,de Castro M,Zanini Maciel LM

更新日期：2007-11-01 00:00:00

abstract：OBJECTIVE:We aimed to evaluate and contrast the hypothalamo-pituitary-adrenal (HPA) response to direct current (DC) cardioversion and electroconvulsive therapy (ECT). SUBJECTS:Six male subjects (mean age 61.2 years, range 46-74) with chronic atrial fibrillation were selected for cardioversion. Six subjects with depres...

journal_title：Clinical endocrinology

authors： Florkowski CM,Crozier IG,Nightingale S,Evans MJ,Ellis MJ,Joyce P,Donald RA

更新日期：1996-02-01 00:00:00

abstract：BACKGROUND:A number of surgical series have been reported on the treatment of acromegaly and their results vary widely. The acceptable definition of remission has changed in recent years and it is known, though in a small series, that growth hormone levels of > 5 mU/l are still associated with an increased mortality fr...

journal_title：Clinical endocrinology

authors： Ahmed S,Elsheikh M,Stratton IM,Page RC,Adams CB,Wass JA

更新日期：1999-05-01 00:00:00

abstract：:Bilateral, selective and simultaneous catheterization of the inferior petrosal sinus with measurements of ACTH after stimulation with ovine corticotrophin-releasing factor (CRF) is now frequently used to establish the differential diagnosis in patients with Cushing's disease and to determine the side of the microadeno...

journal_title：Clinical endocrinology

authors： Schulte HM,Allolio B,Günther RW,Benker G,Winkelmann W,Ohnhaus EE,Reinwein D

更新日期：1988-03-01 00:00:00

abstract：CONTEXT:The inconclusive evidence regarding long-term safety of recombinant human growth hormone (rhGH) therapy underlines the need for long-term large-scale cohorts. OBJECTIVE:To assess long-term mortality and cancer incidence among patients treated with rhGH during childhood in Israel. DESIGN:A population-based coh...

journal_title：Clinical endocrinology

authors： Libruder C,Blumenfeld O,Dichtiar R,Laron Z,Zadik Z,Shohat T,Afek A

更新日期：2016-11-01 00:00:00

abstract：CONTEXT:Few studies have evaluated the metabolic outcomes of growth hormone (GH) treatment in idiopathic short stature (ISS). Moreover, children with ISS appear to need higher GH doses than children with GH deficiency (GHD) to achieve the same amount of growth and may therefore be at increased risk of adverse events du...

journal_title：Clinical endocrinology

authors： Decker R,Albertsson-Wikland K,Kriström B,Nierop AF,Gustafsson J,Bosaeus I,Fors H,Hochberg Z,Dahlgren J

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND:Patients with idiopathic hypoparathyroidism (IH) require variable doses of calcium and 1-α-(OH)D. The reasons for such variability are not clear. As autoimmune mechanisms may play a role in IH, there is a possibility of coexistent coeliac disease with calcium/vitamin D malabsorption. OBJECTIVE:We assessed t...

journal_title：Clinical endocrinology

authors： Saha S,Saini S,Makharia GK,Datta Gupta S,Goswami R

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:We examined the effect of GH substitution on adipose tissue-derived hormones and cytokines and sought to identify predictors for changes in body composition during therapy. Long-standing adult-onset GH deficiency (AO-GHD) is associated with increased body fat mass (FM) which, through production of hormones an...

journal_title：Clinical endocrinology

authors： Ueland T,Jørgensen AP,Godang K,Fougner KJ,Aukrust P,Burman P,Bollerslev J

更新日期：2011-01-01 00:00:00

abstract：:The ultrastructural effects of a Leydig cell tumour of the testis on nontumorous testicular tissue have not yet been reported. Described here are the electron microscopic findings in the nonneoplastic testicular tissue of a patient with a feminizing testicular Leydig cell neoplasm. Serial studies were carried out over...

journal_title：Clinical endocrinology

authors： Sohval AR,Churg J,Suzuki Y,Katz N,Gabrilove JL

更新日期：1977-02-01 00:00:00

abstract：OBJECTIVE:Somatostatin analogues have become the mainstay of the medical treatment of acromegaly. The aim of our study was to evaluate the efficacy and tolerability of octreotide-LAR (OCT-LAR) treatment in acromegalic patients. DESIGN:Prospective open trial. PATIENTS AND METHODS:Eighty acromegalic patients (46 women;...

journal_title：Clinical endocrinology

authors： Jallad RS,Musolino NR,Salgado LR,Bronstein MD

更新日期：2005-08-01 00:00:00

abstract：OBJECTIVE:Therapy with GHRH in patients with mild GH insufficiency appears to be more effective than in those with severe insufficiency. We, therefore, studied the clinical response of children with idiopathic short stature to treatment with GHRH(1-29)NH2 (GHRHa) for a period of 12 months. DESIGN:Eighteen short pre-pu...

journal_title：Clinical endocrinology

authors： Kirk JM,Trainer PJ,Majrowski WH,Murphy J,Savage MO,Besser GM

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE AND DESIGN:The immediate early gene locus AP-1, incorporating the cellular oncogenes c-fos and c-jun (and their oncoprotein products Fos and Jun respectively) play a key role in regulating cell growth and differentiation. The myc-gene is also known to promote cell growth. In order to investigate the possible ...

journal_title：Clinical endocrinology

authors： Raghavan R,Harrison D,Ince PG,James RA,Daniels M,Birch P,Caldwell GI,Kendall-Taylor P

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Discontinuation of dopamine agonist (DA) treatment in women with prolactinoma after menopause is a potential approach; studies systematically assessing long-term outcomes are lacking. Our aim was to investigate the natural history of prolactinoma in this group. DESIGN/PATIENTS:Retrospective cohort study of w...

journal_title：Clinical endocrinology

authors： Santharam S,Fountas A,Tampourlou M,Arlt W,Ayuk J,Gittoes N,Toogood A,Karavitaki N

更新日期：2018-09-01 00:00:00

abstract：:It is believed that the study of gonadal function of the child should be regarded as a whole, beginning with the fetus and ending with the adolescent. Gonadal function depends upon 3 levels of activities: 1) central level (extra-hypothalamic, hypothalamic, and anterior pituitary); 2) an intermediate level (gonadal a...

journal_title：Clinical endocrinology

authors： Forest MG,De Peretti E,Bertrand J

更新日期：1976-09-01 00:00:00

abstract：:Millions of women are treated with hormone replacement therapy (HRT) for relief of menopausal symptoms, including vasomotor flushes and sweats for which oestrogen is uniquely and highly effective. Others may continue longer-term treatment in the hope that HRT will help to prevent chronic disease. The preservation of b...

journal_title：Clinical endocrinology

authors： Armitage M,Nooney J,Evans S

更新日期：2003-08-01 00:00:00

abstract：:To test whether the administration of sodium fluoride in vivo results in an increase in osteocalcin concentration, we administered sodium fluoride to seven healthy male subjects for a period of 3 weeks. Fasting calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone and osteocalcin were meas...

journal_title：Clinical endocrinology

authors： Dandona P,Coumar A,Gill DS,Bell J,Thomas M

更新日期：1988-10-01 00:00:00

abstract：OBJECTIVES:The role of androgen decline in the sexual activity of adult males is controversial. To clarify whether sexual function would benefit from testosterone (T) treatment in men with partially or severely reduced serum T levels, we conducted a systematic review and meta-analysis of placebo-controlled studies publ...

journal_title：Clinical endocrinology

authors： Isidori AM,Giannetta E,Gianfrilli D,Greco EA,Bonifacio V,Aversa A,Isidori A,Fabbri A,Lenzi A

更新日期：2005-10-01 00:00:00

abstract：:Pituitary homogenates were prepared from patients undergoing pituitary ablation for breast or prostatic carcinoma (controls) and from patients with either PRL- and GH-secreting pituitary adenomas or from patients with 'functionless' pituitary tumours. The principal subcellular organelles, plasma membrane, lysosomes, m...

journal_title：Clinical endocrinology

authors： De Marco L,Mashiter K,Peters TJ

更新日期：1984-11-01 00:00:00

abstract：OBJECTIVE:We determined the effect of subclinical hyperthyroidism (defined as low circulating TSH with normal serum free T4) and subclinical hypothyroidism (raised serum TSH with normal free T4) on fasting levels of blood lipids. DESIGN:Prospective study of lipid concentrations in patients identified as having abnorma...

journal_title：Clinical endocrinology

authors： Parle JV,Franklyn JA,Cross KW,Jones SR,Sheppard MC

更新日期：1992-11-01 00:00:00

abstract：BACKGROUND:Proton magnetic resonance spectroscopy ((1) H-MRS) is a sensitive, noninvasive imaging technique capable of measuring brain metabolites in vivo. Chronic exposure to endogenous hypercortisolism in Cushing's syndrome (CS) is associated with negative effects on memory and hippocampal volumes, even after biochem...

journal_title：Clinical endocrinology

authors： Resmini E,Santos A,Gómez-Anson B,López-Mourelo O,Pires P,Vives-Gilabert Y,Crespo I,Portella MJ,de Juan-Delago M,Webb SM

更新日期：2013-11-01 00:00:00

abstract：OBJECTIVE:The aim of the study was to investigate whether the absence of increased 5 alpha-reductase activity explained the absence of hirsutism in premenopausal obese women with increased free testosterone (FT) levels. DESIGN:As in hyperandrogenicity there generally exists evidence for increased 5 alpha-reductase act...

journal_title：Clinical endocrinology

authors： Giagulli VA,De Pergola G,Giorgino F,Cignarelli M,Abbaticchio G,Vermeulen A,Giorgino R

更新日期：1992-06-01 00:00:00

abstract：OBJECTIVE:Low sex hormone-binding globulin (SHBG) is a consistent risk factor for type 2 diabetes, particularly in women. Coffee consumption has been associated with a lower risk of type 2 diabetes, but its effects on SHBG are less known. DESIGN AND METHODS:This was a cross-sectional study of 2377 nondiabetic pre- and...

journal_title：Clinical endocrinology

authors： Pihan-Le Bars F,Gusto G,Boutron-Ruault MC,Fagherazzi G,Bonnet F

更新日期：2017-11-01 00:00:00

abstract：BACKGROUND:Hospital-acquired hyponatraemia is a common and potentially serious condition. Risk factors for hospital-acquired hyponatraemia have not been studied in a controlled fashion. Methods From 1501 patients in whom serum sodium (S(Na)) was determined, 50 cases with hospital-acquired hyponatraemia (in-hospital dec...

journal_title：Clinical endocrinology

authors： Beukhof CM,Hoorn EJ,Lindemans J,Zietse R

更新日期：2007-03-01 00:00:00

abstract：:In recent years the techniques of molecular and cellular biology have made it possible to begin to dissect the origins and behaviour of the ACTH-secreting tumour cell. It is becoming apparent that these tumours represent undifferentiated neuroendocrine cells, and it may be that their peptide-secreting properties may h...

journal_title：Clinical endocrinology

authors： White A,Clark AJ

更新日期：1993-08-01 00:00:00

abstract：OBJECTIVE:The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or...

journal_title：Clinical endocrinology

authors： Binder G,Schweizer R,Blumenstock G,Braun R

更新日期：2015-01-01 00:00:00