Sodium fluoride stimulates osteocalcin in normal subjects.

Abstract:

:To test whether the administration of sodium fluoride in vivo results in an increase in osteocalcin concentration, we administered sodium fluoride to seven healthy male subjects for a period of 3 weeks. Fasting calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone and osteocalcin were measured prior to, during and 6 weeks after fluoride administration. Plasma calcium, phosphate and alkaline phosphatase and serum 25-hydroxyvitamin D and parathyroid hormone concentrations did not alter. Serum osteocalcin concentrations increased following fluoride administration, and the mean osteocalcin concentration at 3 weeks was significantly higher than the pretreatment mean. Plasma urea and creatinine concentrations did not alter. Six weeks after the cessation of fluoride treatment, the mean serum osteocalcin concentration had returned to the pretreatment baseline. We conclude that fluoride administration in normal subjects over a short period increases serum osteocalcin concentration and probably stimulates osteoblastic activity.

journal_name

Clin Endocrinol (Oxf)

journal_title

Clinical endocrinology

authors

Dandona P,Coumar A,Gill DS,Bell J,Thomas M

doi

10.1111/j.1365-2265.1988.tb02893.x

subject

Has Abstract

pub_date

1988-10-01 00:00:00

pages

437-41

issue

4

eissn

0300-0664

issn

1365-2265

journal_volume

29

pub_type

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