Sodium fluoride stimulates osteocalcin in normal subjects.


:To test whether the administration of sodium fluoride in vivo results in an increase in osteocalcin concentration, we administered sodium fluoride to seven healthy male subjects for a period of 3 weeks. Fasting calcium, phosphate, alkaline phosphatase, 25-hydroxyvitamin D, parathyroid hormone and osteocalcin were measured prior to, during and 6 weeks after fluoride administration. Plasma calcium, phosphate and alkaline phosphatase and serum 25-hydroxyvitamin D and parathyroid hormone concentrations did not alter. Serum osteocalcin concentrations increased following fluoride administration, and the mean osteocalcin concentration at 3 weeks was significantly higher than the pretreatment mean. Plasma urea and creatinine concentrations did not alter. Six weeks after the cessation of fluoride treatment, the mean serum osteocalcin concentration had returned to the pretreatment baseline. We conclude that fluoride administration in normal subjects over a short period increases serum osteocalcin concentration and probably stimulates osteoblastic activity.


Clin Endocrinol (Oxf)


Clinical endocrinology


Dandona P,Coumar A,Gill DS,Bell J,Thomas M




Has Abstract


1988-10-01 00:00:00












  • A new 'total' activin B enzyme-linked immunosorbent assay (ELISA): development and validation for human samples.

    abstract:BACKGROUND AND OBJECTIVE:There are currently no sensitive and specific assays for activin B that could be utilized to study human biological fluids. The aim of this project was to develop and validate a 'total' activin B ELISA for use with human biological fluids and establish concentrations of activin B in the circula...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ludlow H,Phillips DJ,Myers M,McLachlan RI,de Kretser DM,Allan CA,Anderson RA,Groome NP,Hyvönen M,Duncan WC,Muttukrishna S

    更新日期:2009-12-01 00:00:00

  • Testosterone administration increases adrenal response to adrenocorticotrophin.

    abstract:OBJECTIVE:Various studies have demonstrated coexistence of ovarian and adrenal hyperandrogenism in women. This study was designed to determine whether testosterone can increase the response of the adrenal gland to stimulation by adrenocorticotrophin (ACTH). DESIGN:Non-randomized intervention in a university teaching h...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Polderman KH,Gooren LJ,van der Veen EA

    更新日期:1994-05-01 00:00:00

  • Recombinant human luteinizing hormone, lutropin alfa, for the induction of follicular development and pregnancy in profoundly gonadotrophin-deficient women.

    abstract:OBJECTIVE:To provide evidence of efficacy and safety for use of lutropin alfa in inducing follicular development and pregnancy in hypogonadotrophic hypogonadal women with profound gonadotrophin deficiency. DESIGN:An open-label, noncomparative extension of a randomized, double-blind, placebo-controlled study PATIENTS:...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Kaufmann R,Dunn R,Vaughn T,Hughes G,O'Brien F,Hemsey G,Thomson B,O'Dea LS

    更新日期:2007-10-01 00:00:00

  • Functional characterization of calcium sensing receptor polymorphisms and absence of association with indices of calcium homeostasis and bone mineral density.

    abstract:OBJECTIVES:Associations between calcium-sensing receptor (CaSR) polymorphisms and serum calcium, PTH and bone mineral density (BMD) have been reported by six studies. However, three other studies have failed to detect such associations. We therefore further investigated three CaSR coding region polymorphisms (Ala986Ser...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Harding B,Curley AJ,Hannan FM,Christie PT,Bowl MR,Turner JJ,Barber M,Gillham-Nasenya I,Hampson G,Spector TD,Thakker RV

    更新日期:2006-11-01 00:00:00

  • Coagulation and fibrinolytic disturbances are related to carotid intima thickness and arterial blood pressure in Turner syndrome.

    abstract:OBJECTIVE:Turner syndrome (TS) is characterized by growth retardation, hypogonadism and a high risk of cardiovascular complications and atherosclerosis; case reports suggest that thrombo-embolic complications may be present. DESIGN:Cross-sectional study. PATIENTS:Sixty women with TS. MEASUREMENTS:We characterized th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Gravholt CH,Mortensen KH,Andersen NH,Ibsen L,Ingerslev J,Hjerrild BE

    更新日期:2012-05-01 00:00:00

  • Lack of endogenous opioid inhibitory tone on LH secretion in early puberty.

    abstract::Thirteen normal children, seven males and six females, during early puberty (I-II according to Tanner), have been studied. Each subject was injected at weekly intervals and in random order with 100 micrograms of LHRH, 0.2 mg/kg of naloxone and 0.9% saline in single bolus. The gonadotrophin response was evaluated. The ...

    journal_title:Clinical endocrinology

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Fraioli F,Cappa M,Fabbri A,Gnessi L,Moretti C,Borrelli P,Isidori A

    更新日期:1984-03-01 00:00:00

  • Silent subtype 3 pituitary adenoma: a clinicopathologic analysis of the Mayo Clinic experience.

    abstract:BACKGROUND:Macroadenomas represent 50% of pituitary tumours and are often (30%) nonfunctioning. Their immunophenotype suggests differentiation toward a specific pituitary cell line. A substantial proportion of tumours with particularly aggressive behaviour are so called 'silent subtype 3 adenoma'. Its diagnosis require...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Erickson D,Scheithauer B,Atkinson J,Horvath E,Kovacs K,Lloyd RV,Young WF Jr

    更新日期:2009-07-01 00:00:00

  • Thyroid status in various degrees of protein-calorie malnutrition in children.

    abstract::The thyroid functional parameters of 102 children with protein-calorie malnutrition (PCM) classified as undernourished, marasmic, kwashiorkor and marasmic-kwashiorkor were studied by measuring the serum T4, T3, T3 percentage uptake (T3%UT), free thyroxine index (FTI), and (in a few subjects) TSH. Total plasma proteins...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Onuora C,Maharajan G,Singh A,Etta KM

    更新日期:1983-01-01 00:00:00

  • Heart rate variability in pubertal girls with type 1 diabetes: its relationship with glycaemic control, insulin resistance and hyperandrogenism.

    abstract:OBJECTIVE:To examine the association between glycaemic control, insulin resistance and hyperandrogenism on cardiac autonomic function in peripubertal girls with type 1 diabetes. DESIGN:Prospective, clinic-based study of 125 girls with diabetes and 46 age-matched nondiabetic girls. MEASUREMENTS:Heart rate variability ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cho YH,Craig ME,Srinivasan S,Benitez-Aguirre P,Mitchell P,Jopling T,Donaghue KC

    更新日期:2014-06-01 00:00:00

  • Acromegaly.

    abstract::A personal series of 256 cases of acromegaly/gigantism seen over a 20-year period from 1963 is described. The insidious nature of the condition resulted in delay in diagnosis which was often made by a doctor when seeing the patient for an unrelated problem. Other features which commonly led to the diagnosis being made...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章,评审


    authors: Nabarro JD

    更新日期:1987-04-01 00:00:00

  • Ultrastructural and steroidogenic characteristics of an androgen-producing adrenocortical tumour.

    abstract::A 16-year-old female patient with an adrenal tumour was studied. Clinically she had progressive hirsutism, showed high urinary 17-oxosteroid excretion with normal plasma cortisol. Plasma C19-steroids, both unconjugated (including testosterone) and sulphate-conjugated, were greatly elevated. On surgical exploration an ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Huhtaniemi I,Kahri AI,Pelkonen R,Salmenperä M,Sivula A,Vihko R

    更新日期:1978-04-01 00:00:00

  • Inappropriate ACTH concentrations in two patients with functioning adrenocortical carcinoma.

    abstract::Two female patients with functioning adrenocortical carcinomas had plasma ACTH detectable by RIA at presentation. In both patients there was evidence for biological activity of ACTH. There was no evidence for an ectopic source of ACTH, nor for a pituitary tumour. Urinary steroid analysis showed patterns of multiple ho...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Law A,Hague WM,Daly JG,Honour JW,Taylor N,Jeffcoate SL,Himsworth RL,Joplin GF

    更新日期:1988-07-01 00:00:00

  • In papillary thyroid carcinoma BRAFV600E is associated with increased expression of the urokinase plasminogen activator and its cognate receptor, but not with disease-free interval.

    abstract:CONTEXT:It has been suggested that patients with papillary thyroid cancer (PTC) harbouring the BRAF(V600E) mutation have a worse prognosis. We showed in PTC that high levels of urokinase plasminogen activator (uPA) and its cognate receptor (uPAR) inversely correlate with disease-free interval (DFI). OBJECTIVES:To inv...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ulisse S,Baldini E,Sorrenti S,Barollo S,Prinzi N,Catania A,Nesca A,Gnessi L,Pelizzo MR,Mian C,De Vito C,Calvanese A,Palermo S,Persechino S,De Antoni E,D'Armiento M

    更新日期:2012-11-01 00:00:00

  • FHIT and TSG101 in thyroid tumours: aberrant transcripts reflect rare abnormal RNA processing events of uncertain pathogenetic or clinical significance.

    abstract:OBJECTIVE:The chromosomal regions containing the two putative tumour suppressors, fragile histidine triad gene (FHIT) and tumour suppressor gene 101 (TSG101), are deleted frequently in thyroid tumours. We therefore analysed FHIT and TSG101 transcripts in a group of advanced thyroid tumours to establish their role in th...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: McIver B,Grebe SK,Wang L,Hay ID,Yokomizo A,Liu W,Goellner JR,Grant CS,Smith DI,Eberhardt NL

    更新日期:2000-06-01 00:00:00

  • The endocrine evaluation of three children with vasomotor flushes following hypothalamic surgery.

    abstract::Although vasomotor instability or hot flushes are a well-known occurrence in women with natural or artificially-induced menopause, they have not previously been described in children. We report three children in different stages of puberty who developed vasomotor instability following surgery involving the hypothalami...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Witt MF,Blethen SL

    更新日期:1983-06-01 00:00:00

  • Correlation between plasma calcium, parathyroid hormone (PTH) and the metabolic syndrome (MetS) in a community-based cohort of men and women.

    abstract:CONTEXT:In recent years, an association has been noted between several abnormalities that characterize the metabolic syndrome (MetS) and primary hyperparathyroidism (pHPT). These abnormalities include dyslipidaemia, obesity, insulin resistance and hypertension. The correlations between plasma calcium, parathyroid hormo...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ahlström T,Hagström E,Larsson A,Rudberg C,Lind L,Hellman P

    更新日期:2009-11-01 00:00:00

  • The relationship between hCG and relaxin secretion in normal pregnancies vs peri-implantation spontaneous abortions.

    abstract:OBJECTIVE:We determined the ovarian response to human chorionic gonadotrophin (hCG) in terms of relaxin and progesterone secretion during the peri-implantation period of normal and failing pregnancies. We wished to test the hypotheses that relaxin production in failing pregnancies is different from that in normal pregn...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Stewart DR,Overstreet JW,Celniker AC,Hess DL,Cragun JR,Boyers SP,Lasley BL

    更新日期:1993-04-01 00:00:00

  • Serum free cortisol as an ancillary tool in the interpretation of the low-dose 1-μg ACTH test.

    abstract:OBJECTIVE:Serum free cortisol, rather than serum total cortisol (TC), determines glucocorticoid activity in vivo, but how the considerable inter-subject variation in ambient serum free cortisol affects the outcome of dynamic hypothalamic-pituitary-adrenal (HPA) assessment in noncritically ill subjects is unknown. DESI...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Limor R,Tordjman K,Marcus Y,Greenman Y,Osher E,Sofer Y,Stern N

    更新日期:2011-09-01 00:00:00

  • Plasma soluble tumour necrosis factor-alpha receptor 2 is elevated in obesity: specific contribution of visceral adiposity.

    abstract:OBJECTIVE:We examined the obesity phenotype most strongly associated with increased plasma concentrations of sTNFR2, and compared which of the two markers, TNF-alpha or sTNFR2, better predicts indices of plasma glucose-insulin homeostasis. DESIGN, PATIENTS AND MEASUREMENTS:Plasma sTNFR2 levels were measured in a sampl...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Cartier A,Côté M,Bergeron J,Alméras N,Tremblay A,Lemieux I,Després JP

    更新日期:2010-03-01 00:00:00

  • Inhibin B plus LH vs GnRH agonist test for distinguishing constitutional delay of growth and puberty from isolated hypogonadotropic hypogonadism in boys.

    abstract:OBJECTIVE:The distinction between constitutional delay of growth and puberty (CDGP) and isolated hypogonadotropic hypogonadism (IHH) in males with delayed puberty is difficult but important for timely treatment. We assessed the accuracy of the GnRH agonist test (triptorelin 0·1 mg) in comparison with inhibin B alone or...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Binder G,Schweizer R,Blumenstock G,Braun R

    更新日期:2015-01-01 00:00:00

  • Prevalence of clinically silent corticotroph macroadenomas.

    abstract:OBJECTIVE:The prevalence of clinically silent corticotroph macroadenomas is unknown. Our aim was to determine the prevalence of clinically silent corticotroph macroadenomas among all pituitary macroadenomas. DESIGN:Patients scheduled to have transsphenoidal surgery for any sellar mass were prospectively evaluated clin...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Guttenberg KB,Mayson SE,Sawan C,Kharlip J,Lee JY,Martinez-Lage M,Loevner LA,Ewanichak J,Grady MS,Snyder PJ

    更新日期:2016-12-01 00:00:00

  • Cushing's disease due to female gonadotroph adenoma of the pituitary.

    abstract::A 39-year-old woman presented with amenorrhoea, hyperprolactinaemia and sellar mass. Bromocriptine normalized PRL levels but failed to suppress tumour growth. Subsequently, she developed clinical signs and elevated blood cortisol levels consistent with a diagnosis of Cushing's disease. A pituitary tumour was removed w...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Ikeda H,Yoshimoto T,Kovacs K,Horvath E

    更新日期:1995-09-01 00:00:00

  • Effects of in vitro fertilization (IVF) therapies on metabolic, endocrine and inflammatory status in IVF-conceived pregnancy.

    abstract:RATIONALE:In vitro fertilization (IVF) is a common treatment for infertility. In mice, IVF is associated with development of glucose intolerance. However, human data are limited regarding the metabolic, endocrine and inflammatory effects of IVF therapy in IVF-conceived pregnancies. OBJECTIVE:To explore effects of IVF ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Coussa A,Hasan HA,Barber TM

    更新日期:2020-12-01 00:00:00

  • Prevalence of thyroid dysfunction in a Large Southern European Population. Analysis of modulatory factors. The APNA study.

    abstract:CONTEXT:To study the prevalence of thyroid dysfunction in a very large unselected population. OBJECTIVE:To determine the prevalence of abnormal thyroid function and evaluate potential modulatory factors. DESIGN AND SETTING:The Estudio de Atención Primaria de Navarra, The APNA Study, is a cross-sectional study conduct...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Santos Palacios S,Llavero Valero M,Brugos-Larumbe A,Díez JJ,Guillén-Grima F,Galofré JC

    更新日期:2018-09-01 00:00:00

  • Relationship between insulin sensitivity and bone mineral density in primary hyperparathyroidism.

    abstract:INTRODUCTION:Evidence of crosstalk between bone and insulin metabolism has been identified. In primary hyperparathyroidism (PHPT), scant data exist on this relationship. AIM:To evaluate the relationship between insulin levels or sensitivity and bone mineral density (BMD) in PHPT. SUBJECT AND METHODS:Two hundred and s...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Gianotti L,Tassone F,Baffoni C,Pellegrino M,Cassibba S,Castellano E,Magro G,Cesario F,Visconti G,Borretta G

    更新日期:2014-09-01 00:00:00

  • Gender differences in the association of C-reactive protein with coronary artery calcium in type-2 diabetes.

    abstract:OBJECTIVES:Plasma C-reactive protein (CRP) is associated with cardiovascular disease (CVD), but effects may vary by gender and degree of CVD risk. Whether CRP has value as a CVD risk marker in type-2 diabetes (T2DM) is unclear. We examined whether CRP has gender differences in association with coronary artery calcium (...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Qasim AN,Budharaju V,Mehta NN,St Clair C,Farouk S,Braunstein S,Schutta M,Iqbal N,Rader DJ,Reilly MP

    更新日期:2011-01-01 00:00:00

  • Familial isolated primary hyperparathyroidism with parathyroid carcinomas: clinical and molecular features.

    abstract:OBJECTIVE:Familial isolated primary hyperparathyroidism (FIHP) is a rare hereditary disorder. We present four patients from a single family with FIHP, and genetic analysis of their parathyroid adenomas and parathyroid carcinoma. DESIGN:DNA was extracted from tumours resected at surgery. Tumours were examined for loss ...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Yoshimoto K,Endo H,Tsuyuguchi M,Tanaka C,Kimura T,Iwahana H,Kato G,Sano T,Itakura M

    更新日期:1998-01-01 00:00:00

  • Determinants of plasma PTH and their implication for defining a reference interval.

    abstract:BACKGROUND:To improve the diagnostic sensitivity of PTH measurements, more data on the upper limit of the reference interval for PTH levels were requested at a recent international consensus conference. As PTH levels vary inversely with plasma 25-hydroxyvitamin D (25OHD) levels and as vitamin D insufficiency is widespr...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Rejnmark L,Vestergaard P,Heickendorff L,Mosekilde L

    更新日期:2011-01-01 00:00:00

  • Which parameters predict the beneficial effect of GnRHa treatment on height in girls with central precocious puberty?

    abstract:OBJECTIVE:Data about GnRHa on adult height in girls with central precocious puberty(CPP) have shown variable results, ranging from improvement of growth prognosis to lack of any benefit.This study was designed to delineate the criteria to decide which girls with idiopathic CPP(iCPP) will have a height benefit from GnRH...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: Vuralli D,Gonc EN,Ozon ZA,Kandemir N,Alikasifoglu A

    更新日期:2021-01-18 00:00:00

  • Recovery of growth hormone secretion following cabergoline treatment of macroprolactinomas.

    abstract:OBJECTIVE:Cabergoline therapy normalizes prolactin levels and reduces the size of macroprolactinomas. However there are no data indicating whether cabergoline can normalize growth hormone secretion in patients who were growth hormone deficient at the time of diagnosis of a macroprolactinoma. SUBJECTS AND METHODS:We st...

    journal_title:Clinical endocrinology

    pub_type: 杂志文章


    authors: George LD,Nicolau N,Scanlon MF,Davies JS

    更新日期:2000-11-01 00:00:00